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Does shifting to professional emergency department staffing affect the decision for chest radiography?

World Journal of Emergency Medicine 2021年第2期12卷 87-92页

作者： Marin Pavlov Lucija Klobucar Iva Klobučar Kristinazgela Vesna Degoricija Department of Cardiology Sestre Milosrdnice University Hospital CentreZagreb 10000Croatia Institute of Emergency Medicine Osijek-Baranja CountyOsijek 31000Croatia University of Zagreb School of Medicine Zagreb 10000Croatia Department of Medicine Sestre milosrdnice University Hospital CentreZagreb 10000Croatia

BACKGROUnD: The study aims to determine whether shifting to professional emergency department(ed) teams leads to a higher rate of radiologic ***: We retrospectively analyzed a total of 2,000 patients presenting to the ed of a tertiary teaching hospital in two time periods: group 1(G1) comprised 1,000 consecutive patients enrolled from December 21, 2012 to January 5, 2013(all patients were examined by an internal medicine specialist);group 2(G2) comprised 1,000 consecutive patients enrolled from December 21, 2018 to January 3, 2019(all patients were examined by an emergency physician).RESULTS: The chest X-ray(CXR) was performed in 40.6% of all patients. There was no difference in the frequency of CXR(38.9% in G1 vs. 42.3% in G2, P=0.152). More CXRs were performed in G2 patients older than 65 years, in female patients older than 65 years, in patients presenting during the evening and night shifts or off-hours, in patients with a history of malignancy, in patients with gastrointestinal bleeding, and in patients with bradycardia, but fewer in patients presenting with arrhythmia. no difference in the rates of pathological CXR was found(47.3% in G1 vs. 52.2% in G2, P=0.186). Compared with G2, higher sensitivity and specificity were obtained for the binary logistic regression model predicting pathological findings in ***: Shifting to professional ed teams does not increase radiologic workup. By implementing deliberate usage of ultrasound, some self-governing procedures, case-oriented investigations, and center-specific recommendations, unnecessary radiologic workup can be avoided. Professional ed teams could lead to a higher standard of emergency care.

关键词： Chest radiography Emergency department Emergency physicians Healthcare organization

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体质量状态变化与高血压发生的相关性

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中华高血压杂志 2016年第6期24卷 581-583页

作者： Parker ed Sinaiko ar Kharbanda EO Margolis KL Daley MF Trower nK Sherwood nE Greenspan LC Lo JC Magid DJ o'connor pj

在美国近1/3的儿童和青少年是肥胖或超重的。虽然最近该比值保持稳定,但在过去40年中则呈快速上升的趋势。儿童肥胖与高血压显著相关。主要在初中和高中学生中进行的流行病学调查研究报道,高血压的发病率在0.8%～3.2%,而在肥胖学生中高... 详细信息

在美国近1/3的儿童和青少年是肥胖或超重的。虽然最近该比值保持稳定,但在过去40年中则呈快速上升的趋势。儿童肥胖与高血压显著相关。主要在初中和高中学生中进行的流行病学调查研究报道,高血压的发病率在0.8%～3.2%,而在肥胖学生中高血压发病率则〉10％。在大型的医疗保健系统门诊和小学儿童中进行的一项研究报道显示，正常体质量的儿童高血压总发病率为0．3％～0．9％，肥胖儿童为1．0％～9．2％。

关键词：正常体质量百分位数流行病学调查儿童肥胖就诊次数正常高值血压肥胖儿童儿童期肥胖状态变化质量指数

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Early social context does not influence behavioral variation at adulthood in ants

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Current Zoology 2022年第3期68卷 335-344页

作者： Iago SAnMarTÍn-VILLar Raphaël JEAnSOn Centre de Recherches Sur la Cognition Animale Centre de Biologie IntégrativeUniversitéde ToulouseCNRSUPSToulouseFrance Universidade de Vigo ECOEVO LabEscola de Enxeñaría ForestalCampus A XunqueiraPontevedraSpain

