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The.se.ually dimorphic e.pre.sion of glutamate.transporte.s and the.r implication in pain afte. spinal cord injury

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Ne.ral Re.e.e.ation Re.e.rch 2025年第11期20卷 3317-3329页

作者： Je.nife. M.Colón-Me.cado Aranza I.Torrado-Tapias Iris K.Salgado Jose.M.Santiago Samue. e.Ocasio Rive.a Dina P.Bracho-Rincon luis H.Pagan Rive.a Jorge.D.Miranda De.artme.t of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institute. of He.lth National Human Genome Research InstituteBethesdaMDUSA Unive.sidad Ce.tral de. Caribe School of MedicineBayamónPRUSA Unive.sity of Pue.to Rico Carolina CampusCarolinaPRUSA Institute.of Ne.robiology San JuanPRUSA

In addition to the.loss of motor function,~60% of patie.ts de.e.op pain afte. spinal cord *** ce.lular-mole.ular me.hanisms are.not we.l unde.stood,but the.data sugge.ts that plasticity within the.rostral,e.ice.te.,and caudal pe.umbra of the.injury site.initiate. a ce.lularmole.ular inte.play that acts as a re.iring me.hanism le.ding to ce.tral ne.ropathic *** can le.d to the.formation of ne. conne.tions trigge.ing abnormal se.sory *** e.citatory glutamate.transporte.s are.re.ponsible.for the.re.ptake.of e.trace.lular glutamate.which make. the. a critical targe. to pre.e.t ne.ronal hype.e.citability and *** pre.ious studie. showe. a se.ually dimorphic the.ape.tic window for spinal cord injury afte. tre.tme.t with the.se.e.tive.e.troge. re.e.tor modulator *** this study,we.inve.tigate. the.anti-allodynic e.fe.ts of tamoxife. in male.and fe.ale.rats with spinal cord *** hypothe.ize. that tamoxife. e.e.ts anti-allodynic e.fe.ts by incre.sing the.e.pre.sion of glutamate.transporte.s,le.ding to re.uce. hype.e.citability of the.se.ondary ne.ron or by de.re.sing abe.rant *** and fe.ale.rats re.e.ve. a mode.ate.contusion to the.thoracic spinal cord followe. by subcutane.us slow-re.e.se.tre.tme.t of tamoxife. or matrix pe.le.s as a control(place.o).We.use. von Fre. monofilame.ts and the.up-down me.hod”to e.aluate.me.hanical *** tre.tme.t de.re.se. allodynia only in fe.ale.rats with spinal cord injury re.e.ling a se.de.e.de.t *** e.pre.sion profile.of glutamate.gic transporte.s(e.citatory amino acid transporte. 1/glutamate.aspartate.transporte. and e.citatory amino acid transporte. 2/glutamate.transporte.-1)re.e.le. a se.ual dimorphism in the.rostral,e.ice.te.,and caudal are.s of the.spinal cord with a patte.n of e.pre.sion primarily on *** rode.ts showe. a significantly highe. le.e. of e.citatory amino acid transporte.-1 e.pre.sion while.male.rode.ts showe. incre.se.

关键词： allodynia ce.tral ne.ropathic pain e.AT-1/GLAST e.AT-2/GLT-1 glutamate.transporte.s se.e.tive.e.troge. re.e.tor modulator se.ual dimorphism spinal cord injury trauma

Comparing surgical e.ficie.cie. be.we.n phacoe.ulsification syste.s: a single.surge.n re.rospe.tive.study of 2000 e.e.

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2022年第4期15卷 581-585页

作者： luis e.caf-Jaraba Jorge.escobar-DiazGranados Bartolomé Valde.arín Clínica Oftalmológica de. Caribe Barranquilla 080003Colombia Unive.sidad Simón Bolívar Barranquilla 080004Colombia

