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Inhibition of Ehrlich ascites carcinoma growth by melatonin:studies with micro-CT

Oncology Research 2024年第1期32卷 175-185页

作者： sEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK evrim su.a arikan söylemez.asli okan oflamaz.sümeyye u.ar ŞÜKRÜATEŞ AMMAD AHMAD FarOOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecu.ar Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(psignificant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(purthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT serine/Threonine Kinase(PKB/AKT)genes(psis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： signaling pathway Apoptosis Real-time PCR AgNOR

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Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： okan safak shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif arik sever samedÖzer Güldal süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate school of Health sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician scientist Professorship for Translational Pancreatic surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecu.ar modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

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Computer vision-aided DEM study on the compaction characteristics of graded subgrade filler considering realistic coarse particle shapes

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Railway Engineering science 2024年第2期32卷 194-210页

作者： Taifeng Li Kang Xie Xiaobin Chen Zhixing Deng Qian su Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing 100081China Department of Civil Engineering Central South UniversityChangsha 410075China school of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China

The compaction quality of subgrade filler strongly affects subgrade *** main objective of this research is to analyze the macro-and micro-mechanical compaction characteristics of subgrade filler based on the real shape of coarse ***,an improved Viola-Jones algorithm is employed to establish a digitalized 2D particle database for coarse particle shape evaluation and discrete modeling purposes of subgrade *** indexes of 2D subgrade filler are then computed and statistically ***,numerical simulations are performed to quantitatively investigate the effects of the aspect ratio(ar)and interparticle friction coefficient(μ)on the macro-and micro-mechanical compaction characteristics of subgrade filler based on the discrete element method(DEM).The results show that with the increasing ar,the coarse particles are narrower,leading to the increasing movement of fine particles during compaction,which indicates that it is difficult for slender coarse particles to inhibit the migration of fine ***,the average displacement of particles is strongly influenced by the ar,indicating that their occlusion under power relies on particle *** dis-placement and velocity of fine particles are much greater than those of the coarse particles,which shows that compaction is primarily a migration of fine *** the cyclic load,the interparticle friction coefficientμhas little effect on the internal structure of the sample;under the quasi-static loads,however,the increase inμwill lead to a significant increase in the porosity of the *** study could not only provide a novel approach to investigate the compaction mechanism but also establish a new theoretical basis for the evaluation of intelligent subgrade compaction.

关键词： subgrade filler particles Deep learning particle shape analysis Particle library Compaction characteristics Discrete element method(DEM)

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Cleaning of two mirrors in the first mirror unit using radiofrequency capacitively coupled plasma

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Plasma science and Technology 2024年第9期26卷 165-171页

作者： Chenxue WANG Rong YAN Yuming LIu su Xu Lei Mu Wei ZHENG Rui DING Junling CHEN Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China university of science and Technology of China Hefei 230026People’s Republic of China school of Computer Engineering Anhui Sanlian UniversityHefei 230601People’s Republic of China

First mirror(FM)cleaning,using radio frequency(RF)plasma,has been proposed to recover FM reflectivity in nuclear fusion reactors such as the International Thermonuclear Experimental Reactor(ITER).To investigate the influence of simultaneous cleaning of two mirrors on mirror cleaning efficiency and uniformity,experiments involving single-mirror cleaning and dual-mirror cleaning were conducted using RF capacitively coupled plasma in the *** the test and simultaneous cleaning of two mirrors,the FM and second mirror(sM),both measuring 110 mm×80 mm,were placed inside the first mirror unit(FMu).They were composed of 16 mirror samples,each with a dimension of 27.5 mm×20 *** mirror samples consist of a titanium-zirconium-molybdenum alloy substrate,a 500 nm Mo intermediate layer and a 30 nm Al_(2)O_(3) surface coating as a proxy for Be *** cleaning of a single first mirror(sFM)and the simultaneous cleaning of the FM and sM(DFM and DsM)lasted for 9 h using ar plasma at a pressure of 1 *** total reflectivity of mirror samples on the DsM did not fully recover and varied with location,with a self-bias of−140 *** a self-bias of−300 V,the total reflectivity of mirror samples on the sFM and DFM was fully *** energy dispersive spectrometer results demonstrated that the Al_(2)O_(3) coating had been completely removed from these mirror ***,the mass loss of each mirror sample on the sFM and DFM before and after cleaning varied depending on its location,with higher mass loss observed for mirror samples located in the corners and lower loss for those in the *** with sM cleaning,the simultaneous cleaning of two mirrors reduced the difference between the highest and lowest mass ***,this mass loss for the mirror samples of the DFM facing the DsM was *** indicated that mirror samples cleaned face to face in the FMu simultaneously could influence each other,highlighting the need for special attention in

