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Change in quality of life after transcatheter aortic valve implantation and aortic valve replacement surgery in Australian patients aged ≥ 75 years： the effects of EuroSCORE and patient operability

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Journal of Geriatric Cardiology 2015年第1期12卷 30-36页

作者： Phillip J. Tully Prakash Roshan Greg D Rice Ajay Sinhal Jayme S Bennetts Robert A baker Cardiac Surgery Research Department of Surgery School of Medicine Flinders University of South Australia Bedford Park 5042 Australia Freemasons Foundation Centre for Men 's Health Discipline of Medicine School of Medicine University of Adelaide North Terrace Adelaide 5005 Australia brd Park 5042 Australia Department of Cardiac and Thoracic Surgery Flinders Medical Centre Level 6 Flinders Private Hospital Bedford Park 5042 Australia

Objective To determine the extent to which differences in generic quality of life （QOL） between transcatheter aortic valve implanta- tion （TAVI） and surgical aortic valve replacement （AVR） patients explained by EuroSCORE and heart-team operability assessment. Methods A total of 146 high-risk patients with EuroSCORE 〉 6 and aged 〉 75 years underwent TAVI （n = 80） or aortic valve replacement （n = 66） between February 2010 and July 2013. A total of 75 patients also completed preoperative and six month SF-12 QOL measures. Analyses examined incident major morbidity, compared six month QOL between groups adjusted for EUroSCORE and operability, and quantified rates of clinically significant QOL improvement and deterioration. Results The AVR group required longer ventilation （〉 24 h）（TAVI 5.0% vs. AVR 20.6%, P = 0.004） and more units of red blood cells [TAVI 0 （0-1） vs. AVR 2 （0-3）, P = 0.01]. New renal failure was higher in TAVI （TAVI 5.0% vs. AVR 0%, P = 0.06）. TAVI patients reported significantly lower vitality （P = 0.01） by comparison to AVR patients, however these findings were no longer significant after adjustment for operability. In both procedures, clinically significant QOL improvement was common [range 25.0% （general health） - 62.9% （physical role）] whereas deterioration in QOL occurred less frequently [range 9.3% （physical role） - 33.3% （mental health）]. Conclusions Clinically significant improvement and deterioration in QOL was evident at six months in high risk elderly aortic valve replacement patients. Overall QOL did not differ between TAVI and AVR once operability was taken into consideration.

关键词： Aortic valve replacement Cardiac surgery EuroSCORE Transcatheter aortic valve implantation Quality of life

Understanding the impact of disease and vaccine mechanisms on the importance of optimal vaccine allocation

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Infectious Disease Modelling 2023年第2期8卷 539-550页

作者： Isobel R.Abell James M.McCaw Christopher M.baker School of Mathematics and Statistics The University of MelbourneMelbourneAustralia Melbourne Centre for Data Science The University of MelbourneMelbourneAustralia Centre for Epidemiology and Biostatistics Melbourne School of Population and Global HealthThe University of MelbourneMelbourneAustralia Peter Doherty Institute for Infection and Immunity The Royal Melbourne Hospital and the University of MelbourneMelbourneAustralia Centre of Excellence for Biosecurity Risk Analysis The University of MelbourneMelbourneAustralia

Vaccination is an important epidemic intervention ***,it is generally unclear how the outcomes of different vaccine strategies change depending on population characteristics,vaccine mechanisms and allocation *** this paper we develop a conceptual mathematical model to simulate strategies for pre-epidemic *** extend the SEIR model to incorporate a range of vaccine mechanisms and disease *** then compare the outcomes of optimal and suboptimal vaccination strategies for three public health objectives(total infections,total symptomatic infections and total deaths)using numerical *** comparison shows that the difference in outcomes between vaccinating optimally and suboptimally depends on vaccine mechanisms,disease characteristics,and objective *** modelling finds vaccines that impact transmission produce better outcomes as transmission is reduced for all *** vaccines that impact the likelihood of symptomatic disease or dying due to infection,the improvement in outcome as we decrease these variables is dependent on the strategy *** a principled model-based process,this work highlights the importance of designing effective vaccine allocation *** conclude that efficient allocation of resources can be just as crucial to the success of a vaccination strategy as the vaccine effectiveness and/or amount of vaccines available.