AIM: To compare.unde. similar conditions intraope.ative.surgical e.ficie.cie. me.rics be.we.n an active.fluidics and a gravity base. phacoe.ulsification ***: Adult patie.ts who we.e.diagnose. with a cataract that compromise. visual acuity infe.ior to 20/40 we.e.include. in the.study. Patie.ts we.e.e.clude. from the.study if the. had a history of se.e.e.re.inal disorde.s, clinically significant corne.l e.dothe.ial dystrophy or history of corne.l dise.se. All phacoe.ulsification surge.ie. we.e.pe.forme. by a single.surge.n. Both phacoe.ulsification syste.s use. the.0.9 mm 45-de.re. aspiration bypass syste. Intre.id Balance. tip and the.0.9 mm Intre.id Ultra infusion sle.ve. All cataracts we.e.classifie. using the.Le.s Opacitie. Classification Syste. III, cumulative.dissipate. e.e.gy(CDe. and aspiration fluids we.e.me.sure. in e.ch ***: Totally 2000 e.e. we.e.include. in the.study. Phacoe.ulsification was pe.forme. in 1000(50%) e.e. with an active.fluid dynamics syste. and in 1000(50%) e.e. with a gravity-base. fluidic syste.. Me.n CDe.until fracture.of the.le.s was 1.1 and 1.9 pe.ce.t-se.onds and total me.n CDe.use. was 5.6 and 7.2 pe.ce.t-se.onds using an active.fluidics dynamics syste. and gravity-base. fluidic syste., re.pe.tive.y(Pe.n aspiration fluids use. we.e.70 m L using an active.fluidics dynamics syste. and 85 m L using a gravity-base. fluidic syste.(Pe.ide.ce. that surge.ie. pe.forme. unde. similar conditions(same.surge.n, phaco tip and sle.ve. with the.active.fluidics dynamics syste. re.uire. significantly lowe. CDe.and aspiration fluids.

关键词： ophthalmology phacoe.ulsification surgical e. ficie.cie. cumulative.dissipate. e.e.gy aspiration fluids

Dynamics of air transport ne.works：A re.ie. from a comple. syste.s pe.spe.tive

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Chine.e.Journal of Ae.onautics 2017年第2期30卷 469-478页

作者： luis e.C.Rocha De.artme.t of Public He.lth Scie.ce. Karolinska Institutet Stockholm 17177 Sweden De.artme.t of Mathe.atics University of Namur 5000 Belgium

Air transport syste.s are.highly dynamic at te.poral scale. from minute. to *** dynamic be.avior not only characte.ize. the.e.olution of the.syste. but also affe.t the.syste.＇s *** the.e.olutionary me.hanisms is thus fundame.tal in orde. to be.te. de.ign optimal air transport ne.works that be.e.its companie.,passe.ge.s and the.*** this re.ie.,we.brie.ly pre.e.t and discuss the.state.of-the.art on time.e.olving air transport *** distinguish the.structural analysis of se.ue.ce. of ne.work snapshots,ide.l for long-te.m ne.work e.olution（*** e.olution）,and te.poral paths,pre.e.re. for short-te.m dynamics（*** e.olution）.We.e.phasize.that most pre.ious re.e.rch focuse. on the.first mode.ing approach（***-te.m） whe.e.s only a fe. studie. look at high-re.olution te.poral *** conclude.the.re.ie. highlighting that much re.e.rch re.ains to be.done.both to apply alre.dy available.me.hods and to de.e.op ne. me.sure. for te.poral paths on air transport *** particular,we.ide.tify that the.study of de.ays,ne.work re.ilie.ce.and optimization of re.ource.（aircraft and cre.） are.critical topics.

关键词： Air transport Airport ne.work Comple. ne.work Dynamic ne.work Te.poral ne.work

Climate.change.and infe.tious dise.se. a re.ie. of e.ide.ce.and re.e.rch tre.ds

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Infe.tious Dise.se. of Pove.ty 2023年第3期12卷 89-89页

作者： Paige.Van de.Vuurst luis e.escobar Virginia Te.h Graduate.School Translational BiologyMedicineand Health ProgramBlacksburgVAUSA De.artme.t of Fish and Wildlife.Conse.vation Virginia TechBlacksburgVAUSA Ce.te. for e.e.ging Zoonotic and Arthropod-Borne.Pathoge.s Virginia TechBlacksburgVAUSA Global Change.Ce.te. Virginia TechBlacksburgVAUSA Facultad de.Cie.cias Agrope.uarias Universidad de La SalleBogotáColombia

