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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

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Science china(Life Sciences) 2024年第5期67卷 865-878页

作者： Wei Jia Yitao Li Kenneth c.p.cheung Xiaojiao Zheng School of chinese Medicine Hong Kong Baptist UniversityHong KongChina center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University School of MedicineShanghai 200233China

Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis.Through the enterohepatic circulation,BAs are synthesized,metabolized,and reabsorbed,with a portion entering the vascular circulation and distributing systemically.This allows BAs to interact with receptors in all major organs,leading to organ-organ interactions that regulate both local and global metabolic processes,as well as the immune system.This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation,including in the brain,heart,liver,intestine,eyes,skin,adipose tissue,and muscle.Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.

关键词： bile acid whole body metabolism immunity

Drought events influence nutrient canopy exchanges and green leaf partitioning during senescence in a deciduous forest

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Forest Ecosystems 2024年第1期11卷 110-119页

作者： J.Touche c.calvaruso p.De Donato M.-p.Turpault INRAE BEFF-54000NancyFrance UMR 7359 GeoRessourcesFaculte des Sciences-Campus des Aiguillettes54506Vandoeuvre Les NancyFrance EcoSustain Environmental Engineering OfficeResearch and DevelopmentKanfen57330France

The increase in the frequency and intensity of drought events expected in the coming decades in Western Europe may disturb forest biogeochemical cycles and create nutrient deficiencies in trees.One possible origin of nutrient deficiency is the disturbance of the partitioning of the green leaf pool during the leaf senescence period between resorption,foliar leaching and senesced leaves.However,the effects of drought events on this partitioning and the consequences for the maintenance of tree nutrition are poorly documented.An experiment in a beech forest in Meuse(France)was conducted to assess the effect of drought events on nutrient canopy exchanges and on the partitioning of the green leaf pool during the leaf senescence period.The aim was to identify potential nutritional consequences of droughts for trees.Monitoring nutrient dynamics,including resorption,chemistry of green and senesced leaves,foliar absorption and leaching in mature beech stands from 2012 to 2019 allowed us to compare the nutrient exchanges for three nondry and three dry years(i.e.,with an intense drought event during the growing season).During dry years,we observed a decrease by almost a third of the potassium(K)partitioning to resorption(i.***.resorption efficiency),thus reducing the K reserve in trees for the next growing season.This result suggests that with the increased drought frequency and intensity expected for the coming decades,there will be a risk of potassium deficiency in trees,as already observed in a rainfall exclusion experiment on the same study site.Reduced foliar leaching and higher parititioning to the senesced leaves for K and phosphorus(p)were also observed.In addition,a slight increase in nitrogen(N)resorption efficiency occurred during dry years which is more likely to improve tree nutrition.The calcium(ca)negative resorption decreased,with no apparent consequence in our study site.Our results show that nutrient exchanges in the canopy and the partitioning of the green leaf pool can be modified by drought events,and may

关键词： Natural drought Beech forest canopy Resorption Foliar leaching Senesced leaves Nutrition

HI in High Gas-phase Metallicity Dwarf Galaxy WISEA J230615.06+143927.9

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Research in Astronomy and Astrophysics 2024年第1期24卷 292-299页

作者： Yan Guo c.Sengupta T.c.Scott p.Lagos Y.Luo purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Sciences University of Science and Technology of ChinaHefei 230026China Institute of Astrophysics and Space Sciences(IA porto) Rua das Estrelas4150-762PortoPortugal

