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Understanding the need for pre-injection from permeability measurements: What is the connection?

Journal of Rock Mechanics and Geotechnical Engineering 2019年第3期11卷 576-597页

作者： Nick Barton eda quadros Nick Barton & Associates OsloNorway BGTech Soil and Rock Engineering Ltd. Sao PauloBrazil

Pre-grouting ahead of tunnels has three main functions:to control water inflow into the tunnel,to limit groundwater drawdown above the tunnel,and to make tunnelling progress more predictable since rock mass quality is effectively *** helps to avoid settlement damage caused by consolidation of clay deposits beneath built-up areas,since towns tend to be built where terrain is more flat,due to the clay *** are so many instances of settlement damage that the profession needs to take note of the need for high-pressure pre-grouting,to use micro-cements and micro-silica *** use of highpressure injection may cause joint jacking,but this is local in extent when the rapid pressure decay away from an injection hole is *** effect is variable and depends on the geometrical parameters of the *** pressure-decay advantage must not be violated by maintaining high pressure when grout flow from the injection hole has *** latter can cause damage to the grouting already *** methods of estimating mean hydraulic apertures(e)from Lugeon testing are described,and from more sophisticated three-dimensional(3D)permeability *** estimation of the larger mean physical joint apertures(E)is based on the joint roughness coefficient(JRC).Comparison is then made with the empirical aperture-particle size criterion E>4d95,where d95 represents almost the largest cement particle *** on joint set orientations and on the available micro-cements,the decision must be made of which range of pre-injection pressure should be aimed for,using successive reductions of the water-cement ratio w/*** simple estimation of permeability,also with depth dependence,can be made with the empirical link between a modified rock mass quality Q and permeability,which is termed *** value of this parameter can be based on core-logging or intunnel face *** 3D before-and-after-grouting permeability measurements have been use

关键词： Pre-grouting Micro-cement Hydraulic apertures Physical joint apertures Joint roughness Particle size Anisotropic permeability

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Modeling and Validation of Base Pressure for Aerodynamic Vehicles Based on Machine Learning Models

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Computer Modeling in Engineering & Sciences 2023年第12期137卷 2331-2352页

作者： Jaimon Dennis quadros Sher Afghan Khan Abdul Aabid Muneer Baig Senior Lecturer of Mechanical Engineering University of BoltonRAK Academic CenterRas Al Khaimah16038UAE Department of Mechanical and Aerospace Engineering Faculty of EngineeringInternational Islamic University MalaysiaSelangor53100Malaysia Department of Engineering Management College of EngineeringPrince Sultan UniversityRiyadh11586Saudi Arabia

The application of abruptly enlarged flows to adjust the drag of aerodynamic vehicles using machine learning models has not been investigated *** process variables(Mach number(M),nozzle pressure ratio(η),area ratio(α),and length to diameter ratio(γ))were numerically explored to address several aspects of this process,namely base pressure(β)and base pressure with cavity(βcav).In this work,the optimal base pressure is determined using the PCA-BAS-ENN based algorithm to modify the base pressure presetting accuracy,thereby regulating the base drag required for smooth flow of aerodynamic *** on the identical dataset,the GA-BP and PSO-BP algorithms are also compared to *** data for training and testing the algorithmswas derived using the regression equation developed using the Box-Behnken Design(BBD).The results show that the PCA-BAS-ENN model delivered highly accurate predictions when compared to the other two *** a result,the advantages of these results are two-fold,providing:(i)a detailed examination of the efficiency of different neural network algorithms in dealing with a genuine aerodynamic problem,and(ii)helpful insights for regulating process variables to improve technological,operational,and financial factors,simultaneously.

