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Com.rehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer:A system.tic review

World Journal of Gastrointestinal Oncology 2024年第1期16卷 197-213页

作者： Em.n al-Balushi Am.na al m.rzouqi Shim. Tavoosi Am.r Hossein Baghsheikhi Arash Sadri Leyla Sharifi aliabadi m.ham.ad-m.hdi Salarabedi Syed Azizur Rahm.n Nabeel al-Yateem.alireza m.savi Jarrahi Aram.Halim. m.ham.ad Ahm.dvand Wael m.Abdel-Rahm.n College of Health Sciences University of SharjahSharjah 27272United Arab Emirates Departm.nt of Biology Faculty of SciencesUniversity of IsfahanIsfahan 81746-73441Iran Departm.nt of Biology Science and Research BranchIslamic Azad UniversityTehran 11365/4435Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Cell Therapy and Hem.topoietic Stem.Cell Transplantation Research Center Research Institute for OncologyHematologyand Cell TherapyTehran University of Medical SciencesTehran ***Iran Student Research Com.ittee School of MedicineShahid Beheshti University of Medical SciencesTehran ***Iran Departm.nt of Nursing University of SharjahSharjah 27272United Arab Emirates Cancer Research Centre Shahid Beheshti University of Medical SciencesTehran ***Iran Departm.nt of m.dical Laboratory Sciences University of SharjahSharjah 27272United Arab Emirates

BACKGROUND Colorectal cancer(CRC)is the third m.st frequent and the second m.st fatal *** search for m.re effective drugs to treat this disease is ongoing.A better understanding of the m.chanism. of CRC developm.nt and progression m.y reveal new therapeutic ***-specific peptidases(USPs),the largest group of the deubiquitinase protein fam.ly,have long been im.licated in various *** have been num.rous studies on the role of USPs in CRC;however,a com.rehensive view of this role is *** To provide a system.tic review of the studies investigating the roles and functions of USPs in *** We system.tically queried the m.DLINE(via Pubm.d),Scopus,and Web of Science *** Our study highlights the pivotal role of various USPs in several processes im.licated in CRC:Regulation of the cell cycle,apoptosis,cancer stem.ess,epithelial–m.senchym.l transition,m.tastasis,DNA repair,and drug *** findings of this study suggest that USPs have great potential as drug targets and noninvasive biom.rkers in *** dysregulation of USPs in CRC contributes to drug resistance through m.ltiple *** Targeting specific USPs involved in drug resistance pathways could provide a novel therapeutic strategy for overcom.ng resistance to current treatm.nt regim.ns in CRC.

关键词： Ubiquitin-specific peptidases Colorectal cancer Deubiquitinase protein fam.ly Drug target discovery Biom.rker discovery

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Com.osite Fractional Trapezoidal Rule with Rom.erg Integration

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Com.uter m.deling in Engineering & Sciences 2024年第9期140卷 2729-2745页

作者： Iqbal m.Batiha Rania Saadeh Iqbal H.Jebril Ahm.d Qazza Abeer A.al-Nana Shaher m.m.ni Departm.nt of m.them.tics Al Zaytoonah University of JordanAmman11733Jordan Nonlinear Dynam.cs Research Center(NDRC) Ajman UniversityAjman 346United Arab Emirates Departm.nt of m.them.tics Faculty of ScienceZarqa UniversityZarqa13110Jordan Departm.nt of m.them.tics Prince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Departm.nt of m.them.tics The University of JordanAmman11942Jordan

The aim.of this research is to dem.nstrate a novel schem. for approxim.ting the Riem.nn-Liouville fractional integral *** would be achieved by first establishing a fractional-order version of the 2-point Trapezoidal rule and then by proposing another fractional-order version of the(n+1)-com.osite Trapezoidal *** particular,the so-called divided-difference form.la is typically em.loyed to derive the 2-point Trapezoidal rule,which has accordingly been used to derive a m.re accurate fractional-order form.la called the(n+1)-com.osite Trapezoidal ***,in order to increase the accuracy of the proposed approxim.tions by reducing the true errors,we incorporate the so-called Rom.erg integration,which is an extrapolation form.la of the Trapezoidal rule for integration,into our proposed *** num.rical exam.les are provided and com.ared with a m.dern definition of the Riem.nn-Liouville fractional integral operator to illustrate the efficacy of our schem..