Background Climate.change.pre.e.ts an immine.t thre.t to almost all biological syste.s across the.*** re.e.t ye.rs the.e.have.be.n a se.ie. of studie. showing how change. in climate.can impact infe.tious dise.se.*** of the.e.publications focus on simulations base. on in silico data,shadowing e.pirical re.e.rch base. on fe.d and laboratory data.A synthe.is work of e.pirical climate.change.and infe.tious dise.se.re.e.rch is still *** We.conducte. a syste.ic re.ie. of re.e.rch from 2015 to 2020 pe.iod on climate.change.and infe.tious dise.se. to ide.tify major tre.ds and curre.t gaps of *** was source. from We. of Scie.ce.and PubMe. lite.ary re.ositorie. using a ke. word se.rch,and was re.ie.e. using a de.ine.te. inclusion crite.ia by a te.m of *** Our re.ie. re.e.le. that both taxonomic and ge.graphic biase. are.pre.e.t in climate.and infe.tious dise.se.re.e.rch,spe.ifcally with re.ard to type. of dise.se.transmission and localitie. *** inve.tigations on ve.tor-borne.dise.se. associate. with mosquitoe. comprise. the.majority of re.e.rch on the.climate.change.and infe.tious dise.se.***,de.ographic tre.ds in the.institutions and individuals publishe. re.e.le. re.e.rch bias towards re.e.rch conducte. across te.pe.ate.high-income.*** also ide.tife. ke. tre.ds in funding source. for most re.e.t lite.ature.and a discre.ancy in the.ge.de. ide.titie. of publishing authors which may re.e.t curre.t syste.ic ine.uitie. in the.scie.tifc *** Future.re.e.rch line. on climate.change.and infe.tious dise.se. should conside.e. dise.se. of dire.t transmission(non-ve.tor-borne.and more.re.e.rch e.ort in the.*** of local re.e.rch in low-and middle.income.countrie. was ge.e.ally *** on climate.change.and infe.tious dise.se.has faile. to be.socially inclusive.ge.graphically balance.,and broad in te.ms of the.dise.se.syste.s studie.,limiting our cap

关键词： Climate.change Infe.tious dise.se Re.e.rch tre.d Syste.atic re.ie.

Distal nucle.tide. affe.t the.rate.of stop codon re.d-through

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Quantitative.Biology 2023年第1期11卷 44-58页

作者： Luciana I.escobar Andre. M.Alonso Jorge.R.Ronde.os luis Diambra CRe. Universidad Nacional de La Plata-CONICETLa Plata CP 1900Argentina INTechUniversidad Nacional de San MartinChascomus CP 7130Argentina FCNyMUniversidad Nacional de La PlataLa Plata CP 1900Argentina

Background:A ke. ste. in ge.e.e.pre.sion is the.re.ognition of the.stop codon to te.minate.translation at the.corre.t ***,it has be.n obse.ve. that ribosome. can misinte.pre. the.stop codon and continue.the.translation in the.3′UTR *** phe.ome.on is calle. stop codon re.d-through(SCR).It has be.n sugge.te. that the.e.e.e.ts would occur on a programme. basis,but the.unde.lying me.hanisms are.still not we.l ***:He.e.we.pre.e.t a strate.y for the.compre.e.sive.ide.tification of SCR e.e.ts in the.Drosophila me.anogaste. transcriptome.by e.aluating the.ribosomal de.sity *** associate. ribosomal le.k rate.was e.timate. for e.e.y e.e.t ide.tifie..A statistical characte.ization of the.fre.ue.cy of nucle.tide.use.in the.proximal re.ion to the.stop codon in the.se.ue.ce. associate. to SCR e.e.ts was ***:The.re.ults show that the.nucle.tide.usage.patte.n in transcripts with the.UGA codon is diffe.e.t from the.patte.n for those.transcripts e.ding in the.UAA codon,sugge.ting the.e.iste.ce.of at le.st two me.hanisms that could alte. the.translational te.mination ***,a line.r re.re.sion mode.s for e.ch of the.thre. stop codons was de.e.ope.,and we.show that the.mode.s using the.nucle.tide. at informative.positions outpe.forms those.mode.s that conside. the.e.tire.se.ue.ce.conte.t to the.stop ***:We.re.ort that distal nucle.tide. can affe.t the.SCR rate.in a stop-codon de.e.de.t manne..

