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Comprehensive geriatric assessment and its role in oncology:a brief review

肿瘤 2024年第1期44卷 20-24页

作者： evelyne Yehudit bischof 上海交通大学医学院附属仁济医院肿瘤中心上海200127

As the global population ages,the incidence of cancer among older adults is *** management of older patients with cancer poses unique challenges due to the age-related physiological changes,multiple comorbidities,and functional decline often observed in this *** Geriatric Assessment(CGA)has emerged as a valuable tool in oncology to evaluate the overall health and functional status of older cancer patients in order to optimise cancer care for older *** comprehensive approach acknowledges the unique challenges faced by elderly patients with cancer and seeks to optimize outcomes by considering their specific circumstances and individual requirements.

关键词： Comprehensive geriatric assessment Oncology Older adults Cancer care Treatment decisionmaking Functional status Multidimensional evaluation

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Genomic profiling of colorectal cancer in large-scale Chinese patients:amplification and somatic mutations in ERBB2

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Oncology Research 2024年第9期32卷 1429-1438页

作者： YUZHI LIU evelyne bischof ZHIQIN CHEN JIAHUAN ZHOU BEI ZHANG DING ZHANG YONG GAO MING QUAN Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghaiChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteDepartment of OncologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Jiangsu Hengrui Pharmaceuticals Co. Ltd.ShanghaiChina D Medicines Inc. ShanghaiChina

Objectives:Human epidermal growth factor receptor 2(HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer(mCRC)patients with HER2 amplification,but are not satisfactory in cases of HER2 mutant ***:Consequently,further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2(ERBB2)is *** genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes,tumor mutational burden,microsatellite instability,and programmed death ligand 1(PD-L1)***:Among 2454 CRC patients,85 cases(3.46%)exhibited ERBB2 amplification,and 55 cases(2.24%)carried ERBB2 mutation.p.R678Q(28%),p.V8421(24%),and p.S310F/Y(12%)were the most prevalent of the 16 detected mutation *** comparison to the ERBB2 altered(alt)group,KRAS/BRAF mutations were more prevalent in ERBB2 wild-type(wt)samples(ERBB2wt ***2alt,KRAS:50.9%vs.25.6%,p<0.05;BRAF:8.5%vs.2.3%,p<0.05).32.7%(18/55)of CRCs with ERBB2 mutation exhibited microsatellite instability high(MSI-H),while no cases with HER2 amplification displayed *** genes varied between ERBB2 copy number variation(CNV)and ERBB2 single nucleotide variant(SNV);TP53 alterations tended to co-occur with ERBB2 amplification(92.3%)as opposed to ERBB2 mutation(58.3%).KRAS and PIK3CA alterations were more prevalent in ERBB2 SNV cases(KRAS/PIK3CA:45.8%/31.2%)compared to ERBB2 amplification cases(KRAS/PIK3CA:14.1%/7.7%).Conclusion:Our study delineates the landscape of HER2 alterations in a large-scale cohort of CRC patients from *** findings enhance our understanding of the molecular features of Chinese CRC patients and offer valuable implications for further investigation.

关键词： Colorectal cancer ERBB2 HER2 Human epidermal growth factor receptor 2 Genetic profiling Precision oncology

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Anesthesia with ciprofol in cardiac surgery with cardiopulmonary bypass:A case report

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World Journal of Clinical Cases 2023年第1期11卷 157-163页

作者： Le Yu evelyne bischof Hui-Hong Lu Department of Anesthesiology East HospitalTongji University School of MedicineShanghai 200120China Laboratory of Tumor Molecular Biology School of Basic Medical SciencesShanghai University of Medicine and Health SciencesShanghai 201318China Department of Anesthesiology Shanghai East Hospital of Tongji UniversityShanghai 200120China

BACKGROUND Ciprofol is a novel agent for intravenous general *** February 2022,it was approved by the National Medical Products Administration for general anesthesia induction and *** has the advantages of fast onset,fast elimination,stable circulation,and few adverse ***,the efficacy and safety of ciprofol in cardiac surgery with cardiopulmonary bypass have not been *** we describe a case where ciprofol was successfully used for anesthesia in cardiac surgery with cardiopulmonary *** SUMMARY A 72-year-old man(height 176 cm;weight 70 kg)was diagnosed with coronary atherosclerotic cardiomyopathy requiring coronary artery bypass grafting and left ventricular *** was administered for induction(0.4 mg/kg)and maintenance(0.6-1.0 mg/kg/h)of general *** the entire operation,the bispectral index,hemodynamics,and blood oxygen saturation were maintained at normal *** patient recovered well after surgery,with no serious adverse events related to *** Ciprofol is safe and effective for anesthesia in cardiac surgery with cardiopulmonary bypass.

关键词： Ciprofol Coronary artery bypass grafting Left ventricular aneurysmectomy Cardiopulmonary bypass Case report

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