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Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-Chun Teoh Chi-Kwok chan Maggie Haitian Wang Chi-Ho Leung eddie Shu-Yin chan Peter Ka-Fung Chiu Chi-Hang Yee Hon-Ming Wong Simon See-Ming Hou Chi-Fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the Hong Kong Special Administrative Region(Hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

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Randomized controlled trial of antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy

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Chinese Medical Journal 2012年第14期125卷 2432-2435页

作者： chan eddie Shu-yin LO Ka-lun NG Chi-fai HOU See-ming YIP Sidney Kam-hung Division of Urology Department of Surgery 4/F. Clinical ScienceBuilding Prince of Wales Hospital Chinese University of HongKong Shatin Hong Kong SAR China

Background A prior study showed aimed to evaluate and compare the transrectal ultrasound-guided prostate Methods A prospective randomized significant antibiotic resistance to quinolone in our population. In this study we efficacy of a single versus a combined prophylactic antibiotic regimen before biopsy （TRUGPB）. study was conducted at a university hospital. Patients undergoing TRUGPB were randomized into an amoxicillin-clavulanate alone （1 mg; one dose before and two doses after biopsy） or an amoxicillin-clavulanate ＋ ciprofloxacin group （250 mg; one dose before and two doses after biopsy）. Patients were surveyed for infection symptoms by phone on days 3 and 30 after TRUGPB. We defined an infective complication as the occurrence of symptoms including fever, chills or rigor within 30 days after prostate biopsy, requiring medical treatment or hospitalization, aided by a territory-wide electronic medical record system. Results Between November 2007 and July 2009, 367 patients were randomized to either amoxicillin-clavulanate alone or amoxicillin-clavulanate ＋ ciprofloxacin group. The infection rates after TRUGPB were 3.91% in the former group （7 out of 179 patients） versus 0.53% （1 out of 188 patients） in the latter. Sixty-three percent （5/8） of patients with infective complications needed hospitalization. There was no intensive care unit admission or mortality during the study period. Conclusions Combining prophylactic antibiotics with amoxicillin-clavulanate ＋ ciprofloxacin significantly reduced the incidence of infective complications after TRUGPB. We recommended a combination regimen, especially in centre with high incidence of post-TRUGPB infection.

关键词： antibiotic prophylaxis, biopsy, prostate, complications

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Validation of an Algorithm based on parameters in Non-Contrast Computerized Tomogram for selection of upper ureteral stone for shock wave lithotripsy

Validation of an Algorithm based on parameters in Non-Contra...

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第十五届全国泌尿外科学术会议

作者： Chi-Fai Ng Annie Wong Deyond Siu Kak-tak Wong eddie chan Department of Surgery and Department of Diagnostic Radiology and Organ Imaging The Chinese University of Hong Kong

Introduction and Objective: There is increase recognition of the role of various parameters measured by non-contrast computerized tomogram (NCCT) in predicting treatment outcomes of urinary stone by shockwave lithotripsy (SWL). In our previous analysis, a clinical algorithm, based on stone volume (SV), mean stone density (MSD) and skin-to-stone distance (SSD), was formulated. (J Urol 2007;177 supp: A1316) Therefore, we would like to use our subsequent patients to validate the usefulness of this algorithm. Methods: After our first part of study, a further prospective collection of data from patients diagnosed to have solitary upper ureteral stone by NCCT and received primary SWL was performed. The primary outcome was the stone free rate at 3-month after one session of SWL by Sonolith 4000+. Pre-treatment NCCT were reviewed by a single radiologist with SV, MSD and SSD measured. These patient parameters were then applied into our algorithm to assess its validity in predicting treatment outcome. Results: 37 patients (24 males and 13 females) were recruited. The overall stone free rate was 45.9%. By applying the algorithms, for patients with either SV ≤ 0.2cc or MSD ≤600 or SDep ≤ 85mm, the stone free rate was 52.2% (95% CI 31.7%, 72.7%). For those patients without any favourable factors, the stone free rate was 35.7% (95% CI 10.6%, 60.8%). Although the difference was not statistically significant, a trend of difference can still be observed in this small sample. Conclusions: Clinical algorithm based on the measurement of stone volume, mean stone density and skin to stone distance from NCCT can help to predict the treatment outcome of SWL in upper ureteral stone.

