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Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture:In silico toxicogenomic approach

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BIOCELL 2022年第2期46卷 519-533页

作者： KATARINA BARALIĆ KATARINAŽIVANČEVIĆ DRAGICA BOŽIĆ DANYEL JENNEN ALEKSANDRA BUHA DJORDJEVIC evica antonijevićmiljaković DANIJELAĐUKIĆ-ĆOSIĆ11 Department of Toxicology“Akademik Danilo Soldatović” University of Belgrade-Faculty of PharmacyBelgrade11000Serbia Department of Toxicogenomics GROW School for Oncology and Developmental BiologyMaastricht UniversityMaastricht6221The Netherlands

This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A(BPA)co-exposure and obesity,as well as its comorbid conditions,in order to construct a possible set of genomic *** Comparative Toxicogenomics Database(CTD;http://***)was used as the main data mining tool,along with GeneMania(https://***),ToppGene Suite(https://***)and DisGeNET(http://***).Among the phthalates,bis(2-ethylhexyl)phthalate(DEHP)and dibutyl phthalate(DBP)were chosen as the most frequently curated phthalates in CTD,which also share similar mechanisms of ***,DBP and BPA interacted with 84,90 and 194 obesity-related genes/proteins,involved in 67,65 and 116 pathways,*** these,53 genes/proteins and 42 pathways were common to all three substances.31 genes/proteins had matching interactions for all three investigated substances,while more than half of these genes/proteins(56.49%)were in co-expression.7 of the common genes/proteins(6 relevant to humans:CCL2,IL6,LPL,PPARG,SERPINE1,and TNF)were identified in all the investigated obesity comorbidities,while PPARG and LPL were most closely linked to *** genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP,DBP and BPA mixture obesogenic *** reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.

关键词： Endocrine disruptors Data mining Bioinformatics Toxicology

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Comparative morphological and crystallographic analysis of copper powders obtained under different electrolysis conditions

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Transactions of Nonferrous Metals Society of China 2019年第6期29卷 1275-1284页

作者： Nebojsa D. NIKOLIC Ljiljana AVRAMOVIC evica R. IVANOVIC Vesna M. MAKSIMOVIC Zvezdana BASCAREVIC Nenad IGNJATOVIC ICTM-Department of Electrochemistry University of Belgrade Njego.eva 12 Belgrade Serbia Mining and Metallurgy Institute Zeleni Bulevar 35 Bor Serbia Faculty of Agriculture University of Belgrade Nemanjina 6 Belgrade-Zemun Serbia Vinca Institute of Nuclear Sciences University of Belgrade Belgrade Serbia Institute for Multidisciplinary Research University of Belgrade Kneza Viseslava 1a Belgrade Serbia Institute of Technical Sciences of the Serbian Academy of Science and Arts Knez Mihailova 35/IV Belgrade Serbia

Production of copper powders by the potentiostatic electrolysis under different hydrogen evolution conditions was investigated. Copper powders were characterized by the scanning electron microscope(SEM),X-ray diffraction(XRD),particle size distribution(PSD), and by the determination of the specific surface area(SSA) of the formed powders. Depending on quantity of hydrogen generated during electrolysis, the two types of particles were formed: dendrites and cauliflower-like particles. The dendrites were formed without, while cauliflower-like particles with the quantity of evolved hydrogen enough to achieve strong effect on hydrodynamic conditions in the near-electrode layer. Although macro structure of the particles was very different, they showed similar micro structure. Namely, both types of the particles consisted of smalal agglomerates of approximately spherical Cu grains at the micro level. The existence of the spherical morphology was just responsible for random orientation of Cu crystallites in both types of particles. The SSA of cauliflower-like particles was more than two times larger than that of the dendrites, while their size was considerably smaller than that of the dendritic particles. In this way, the useful benefit of Cu powder formation in the conditions of vigorous hydrogen evolution is shown.

关键词： electrolysis copper particles specific surface area(SSA) particle size distribution(PSD)

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Correlation between crystal structure and morphology of potentiostatically electrodeposited silver dendritic nanostructures

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Transactions of Nonferrous Metals Society of China 2018年第9期28卷 1903-1912页

作者： Ljiljana AVRAMOVIC evica R.IVANOVIC Vesna M.MAKSIMOVIC Miroslav M.PAVLOVIC Marina VUKOVIC Jasmina S.STEVANOVIC Nebojsa D.NIKOLIC Mining and Metallurgy Institute Zeleni bulevar 35BorSerbia Faculty of Agriculture University of BelgradeNemanjina 6Belgrade-ZemunSerbia Vinca Institute of Nuclear Sciences University of BelgradeBelgradeSerbia Institute of Chemistry Technology and MetallurgyDepartment of ElectrochemistryUniversity of BelgradeNjegoseva 12BelgradeSerbia Institute for Multidisciplinary Research University of BelgradeKneza Viseslava 1aBelgradeSerbia

Silver dendritic nanonstructures obtained by the potentiostatic electrolysis from different electrolytes at different overpotentials were characterized by the scanning electron microscopy(SEM)technique and X-ray diffraction analysis of the produced *** needle-like and fern-like dendrites were formed from the nitrate electrolyte at overpotentials inside and outside plateaus of the limiting diffusion current density,*** three-dimensional pine-like dendrites constructed from approximately spherical grains were formed from the ammonium electrolyte at overpotentials both inside and outside plateaus of the limiting diffusion current *** morphology of silver dendrites was correlated with their crystal structure at the semi quantiative *** change of crystal orientation from the strong(111)preferred orientation for the needle-like dendrites to almost randomly orientied spherical grains in the pine-like dendrites obtained at the overpotential outside the plateau of the limiting diffusion current density was *** trend in change of crystal orientation and morphology of Ag nanostructures was accompanied by considerable increase of the specific surface area(SSA)of the produced *** average crystallite sizes were in the range of 38-50 nm,proving nanostructural character of the formed Ag particles.

关键词： electrodeposition silver dendrites SEM XRD

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