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Lung Cancer Segmentation with Three-Parameter Logistic Type Distribution Model

Computers, Materials & Continua 2023年第4期75卷 1447-1465页

作者： Debnath Bhattacharyya ealistephen neal joshua N.Thirupathi Rao Yung-cheol Byun Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaramGuntur522302Andhra PradeshIndia Department of Computer Science&Engineering Vignan’s Institute of Information Technology(A)Visakhapatnam530049Andhra PradeshIndia Department of Computer Engineering Jeju National University102 Jejudaehak-roJeju-siJeju-do690-756Korea

Lung cancer is the leading cause of mortality in the world affectingboth men and women *** a radiologist just focuses on the patient’sbody, it increases the amount of strain on the radiologist and the likelihoodof missing pathological information such as abnormalities are *** of the primary objectives of this research work is to develop computerassisteddiagnosis and detection of lung cancer. It also intends to make iteasier for radiologists to identify and diagnose lung cancer accurately. Theproposed strategy which was based on a unique image feature, took intoconsideration the spatial interaction of voxels that were next to one *** the U-NET+Three parameter logistic distribution-based technique, wewere able to replicate the situation. The proposed technique had an averageDice co-efficient (DSC) of 97.3%, a sensitivity of 96.5% and a specificity of94.1% when tested on the Luna-16 dataset. This research investigates howdiverse lung segmentation, juxta pleural nodule inclusion, and pulmonarynodule segmentation approaches may be applied to create Computer AidedDiagnosis (CAD) systems. When we compared our approach to four otherlung segmentation methods, we discovered that ours was the most *** employed 40 patients from Luna-16 datasets to evaluate this. In termsof DSC performance, the findings demonstrate that the suggested techniqueoutperforms the other strategies by a significant margin.

关键词： Magnetic resonance imaging(MRI) lung cancer Luna-16 logistic distribution segmentation deep learning juxta plural pulmonary nodules

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Re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs

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World Journal of Gastroenterology 2015年第43期21卷 12430-12438页

作者： joshua Hartman Kian Bichoupan neal Patel Sweta Chekuri Alyson Harty Douglas Dieterich Ponni Perumalswami Andrea D Branch Department of Medicine Icahn School of Medicine at the Mount Sinai Medical Center Division of Liver Disease Icahn School of Medicine at the Mount Sinai Medical Center

AIM: To determine risk factors associated with hepatitis C virus(HCV) treatment failure after direct acting antivirals in patients with complex treatment ***: All HCV mono-infected patients who received treatment at our institution were *** was restricted to patients who previously failed treatment with boceprevir(BOC) or telaprevir(TVR) and started simeprevir(SMV) and sofosbuvir(SOF) ± ribavirin(RBV) between December 2013 and June 2014. Patients with human immunodeficiency virus(HIV)/HCV co-infection or patients who received a liver transplant in the past were excluded. Viral loads were recorded while on treatment and after treatment. Data collection continued until December,31 st 2014 when data analysis was initiated. Patients missing virologic outcomes data were not included in the analysis. Analysis of 35 patients who had virologic outcome data available resulted in eight patients who were viral load negative at the end of treatment with SMF/SOF but later relapsed. Data related to patient demographics,HCV infection,and treatment history was collected in order to identify risk factors shared among patients who failed treatment with SMF/***: Eight patients who were treated with the first generation HCV protease inhibitors BOC or TVR in combination with pegylated-interferon(PEG) and RBV who failed this triple therapy were subsequently retreated with an off-label all-oral regimen of SMV and SOF for 12 wk,with RBV in seven cases. Treatment was initiated before the Food and Drug Administration approved a 24-wk SMV/SOF regimen for patients with liver cirrhosis. All eight patients had an end of treatment response,but later relapsed. Eight(100%) patients were male. Mean age was 56(range,49-64). Eight(100%) patients had previously failed PEG/RBV dual therapy at least once in addition to prior failure with triple therapy. Total number of times treated ranged from 3-6(mean 3.8). Eight(100%) patients were male had liver cirrhosis as determi

关键词： Hepatitis C Protease inhibitor Relapse Simeprevir

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Treatment of the ulnar nerve for overhead throwing athletes undergoing ulnar collateral ligament reconstruction

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World Journal of Orthopedics 2016年第10期7卷 650-656页

作者： Matthew S Conti Christopher L Camp neal S Elattrache David W Altchek joshua S Dines Department of Orthopaedic Surgery Hospital for Special Surgery Shoulder and Sports Medicine Service Hospital for Special Surgery Kerlan-Jobe Orthopaedic Clinic

Ulnar nerve(UN) injuries are a common complaint amongst overhead athletes. The UN is strained during periods of extreme valgus stress at the elbow, especially in the late-cocking and early acceleration phases of throwing. Although early ulnar collateral ligament(UCL) reconstruction techniques frequently included routine submuscular UN transposition, this is becoming less common with more modern techniques. We review the recent literature on the sites of UN compression, techniques to evaluate the UN nerve, and treatment of UN pathology in the overhead athlete. We also discuss our preferred techniques for selective decompression and anterior transposition of the UN when indicated. More recent studies support the use of UN transpositions only when there are specific preoperative symptoms. Athletes with isolated ulnar neuropathy are increasingly being treated with subcutaneous anterior transposition of the nerve rather than submuscular transposition. When ulnar neuropathy occurs with UCL insufficiency, adoption of the muscle-splitting approach for UCL reconstructions, as well as using a subcutaneous UN transposition have led to fewer postoperative complications and improved outcomes. Prudent handling of the UN in addition to appropriate surgical technique can lead to a high percentage of athletes who return to competitive sports following surgery for ulnar neuropathy.

关键词： Ulnar nerve Neuropathy Ulnar collateral ligament reconstruction Management Athletes

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Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results

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World Journal of Virology 2017年第4期6卷 59-72页

作者： Kian Bichoupan Neeta Tandon James F Crismale joshua Hartman David Del Bello neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Janssen Scientific Affairs LLC Division of General Internal Medicine Icahn School of Medicine at Mount Sinai

AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) *** The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic *** SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs.

关键词： Cirrhosis Cost Sustained virological response Protease inhibitor Polymerase inhibitor

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