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Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of Urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So Jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong eddie Shu-Yin chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat Michael Wong Anthony Chi-Fai Ng Yong Loo Lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina Department of Urology Juntendo University Graduate School of MedicineTokyoJapan Department of Urology National University HospitalSingapore Department of Urology Beijing United Family HospitalBeijingChina Department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of Urology Department of SurgeryTuen Mun HospitalHong Kong Department of Urology Ramathibodi HospitalMahidol UniversitySalayaThailand Department of Urology Beijing HospitalBeijingChina Department of Urology Chiangmai Ram HospitalChiang MaiThailand International Urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： The Fundamentals of Laparoscopic Surgery Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

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How does Covid-19 affect global equity markets?

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Financial Innovation 2022年第1期8卷 624-642页

作者： eddie C.M.Hui Ka Kwan Kevin chan ZN744 Department of Building and Real EstateThe Hong Kong Polytechnic UniversityHung HomHong KongChina

This study applies OLS,panel regression and Granger causality test to investigate the impact of the Coronavirus disease 2019(Covid-19)outbreak on the global equity markets during the early stage of the *** find that the Covid-19 outbreak has a significant negative impact on the overall equity index return of the eight economies even at 0.1%significance ***,the pandemic has a more significant impact on the European countries than on the East Asian *** results have three main ***,policy makers should react fast to mitigate the impact of a ***,investors should be aware of an outbreak of disease or other risks and adjust their investments ***,the Covid-19 outbreak results in a shift of power from the west to the east.

关键词： Covid-19 Confirmed cases Panel regression Equity index

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A Provably Secure and Efficient Remote Password Authentication Scheme Using Smart Cards

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Computers, Materials & Continua 2022年第6期71卷 6125-6145页

作者： Fairuz Shohaimay eddie Shahril Ismail Department of Mathematical Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM Bangi43600SelangorMalaysia Department of Mathematics Faculty of Computer and Mathematical SciencesUniversiti Teknologi MARA PahangRaub CampusRaub27600PahangMalaysia

Communication technology has advanced dramatically amid the 21st century,increasing the security risk in safeguarding sensitive *** remote password authentication(RPA)scheme is the simplest cryptosystem that serves as the first line of defence against unauthorised entity *** the literature contains numerous RPA schemes,to the best of the authors’knowledge,only few schemes based on the integer factorisation problem(IFP)and the discrete logarithm problem(DLP)that provided a provision for session key agreement to ensure proper mutual ***,none of the previous schemes provided formal security proof using the random oracle ***,this study proposed an improved RPA scheme with session key establishment between user and *** design of the proposed RPA scheme is based on the widely established Dolev-Yao adversary ***,as the main contribution,a novel formal security analysis based on formal definitions of IFP and DLP under the random oracle model was *** proposed scheme’s performance was compared to that of other similar competitive schemes in terms of the transmission/computational cost and time *** findings revealed that the proposed scheme required higher memory storage costs in smart ***,the proposed scheme is more efficient regarding the transmission cost of login and response messages and the total time complexity compared to other scheme of similar security ***,the proposed scheme outperformed the other RPA schemes based on IFP and ***,the potential application of converting the RPA scheme to a user identification(UI)scheme is considered for future *** RPA and UI schemes are similar,the proposed approach can be expanded to develop a provably secure and efficientUI scheme based on IFP and DLP.

关键词： Authentication scheme discrete logarithm factorisation password provable security

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Liver natural killer cells： subsets and roles in liver immunity

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Cellular & Molecular Immunology 2016年第3期13卷 328-336页

作者： Hui Peng eddie Wisse Zhigang Tian Institute of Immunology and The CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences and Medical Center University of Science and Technology of China Hefei Anhui China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang China Maastricht Multimodal Molecular Imaging Institute Division of Nanoscopy Universiteitssingel 50 Maastricht The Netherlands

The liver represents a frontline immune organ that is constantly exposed to a variety of gut-derived antigens as a result of its unique location and blood supply, With a predominant role in innate immunity, the liver is enriched with various innate immune cells, among which natural killer （NK） cells play important roles in host defense and in maintaining immune balance, Hepatic NK cells were first described as ＇pit cells＇ in the rat liver in the 1970s, Recent studies of NK cells in mouse and human livers have shown that two distinct NK cell subsets, liver-resident NK cells and conventional NK （cNK） cells, are present in this organ, Here, we review liver NK cell subsets in different species, revisiting rat hepatic pit ceils and highlighting recent progress related to resident NK cells in mouse and human livers, and also discuss the dual roles of NK cells in liver immunity,

关键词： conventional NK cell liver liver-resident NK cell pit cell tolerance.