关键词： High speed flow Mach number machine learning PCA-BAS-ENN algorithm

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Shock index and its variants as predictors of mortality in severe traumatic brain injury

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World Journal of Critical Care Medicine 2024年第1期13卷 40-48页

作者： Randhall B Carteri Mateus Padilha Silvaine Sasso de quadros Eder Kroeff Cardoso Mateus Grellert Department of Nutrition Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Analysis and Systems Development Centro Universitário CESUCAPorto Alegre 94935-630Brazil Department of Nutrition Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Department of Physiotherapy Hospital Pronto Socorro de Porto AlegrePorto Alegre 90040-192Rio Grande do SulBrazil Institute of Informatics Federal University of Rio Grande do Sul(UFRGS)Porto Alegre 91501-970Rio Grande do SulBrazil

BACKGROUND The increase in severe traumatic brain injury(sTBI)incidence is a worldwide phenomenon,resulting in a heavy disease burden in the public health systems,specifically in emerging *** shock index(SI)is a physiological parameter that indicates cardiovascular status and has been used as a tool to assess the presence and severity of shock,which is increased in *** the high mortality of sTBI,scrutinizing the predictive potential of SI and its variants is *** To describe the predictive potential of SI and its variants in *** This study included 71 patients(61 men and 10 women)divided into two groups:Survival(S;n=49)and Non-survival(NS;n=22).The responses of blood pressure and heart rate(HR)were collected at admission and 48 h after *** SI,reverse SI(rSI),rSI multiplied by the Glasgow Coma Score(rSIG),and Age multiplied SI(AgeSI)were *** comparisons included Shapiro-Wilk tests,and independent samples *** predictive analysis,logistic regression,receiver operator curves(ROC)curves,and area under the curve(AUC)measurements were *** No significant differences between groups were identified for SI,rSI,or *** AgeSI was significantly higher in NS patients at 48 h following admission(S:26.32±14.2,and NS:37.27±17.8;P=0.016).Both the logistic regression and the AUC following ROC curve analysis showed that only AgeSI at 48 h was capable of predicting sTBI *** Although an altered balance between HR and blood pressure can provide insights into the adequacy of oxygen delivery to tissues and the overall cardiac function,only the AgeSI was a viable outcome-predictive tool in sTBI,warranting future research in different cohorts.

关键词： Head trauma Critical patient Neuro-cardio axis Predictive tool Clinical practice

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COVID-19 impact in Crohn’s disease patients submitted to autologous hematopoietic stem cell transplantation

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World Journal of Hematology 2024年第1期11卷 1-8页

作者： Milton Artur Ruiz Roberto Luiz Kaiser Junior Lilian Piron-Ruiz Tainara Souza Pinho Lilian Castiglioni Luiz Gustavo de quadros Department of Bone Marrow Transplantation Associação Portuguesa de BeneficênciaSão Josédo Rio Preto SP 15090470Brazil Department of Surgery Kaiser Hospital DiaSão Josédo Rio Preto 08010-150São PauloBrazil Department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470São PauloBrazil FAMERP Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090000São PauloBrazil Beneficência Portuguesa Hospital ABC Medical SchoolSão Bernardo 15015110São PauloBrazil

BACKGROUND Severe acute respiratory syndrome coronavirus 2 is the virus responsible for coronavirus disease 2019(COVID-19),a disease that has been blamed for inducing or exacerbating symptoms in patients with autoimmune ***'s disease(CD)is an inflammatory bowel disease that affects genetically susceptible patients who develop an abnormal mucosal immune response to the intestinal *** who underwent hematopoietic stem cell transplantation(HSCT)are considered at risk for *** To describe for the first time the impact of COVID-19 in CD patients who had undergone autologous,non-myeloablative *** In this descriptive study a series of 19 patients were diagnosed with positive *** two patients there were reports of the occurrence of two infectious *** related to HSCT,such as time elapsed since the procedure,vaccination status,CD status before and after infection,and clinical manifestations resulting from COVID-19,were *** Among the patients with COVID-19,three,who underwent Auto HSCT less than six months ago,relapsed and one,in addition to the CD symptoms,started to present thyroid impairment with positive *** one of the patients required hospitalization for five days to treat COVID-19 and remained in CD clinical *** patients reported late symptoms that may be related to *** were no deaths,and a statistical evaluation of the series of COVID-19 patients compared to those who did not present any infectious episode did not identify significant differences regarding the analyzed *** Despite the change in CD status in three patients and the presence of nine patients with late symptoms,we can conclude that there was no significant adverse impact concerning COVID-19 in the evaluated patients who underwent HSCT to treat CD.