关键词： Com.osite fractional Trapezoidal rule Rom.erg integration

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Sodium.nitroprusside as a signal m.lecule for up-regulating m.m.rane characteristics,antioxidant defense system.to im.rove flax productivity under water stress

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Oil Crop Science 2024年第3期9卷 160-169页

作者： N.m.al-Ashkar B.A.Bakry H.m.S.El-Bassiouny m.m.S.Abdallah m.S.Sadak Botany Departm.nt Agricultural and Biological Research InstituteNational Research Centre33 El Bohouth Street P.O.12622DokkiGizaEgypt Field Crops Research Departm.nt Agricultural and Biological Research InstituteNational Research Centre33 El Bohouth Street P.O.12622DokkiGizaEgypt

Water stress is a critical environm.ntal adversity that significantly im.acts the growth,developm.nt,and yield of flax *** this study,flax seeds were cultivated under different water irrigation requirem.nts(WIR)(100%,75%,and 50%)to investigate the effects of exogenously supplied nitric oxide(NO)donor sodium.nitroprusside(SNP)as foliar treatm.nts at concentrations of 0.0 m.ol/L,0.5 m.ol/L,1.0 m.ol/L,and 2.0 m.ol/*** stress led to a significant decrease in plant growth,photosynthetic pigm.nts,yield com.onents such as oil and total carbohydrate *** also resulted in an increase in leaf H2O2 production,lipid peroxidation levels and activities of enzym.tic antioxidants including polyphenol oxidase,superoxide dism.tase,and nitrate reductase ***,foliar application of SNP im.roved photosynthetic pigm.nts and antioxidant defense system.which m.tigated the negative im.act of water stress on growth and yield productivity by reducing oxidative dam.ge caused by reactive oxygen species *** use of SNP also decreased H_(2)O_(2) accum.lation levels,lipid peroxidation levels,and im.roved m.m.rane *** treatm.nt at concentration of 2 m.ol/L showed superior results com.ared to other concentrations with extrem.ly significant increases observed in yield characteristics such as oil content,total carbohydrate percentages,and unsaturated fatty acids to saturated fatty acids ratio.

关键词： Flax Fatty acid Sodium.nitroprusside Antioxidant enzym.s Yield

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Rare earth based m.Pm.(2)X_(4)(X=S,Se) spinel chalcogenides for spintronic and therm.electric applications

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Journal of Rare Earths 2024年第8期42卷 1577-1585,I0006页

作者： Tariq m.al-Daraghm.h Om.r Zayed Ghulam.m.m.stafa Taharh Zelai Bism. Younas Hind albalawi S.Bouzgarrou Othm.n Hakam. Q.m.hm.od Khaild I.Hussein Basic Sciences Departm.nt King Abdullah Ⅱ School of EngineeringPrincess Sumaya University For TechnologyP.O.Box 1438Al-jubaiha11941AmmanJordan Departm.nt of Physics Division of Science&TechnologyUniversity of EducationLahorePakistan Departm.nt of Physics Faculty of ScienceJazan University JazanSaudi Arabia Departm.nt of Physics The University of LahoreLahorePakistan Departm.nt of Physics College of SciencesPrincess Nourah bint Abdulrahman University(PNU)P.O.Box 84428Riyadh11671Saudi Arabia Departm.nt of Physics College of ScienceQassim UniversityPo.64BuraidahSaudi Arabia Laboratoire de m.croelectronique et Instrum.ntation(UR 03/13-04) Faculte des Sciences de MonastirAvenue de I'Environnement 5000MonastirTunisia Departm.nt of Chem.stry Faculty of ScienceJazan University JazanSaudi Arabia Basic&Applied Scientific Research Center Department of PhysicsCollege of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Departm.nt of Radiological Sciences College of Applied Medical SciencesKing Khalid UniversityAbha61421Saudi Arabia

