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临床与实验病理学杂志 2020年第2期36卷 232-232,234页

作者： Al-Obaidy K I eble j n nassiri M 魏建国(摘译方三高(审校) Sarkozy C Copie-Bergman C Damotte D 刘谦(摘译) 刘勇(审校) 不详浙江省绍兴市人民医院病理科绍兴312000 中国人民解放军陆军特色医学中心病理科重庆400042 江西省人民医院病理科南昌330006

具有极性反转的乳头状肾肿瘤常存在KRAS基因突变Al-Obaidy K I,eble j n,nassiri M,et al.Recurrent KRAS mutations in papillary renal neoplasm with reverse polarity.Mod Pathol,2019.[Epub ahead of print]作者新近提出肾上皮性肿瘤亚型--“具有极性反转的乳头状肾肿瘤”,是一个独特的肿瘤实体。在参与的研究机构中,具有极性反转的乳头状肾肿瘤占先前诊断为乳头状肾细胞癌的4%。组织学以乳头状或管状、乳头状结构为特征,由单层嗜酸性细胞衬覆,胞质呈细颗粒状,核位于细胞顶端。具有特征性的免疫表型:GATA3和L1CAM均表达,vimentin表达缺失,AMACR/P504S轻度表达缺失。

关键词： GATA3 乳头状结构嗜酸性细胞肾肿瘤免疫表型极性反转 neoplasm

具有极性反转的乳头状肾肿瘤常存在KRAS基因突变

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临床与实验病理学杂志 2020年第2期 232-232页

作者： Al-Obaidy K I eble j n nassiri M 魏建国方三高浙江省绍兴市人民医院病理科中国人民解放军陆军特色医学中心病理科

作者新近提出肾上皮性肿瘤亚型——"具有极性反转的乳头状肾肿瘤",是一个独特的肿瘤实体。在参与的研究机构中,具有极性反转的乳头状肾肿瘤占先前诊断为乳头状肾细胞癌的4%。组织学以乳头状或管状、乳头状结构为特征,由单层嗜酸性细胞衬... 详细信息

作者新近提出肾上皮性肿瘤亚型——"具有极性反转的乳头状肾肿瘤",是一个独特的肿瘤实体。在参与的研究机构中,具有极性反转的乳头状肾肿瘤占先前诊断为乳头状肾细胞癌的4%。组织学以乳头状或管状、乳头状结构为特征,由单层嗜酸性细胞衬覆,胞质呈细颗粒状,核位于细胞顶端。具有特征性的免疫表型:GATA3和L1CAM均表达,vimentin表达缺失,AMACR/P504S轻度表达缺失。

关键词：肾肿瘤乳头状基因突变极性反转

具有极性反转的乳头状肾肿瘤:形态学、免疫组化和分子学研究

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临床与实验病理学杂志 2019年第8期35卷 910-910页

作者：魏建国(摘译) 方三高(审校) Al-Obaidy K I eble j n Cheng L 浙江省绍兴市人民医院病理科绍兴312000 中国人民解放军陆军特色医学中心病理科重庆400042 不详

作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP ... 详细信息

作者评估了特殊类型乳头状肾肿瘤的临床病理和染色体特征,并将其与1型和2型乳头状肾细胞癌进行比较。18例中,9例男性,9例女性;年龄范围46~80岁(平均64岁,中位年龄66岁);肿瘤直径0.6~3 cm(平均1.63 cm,中位直径1.4 cm);其中14例WHO/ISUP 2级,4例WHO/ISUP 1级,肿瘤分期均为pT1期。这类肿瘤具有细小纤维血管轴心的分支状乳头,被覆立方/柱状细胞,胞质颗粒状嗜酸性,管腔边缘光滑,核规则且多位于细胞顶端,偶尔核仁明显或不明显。5例形成小管状结构,9例有明显的胞质空泡,10例具有假包膜。18例肿瘤均无砂粒体、坏死、核分裂象和细胞内含铁血黄素沉积。相比之下,1型乳头状肾细胞癌具有纤细的乳头状结构,被覆单层细胞,胞质稀少,细胞核通常位于乳头状结构基底部呈单层排列,而2型乳头状肾细胞癌具有较宽的乳头状结构,表面被覆细胞呈假复层排列,胞质嗜酸性,核无规则分布。1型和2型乳头状肾细胞癌可见砂粒体、泡沫样巨噬细胞以及细胞内含铁血黄素沉积。免疫组化结果显示,18例肿瘤中CK(AE1/AE3)、EMA、MUC1、CD10、GATA3和L1CAM均阳性。

关键词：乳头状结构 GATA3 基底部泡沫样肿瘤分期假包膜肾肿瘤免疫组化

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伴有乳头状结构和透明细胞成分的肾细胞癌

临床与实验病理学杂志 2009年第3期25卷 310-310页

作者： Gobbo S eble j n Maclennan G T, et al. 李磊(摘译) 李岩(摘译) 张仁亚(审校) 不详济宁医学院附属医院病理科济宁272029

尽管大多数肾癌通过组织学特征能够得到准确诊断,但是一些肾癌之间形态学的重叠使其亚型分类变得困难.虽然一些肾癌表现为乳头状结构,但是大部分由透明细胞组成,无法将他们分为透明细胞肾细胞癌还是乳头状肾细胞癌.