关键词： Mathematical modelling Epidemiology

The role of phase impurities and lattice defects on the electron dynamics and photochemistry of CuFeO2 solar photocathodes

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Nano Research 2019年第9期12卷 2390-2399页

作者： Elizabeth A. Fugate Somnath Biswas Mathew C. Clement Minkyu Kim Dongjoon Kim Aravind Asthagiri L. Robert baker Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOH 43210USA Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA

CuFeO2 is a promising photocathode for H2 evolution and CO2 reduction *** better understand the complex defect chemistry and role of impurity phases in this material and their effect on the photochemical performance,we employ visible light transient absorption spectroscopy and density functional theory(DFT)calculations to investigate the electron dynamics in electrochemically deposited Cu-Fe oxide thin *** analysis of carrier lifetime shows a fast,sub-ps contribution to relaxation followed by persistence of a Iong-lived state to time delays greater than 2 *** amplitude of the Iong-lived state is shown to correlate with the rate of fast initial relaxation,and this is explained in terms of a competition between charge carrier trapping and charge *** separation in CuFeO2 occurs via hole thermalizati on from O 2p to Cu 3d vale nee band states leadi ng to segregatio n of electr ons and holes across layers in the CuFeO2 *** between transient absorption measurements and DFT calculations suggest that Cu vacancies enhanee photochemical performance by facilitating charge separation *** contrast,O interstitials are predicted to switch the relative positions of O 2p and Cu 3d vale nee band states,which would in hibit charge separatio n by in ter-band hole thermal izatio *** ally,we find no evide nee for electron in jecti on from CuFeO2 to CuO suggest!ng that charge separati on at this heterostructure in terface does not play a role in the carrier lifetime or photochemical performance of the catalysts studied here.

关键词： delafossite CuFeO2 charge-carrier dynamics transient absorption spectroscopy Cu vacancy O interstitial

Tourismification and Integration of Buganda＇s Culture in Community Socio-economic Activities for Poverty Reduction and Sustainable Development

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Journal of Environmental Science and Engineering(A) 2017年第2期6卷 98-109页

作者： Jockey baker Department of Forestry Biodiversity and Tourism School of Forestry Environment and Geographical Sciences College of Agriculture and Environmental Sciences Makerere University Kampala 7062 Uganda

Buganda, one of oldest kingdoms in Uganda, has got a rich tangible and non-tangible cultural heritage which can be devetoped into cultural tourism products and integrated in the community socio-economic activities for national sustainable development. The paper highlights the major cultural heritage of Buganda, its development for tourism, integration in the daily socio-economic activities of the communities and contribution to SDGs （Sustainable Development Goals）. Buganda＇s culture include the Kings （Kabakas） burial grounds, Kabaka＇s lake and trail, music, dance, drama, handicrafts, traditions and food which provide an authentic cultural tourism product which compliments Uganda＇s nature tourism. Community participation and provide employment opportunities to the youth and women there by returning the tourism dollar to the community and this is important for sustainable development. The tourismification of Buganda＇s culture shall not only diversify Uganda＇s tourism industry but contribute to national sustainable development.

关键词： Tourismification integration culture sustainability tourism development.

Tangible Results in China's Eco-Environmental Protection

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China Today 2022年第10期71卷 66-68页

作者： JOHN baker WildAid

I have been working in the wildlife conservation and environmental protection field for nearly 40 ***2013 to before the outbreak of the COVID-19 pandemic,I visited China for one or two months every year,working with my Chinese colleagues,and visiting and learning from NGO peers,researchers,government agencies,and media *** this time I also personally experienced and witnessed the process of China’s sustainable development and a society that became more conscious about conservation.

关键词： partner visiting witnessed

Phosphorylation of Izumo1 and its role in male nfertility

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Asian Journal of Andrology 2015年第5期17卷 708-710,I0005页

作者： Samantha AM Young John Aitken Mark A baker priority Research Centre in Reproductive Science Discipline of Biological Sciences Faculty of Science and IT University of Newcastle Callaghan NSW Australia Animal Resource Centre for Infectious Diseases Research Institute for Microbial Diseases Osaka University Suita Osaka Japan

Izumol is a testis-specific gene product, whose function is essential for sperm-egg fusion. Throughout its lifespan, Izumol is posttranslationally modified, being both N-linked glycosylated on its extracellular domain and phosphorylated on the intracellular C-terminal tail. Within the caput regions of the rat epididymis, two phosphorylation events have been documented. However, as sperm pass through the epididymis, this cytoplasmic portion of Izumol has been shown to contain up to seven phosphorylation sites. Remarkably, in the rat, in correlation with these events, Izumol undergoes sub-cellular re-location, moving from the head/tail regions of the spermatozoa, to a predominantly equatorial segment location once they have reached the caudal end of the epididymis.