Early experience can prepare offspring to adapt their behaviors to the environment they are likely to encounter later in life. In several species of ants, colonies show ontogenic changes in the brood-to-worker ratio that are known to have an impact on worker morphology. However, little information is available on the influence of fluctuations in the early social context on the expression of behavior in adulthood. Using the ant Lasius niger, we tested whether the brood-to-worker ratio during larval stages influenced the level of behavioral variability at adult stages. We raised batches of 20 or 180 larvae in the presence of 60 workers until adulthood. We then quantified the activity level and wall-following tendency of callow workers on 10 successive trials to test the prediction that larvae reared under a high brood-to-worker ratio should show greater behavioral variations. We found that manipulation of the brood-to-worker ratio influenced the duration of development and the size of individuals at emergence. We detected no influence of early social context on the level of between- or within-individual variation measured for individual activity level or on wall-following behavior. Our study suggests that behavioral traits may be more canalized than morphological traits.

关键词： brood care canalization locomotion metamorphosis ontogeny variability

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肺动脉高压患者脂肪酸代谢异常与右心室脂毒性的关系

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中华高血压杂志 2016年第4期24卷 399-399页

作者： Brittain EL Talati M Fessel JP Zhu H Penner n Calcutt MW West J Funke M Lewis GD Gerszten RE Hamid R Pugh ME Austin ed newman JH Hemnes ar 刘莉叶鹏

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,... 详细信息

肺动脉高压（pulmonary arterial hypertension,PAH）中右心衰竭的机制尚未完全阐明。在PAH动物实验模型中发现脂肪酸代谢异常,然而,还没有研究针对人类PAH的全身和心肌脂肪酸代谢情况进行分析。方法与结果：获取人类血液和右心室组织,应用无创成像检测PAH患者及对照人群脂肪酸代谢途径不同阶段的特点。与对照组比较,PAH患者循环游离脂肪酸和长链酰基肉碱水平升高;右心室长链脂肪酸增加,长链酰基肉碱显著减少。

关键词：脂肪酸代谢长链酰基肉碱肺动脉高压右心室脂毒性长链脂肪酸动物实验模型右心衰竭三酰甘油水平脂肪变性

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Pharmacological characterizationof synthetic cannabinoid MAM-2201：radioligand binding and abuse-related effects

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中国药理学与毒理学杂志 2017年第10期31卷 1016-1017页

作者： William E FAnTEGROSSI Aaron JAnOWSKY Amy J ESHLEMAn Lauren n RUSSELL Saki FUKUDA Jyoti GOGOI Cassandra PRIOLEAU Ambuja S BALE Srihari R TELLA Merle G PAULE Takato HIRAnITA Department of Pharmacology and Toxicology College of Medicine University of Arkansas for Medical Sciences AR 72207 Division of neurotoxicology National Center for Toxicological Research Food and Drug Administration AR 72079 Departments of Psychiatry and Behavioral neuroscience Oregon Health & Science University Portland OR 97239-3098 VA Portland Health Care System Portland OR 97239 Drug and Chemical Evaluation Section Drug Enforcement Administration