关键词： Inflammatory bowel disease Crohn disease SARS-CoV-2 COVID-19 Autologous hematopoietic stem cell transplantation Stem cell therapy

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Dendrochronology and climatic signals in the wood of Nectandra oppositifolia from a dense rain forest in southern Brazil

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Journal of Forestry Research 2019年第2期30卷 545-553页

作者： Daniela Granato-Souza Eduardo Adenesky-Filho Karin Esemann-quadros Postgraduate Program in Forestry Regional University of Blumenau-FURB Department of Biological Sciences University of Joinville Region-UNIVILLE

Nectandra is one of the most representative genera of Lauraceae in the subtropical Atlantic Forest of Brazil. The objective of this work was to study the dendrochronological potential of Nectandra oppositifolia Nees and Mart. from two sites in Santa Catarina State in southern Brazil. A tree-ring chronology of 34 trees was developed. The time span ranged from 1843 to 2013. The oldest and youngest trees were 171 and 47 years-old and the average length of the series was 103 years. Average diameter and annual increment were 20.64 cm and0.74 mm a-1; diameter and age were unrelated. The species has good dendrochronological potential with an intercorrelation of 0.61 between sites, indicating the existence of a synchronous pattern in the development of the trees. The climate response of the species could be seen by negative tree growth effects for previous hot and current rainy growth seasons.

关键词： Climate response Dendroclimatology Atlantic forest Growth rings Lauraceae

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Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

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Cancer Communications 2021年第12期41卷 1275-1313页

作者： Valdenizia R.Silva Luciano de S.Santos Rosane B.Dias Claudio A.quadros Daniel P.Bezerra Gonçalo Moniz Institute Oswaldo Cruz Foundation(IGM-FIOCRUZ/BA)SalvadorBahia 40296-710Brazil São Rafael Hospital Rede D’Or/São LuizSalvadorBahia 41253-190Brazil Bahia State University SalvadorBahia 41150-000Brazil

Colorectal cancer(CRC)represents the third most commonly diagnosed cancer and the second leading cause of cancer death *** modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells(CSCs),which present both pluripotency and self-renewal *** cells are considered responsible for the progression of the disease,recurrence and tumor ***,some cell signaling pathways participate in CRC survival,proliferation,and selfrenewal properties,and most of them are dysregulated in CSCs,including the Wingless(Wnt)/β-catenin,Notch,Hedgehog,nuclear factor kappa B(NF-κB),Janus kinase/signal transducer and activator of transcription(JAK/STAT),peroxisome proliferator-activated receptor(PPAR),phosphatidyl-inositol-3-kinase/Akt/mechanistic target of rapamycin(PI3K/Akt/mTOR),and transforming growth factor-β(TGF-β)/Smad *** this review,we summarize the strategies for eradicating CRC stem cells by modulating these dysregulated pathways,which will contribute to the study of potential therapeutic schemes,combining conventional drugs with CSC-targeting drugs,and allowing better cure rates in anti-CRC therapy.

关键词： colorectal cancer stem cells cell signaling Wnt/β-catenin pathway Notch Hedgehog NF-κB JAK/STAT signaling PI3K/Akt/mTOR signaling targeted therapy

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新热带区两种潮虫的生态特征(甲壳纲:等足目)(英文)

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动物学报 2007年第2期53卷 241-249页

作者： Aline Ferreira quadros Paula Beatriz ARAUJO Programa de Pós-Gradua■o em Biologia Animal Departamento de ZoologiaIB Universidade Federal do Rio Grande do Sul Av. Bento Gonalves 9500 pr. 43435 91501-970 Porto AlegreRS Brasil

