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Effect of coenzyme Q10 supplementation on post-vitrification mouse embryo development

Asian pacific Journal of reproduction 2024年第3期13卷 126-132页

作者： Anisa-Annur.s.Wan-Hafizah WJ Nor-Ashikin MNK Muhammad-Zaki r Faculty of Pharmacy and Health sciences Royal College of Medicine PerakUniversiti Kuala Lumpur30450 IpohPerakMalaysia Maternofetal and Embryo r.s.arch Group Faculty of MedicineUniversiti Teknologi MARASelangor BranchSungai Buloh Campus47000 Sungai BulohSelangorMalaysia

Objective:To investigate the effects of coenzyme Q10(CoQ10)supplementation on post-vitrification embryo development and gr.s. ***:Balb/c mouse embryos were cultured in potassium simplex optimised medium(KsOM)with varying CoQ10 concentrations[0(control),20,40,and 60μM].The most effective CoQ10 concentration(40μM)was selected for.s.bsequent post-vitrification morphology *** were randomly divided into four groups:Group A(non-vitrified without CoQ10),Group B(non-vitrified with CoQ10),Group C(vitrified without CoQ10),and Group D(vitrified with CoQ10),followed by vitrification at the 8-cell *** rates and development until the blastocyst stage were evaluated through morphological examinations using AsEBIr.s.system,distinguishing normal and abnormal ***:supplementation of 40μM CoQ10 significantly increased blastocyst formation(95%)compared to the control group(92%),20μM(62%),and 60μM(56%)(Prification,Group D exhibited a significant increase in blastocyst formation(92%)compared to Group C(82%)(Prphological assessments indicated superior embryo quality in Group B over Group D during the cleavage stage,morula,and blastocyst(Psions:CoQ10 supplementation exhibits promising potential to enhance preimplantation embryo development,increase blastocyst formation rates,and improve embryo quality *** offers a promising approach to mitigate oxidative str.s. on embryos,potentially improving overall assisted reproductive technology outcomes.

关键词： Coenzyme Q10 Antioxidant Embryo development Vitrification Morphology Assisted reproductive technology

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structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do rego A.s.Viana A.J.s.Fernandes A.J.Fielding r.A.Videira M.C.Oliveira CQ-Vr and Chemistry Department University of Trás-os-Montes e Alto Douro BsIrG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa Centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Department University of AveiroCampus de Santiago Faculty of science Pharmacy and Biomolecular SchoolLiverpool John Moores University rEQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towar.s.linear.s.acking structur.s.of small nanoparticles （rallel,alcohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic r.s.nance （EPr） revealed a r.s.nance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under.s.udy to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon surface functionalization NMr XPs Hydrophilic carbon Paramagnetic

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Effect of adrenalectomy on rat epididymidis

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Asian Journal of Andrology 2002年第4期4卷 273-279页

作者： Neena Nair r.s. Bedwal r.s. Mathur Cell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur-302 004 India

AIM: To investigate the effect of adrenalectomy (ADX) on the epididymidis of sprague-Dawley rats. METHODs: The histological, biochemical (cholesterol protein, zinc, copper, alkaline and acid phosphatase aryl sulphatase, lactic dehydrogenase and leucine amino peptidase) and hormonal (FsH, LH and testosterone) changes of caput and cauda epididymis in ADX rats were observed. r.s.LTs: Organ wet weight, histological studies and morphometric measurements indicated a cellular degeneration in caput and cauda epididymis of ADX rats. serum testosterone level was significantly lower in ADX than in sham-operated rats, while the serum FsH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham-operated rats. Epididymal zinc level increased whereas copper level decreased in ADX rats compared to the sham-operated. CONCLUsION: Adrenalectomy leads to degeneration of caput and cauda epididymidis epithelial cells as a r.s.lt of decreased supply of testosterone.