OBJECTIVE Over 30% of all new psychoactive substances identified by the Un Office on Drugs and Crime in 2016 were synthetic *** recent emergence of MAM-2201 on the illicit market is troubling because this drug has no precedent in either the scientific or patent literature,and appears to be a novel compound developed specifically as a "graymarket" drug of abuse bystructurally combining the known synthetic cannabinoids JWH-122 and *** is currently no published information regarding the pharmacology of *** The present studies characterized cannabinoid-like effects of MAM-2201 in vitro(interactions with cannabinoid type 1 receptors[CB1 Rs]) and in vivo(in mice and rats).RESULTS In a radioligand binding assay using [3 H]CP55,940 in HEK cell membranes transfected with the CB1 R,MAM-2201(K i=5.4 nmol·L^(-1)),had higher binding affinity than WIn 55,212-2(K i=80 nmol·L^(-1)),and D9-THC(K i=8.3 nmol·L^(-1)).The E max values for MAM-2201 and WIn 55,212-2 in an assay of agonist inhibition of forskolin-stimulated c AMP were 85%(EC50=0.45 nmol·L^(-1)) and 95%,respectively,as compared with the D9-THC E max of 74%.In mice,MAM-2201(0.003-1.0 mg·kg^(-1),IP) produced dose-dependent cannabimimetic effects which were both more potent and more effective than those of ***-2201 and D9-THC dose-dependently produced hypothermia:ed50=0.287 and 25.4 mg·kg^(-1),analgesia:ed50=0.125 and 29.4 mg·kg^(-1),and catalepsy:ed50=0.301 and18.9 mg·kg^(-1) in adult male CD1 ***,MAM-2201 also elicited convulsant effects at a dose of 1.0 mg·kg^(-1) in 8/8 murine *** rats,MAM-2201 produced dose-dependent D9-THC-like interoceptive effects in subjects trained to discriminate 3.0 mg·kg^(-1)(IP) D9-THC from *** MAM-2201 binds CB1 Rs with high affinity and agonist efficacy,and functions as a potent cannabinoid agonist in vivo across several complementary measures of cannabinoid activity in two rodent species.

关键词： cannabinoid CB1 receptor behavior abuse liability

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晶体超声乳化术后隐匿性前房金属碎片易被误诊为慢性难治性术后炎症反应

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 29-30页

作者： Stangos A.n. Pournaras C.J. Petropoulos I.K. 刘玮 Division of Op hthalmology Department of Clinical Neurosciences University Hospitals of Genev a 22 Alcide-Jentzer 1211 Geneva Switzerland Dr.

PURPOSE: To report a case of an occult, metallic, anterior-chamber intraocula r foreign body after uneventful phacoemulsification that was masquerading as chr onic recalcitrant postoperative inflammation. DESIGn: Interventional case report . METHODS: A 73-year-old patient was referred to us for recalcitrant anterior -chamber inflammation after uneventful phacoemulsification; the patient present ed with visual disturbances, anterior-chamber inflammation, and macular epireti nal membrane with concomitant cystoid macular edema. RESULTS: After meticulous e valuations and repeated clinical examinations, a metallic intraocular foreign bo dy was discovered on the iris, which was surgically removed and analyzed. Chemic al analysis revealed copper, aluminum, and zinc. Pars plana vitrectomy with epir etinal membrane and indocyaninegreen-assisted internal limiting membrane peelin g followed, with subsequent improvement of visual acuity. COnCLUSIOnS: Intraocul ar foreign bodies should always be considered in the differential diagnosis of r ecalcitrant inflammation postphacoemulsification. However, in the absence of int raocular inflammation, surgical removal of such particles is questionable.

关键词：超声乳化术术后炎症反应隐匿性玻璃体切除术内界膜睫状体平坦部黄斑视网膜前膜黄斑囊样水肿眼内异物干预性

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Temporal Periods and Duration of Formation of Cu-Mo Porphyry Deposits(Siberia and Mongolia)

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Global Geology 1999年第2期4卷 187-191页

作者： Sotnikov V.I., Ponomarchuk V.A., Berzina A.n., Berzina A.P., Kiseleva V.Yu. and Shevchenko D.O. (United Institute of Geology, Geophysics and Mineralogy, novosibirsk, 630090, Russia)