对体型大小不同的两种陆生等足类动物进行形态特征和行为特征研究,探讨环境变化对其繁殖特征和种群结构的影响。自2004年5月至2005年4月,在巴西Parque Estadual de Itapua进行野外采样,其中每月采集12个凋落物和土壤样品,实验室手拣法... 详细信息

对体型大小不同的两种陆生等足类动物进行形态特征和行为特征研究,探讨环境变化对其繁殖特征和种群结构的影响。自2004年5月至2005年4月,在巴西Parque Estadual de Itapua进行野外采样,其中每月采集12个凋落物和土壤样品,实验室手拣法收集等足类,共获得2540只,同时进行个体性别鉴定与测量。结果表明,Atlantoscia floridana平均密度为114只Pm2,Balloniscus glaber平均密度为133只Pm2。***雌性个体全年可育,***雌性个体只在早春至初夏时段可育,其中春季这两种动物雌性可育个体数量高。2005年夏季干旱,该气候因子对两种动物种群影响存在差异,其中干旱使***种群减少,而***种群基本保持稳定,两种动物间形态结构不同是上述差异的主要原因,尤其是***,特殊的体型和腹肢肺的存在使其更能忍耐干燥。此外,***可能也依赖行为策略适应环境,例如挖掘活动,在不利气候条件下挖掘活动能够增加年轻个体生存的机会,也可能对成年个体起到保护作用。对于***来说,它具有连续繁殖、性成熟时间短和高雌性生育比率的特征。

关键词：新热带区潮虫生态形态类群幼体死亡率忍耐干燥

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Hematopoietic stem cell transplantation for Crohn's disease: Gaps, doubts and perspectives

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World Journal of Stem Cells 2018年第10期10卷 134-137页

作者： Milton Artur Ruiz Roberto Luiz Kaiser Junior Lilian Piron-Ruiz Tatiana Pena-Arciniegas Priscila Samara Saran Luiz Gustavo De quadros Bone Marrow Transplant Department Associaaao Portuguesa de BeneficenciaSao Joseo Rio PretoSP 15090 470Brazil

Crohn's disease(CD) is an inflammatory bowel disease that can affect any site of the digestive system. It occurs due to an immunological imbalance and is responsible for intestinal mucosal lesions and complications such as fistulas and stenoses. Treatment aims to stabilize the disease, reducing the symptoms and healing intestinal lesions. Surgical procedures are common in patients. Cell therapy was initially used to treat this disease in patients who also suffered from lymphoma and leukemia and were considered to be good candidates for autologous and allogeneic transplantation. After transplantation, an improvement was also observed in their CD. In 2003, the procedure began to be used to treat the disease itself, and several case series and randomized studies have been published since then; this approach currently comprises a new option in the treatment of CD. However, considerable doubt along with significant gaps in our knowledge continue to exist in relation to cell therapy for CD. Cell therapy is currently restricted to the autologous modality of hematopoietic stem cell transplantation and, experimentally, to mesenchymal stromal cells to directly treat lesions of the anal mucosa. This article presents the supporting claims for transplantation as well as aspects related to the mobilization regime, conditioning and perspectives of cell therapy.

关键词： Stem cell therapy Hematopoietic stem cell transplantation Treatment Crohn's disease

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Medical,ethical,and legal aspects of hematopoietic stem cell transplantation for Crohn’s disease in Brazil

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World Journal of Stem Cells 2020年第10期12卷 1113-1123页

作者： Milton Artur Ruiz Roberto Luiz Kaiser Junior Lilian Piron-Ruiz Priscila Samara Saran Lilian Castiglioni Luiz Gustavo de quadros Tainara Souza Pinho Richard K Burt Department of Bone Marrow Transplant Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470Brazil Department of Proctology Beneficencia Portuguesa HospitalSão Josédo Rio Preto 15090470Brazil Department of Bone Marrow Transplantation Beneficência Portuguesa HospitalSão Josédo Rio Preto 15090470Brazil Genetics and Molecular Biology FAMERP-Faculdade de Medicina de São Josédo Rio PretoSão Josédo Rio Preto 15090470 Brazil Department of Endoscopy Beneficência Portuguesa HospitalABC Medical SchoolSão Bernardo 15015110Brazil Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