关键词： Adrenalectomy Acid Phosphatase Alkaline Phosphatase Animals Arylsulfatases Cholesterol Comparative study Copper Epididymis Follicle stimulating Hormone L-Lactate Dehydrogenase Leucyl Aminopeptidase Luteinizing Hormone Male Organ size rats rats, sprague-Dawley reference Values r.s.arch support, Non-U.s. Gov't Testosterone Time Factors Zinc

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Multidimensional images and aberrations in sTEM

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Chinese Physics B 2024年第9期33卷 68-74页

作者： Eric r.Hoglund Andrew r.Lupini Center for Nanophase Materials sciences Oak Ridge National LaboratoryOak RidgeTN 37831United States

recent advances in scanning transmission electron micr.s.opy(sTEM)have led to increased development of multidimensional sTEM imaging modalities and novel image reconstruction *** inter.s. ar.s.s because the main electron lens in a modern transmission electron micr.s.ope usually has a diffraction-space information limit that is significantly better than the real-space r.s.lution of the same *** state-of-affairs is sometimes shared by other.s.attering methods in modern physics and contributes to a broader excitement surrounding multidimensional techniques that scan a probe while recording diffraction-space images,such as ptychography and scanning nano-beam ***,the contr.s.ing r.s.lution in the two spaces raises the question as to what is limiting their effective ***,we examine this paradox by considering the effects of aberrations in both image and diffraction planes,and likewise separate the contributions of pre-and post-sample *** consideration provides insight into aberration-measurement techniques and might also indicate improvements for.s.per-r.s.lution techniques.

关键词： scanning transmission electron micr.s.opy (sTEM) aberrations

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The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Dr.s.phila model of Parkinson’s disease

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Neural regeneration r.s.arch 2024年第5期19卷 1150-1155页

作者： shuanglong Yi Linfang Wang Margaret s.Ho shiping Zhang school of Life science and Technology ShanghaiTech UniversityShanghaiChina College of Life sciences University of Chinese Academy of SciencesBeijingChina

Parkinson’s disease is a progr.s.ive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy *** in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s ***,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the *** the pr.s.nt study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expr.s.ed in Dr.s.phila glia from adult *** from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in ***9 is persistently in contact with these *** glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate *** suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic ***,loss of glial atg9 induces parkinsonian symptoms in Dr.s.phila including progr.s.ive loss of dopaminergic neurons,locomotion deficits,and glial *** findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s *** r.s.lts may provide new insights on the underlying mechanism of Parkinson’s disease.

关键词： Atg9 autophagy glia Parkinson’s disease

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Characterization of early maturing elite genotypes based on MTsI and MGIDI indexes:an illustration in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton r.s.arch 2024年第3期7卷 253-265页

作者： D s rAJ supritha PATIL rajesh s. PATIL Bhuvaneshwara r. NAYAK spurthi N. PAWAr Kasu N. Department of Genetics and Plant Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural r.s.arch station Dharwad 580005India Department of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Physiology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Globally,the cultivation of cotton is constrained by its tendency for extended periods of *** maturity plays a potential role in rainfed-based multiple cropping system especially in the current era of climate *** the current study,a set of 20 diverse Gossypium hirsutum genotypes were evaluated in two crop seasons with three planting densities and assessed for 11 morphological traits related to early *** study aimed to identify genotype(s)that mature rapidly and accomplish well under diverse environmental conditions based on the two robust multivariate techniques called multi-trait stability index(MTsI)and multi-trait genotype-ideotype distance index(MGIDI).r.s.lts MTsI analysis revealed that out of the 20 genotypes,three genotypes,viz.,NNDC-30,A-2,and s-32 accomplished well in ter.s.of early maturity traits in two ***,three genotypes were selected using MGIDI method for each planting densities with a selection intensity of 15%.The strengths and weaknesses of the genotypes selected based on MGIDI method highlighted that the breeders could focus on developing early-maturing genotypes with specific traits such as days to first flower and boll *** selected genotypes exhibited positive genetic gains for traits related to earliness and a successful harvest during the first and second ***,there were negative gains for traits related to flowering and boll *** The study identified three genotypes exhibiting early maturity and accomplished well under different planting *** multivariate methods(MTsI and MGIDI)serve as novel approaches for.s.lecting desired genotypes in plant breeding programs,especially acr.s. various growing *** methods offer exclusive benefits and can easily construe and minimize multicollinearity issues.