关键词：乳头状肾细胞癌乳头状结构透明细胞细胞成分荧光原位杂交免疫组织化学 17号染色体男性患者

The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

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neural Regeneration Research 2024年第2期19卷 399-400页

作者： Emilio j.Galván Angelica Zepeda Departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney j.Rouse Victoria n.jensen Coy D.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for n-acetyl-alpha-glucosaminidase.This results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological dysfunction.Current treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢB.Adeno-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential cures.Our group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores n-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy mice.Here,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB n-acetyl-alpha-glucosaminidase newborn screening

Wettability,reactivity,and interface structure in Mg/ni system

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journal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka n.Sobczak Ł.Maj P.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop method was applied to the experimental investigation of the wetting and spreading behaviors of liquid Mg drops on pure ni substrates.For comparison,the experiments were performed in two variants:(1)using the Capillary Purification(CP)procedure,which allows the non-contact heating and squeezing of a pure oxide-free Mg drop;(2)by classical Contact Heating(CH)procedure.The high-temperature tests were performed under isothermal conditions(CP:760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) atmosphere.During the sessile drop tests,images of the Mg/ni couples were recorded by CCD cameras(57 fps),which were then applied to calculate the contact angles of metal/substrate couples.Scanning and transmission electron microscopy analyses,both coupled with energy-dispersive X-ray spectroscopy,were used for detailed structural characterization of the solidified couples.It was found that an oxide-free Mg drop obtained by the CP procedure showed a wetting phenomenon on the ni substrate(an average contact angleθnng and good wetting over the ni substrate(θ_((CP))~20°in 5 s)to form a final contact angle ofθ_(f(CP))~18°.In contrast,a different wetting behavior was observed for the CH procedure,where the unavoidable primary oxide film on the Mg surface blocked the spreading of liquid Mg showing apparently non-wetting behavior after 300 s contact at the test temperature.However,in both cases,the deep craters formed in the ni substrates under the Mg drops and significant change in the structure of initially pure Mg drops to Mg-ni alloys suggest a strong dissolution of ni in liquid Mg and apparent values of the final contact angles measured for the Mg/ni system.

关键词： Magnesium-based alloys Sessile drop tests Capillary purification procedure Wettability Reactivity Contact angle

Characterization of bright betatron radiation generated by direct laser acceleration of electrons in plasma of near critical density

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Matter and Radiation at Extremes 2024年第2期9卷 26-35页

作者： j.Cikhardt M.Gyrdymov S.Zähter P.Tavana M.M.Günther n.Bukharskii n.Borisenko j.jacoby X.F.Shen A.Pukhov n.E.Andreev O.n.Rosmej Faculty of Electrical Engineering Czech Technical University in Prague16627 Prague 6Czech Republic Goethe University FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany Focused Energy GmbH Im Tiefen See 4564293 DarmstadtGermany national Research nuclear University MEPhI Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev Physical Institute RAS Leninskiy Prospekt 53119991 MoscowRussian Federation Heinrich-Heine-University Düsseldorf Universitätsstrasse 1DüsseldorfGermany joint Institute for High Temperatures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation Moscow Institute of Physics and Technology Institutskiy Pereulok 9141700 DolgoprudnyRussia

Directed x-rays produced in the interaction of sub-picosecond laser pulses of moderate relativistic intensity with plasma of near-critical density are investigated. Synchrotron-like (betatron) radiation occurs in the process of direct laser acceleration (DLA) of electrons in a relativisticlaser channel when the electrons undergo transverse betatron oscillations in self-generated quasi-static electric and magnetic fields. In anexperiment at the PHELIX laser system, high-current directed beams of DLA electrons with a mean energy ten times higher than the ponderomotive potential and maximum energy up to 100 MeV were measured at 10^(19) W/cm^(2)laser intensity. The spectrum of directed x-raysin the range of 5–60 keV was evaluated using two sets of Ross filters placed at 0°and 10°to the laser pulse propagation axis. The differential x-ray absorption method allowed for absolute measurements of the angular-dependent photon fluence. We report 10^(13) photons/sr withenergies >5 keV measured at 0°to the laser axis and a brilliance of 10^(21) photons s^(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular distributionof the emission has an FWHM of 14°–16°. Thanks to the ultra-high photon fluence, point-like radiation source, and ultra-short emissiontime, DLA-based keV backlighters are promising for various applications in high-energy-density research with kilojoule petawatt-class laserfacilities.

关键词： laser acceleration critical

Mathematical modeling and simulations of stress mitigation by coating polycrystalline particles in lithium-ion batteries

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 947-962页

作者： n.IQBAL j.CHOI S.F.SHAH C.LEE S.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is developed to investigate the effects on the stress development of the coating of polycrystalline ni-rich LinixMnyCo_(z)O_(2)(x≥0.8)(nMC)particles with poly(3,4-ethylenedioxythiophene)(PEDOT).The simulation results show that the coating of primary nMC particles significantly reduces the stress generation by efficiently accommodating the volume change associated with the lithium diffusion,and the coating layer plays roles both as a cushion against the volume change and a channel for the lithium transport,promoting the lithium distribution across the secondary particles more homogeneously.Besides,the lower stiffness,higher ionic conductivity,and larger thickness of the coating layer improve the stress mitigation.This paper provides a mathematical framework for calculating the chemo-mechanical responses of anisotropic electrode materials and fundamental insights into how the coating of nMC active particles mitigates stress levels.

关键词： lithium-ion battery(LIB) polycrystalline particle coating finite element simulation ni-rich LinixMnyCo_(z)O_(2)(x>0.8)(nMC)