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SARS-CoV-2 infection rates after different vaccination schemes:An online survey in Turkey

Asian Pacific Journal of Tropical Medicine 2022年第4期15卷 171-178页

作者： Oya Baydar Toprak Sennur Ozen Berker ozturk Burcu ozturk ebru ozturk Mehmet Kitapci Nurdan Kokturk Chest Diseases Department Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Delta HospitalIstanbulTurkey Chest Diseases Department Aksaray Training and Research HospitalAksarayTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Hacettepe UniversityAnkaraTurkey Department of Nuclear Medicine Integra Medical Imaging CenterAnkaraTurkey

Objective:To identify effects of various nationwide vaccination protocols on the evolution of new SARS-CoV-2 infections among adult population and to evaluate the safety of mRNA(BioNTech/Pfizer)***:Totally 10735 adult volunteers that received at least one dose of BioNTech/Pfizer or triple doses of CoronaVac participated in this cross-sectional-online survey between 1 and 10 September *** information was collected covering a 5-month period from April 2021 to September *** about people who were vaccinated with only single and double dose CoronaVac were not included in this ***:At least one side effect after single and double dose of BioNTech/Pfizer and triple doses of CoronaVac were observed in 42.1%,42.5%and 10.9%,*** most common side effects were shoulder/arm pain,weakness/fatigue,muscle/joint pain and *** side effects were the most frequent in single BioNTech/Pfizer,while it was the least in triple *** rate of positive PCR tests before vaccination was 17.6%,and decreased to 3.0%after *** rates of positive SARS CoV-2-PCR were 18.8%,3.5%,3.1%,0.5%and 4.6%in single BioNTech/Pfizer,double BioNTech/Pfizer,double CoronaVac+single BioNTech/Pfizer,double CoronaVac+double BioNTech/Pfizer and triple CoronaVac,*** 1.8%of PCR positive COVID-19 cases needed intensive unit care in the pre-vaccination period,intensive care unit was required in 0%,1.5%,2.4%,0%and 4.2%after single BioNTech/Pfizer,double BioNTech/Pfizer,double CoronaVac+single BioNTech/Pfizer,double CoronaVac+double BioNTech/Pfizer and triple CoronaVac,*** rate after vaccination was 0.4%.Conclusions:The rarity of COVID-19 infection after vaccination suggests that efficacy of vaccines is *** the other hand,the data underscore the critical importance of continued public health mitigation.

关键词： mRNA vaccine COVID-19 SARS-CoV-2 Vaccine schemes Reinfection Positivity rate after vaccination

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Risk scoring model for prediction of non-home discharge after transcatheter aortic valve replacement

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Journal of Geriatric Cardiology 2020年第10期17卷 621-627页

作者： Alexis K Okoh ebru ozturk Justin Gold Emaad Siddiqui Nehal Dhaduk Bruce Haik Chun-Guang CHEN Marc Cohen Mark J Russo Cardiovascular Outcomes Research Institute RWJ Barnabas Health-NBIMCNewarkNew JerseyUSA Department of Medicine Division of BiostatisticsHacettepe UniversityAnkaraTurkey Rutgers New Jersey Medical School NewarkNew JerseyUSA Department of Surgery Division of Cardiothoracic SurgeryRutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA

Background Patients undergoing transcatheter aortic valve replacement(TAVR) are likely to be discharged to a location other than home. We aimed to determine the association between preoperative risk factors and non-home discharge after TAVR. Methods Patients discharged alive after TAVR at three centers were identified from a prospectively maintained database randomly divided into 80% derivation and 20% validation cohorts. Logistic regression models were fit to identify preoperative factors associated with non-home discharge in the derivation cohort. Multivariable models were developed and a nomogram based risk-scoring system was developed for use in preoperative counseling. Results Between June 2012 and December 2018, a total of 1,163 patients had TAVR at three centers. Thirty-seven patients who died before discharge were excluded. Of the remaining 1,126 patients(97%) who were discharged alive, the incidence of non-home discharge was 25.6%(n = 289). The patient population was randomly divided into the 80%(n = 900) derivation cohort and 20%(n = 226) validation cohort. Mean ± SD age of the study population was 83 ± 8 years. In multivariable analysis, factors that were significantly associated with non-home discharge were extreme age, female sex, higher STS scores, use of general anesthesia, elective procedures, chronic liver disease, non-transfemoral approach and postoperative complications. The unbiased estimate of the C-index was 0.81 and the model had excellent calibration. Conclusions One out of every four patients undergoing TAVR is discharged to a location other than home. Identification of preoperative factors associated with non-home discharge can assist patient counseling and postoperative disposition planning.

关键词： Aortic valve replacement Non-home discharge Postoperative risk Transcatheter Transfemoral

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