关键词： epididymis Izumol LC-MS phosphorylation proteomics

微粒对多晶冰及冰川流变行为的影响——(Ⅰ)基于位错的弛豫模型

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地球物理学报 2007年第1期50卷 126-130页

作者：宋旼 David M.Cole Ian baker 中南大学粉末冶金国家重点实验室 US Army Cold Regions Research and Engineering Laboratory Hanover NH03755U.S.A. Thayer School of Engineering Dartmouth CollegeHanover NH03755U.S.A.

为量化冰及冰川在流变过程中位错密度随流变应力的变化,发展了一个基于位错的非线性弛豫模型.模型的计算表明:在冰的指数蠕变阶段,滞弹性试验所形成的应力/应变滞后环的宽度与面积随流变应力的增加呈线性增加,位错密度随流变应力的增加... 详细信息

为量化冰及冰川在流变过程中位错密度随流变应力的变化,发展了一个基于位错的非线性弛豫模型.模型的计算表明:在冰的指数蠕变阶段,滞弹性试验所形成的应力/应变滞后环的宽度与面积随流变应力的增加呈线性增加,位错密度随流变应力的增加呈平方增加;在冰的线性蠕变阶段,滞弹性试验所形成的应力/应变滞后环的宽度、面积和位错密度保持不变.

关键词：冰与冰川位错弛豫流变非线性模型

Burden of injuries and diseases in Yunnan Tin Miners

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Chinese Medical Journal 2003年第6期116卷 957-958页

作者： TimothyD.baker QIAOYoulin YAOShuxiang DepartmentofInternationalHealth SchoolofPublicHealthJohnsHopkinsUniversity615N.WolfeStreetBaltimoreMaryland21205，USA DepartmentofCancerEpidemiology CancerInstituteChineseAcademyofMedicalSciencesBeijing100021China LaborProtectionInstitute YunnanTinCorporationYunnan66100China

The burden of injuries is underestimated to an evengreater extent in developing countries than inindustrialized countries. The objective of this paper is toanalyze injuries and diseases in the monitored work place

关键词： burden of diseases· burden of injures·potential productive years of life lost·radon arsenic·lung cancer

Identification of predictive MRI and functional biomarkers in a pediatric piglet traumatic brain injury model

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Neural Regeneration Research 2021年第2期16卷 338-344页

作者： Hongzhi Wang Emily W.baker Abhyuday Mandal Ramana M.Pidaparti Franklin D.West Holly A.Kinder Department of Statistics University of GeorgiaAthensGAUSA Regenerative Bioscience Center University of GeorgiaAthensGAUSA Department of Animal and Dairy Science University of GeorgiaAthensGAUSA College of Engineering University of GeorgiaAthensGAUSA

Traumatic brain injury(TBI) at a young age can lead to the development of long-term functional impairments. Severity of injury is well demonstrated to have a strong influence on the extent of functional impairments;however, identification of specific magnetic resonance imaging(MRI) biomarkers that are most reflective of injury severity and functional prognosis remain elusive. Therefore, the objective of this study was to utilize advanced statistical approaches to identify clinically relevant MRI biomarkers and predict functional outcomes using MRI metrics in a translational large animal piglet TBI model. TBI was induced via controlled cortical impact and multiparametric MRI was performed at 24 hours and 12 weeks post-TBI using T1-weighted, T2-weighted, T2-weighted fluid attenuated inversion recovery, diffusion-weighted imaging, and diffusion tensor imaging. Changes in spatiotemporal gait parameters were also assessed using an automated gait mat at 24 hours and 12 weeks post-TBI. Principal component analysis was performed to determine the MRI metrics and spatiotemporal gait parameters that explain the largest sources of variation within the datasets. We found that linear combinations of lesion size and midline shift acquired using T2-weighted imaging explained most of the variability of the data at both 24 hours and 12 weeks post-TBI. In addition, linear combinations of velocity, cadence, and stride length were found to explain most of the gait data variability at 24 hours and 12 weeks post-TBI. Linear regression analysis was performed to determine if MRI metrics are predictive of changes in gait. We found that both lesion size and midline shift are significantly correlated with decreases in stride and step length. These results from this study provide an important first step at identifying relevant MRI and functional biomarkers that are predictive of functional outcomes in a clinically relevant piglet TBI model. This study was approved by the University of Georgia I

关键词： controlled cortical impact gait analysis linear regression magnetic resonance imaging motor function pediatric pig model principal component analysis traumatic brain injury