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国际药品监管的发展趋势和契机--《中国新药杂志》专访赛诺菲公司首席注册官及全球注册事务负责人eddie Reilly

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中国新药杂志 2022年第24期31卷 I0007-I0009页

作者： eddie Reilly 赛诺菲公司

《中国新药杂志》:eddie先生您好,我们看到制药企业正在经历着行业内外复杂而深刻的形势变化,能否谈谈您对制药行业总体环境和趋势的看法呢?eddie:您好,很荣幸接受贵刊采访!的确,我们正处在变化之中。众所周知,目前全球人口已达80亿。... 详细信息

《中国新药杂志》:eddie先生您好,我们看到制药企业正在经历着行业内外复杂而深刻的形势变化,能否谈谈您对制药行业总体环境和趋势的看法呢?eddie:您好,很荣幸接受贵刊采访!的确,我们正处在变化之中。众所周知,目前全球人口已达80亿。随着人口增长和其他驱动因素如气候变化、世界多地生活方式的改变(增加了罹患代谢性疾病、肥胖和心血管疾病的风险,且风险持续上升)。

关键词：制药企业制药行业药品监管代谢性疾病心血管疾病总体环境气候变化驱动因素

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Dynamic responses of two buildings connected by viscoelastic dampers under bidirectional earthquake excitations

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 137-150页

作者： Z.D. Yang eddie S.S. Lam Department of Civil and Environmental Engineering The Hong Kong Polytechnic University

In this study,dynamic responses of two buildings connected by viscoelastic dampers under bidirectional excitations are extensively *** two buildings are a 10-story building and a 16-story building,with the shorter building on the *** dampers are installed at all fl oors of the shorter *** of motion are formulated using a fractional derivative model to represent the viscoelastic *** cases are considered with mass eccentricities at 0,10% and-10% with respect to the dimensions of the *** responses of the buildings are numerically predicted at different damper *** simulation results indicated that the maximum horizontal responses of the buildings without eccentricities are signifi cantly ***,torsional effects are adversely *** asymmetric buildings,the effectiveness of the connecting dampers is affected by building *** a result,mass eccentricities must be taken into account in damper *** compared with vibrations induced by unidirectional excitations,bidirectional excitations can increase the responses of coupled asymmetric *** addition,installing dampers only at the top fl oor of the shorter building may cause a sudden change in lateral stiffness of the taller ***,the story shear envelopes of the taller building are changed.

关键词： bidirectional excitations connecting dampers adjacent buildings fractional derivative

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Quantifying cold front induced water transport of a bay with in situ observations using manned and unmanned boats

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Acta Oceanologica Sinica 2018年第11期37卷 1-7页

作者： WEEKS eddie ROBINSON Mark E LI Chunyan Coastal Studies Institute Department of Oceanography and Coastal Sciences Louisiana State University Department of Geography and Anthropology Louisiana State University

The generation of high-resolution data is increasingly important in understanding the complexities of coastal ocean and developing sound management strategies, especially in view of the long-term impact of severe weather systems. The impact of severe weather systems, when integrated over time, can be significant when compared with tidal oscillations. This paper presents a study of water transport out of Vermilion Bay in response to a short, intense event associated with a passing atmospheric cold front, and reports the application of an Acoustic Doppler Current Profiler （ADCP） mounted on an Automated Surface Craft （ASC）, known as the auto-boat or unmanned boat, developed in our lab at the Louisiana State University, to generate high resolution data accurately at a fraction of the cost of a manned boat. In our study, we used a manned boat and an unmanned boat, each for over 24 h to cover an entire diurnal tidal cycle, to measure flow velocity profiles to calculate the total transport. A stationary ADCP was deployed in the Southwest Pass of the Vermilion Bay from May 2009 to April 2012, providing data almost continuously （with only one major gap）, with a 717-day record of water transport between the northern Gulf of Mexico and Vermilion Bay, and demonstrates the importance of the pass in water transport.

关键词： cold fronts unmanned boat Vermillion Bay Acoustic Doppler Current Profiler surveys regression on transport

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