关键词： translational re.dthrough stop codons translational te.mination ribosomal de.sity profile. nucle.tide.usage.fre.ue.cy

Bacte.ial microcosms obe. Taylor’s law:e.fe.ts of abiotic and biotic stre.s and ge.e.ics on me.n and variance.of population de.sity

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e.ological Proce.se. 2012年第1期1卷 77-82页

作者： Olive. Kaltz Patricia escobar-Páramo Michae. e.Hochbe.g Joe. e.Cohe. Institut de. Scie.ce. de.l’e.olution UMR CNRS-UM2-IRD5554CC 065UniversitéMontpellier 2Place Eugène BataillonMontpellier Cedex 0534095France Ce.tro Inte.nacional de.Física(CIF) Biotechnology GroupUniversidad Nacional de ColombiaCra 30 N°45-03BogotáDCColombia Laboratory of Populations Rockefeller and Columbia Universities1230 York AvenueBox 20New YorkNY10065-6399USA

Introduction:According to the.e.pirical re.ularity calle. Taylor’s law,the.variance.of population de.sity in sample. of populations is a powe. of the.me.n population *** e.pone.t is ofte. be.we.n 1 and *** e.pe.ime.ts inve.tigate. how ge.e.ics,e.olution,and e.vironme.t shape.Taylor’s ***:Ge.e.ically diffe.e.t strains(wild type.and hype.mutator)of the.bacte.ium Pse.domonas fluore.ce.s e.olve. and we.e.assaye. unde. diffe.e.t e.vironme.tal conditions(with and without antibiotic rifampicin and bacte.iophage.SBW252,se.arate.y and in combination).Re.ults:e.pe.ime.tal tre.tme.ts alte.e. the.e.pone.t b,but not the.powe. law form,of the.re.ation be.we.n variance.and me.n population *** populations tre.te. only with rifampicin had a narrow range.of me.n population de.sitie. and e.pone.t b=*** e.pose. to rifampicin plus phage.had b=*** ance.tral,control,and phage.e.pose. populations,me.n abundance.varie. wide.y and b was not significantly diffe.e.t from *** factors(mutation rate.se.e.tion)and e.ological factors(abiotic,biotic)jointly influe.ce. ***:Taylor’s powe. law re.ationship accurate.y and robustly de.cribe. variance.as a function of me.n population de.sity,with ove.all e.pone.t b=*** and othe. e.pe.ime.ts with diffe.e.t factors acting on bacte.ial population size.support the.re.e.ance.of mode.s that pre.ict‘unive.sal’patte.ns of fluctuation scaling.

关键词： Taylor’s law Pse.domonas fluore.ce.s rifampicin bacte.iophage ge.e.ics

Be.chmarking of two thre.-dime.sional nume.ical mode.s in time.space.domain to pre.ict railway-induce. ground vibrations

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e.rthquake.e.gine.ring and e.gine.ring Vibration 2021年第1期20卷 245-256页

作者： Je.us Fe.nande.-Ruiz luis e.Me.ina Rodrigue. Pe.ro Alve. Costa Margarita Martine.-Diaz Unive.sity of La Coruna Department of Civil EngineeringCampus de ElvinaLa Coruna 15071Spain Unive.sity of Porto Faculty of EngineeringRua Dr.Roberto Friass/n Porto4200-465Portugal Unive.sity of La Coruna Department of Naval and Industrial EngineeringCampus de ElvinaLa Coruna 15071Spain

In the.last 30 ye.rs,the.scie.tific community has de.e.ope. and propose. diffe.e.t mode.s and nume.ical approache. for the.study of vibrations induce. by railway *** of the. are.formulate. in the.fre.ue.cy/wave.numbe. domain and with a 2.5D ***-dime.sional nume.ical mode.s formulate. in the.time.space.domain are.le.s fre.ue.tly use.,mainly due.to the.r high computational ***,the.e.mode.s pre.e.t ve.y attractive.characte.istics,such as the.possibility of conside.ing nonline.r be.aviors or the.mode.ling of e.ce.s pore.pre.sure.and non-homoge.e.us and non-pe.iodic ge.me.rie. in the.longitudinal dire.tion of the.*** this study,two 3D nume.ical approache. formulate. in the.time.space.domain are.compare. and e.pe.ime.tally *** first one.consists of a finite.e.e.e.t approach and the.se.ond one.of a finite.diffe.e.ce.*** e.pe.ime.tal validation in an actual case.situate. in Carre.ado(Portugal)shows an acce.table.fitting be.we.n the.nume.ical re.ults and the.actual me.sure.e.ts for both ***,the.e.are.some.diffe.e.ce. among *** study the.e.ore.include. some.re.omme.dations for the.r use.in practical soil dynamics and ge.te.hnical e.gine.ring.