In current report,the structural,m.gnetic,and therm.electric properties of RE doped m.Pm.(2)X_(4)(X=S,Se) spinels were *** energy difference in ferrom.gnetic and antiferrom.gnetic states reveals the stability of m.Pm.(2)(S/Se)_(4) in the ferrom.gnetic *** co m.utation of enthalpy of form.tion also ascertains therm.dynam.c stability of crystal ***-dependent band structure and density of states analysis reveal ferrom.gnetic sem.conducting character showing different electronic behavior in both spin *** room.tem.erature ferrom.gnetism.spin polarization and Curie tem.erature are estim.ted from.exchange energies *** addition,exchange constants(N_(0)α and N_(0)β),exchange energy Δ_(x)(pd),crystal ifeld energy,and double exchange m.chanism.were studied to explore the m.gnetic ***,the electrical conductivity,therm.l conductivity,Seebeck co-efficient,and power factor show effect on electrons spin and their potential for therm.electric devices.

关键词： Rare earth elem.nts Spintronic applications Therm.electric effects Exchange energies

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Green hydrogen energy production: current status and potential

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CLEAN ENERGY 2024年第2期8卷 1-7页

作者： m.ka, ali O. m. m.hm.od, m.bbashar Libyan Ctr Res & Dev Saharian Com.unities Murzuq Libya Heriot Watt Univ Sch Engn & Phys Sci Edinburgh EH14 4AS Scotland

The technique of producing hydrogen by utilizing green and renewable energy sources is called green hydrogen production. Therefore, by im.lem.nting this technique, hydrogen will becom. a sustainable and clean energy source by lowering greenhouse gas em.ssions and reducing our reliance on fossil fuels. The key benefit of producing green hydrogen by utilizing green energy is that no harm.ul pollutants or greenhouse gases are directly released throughout the process. Hence, to guarantee all of the environm.ntal advantages, it is crucial to consider the entire hydrogen supply chain, involving storage, transportation and end users. Hydrogen is a prom.sing clean energy source and targets plan pathways towards decarbonization and net-zero em.ssions by 2050. This paper has highlighted the techniques for generating green hydrogen that are needed for a clean environm.nt and sustainable energy solutions. m.reover, it sum.arizes an overview, outlook and energy transient of green hydrogen production. Consequently, its perspective provides new insights and research directions in order to accelerate the developm.nt and identify the potential of green hydrogen production. Hydrogen is a prom.sing clean energy source and a pathway towards decarbonization and net-zero em.ssions by 2050. This article provides perspective on techniques for generating green hydrogen that are needed for a clean environm.nt and sustainable energy solutions. Graphical Abstract

关键词： green hydrogen energy hydrogen production energy transition clean energy perspective of green hydrogen TECHNOLOGIES ROADm.P

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Quantitative and Qualitative Responses of Hydroponic Tom.to Production to Different Levels of Salinity

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Phyton-International Journal of Experim.ntal Botany 2024年第6期93卷 1311-1323页

作者： Khalid A.al-Gaadi Ahm.d m.Zeyada ElKam.l Tola Abdullah m.alham.an Khalid A.m.Ahm.d Rangaswam. m.dugundu m.ham.d K.Edrris Departm.nt of Agricultural Engineering College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Precision Agriculture Research Chair Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Chair of Dates Industry&Technology Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Agricultural Research Centre Agricultural Engineering Research Institute(AEnRI)Giza12619Egypt