Copper-molybdenum porphyry deposits of Russia (Sib eria) and Mongolia were formed within the interaction zone of the Siberian conti nent with Paleo-As ian (Pt 2-Pz 2), Paleo-Tethys (Pz 3) and Mongolo-Okhotsk (Pz 2-Mz) ocean s. Ore-beari ng magmatic (porphyry) complexes, which are closely associated in time and space with Cu-Mo mineralization, are represented by small stocks (up to 1 km 2) and numerous dikes of basic to acid composition. Rb-Sr and 40 ar/ 39 ar dating fix three temporal periods of activity o f ore-form ing process within Siberia and Mongolia which resulted in a wide appearance of C u-Mo porphyry mineralization. A series of large-scale deposits was formed at t ha t time: 1) Early Devonian (Mo-porphyry Sora deposit, Kuznetsk-Alatau; Cu-Mo- porp hyry Aksug deposit, Tuva), 2) Triassic (Cu-Mo-porphyry Erdenetuin-Obo, northe rn Mongolia), 3) Late Jurassic (Cu-Mo-porphyry Zhireken and Shakhtama deposits, Eastern Transbaikalia). The deposits of small size were formed between these periods (Cu-Mo-porphyry Tsagan-Suburga, Cu-porphyry Kharmagtai deposits in Southern Mongolia, etc.). C u- Mo-porphyry deposits within Siberia and Mongolia as a whole were formed with a regular periodicity at 20～30 Ma intervals. Large copper-molybdenum porphyry deposits are characterized by the manifestat ion of multiple ore-forming processes which are related to separate pulses of o r e-bearing magmatism. Three pulses of ore-bearing magmatism are established at th e large scale Erdenetuin-Obo deposit: I-250～240 Ma, II-225～220 Ma, III-225 ～195 M a. Every magmatic pulse is accompanied by ore mineralization. The Erdenet ore di strict includes three deposits of different sizes. Large-scale deposits are in principle multi-stage formations. They are charac terized by the repeated manifestation of ore-bearing magmatism and the ore-for mi ng processes during the long period of geological time within a relatively limit ed space.

关键词： Cu-Mo-porphyry deposits temporal periods sources of matter large -scale deposits

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芽孢杆菌SPA3β-葡聚糖酶基因在大肠杆菌中的表达

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上海交通大学学报（农业科学版） 2004年第3期22卷 277-280页

作者：李卫芬许梓荣吕文平孙建义浙江大学动物科学学院教育部动物分子营养学重点实验室杭州310029

将含β-葡聚糖酶基因的重组克隆载体进行亚克隆,用BamHⅠ和XhoⅠ双酶切后,与相同酶切的表达载体pET-30a相连接,构建重组表达载体,在大肠杆菌BL21中表达,蛋白质电泳结果表明在25.0KD处有表达带,酶活力达85.9U·mL-1,为出发菌的31多倍。

关键词：芽孢杆菌 β-葡聚糖酶大肠杆菌基因表达

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疑似阿尔茨海默病患者不自觉认知功能缺陷(认知功能病感失认)的对照研究

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 50-50页

作者： Barrett A.M. Eslinger P.J. Ballentine n.H. Heilman K.M. 邓剑平 Kess ler Med. Rehab. Res./educ. Corp. 1199 Pleasant Valley Way West Orange NJ 07052 United States Dr.

Objective: To develop a quantitative method of assessing cognitive anosognosia in six cognitive and two noncognitive ***: Control (n =32) and prob able Alzheimer disease(pAD) (n = 14) subjects self-estimated memory, attention, generative behavior, naming, visuospatial skill, limb praxis, mood,and uncorrec ted vision, both before and after these abilities were assessed. Based on this e stimate and their performance the authors calculated an anosognosia ratio (ar) b y dividing the difference between estimated and actual performance by an estimat ed and actual performance sum. With perfect awareness,ar = 0. Overestimating abi lities would yield a positive ar (≤1); underestimation would yield a negative A R (≥-1). Results: Relative to controls, pAD subjects demonstrated anosognosia. Pre-testing (off-line), pAD subjects overestimated their visuospatial skill; p ost-testing (on-line), pAD subjects overestimated their memory. Control subjec ts also made selfrating errors, underestimating their attention pre-testing and overestimating limb praxis and vision post-testing. Conclusions:This anosognos ia assessment method may allow more detailed examination of distorted self-awar eness. These results suggest that screening for anosognosia in probable Alzheime r disease (pAD) should include self-estimates of visuospatial function, and tha t, in pAD, it may be useful to assess anosognosia for amnesia both before and af ter memory testing.

关键词：认知功能阿尔茨海默病失认病感记忆测试视觉空间过高估计矫正视力不自觉自我评价

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