检索结果-南通市图书馆

Acta Mathematica Sinica,English Series 2014年第2期30卷 229-250页

作者： edcarlos domingos da silva Francisco Odair DE PAIVA Universidade Federal de Gois Departamento de Matemtica Universidade Federal de So Carlos Departamento de Matemtica

We establish the existence and multiplicity of solutions for Steklov problems under non- resonance or resonance conditions using variational methods. In our main theorems, we consider a weighted eigenvalue problem of ... 详细信息

关键词： Neumann-Steklov eigenvalue problems resonance Landesman-Lazer conditions

Small-scale self-driving cars:A systematic literature review

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 271-292页

作者： Felipe Caleffi Lauren da silva Rodrigues Joice da silva Stamboroski Brenda Medeiros Pereira Autonomous Vehicles Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil Mobility and Logistics Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil

The autonomous vehicle(AV)technology has the potential to significantly improve safety and efficiency of the transportation and logistics industry.Full-scale AV testing is limited by time,space,and cost,while simulation-based testing often lacks the necessary accuracy of AV and environmental modeling.In recent years,several initiatives have emerged to test autonomous software and hardware on scaled vehicles.This systematic literature review provides an overview of the literature surrounding small-scale self-driving cars,summarizing the current autonomous platforms deployed and focusing on the software and hardware developments in this field.The studies published in English-language journals or conference papers that present small-scale testing of self-driving cars were included.Web of Science,Scopus,Springer Link,Wiley,ACM Digital Library,and TRID databases were used for the literature search.The systematic literature search found 38 eligible studies.Research gaps in the reviewed papers were identified to provide guidance for future research.Some key takeaway emerging from this manuscript are:(i)there is a need to improve the models and neural network architectures used in autonomous driving systems,as most papers present only preliminary results;(ii)increasing datasets and sharing databases can help in developing more reliable control policies and reducing bias and variance in the training process;(iii)small-scaled vehicles to ensure safety is a major benefit,and incorporating data about unsafe driving behaviors and infrastructure problems can improve the accuracy of predictive models.

关键词： Self-driving car Autonomous vehicle Small-scale vehicle Systematic literature review

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第6期48卷 897-904页

作者： CARLOS ALBERTO-silva BRENda RUFINO da silva Natural and Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological proﬁles,allowing for the discovery of new medicinal products and therapeutic applications.This review speciﬁcally examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake venom.It also includes a brief evaluation of short peptides that are being considered as potential therapeutic agents.Proline-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial functions.Three signiﬁcant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces N-methyl-D-aspartate(NMda)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关键词： Neuroprotective peptides Neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides

Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos Rafael silva de Oliveira Patrícia Viera de Oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da silva Júnior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and effluents.Faced with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing processes.As an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile future.Supercritical fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial gains.The main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary chemicals.Despite being still a non-scalable and evolving technology,SFD is the future of dyeing.This review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of SFD.The SFD technique was introduced,along with its latest advances and future perspectives.Financial and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 598-608页

作者： daniella da silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular metabolism.It has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of injury.In this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain injuries.We investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/cm2.As adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory effects.Our findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control group.Interestingly,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal markers.Through biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic factor.Overall,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Effect of Adhesive Type on the Quality of Coconut Shell Charcoal Briquettes Prepared by the Screw Extruder Machine

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第2期12卷 381-396页

作者： Samsudin Anis Deni Fajar Fitriyana Aldias Bahatmaka Muhammad Choirul Anwar Arsyad Zanadin Ramadhan Fajar Chairul Anam Raffanel Adi Permana Ahmad Jazilussurur Hakim Natalino Fonseca da silva Guterres Mateus De Sousa da silva Department of Mechanical Engineering Faculty of EngineeringUniversitas Negeri SemarangGunung patiSemarang50229Indonesia Arka Tama Indonesia Co.Ltd.KarawangWest Java41382Indonesia Department of Mechanical Engineering Dili Institute of TechnologyAi-meti Laran StreetDiliTimor Leste