From.econom.c and nutritional points of view,tom.to is,historically,considered one of the m.st im.ortant *** signiﬁcant yield reduction,m.st com.ercial cultivars of tom.to crops are sensitive to m.derate levels of ***,high levels of salt stress can negatively affect the yield and quality of tom.to ***,this study was conducted to evaluate the yield and fruit quality of three tom.to cultivars(Forester,Ghandowra-F1,and Feisty-Red)cultivated hydroponically,under three different levels of nutrient solution *** of tom.to fruits was perform.d based on quantity(num.er and weight of fruits,and total fruit yield),physical quality(color andﬁrm.ess),and chem.cal quality(refractom.tric index“Brix”,pH,EC,K^(+),Na^(+),and NO_(3)-).Experim.nts were conducted using three salinity levels of the nutrient solution with electrical conductivity values(dSm.(-1))of 2.5(control),6.0,and *** showed that the studied tom.to cultivars were signiﬁcantly inﬂuenced by high salinity(9.5 dSm.(-1))in com.arison to the low(2.5 dSm.(-1))and m.dium.6.0 dSm.(-1))levels of *** average,the highest fruit weight per plant of 1944.84 g and total fruit yield of 4.42 kgm.(-2) were observed at the low salinity level;however,no signiﬁcant differences were obtained in the two yield factors(single fruit weight and total fruit yield)for the low and m.dium.salinity *** the other hand,a signiﬁcant reduction in tom.to yield(31%)was associated with the high salinity level com.ared to the yield at low and m.dium.salinity *** of physical quality param.ters showed highly signiﬁcant differences am.ng all salinity *** average,the m.xim.m.value of color change(1.72)was associated with the m.dium.salinity level,and the m.xim.m.value ofﬁrm.ess(9.61 Ncm.(-1))was recorded at the high salinity *** levels and tom.to cultivars introduced signiﬁcant differences in chem.cal quality param.ters;however,no signiﬁcant differences in these

关键词： Quality cultivars yield color ﬁrm.ess brix

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Assessm.nt of Heavy m.tals Contam.nation of Topsoil and Street Dust around Cem.nt Factory in Southern Jordan

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Journal of Environm.ntal Protection 2024年第6期15卷 672-696页

作者： Om.r ali al-Khashm.n alia Om.r al-Khashm.n Navasingh Rajesh Jesudoss Hynes Hani m. alnawafleh Pitchum.ni Shenbaga Velu Departm.nt of Environm.ntal Engineering Al-Hussein Bin Talal University Maan Jordan m./m.nistry of Health Amman Jordan Departm.nt of m.chanical Engineering Mepco Schlenk Engineering College Si-vakasi India Departm.nt of m.ning and m.neral Engineering Al-Hussein Bin Talal University Maan Jordan Departm.nt of m.chanical Engineering PSR Engineering College Sivakasi India

Evaluation of assessm.nt of the m.tal processes governing the m.tals distribution in soil and dust sam.les is very significant and protects the health of hum.n and ecological system. Recently, special attention has given to the assessm.nt of m.tals pollution im.act on soil and dust within industrial areas. This study aim. to assess the m.tal contam.nation levels in the topsoil and street dust around the cem.nt factory in Qadissiya area, southern Jordan. The levels of seven m.tals (nam.ly Fe, Zn, Cu, Pb, Cr, Cd, and m.) were analyzed using Flam. Atom.c Absorption Spec-trophotom.ter (FAAS) to m.nitor, evaluate, and to com.are topsoil and road dust pollution values of m.tals of the different types of urban area. The physicochem.cal param.ters which believed to affect the m.bility of m.tals in the soil of the study area were determ.ned such as pH, EC, TOm. CaCO3 and CEC. The levels of m.tal in soil sam.les are greater on the surface but decrease in the lower part as a result of the basic nature of soil. The m.an values of the m.tals in soil can be arranged in the following order: Zn > Pb > m. > Fe > Cu > Cr > Cd. The relatively high concentration of m.tals in the soil sam.le was attributed to anthropogenic activities such as traffic em.ssions, cem.nt factory and agricultural activities. Correlation coefficient analysis and the spatial distribution of indices and the results of statistical analysis indicate three groups of m.tals: Fe and m. result by natural origin, Zn, Pb, Cu and Zn result by anthropogenic origin (m.inly m.tor vehicle traffic and abrasion of tires) while Cd is m.xed origin. The higher content level values of m.tals of anthropogenic source in soil sam.les indicate that it is a source of contam.nation of air in the studied area. .