关键词： Cotton MTsI MGIDI Genotype environment interaction Early maturity Multi-trait Multi-environment

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The Ca^(2+)-sensing receptor and the pocketome:comparing nature's complexity with human intervention in receptor modulation

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signal Transduction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda s.F.Matthees Carsten Hoffmann Institut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-schiller-Universitat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper published in Nature,the relatively understudied Ca^(2+)-sensing,receptor(Casr)within the Gprotein-coupled receptor(GPCr)family C,gained attention due to pioneering r.s.arch led by Georgios skiniotis ... 详细信息

关键词： stanford gained skin

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C19MC mirNA-520G induces sP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.smallin Nino Mtchedlidze Isha Godwin Marco Napoli Nicole Hackel Manali s.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden r.Baldwin suehelay Acevedo-Acevedo Yifeng Gao Michelle A.reiser Keiran s.M.smalley Elsa r.Flor.s.Andrew s.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

sP100 is an antiviral protein that r.s.ricts the productive stage of human papillomavir.s.HPV)and multiple other vir.s.s,and vir.s.s in turn block sUMO-1-mediated stabilization of sP100 and promotes its degradation(Table s1).Interferon(IFN)signaling could still produce more sP100 through transcription to counteract vir.s.s.1 Vir.s.s also disable the transcriptional up-regulation of sP100 to achieve persistent infection in hosts.

关键词： sP100 melanoma stabilization

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Effect of proton irradiation on the optical properties of thermal control coating based on polystyrene with silica filler

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Propulsion and Power r.s.arch 2024年第1期13卷 1-11页

作者： N.I.Cherkashina V.I.Pavlenko M.M.Mikhailov A.N.Lapin s.A.Yuriev r.V.sidelnikov D.s.romanyuk Belgorod state Technological University named after V.G.shoukhov Kostyukov Str.46Belgorod 308012Russia Tomsk state University of Control systems and radioelectronics 40Prospect LeninaTomsk 634050Russia

This paper pr.s.nts the r.s.lts of studying the surface properties changes of a ther-moregulating coating based on polystyrene and silicaﬁller after proton irradiation with an en-ergy of 50 keV at afluence of 3�1015 cm�*** proton irradiation,the values of the contact angle of wetting with water increase by 3.5%and 14.9%for polystyrene and the coating,*** free surface energy(energy of the surface layer)of polystyrene and the coat-ings before and after proton irradiation was calculated using the Owens-Wendt-rabel-Kaelble *** was a signiﬁcant increase in the polarity of the polystyrene surface(gp increased by a factor of 2.2)after proton *** the coating,an increase in gp by a factor of 3.89 was observed after proton *** changes in the coating were pr.s.nted by Ir Fourier.s.ectr.s.opy.A slight decrease in the absorption intensity of all character.s.ic bands compared to the unirradiated sample was *** was found that the irradiation of the coating with protons led to the formation of macromolecules with hydroxyl,carbonyl,and carboxyl bonds,as well as the formation of dimeric and oligomeric siloxane *** was also found that after irradiation of a pure polystyrene sample with protons,the value of the solar absorption as increased by only 4.2%;whereas for the coating with silicaﬁller,the value of as increased by 28.6%.

关键词： Thermal control coating Proton irradiation Hydrophobicity Free surface energy radiation cr.s.linking

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sleep-based neuronal oscillations as a physiological biomarker for Alzheimer.s.disease:is night time the right time?

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Neural regeneration r.s.arch 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Erica s.Brady Michael T.Craig Department of Clinical and Biomedical sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladstone Institute for Neurological Disease San FranciscoCAUSA school of Psychology and Neur.s.ience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is a devastating syndrome characterized by memory problems,confusion,and behavior changes that prevent people from performing everyday *** is the leading cause of dependency and disability amongst older people,r.s.lting in a global economic cost of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer.s.disease(AD) causing most(60-70%) of these cases.

关键词： Alzheimer everyday performing

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