Crohn's disease(CD)is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal *** etiology of CD is unknown;however,genetic,epigenetic,environmental,and lifestyle factors could play an essential role in the onset and establishment of the *** results from immune dysregulation due to loss of the healthy symbiotic relationship between host and intestinal flora and or its *** affects both sexes equally with a male to female ratio of 1.0,and its onset can occur at any age,but the diagnosis is most commonly observed in the range of 20 to 40 years of *** diminishes quality of life,interferes with social activities,traumatizes due to the stigma of incontinence,fistulae,strictures,and colostomies,and in severe cases,affects survival when compared to the general *** fluctuate between periods of remission and activity in which complications such as fistulas,strictures,and the need for bowel resection,surgery,and colostomy implantation make up the most severe aspects of the *** can be progressive and the complications recurrent despite treatment with anti-inflammatory drugs,corticosteroids,immunosuppressants,and biological ***,over time many patients become refractory without treatment alternatives,and in this scenario,hematopoietic stem cell transplantation(HSCT)has emerged as a potential treatment *** rationale for the use of HSCT for CD is anchored in animal studies and human clinical trials where HSCT could reset a patient's immune system by eliminating disease-causing effector cells and upon immune recovery increase regulatory and suppressive immune *** HSCT using a non-myeloablative regimen of cyclophosphamide and anti-thymocyte globulin without CD34+selection has been to date the most common transplant conditioning regimen *** this review we will address the current situation regarding CD treatment with HSCT and emphasize the medical,ethical,and legal aspect

关键词： Crohn disease Hematopoietic stem cell transplant Stem cell therapy Autologous transplant Ethics Treatment

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Synchronic Duodenal Gastrointestinal Stromal Tumor and Neuroendocrine Tumor in Association with Neurofibromatosis Type 1: A Case Report

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Journal of Cancer Therapy 2018年第8期9卷 589-597页

作者： Priscila Doria Claudio Almeida quadros Marcos Lyra Luciano Espinheira Clinical Oncological Division Sao Rafael Hospital Salvador Bahia Brazil Surgical Oncological Team Sao Rafael Hospital Salvador Bahia Brazil Pathological Division Sao Rafael Hospital Salvador Bahia Brazil

Introduction: The coexistence of synchronic duodenal gastrointestinal stromal tumor (GIST) and neuroendocrine tumor in a patient with neurofibromatosis type 1 (NF1) is extremely rare, and only eight cases were described in the literature. Clinical Case: This is a rare case of a 38-year-old female patient with NF1 who developed synchronic GIST and neuroendocrine tumor, which were both in the second portion of the duodenum. The first symptoms were abrupt digestive bleeding and anemia. Upper digestive endoscopy revealed two tumors, sizes 2.5 and 3.0 cm, in the second portion of duodenum, with biopsies identifying a GIST and a neuroendocrine tumor. Therapeutic decision was to proceed to surgical resection, and Whipple’s procedure was indicated. Surgical procedure was performed with good outcome. Currently the patient has excellent quality of life and maintains follow up for thirty months without recurrence. Discussion: Long-term disease-free survival and excellent quality of life are reported when these tumors are fully resected in this context. However, it is not always easy to access the gastrointestinal tract, especially the small intestine, and proceed to the histopathologic diagnosis of these tumors. Conclusion: It is important to be aware of the possibility of the coexistence of various tumors in the NF1 scenario for adequate screening, staging, and surgical treatment of these patients, as good prognosis can be achieved when such tumors are detected and treated properly.

关键词： Gastrointestinal Stromal Tumor GIST Neuroendocrine Tumor Neurofibromatosis NF1 Von Recklinghausen’s Disease

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