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Preparation and Characterization of IPN Microspheres for Controlled Delivery of Naproxen

Journal of Biomaterials and Nanobiotechnology 2011年第4期2卷 445-453页

作者： ebru kondolot solak 不详

Interpenetrating network (IPN) microspheres of sodium alginate (NaAlg) and poly (vinyl alcohol) (PVA) were prepared and crosslinked with glutaraldehyde (GA) by using the water in oil (W/O) emulsification method to deliver naproxen sodium (NS). NS was successfully encapsulated into IPN microspheres in different ratios of NaAlg and PVA (w/w), drug loading percentage (w/w) and crosslinking time. Crosslink density of the matrices was affected by the time of crosslinker. The prepared microspheres were characterized by Fourier transform infrared spectroscopy (FTIR). Pictures of selected microspheres were determined using optic microscope. Results confirmed the dispersion of NS in the microspheres. Release of NS from the microspheres was investigated in pH 1.2, 6.8 and 7.4 media for two hours respectively. The highest NS release was obtained as 92% (w/w) by using UV spectroscopy. Equilibrium swelling was performed in pH 7.4 buffer solution at 37℃.

关键词： Controlled Release Microspheres Alginate

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Separation Performance of Sodium Alginate/Poly(Vinyl Pyrrolidone)Membranes for Aqueous/Dimethylformamide Mixtures by Vapor Permeation and Vapor Permeation with Temperature Difference Methods

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Advances in Chemical Engineering and Science 2011年第4期1卷 305-312页

作者： ebru kondolot solak Oya Sanli Department of Cemistry and Chemical Processing Technology Atatürk Vocational High SchoolGazi UniversityTeknikokullarAnkaraTurkey Faculty of Science Department of ChemistryGazi UniversityTeknikokullarAnkaraTurkey

In this study sodium alginate (NaAlg)/poly (vinyl pyrrolidone) (PVP) blend membranes were prepared and crosslinked with CaCl2 (0.1 Molarity (M)) for the separation of aqueous/dimethylformamide (DMF) mixtures. Membranes were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and their performance was examined by varying experimental parameters such as feed composition (0 - 100 wt%), operating temperature (30℃ - 50℃) and membrane thickness (30 - 90 micrometer (μm)). Blending NaAlg with PVP, decreased separation factor whereas increased the permeation rate as the permeation temperature was increased in Vapor Permeation (VP) and Vapor Permeation with Temperature Difference (TDVP) methods. In the TDVP method, the separation factors increased and the permeation rates decreased as the temperature of the membrane surrounding is decreased. The highest separation factor of 60 was obtained in TDVP method for 90 wt% DMF concentration in the feed.

关键词： Vapor Permeation Sodium Alginate Dimethylformamide Membrane Poly(Vinyl Pyrrolidone)

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Release of Anticancer Drug 5-Fluorouracil from Different Ionically Crosslinked Alginate Beads

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Journal of Biomaterials and Nanobiotechnology 2012年第4期3卷 469-479页

作者： Merve Olukman Oya Sanli ebru kondolot solak Department of Chemistry Faculty of ScienceGazi UniversityAnkaraTurkey Department of Chemistry and Chemical Processing Technology Ataturk Vocational High SchoolGazi UniversityAnkaraTurkey

In this research;the release of 5-Fluorouracil (5-FU) from different ionically crosslinked alginate (Alg) beads was investigated by using Fe3+, Al3+, Zn2+, and Ca2+, ions as crosslinking agent. The prepared beads were characterized by Fourier Transform Infrared Spectroscopy (FTIR) Differential Scanning Calorimetry (DSC) and Scanning Electron Micros-copy (SEM). The drug release studies were carried out at three pH values 1.2, 6.8 and 7.4 respectively each for two hours. The effects of the preparation conditions as crosslinker type, drug/polymer (w/w) ratio, crosslinker concentration and time of exposure to crosslinker on the release of 5-FU were investigated for 6 hours at 37℃. It was observed that 5-FU release from the beads followed the order of Fe > Zn > Al > Ca-Alg and increased with increasing drug/polymer ratio. At the end of 6 hours, the highest 5-FU release was found to be 90% (w/w) for Fe-Alg beads at the drug/polymer ratio of 1/8 (w/w), crosslinker concentration of 0.05 M, exposure time of 10 minutes respectively. The swelling measurements of the beads supported the release results. Release kinetics was described by Fickian and non-Fickian approaches.

关键词： Anticancer Drug pH Responsive Release Alginate Ionically Crosslinking Controlled Release 5-Fluorouracil

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Preparation and Characterization of IPN Microspheres for Controlled Delivery of Naproxen

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Journal of Biomaterials and Nanobiotechnology（生物材料与纳米技术） 2011年第4期

作者： ebru kondolot solak

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Release of Anticancer Drug 5-Fluorouracil from Different Ionically Crosslinked Alginate Beads

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Journal of Biomaterials and Nanobiotechnology（生物材料与纳米技术） 2012年第4期

作者： Merve Olukman Oya Sanlı ebru kondolot solak

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