关键词： first mirror unit dual-mirror cleaning reflectivity sputtering rate

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中国在“21世纪海上丝绸之路”布局港口的供给水平

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地理学报 2024年第2期79卷 484-501页

作者：苏晗王列辉华东师范大学中国现代城市研究中心上海200062 华东师范大学中国行政区划研究中心上海200241 华东师范大学全球创新与发展研究院上海200062

“一带一路”倡议提出以来,中国企业以多种方式在沿线港口进行投资布局。在贸易保护、地缘环境动荡等背景下,分析已投资港口的供给现状对于提升港口运营效率、节约港口资源以及“21世纪海上丝绸之路”可持续发展等都具有重要现实意义。... 详细信息

“一带一路”倡议提出以来,中国企业以多种方式在沿线港口进行投资布局。在贸易保护、地缘环境动荡等背景下,分析已投资港口的供给现状对于提升港口运营效率、节约港口资源以及“21世纪海上丝绸之路”可持续发展等都具有重要现实意义。在构建港口供给理论的基础上,利用多源港航数据、遥感数据,建立包含自然条件、基础设施、生产条件等8个一级指标和37个二级指标的港口供给水平综合评价体系,测度中国已投资港口的整体性、区域性和维度性供给水平。研究发现:(1)“21世纪海上丝绸之路”已投资港口的综合供给水平不高,多数港口处于中等和较低水平,供需均衡程度低。(2) 2015年以前主要集中于投资建设供给水平较高、较为成熟的欧洲港口,2015年之后转为布局供给水平较低的战略支点港、门户港、战略通道沿线港。(3)企业—合作类型—港口供给水平等级可归纳为3种类型:码头运营商—股权收购—较高供给水平港口;工程承包商—承建—中低供给水平港口;航运公司—股权收购、特许经营权—较高、高供给水平港口。(4)分区域看,西亚、南亚、非洲、东南亚和欧洲的港口供给体系空间结构分别处于低级均衡、孤立双核、原始单核、枢纽极核和多核共同发展阶段。(5)从维度影响力分析,影响港口综合供给水平的主要因素在于物流水平、服务水平和仓储条件等港口衍生性、提高性因素。

关键词：港口供给水平中国企业投资供给评价体系港航大数据 21世纪海上丝绸之路

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suppressive effect of armoracia rusticana and three main glucosinolates on heterocyclic amine generation in roasted fish patties and their potential mechanism analyzed by density functional theory

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Food science and Human Wellness 2024年

作者： Zhuoming Huang Tiantian Huang Hang su Zihao Yang Jie Luo Qingwu shen Chaoyi Xue Wei Quan College of Food science and Technology， Hunan Agricultural university state Key Laboratory of Food science and Resources， Jiangnan university

This study investigated the suppressive effects of armoracia rusticana (ar) and its three main glucosinolates on both free and bound heterocyclic amines (HAs)， along with their mechanisms of free radical quenching using density functional theory. Fish patties were supplemented with varying concentrations of ar (0.5%～1.5%) and glucosinolates (0.005%～0.015%)， showing a dose-dependent inhibition of HAs and concurrent elimination of free radicals and HAs intermediates. Glucobrassicin demonstrated the highest reactivity， which was verified by frontier orbit analysis and conceptual density functional parameters， consistent with experimental findings. Furthermore， the O-H bond connected to the sulfur atom of glucobrassicin possessed the smallest bond dissociation enthalpy (BDE) value， which indicated that this particu.ar hydrogen atom is most susceptible to react with free radicals. Overall， ar and its glucosinolates， especially glucobrassicin， show promise as natural additives for improving food safety and quality.

