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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 5-5页

作者： eberting c.l.d. davis J. Puck J.M. 刘超 dermatology Branch Center for Cancer Research National Cancer Institute 10 Center Dr Bethesda MD 20892-1908 United States Dr.

Objective: To characterize the dermatitis, the newborn rash, and cutaneous findings in hyper-IgE syndrome, also known as Job’s syndrome. design: Prospective and retrospective evaluation and treatment of cutaneous manifestations in patients with a clinic.l.d.agnosis of hyper-IgE syndrome (HIES). Analysis of the newborn rash encountered in this population. Setting: dermatology clinic at the National Institutes of Health, Bethesda, Md. Patients: Forty-three patients seen in our clinic between January 1998 and August 2003 who had a clinic.l.d.agnosis of HIES. Interventions: The UK Working Party’s diagnostic criteria for Atopic dermatitis were used to assess for atopic dermatitis in this population. To assess the newborn rash, we performed a retrospective chart review and an in-person or telephone interview of the parent or caregiver of each patient. Results: Twenty-eight (65%) of 43 patients fulfilled the criteria for atopic dermatitis. Thirty-five (81%) of 43 patients reported a newborn rash, Eight (19%) of 43 were born with the rash; 23 (53%) of 43 had acquired the rash within 7 days; 32 (74%) of 43 within 14 days; 34 (79%) of 43 within 30 days; and 35 (81%) of 43 had the rash within 35 days of birth. conclusions: The dermatitis in HIES resembles classic atopic dermatitis but may have distinctive features. A newborn rash is almost always a presenting sign of HIES. After the newborn period, skin findings include retroauricular fissures, external otitis, infected dermatitis of the axillae and groin, folliculitis of the upper back and shoulders, cutaneous abscesses, mucocutaneous candidiasis, and in some patients pitted scarring of the face.

关键词：出生后皮损情况外耳道炎诊断标准凹陷性瘢痕回顾性评价临床诊断肩背部为高感染性

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