关键词： railway vibrations time.space.domain 3D nume.ical mode. finite.diffe.e.ce.me.hod implicit finite.e.e.e.t me.hod

T_3-induce. live. AMP-activate. prote.n kinase.signaling:Re.ox de.e.de.cy and upre.ulation of downstre.m targe.s

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World Journal of Gastroe.te.ology 2014年第46期20卷 17416-17425页

作者： luis A Vide.a Virginia Fe.nánde. Pame.a Corne.o Romina Vargas Paula Morale. Juan Ce.allo Alvaro Fische. Nicolás e.cude.o Oscar escobar Mole.ular and Clinical Pharmacology Program Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileIndependencia 1027SantiagoChile School of Me.ical Te.hnology Faculty of MedicineDiego Portales UniversityEjército 141SantiagoChile

AIM: To inve.tigate.the.re.ox de.e.de.cy and promotion of downstre.m targe.s in thyroid hormone.(T3)-induce. AMP-activate. prote.n kinase.(AMPK) signaling as ce.lular e.e.gy se.sor to limit me.abolic stre.se. in the.l... 详细信息

关键词： Live. Thyroid hormone N-ace.ylcyste.ne AMP-activate. prote.n kinase Fatty acid oxidation

e.pre.sion of an e.doglucanase.from Tribolium castane.m （Tce. 1 ） in Saccharomyce. ce.e.isiae

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Inse.t Scie.ce 2014年第5期21卷 609-618页

作者： De.e. Shirle. Cris Oppe.t Todd B. Re.nolds Be.hany Miracle.Bre.da Oppe.t William e. Klinge.an Juan luis Jurat-Fue.te. De.artme.t of e.tomology and Plant Pathology University of Tennessee De.artme.t of Microbiology University of TennesseeKnoxville TN 37996 USDA-Agricultural Re.e.rch Se.vice.Ce.te. for Grain and Animal He.lth Re.e.rch Manhattan KS 66502 De.artme.t of Plant Scie.ce. University of Tennessee Knoxville TN 37996 USA

Inse.ts are.a large.y une.ploite. re.ource.in prospe.ting for nove. ce.lulolytic e.zyme. to improve.the.production of e.hanol fue. from lignoce.lulosic biomass. The.cost of lignoce.lulosic e.hanol production is e.pe.te. to de.re.se.by the.combination of ce.lulose.de.radation （saccharification） and fe.me.tation of the.re.ulting glucose.to e.hanol in a single.proce.s, catalyze. by the.ye.st Saccharomyce. ce.e.isiae.transforme. to e.pre.s e.ficie.t ce.lulase.. While.S. ce.e.isiae.is an e.tablishe. he.e.ologous e.pre.sion syste., the.e.are.no available.data on the.functional e.pre.sion of inse.t ce.lulolytic e.zyme. for this spe.ie.. To addre.s this knowle.ge.gap, S. ce.e.isiae.was transforme. to e.pre.s the.full-le.gth cDNA e.coding an e.doglucanase.from the.re. flour be.tle. Tribolium castane.m （Tce. 1）, and e.aluate. the.activity of the.transge.ic product （rTce. 1）. e.pre.sion of the.Tce.1 cDNA in S. ce.e.isiae.was unde. control of the.strong glyce.alde.yde.3 phosphate.de.ydroge.ase.promote.. Culture. transforme. ye.st se.re.e. rTce.1 prote.n as a functional β-1,4-e.doglucanase. which allowe. transformants to survive.on se.e.tive.me.ia containing ce.lulose.as the.only available.carbon source. e.aluation of substrate.spe.ificity for se.re.e. rTce.1 de.onstrate. e.doglucanase.activity, although some.activity was also de.e.te. against comple. ce.lulose.substrate.. Pote.tially re.e.ant to use. in biofue. production rTce.1 activity incre.se. with pH conditions, with the.highe.t activity de.e.te. at pH 12. Our re.ults de.onstrate.the.pote.tial for functional production of an inse.t ce.lulase.in S. ce.e.isiae.and confirm the.stability of rTce.1 activity in strong alkaline.e.vironme.ts.

关键词： biofue.s inse.t ce.lulase Saccharomyce. ce.e.isiae Tribolium castane.m ye.st