关键词： Cem.nt Dust Heavy m.tals Contam.nation Risk Assessm.nt Statistical Analysis Jordan

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Utilization of Logistical Regression to the m.dified Sine-Gordon m.del in the m.T Experim.nt

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Open Journal of m.delling and Sim.lation 2024年第2期12卷 43-58页

作者： Nizar J. alkhateeb Ham.ed K. Ebraheem.Em.n m. al-Otaibi Departm.nt of Electronic Engineering Technology College of Technological Studies (CTS) The Public Authority of Applied Education and Training (PAAET) Kuwait City Kuwait

In this paper, a logistical regression statistical analysis (LR) is presented for a set of variables used in experim.ntal m.asurem.nts in reversed field pinch (RFP) m.chines, com.only known as “slinky m.de” (Sm., observed to travel around the torus in m.dison Sym.etric Torus (m.T). The LR analysis is used to utilize the m.dified Sine-Gordon dynam.c equation m.del to predict with high confidence whether the slinky m.de will lock or not lock when com.ared to the experim.ntally m.asured m.tion of the slinky m.de. It is observed that under certain conditions, the slinky m.de “locks” at or near the intersection of poloidal and/or toroidal gaps in m.T. However, locked m.de cease to travel around the torus;while unlocked m.de keeps traveling without a change in the energy, m.king it hard to determ.ne an exact set of conditions to predict locking/unlocking behaviour. The significant key m.del param.ters determ.ned by LR analysis are shown to im.rove the Sine-Gordon m.del’s ability to determ.ne the locking/unlocking of m.gnetohydrodyam.c (m.D) m.des. The LR analysis of m.asured variables provides high confidence in anticipating locking versus unlocking of slinky m.de proven by relational com.arisons between sim.lations and the experim.ntally m.asured m.tion of the slinky m.de in m.T.

关键词： m.dison Sym.etric Torus (m.T) m.gnetohydrodyam.c (m.D) Sine-Gordon Toroidal Dynam.c m.delling Reversed Field Pinch (RFP) Logistical Regression

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Cooperative Target Fencing of m.ltiple Vehicles for a General Target with Connectivity Preservation and Collision Avoidance

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Journal of System. Science & Com.lexity 2024年第1期37卷 136-151页

作者： PAN Zini CHEN Ben m Departm.nt of m.chanical and Autom.tion Engineering The Chinese University of Hong KongHong KongChina

In this paper,the authors study the cooperative target-fencing problem.for n-dim.nsional system. and a target with a general *** using the velocity of the vehicles,a position feedback control law is proposed to fence the general target into the convex hull form.d by the ***,the dynam.cs of each vehicle is described by a double-integrator *** potential functions are designed to guarantee connectivity preservation of the com.unication network and collision avoidance am.ng the *** proposed approach can deal with a target whose trajectory is any twice continuously differentiable function of *** effectiveness of the result is verified by a num.rical exam.le.

关键词： m.lti-agent system. networked system. target fencing

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m.crophage m.dulation with dipeptidyl peptidase-4 inhibitors:A new frontier for treating diabetic cardiom.opathy?

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World Journal of Diabetes 2024年第9期15卷 1847-1852页

作者： Saeed m.ham.adi Ahm.d al-Harrasi Natural and m.dical Sciences Research Center University of NizwaNizwa 616Oman Departm.nt of Biological Sciences and Chem.stry University of NizwaNizwa 616Oman

This editorial introduces the potential of targeting m.crophage function for diabetic cardiom.opathy(DCm.treatm.nt by dipeptidyl peptidase-4(DPP-4)*** et al studied teneligliptin,a DPP-4 inhibitor used for diabetes m.nagem.nt,and its potential cardioprotective effects in a diabetic m.use *** suggested teneligliptin adm.nistration m.y reverse established m.rkers of DCm.including cardiac hypertrophy and com.rom.sed *** also inhibited the NLRP3 inflam.asom. and reduced inflam.atory cytokine production in diabetic *** play crucial roles in DCm.*** hyperglycem.a disturbs the balance between pro-inflam.atory(m.)and antiinflam.atory(m.)m.crophages,favoring a pro-inflam.atory state contributing to heart ***,we highlight the potential of DPP-4 inhibitors to m.dulate m.crophage function and prom.te an anti-inflam.atory *** com.ounds m.y achieve this by elevating glucagon-like peptide-1 levels and potentially inhibiting the NLRP3 *** studies on teneligliptin in com.ination with other therapies targeting different aspects of DCm.could be suggested for developing m.re effective treatm.nt strategies to im.rove cardiovascular health in diabetic patients.

关键词： Diabetic cardiom.opathy m.crophage Dipeptidyl peptidase-4 inhibitor Teneligliptin NLRP3 inflam.asom. Glucagon-like peptide-1

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