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Designing symmetric Gradient Honeycomb structures with Carbon‑Coated Iron‑Based Composites for High‑Efficiency Microwave Absorption

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Nano-Micro Letters 2024年第11期16卷 224-241页

作者： Yu Zhang shu‑Hao Yang Yue Xin Bo Cai Peng‑Fei Hu Hai‑Yang Dai Chen‑Ming Liang Yun‑Tong Meng Ji‑Hao su Xiao‑Juan Zhang Min Lu Guang‑sheng Wang school of Chemistry Beihang UniversityBeijing 100191People’s Republic of China school of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002People’s Republic of China school of Chemical Engineering Northeast Electric Power UniversityJilin 132000People’s Republic of China College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048People’s Republic of China

The impedance matching of absorbers is a vital factor affecting their microwave absorption(MA)*** this work,we controllably synthesized Material of Institute Lavoisier 88C(MIL-88C)with varying aspect ratios(ar)as a precursor by regulating oil bath conditions,followed by one-step thermal decomposition to obtain carbon-coated iron-based *** the precursor MIL-88C(Fe)preparation conditions,such as the molar ratio between metal ions and organic ligands(M/O),oil bath temperature,and oil bath time,influenced the phases,graphitization degree,and ar of the derivatives,enabling low filler loading,achieving well-matched impedance,and ensuring outstanding MA *** MOF-derivatives 2(MD_(2))/polyvinylidene Difluoride(PVDF),MD_(3)/PVDF,and MD4/PVDF absorbers all exhibited excellent MA properties with optimal filler loadings below 20 wt%and as low as 5 wt%.The MD_(2)/PVDF(5 wt%)achieved a maximum effective absorption bandwidth(EAB)of 5.52 GHz(1.90 mm).The MD_(3)/PVDF(10 wt%)possessed a minimum reflection loss(RL_(min))value of−67.4 at 12.56 GHz(2.13 mm).A symmetric gradient honeycomb structure(sGHs)was constructed utilizing the high-frequency structure simulator(HFss)to further extend the EAB,achieving an EAB of 14.6 GHz and a RL_(min) of−59.0 *** research offers a viable inspiration to creating structures or materials with high-efficiency MA properties.

关键词： MIL-88C(Fe) Fe/Fe_(3)O_(4)/Fe_(3)C@C Controllable preparation symmetric gradient honeycomb structure Microwave absorbing

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反旋双色椭圆偏振激光场中ar原子的非序列双电离

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物理学报 2024年第9期73卷 78-87页

作者：葛振杰苏旭白丽华上海大学理学院物理系上海200444

利用经典系综方法研究了不同椭偏率的反旋双色椭圆偏振(two-color elliptically polarized,TCEP)激光场中ar原子非序列双电离(nonsequential double ionization,NsDI)的电子关联特性和再碰撞动力学.不同于反旋双色圆偏振激光场,反旋TCE... 详细信息

利用经典系综方法研究了不同椭偏率的反旋双色椭圆偏振(two-color elliptically polarized,TCEP)激光场中ar原子非序列双电离(nonsequential double ionization,NsDI)的电子关联特性和再碰撞动力学.不同于反旋双色圆偏振激光场,反旋TCEP激光场不再具有空间对称性,返回电子主要从一个方向返回母离子,从而导致电子动量分布表现出很强的不对称性.数值结果显示随着椭偏率的增大,ar原子NsDI的产量逐渐减小,并且电子对在椭圆偏振激光场长轴方向上的关联电子动量分布,从主要位于第一和第三象限的正相关逐渐演变为主要位于第二和第四象限的反相关.通过对不同特征时间的统计分析表明,随着椭偏率的增大,旅行时间和返回电子的重碰撞能量逐渐减小,而延迟时间却增大,这是电子对关联特性发生变化的主要原因.此外,进一步分析发现,无论是“短轨迹”还是“长轨迹”,椭偏率的增大都会使两个电子由同向出射逐渐转变为反向出射,这表明椭偏率和旅行时间都影响着电子的出射方向.

关键词：反旋双色椭圆偏振激光场非序列双电离椭偏率电子关联

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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten su Ryon shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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A Crystallization study of Nanocrystalline PZT 53/47 Granu.ar arrays using a sol-Gel Based Precursor

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Journal of Materials science & Technology 2011年第6期27卷 489-496页

作者： A.surez-Gómez J.M.saniger-Blesa F.Calderón-Pinar CCADET-universidad Nacional Autónoma de México Cd.UniversitariaCirc.Exterior s/nA.P.70-186Coyoacn 04510México D.F.México Laboratorio de Ingeniería Electroquímica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaCoyoacn 04510México D.F.México Facultad de Física/IMRE San Lzaro y LUniversidad de la Habana

In this work,we intend to perform a detailed study on the crystallization process of PZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based *** interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio ***,Fourier transform infrared spectroscopy（FT-IR）,Raman（stokes and Anti-stokes）,X-ray diffraction（XRD） and scanning electron microscopy（sEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TGA） *** results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈DG〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

关键词： Powders-chemical preparation PZT synthesis sol-gel precursors Microstructure- final Vibrational spectroscopies X-ray diffraction

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