Indonesia is one of the largest coconut-producing countries in the world.The utilization of coconut shell waste into briquettes will increase the selling value and become a great export opportunity.However,the effect of adhesives on the quality of coconut shell charcoal briquettes made using screw extruder machine has not been widely studied.This study aims to determine the effect of adhesive type on the quality of coconut shell charcoal briquettes.The process of fabricating briquettes in this study included crushing,mixing,blending,pressing,and drying.In the mixing process,3 types of adhesives were used,namely tapioca flour(Briquette_1),cassava flour(Briquette_2),and modified cassava flour(Briquette_3)with a concentration of 5%of the weight of coconut shell charcoal powders.The quality of the resulting briquettes and commercial briquettes will be evaluated by moisture content,ash content,volatile matter,fixed carbon,calorific value,density,compressive,and drop test testing.The results of this research showed that the type of adhesive had a significant effect on the quality of the briquettes produced.Specimen Briquette_1 had better quality than commercial briquettes(Briquette_4)and other briquette specimens.The test results showed that Briquette_1 produced briquettes with better compressive strength and friability than the other specimens,at 6.95 N/mm^(2) and 4.44%,respectively.The moisture content,ash content,fixed carbon,and calorific value of Briquette_1 have met the requirements set by the Indonesian National Standard(SNI)number 01-6235-2000.Meanwhile,the volatile matter content and density of Briquette_1 are by the standards of Japan and the United States America(USA).

关键词： Coconut charcoal briquettes adhesive mixing blending pressing

What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo da silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco Jose Barcellos Sampaio Diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent model.Twenty male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt supplementation.After 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were analyzed.In addition,testicles were collected and processed for histomorphometrical analyses.data were compared using the Student's t-test and considered significant when P

关键词： morphometry testicle Tribulus terrestris

Transarterial embolization is an acceptable bridging therapy to hepatocellular carcinoma prior to liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Transplantation 2024年第2期14卷 126-134页

作者： Gabriel Lazzarotto-da-silva Leandro A Scaffaro Mauricio Farenzena Lucas Prediger Rafaela K silva Flávia Heinz Feier Tomaz J M Grezzana-Filho Pablo D Rodrigues Alexandre de Araujo Mario Reis Alvares-da-silva Roberta C Marchiori Cleber Rosito Pinto Kruel Marcio Fernandes Chedid Department of Liver Transplant and Hepatobiliary Surgery Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Interventional Radiology Unit Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Department of Gastroenterology and Hepatology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil

BACKGROUND Hepatocellular carcinoma(HCC)is an aggressive malignant neoplasm that requires liver transplantation(LT).Despite patients with HCC being prioritized by most organ allocation systems worldwide,they still have to wait for long periods.Locoregional therapies(LRTs)are employed as bridging therapies in patients with HCC awaiting LT.Although largely used in the past,transarterial embolization(TAE)has been replaced by transarterial chemoembolization(TACE).However,the superiority of TACE over TAE has not been consistently shown in the literature.AIM To compare the outcomes of TACE and TAE in patients with HCC awaiting LT.METHODS All consecutive patients with HCC awaiting LT between 2011 and 2020 at a single center were included.All patients underwent LRT with either TACE or TAE.Some patients also underwent percutaneous ethanol injection(PEI),concom-itantly or in different treatment sessions.The choice of LRT for each HCC nodule was determined by a multidisciplinary consensus.The primary outcome was waitlist dropout due to tumor progression,and the secondary outcome was the occurrence of adverse events.In the subset of patients who underwent LT,complete pathological response and post-transplant recurrence-free survival were also assessed.RESULTS Twelve(18.5%)patients in the TACE group(only TACE and TACE+PEI;n=65)and 3(7.9%)patients in the TAE group(only TAE and TAE+PEI;n=38)dropped out of the waitlist due to tumor progression(P log-rank test=0.29).Adverse events occurred in 8(12.3%)and 2(5.3%)patients in the TACE and TAE groups,respectively(P=0.316).Forty-eight(73.8%)of the 65 patients in the TACE group and 29(76.3%)of the 38 patients in the TAE group underwent LT(P=0.818).Among these patients,complete pathological response was detected in 7(14.6%)and 9(31%)patients in the TACE and TAE groups,respectively(P=0.145).Post-LT,HCC recurred in 9(18.8%)and 4(13.8%)patients in the TACE and TAE groups,respectively(P=0.756).Posttransplant recurrence-free survival was similar between the groups(P log-rank test=0.71).CONCL

关键词： Hepatocellular carcinoma Transarterial embolization Transarterial chemoembolization Liver transplantation Locoregional therapy Bridging

Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da silva Abreu Taysse Holanda Joice Farias do Nascimento Henety Nascimento Pinheiro Rachel Menezes Castelo Hélcio silva dos Santos Thais Benincá Patrícia da silva Malheiros Júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing diseases.DB-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous media.Nanoemulsions can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged release.The objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial properties.Results showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion preparation.Nanoemulsions with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive controls.Notably,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive control.CNM nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against S.minnesota and Staphylococcus aureus.The greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

Effect of resistance training volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females:Systematic review and meta-analysis of randomized controlled trials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第2期13卷 145-159页

作者： Paulo Ricardo Prado Nunes Pamela Castro-e-Souza Anselmo Alves de Oliveira Bruno de Freitas Camilo Gislaine Cristina-Souza Lucio Marques Vieira-Souza Marcelo Augusto da silva Carneiro Department of Body and Human Movement Minas Gerais State University(UEMG)37902-092 PassosMGBrazil University Center of Planalto de Araxa(UNIARAXA) 38180-129 AraxaMGBrazil Physical Activity Health and Ageing Research Group(GPASE)Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Exercise and Nutrition Research Group(GPEN) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Sport Sciences and Physical Exercise Study and Research Group(GEPCEEX) Minas Gerais State University(UEMG)37902-092 PassosMGBrazil Metabolism Nutrition and Exercise LaboratoryPhysical Education and Sport CenterLondrina State University(UEL)86050-070 LondrinaPRBrazil Postgraduate Program in Physical Education Federal University of Sergipe(UFS)49107-230 Sao CristovaoSEBrazil

Purpose:This meta-analytical study aimed to explore the effects of resistance training(RT) volume on body adiposity,metabolic risk,and inflammation in postmenopausal and older females.Methods:A systematic search was performed for randomized controlled trials in PubMed,Scopus,Web of Science,and SciELO.Randomized controlled trials with postmenopausal and older females that compared RT effects on body adiposity,metabolic risk,and inflammation with a control group(CG) were included.Independent reviewers selected the studies,extracted the data,and performed the risk of bias and certainty of the evidence(Grading of Recommendations,Assessment,Development,and Evaluation(GRADE)) evaluations.Total body and abdominal adiposity,blood lipids,glucose,and C-reactive protein were included for meta-analysis.A random-effects model,standardized mean difference(Hedges’ g),and 95% confidence interval(95%CI) were used for meta-analysis.Results:Twenty randomized controlled trials(overall risk of bias:some concerns;GRADE:low to very low) with overweight/obese postmenopausal and older females were included.RT groups were divided into low-volume RT(LVRT,~44 sets/week) and high-volume RT(HVRT,~77 sets/week).Both RT groups presented improved body adiposity,metabolic risk,and inflammation when compared to CG.However,HVRT demonstrated higher effect sizes than LVRT for glucose(HVRT=-1.19;95%CI:-1.63 to-0.74;LVRT=-0.78;95%CI:-1.15 to-0.41) and C-reactive protein(HVRT=-1.00;95%CI:-1.32 to-0.67;LVRT=-0.34;95%CI,-0.63 to-0.04)) when compared to CG.Conclusion:Compared to CG,HVRT protocols elicit greater improvements in metabolic risk and inflammation outcomes than LVRT in overweight/obese postmenopausal and older females.

关键词： C-reactive protein Fat mass Lipid profile Menopause Strength training