We present resolved Giant Metrewave Radio Telescope H I observations of the high gas-phase metallicity dwarf galaxy WISEA J230615.06+143927.9(z = 0.005)(hereafter J2306) and investigate whether it could be a Tidal Dwarf Galaxy(TDG) candidate. TDGs are observed to have higher metallicities than normal dwarfs. J2306 has an unusual combination of a blue g-r color of 0.23 mag, irregular optical morphology and high-metallicity(12 +log(O/H) = 8.68 ± 0.14), making it an interesting galaxy to study in more detail. We find J2306 to be an H I rich galaxy with a large extended, unperturbed rotating H I disk. Using our H I data we estimated its dynamical mass and found the galaxy to be dark matter(DM) dominated within its H I radius. The quantity of DM, inferred from its dynamical mass, appears to rule out J2306 as an evolved TDG. A wide area environment search reveals J2306 to be isolated from any larger galaxies which could have been the source of its high gas metallicity. Additionally, the H I morphology and kinematics of the galaxy show no indication of a recent merger to explain the high-metallicity.Further detailed optical spectroscopic observations of J2306 might provide an answer to how a seemingly ordinary irregular dwarf galaxy achieved such a high level of metal enrichment.

关键词： galaxies:abundances galaxies:dwarf galaxies:irregular radio lines:galaxies radio lines:ISM

Effect of radiative loss mechanisms on FIR thermometric parameters of Nd3+-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257页

作者： c.Y.Morassuti A.p.L Silva L.A.O.Nunes S.M.Lima L.H.c.Andrade Optical and photothermal Spectroscopy Group (GEOF) Center for Studies in Natural Resources (CERNA)State University of Mato Grosso do Sul(UEMS) Renato Archer Information Technology center Institute of physics of Sao carlos University of S?o Paulo

Nd3+-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio（FIR） technique.Nevertheless,at high Nd3+concentrations,energy transfer（ET） processes such as optical reabsorption and cross-relaxation can affect the Nd3+emission,which has been little explored in the literature.Therefore,the present work investigated the use of Nd3+-doped tellurite glass(samples doped with Nd3+at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%) in fluorescence thermometers,in the temperature range from 299 to 371 K.The results indicate a strong dependence of the FIR parameters on the Nd3+concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd3+emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio4F5/2→4I9/2/4F3/2→4I9/2is observed for samples doped with higher amounts of Nd3+.The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd3+ions.

关键词： Fluorescence intensity ratio Judd-Ofelt Nd3+-doped tellurite glass Optical thermometry Rare earths

Laser-induced graphene-coated wearable smart textile electrodes for biopotentials signal monitoring

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Frontiers of Materials Science 2024年第1期18卷 95-111页

作者： c.M.Vidhya Yogita Maithani Sakshi Kapoor J.p.Singh Department of physics Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

This paper describes how to produce a wearable dry electrode at a reasonable cost and how to use it for the monitoring of biopotentials in electrocardiography.Smart textiles in wearable technologies have made a great advancement in the health care management and living standards of humans.Graphene was manufactured using the low-cost single-step process,laser ablation of polyimide,a commercial polymer.Graphene dispersions were made using solvent isopropyl alcohol which has low boiling point,nontoxicity,and environmental friendliness.After successive coating of the graphene dispersion on the cotton fabric to make it conductive,the sheet resistance of the resulting fabric dropped to 3% of its initial value.The laser-induced graphene(LIG)cotton dry electrodes thus manufactured are comparable to Ag/Agcl wet electrodes in terms of the skin-to-electrode impedance,measuring between 78.0 and 7.2 kΩ for the frequency between 40 Hz and 1 kHz.The LIG cotton electrode displayed a signal-to-noise ratio of 20.17 dB.Due to its comfort,simplicity,and good performance over a longer period of time,the textile electrode appears suited for medical applications.

关键词： biopotential electrocardiogram electromyogram flexible electrode textile porous graphene

Radiative decays D*(s)→ D(s)γ in covariant confined quark model

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chinese physics c 2024年第2期48卷 45-56页

作者： c.T.Tran M.A.Ivanov p.Santorelli Q.c.Vo Department of physics HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretical physics Joint Institute for Nuclear Research141980 DubnaRussia Dipartimento di Fisica"E.pancini" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisica Nucleare Sezione di Napoli80126 NapoliItaly University of Science 700000 Ho Chi Minh CityVietnam

Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢcollaborations.The radiative couplings gD*Dγencoding nonperturbative QcD effects are calculated in the framework of the covariant confined quark model developed by us.We compare our results with other theoretical studies and experimental data.The couplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)calculated in our model agree with the corresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting case is the decay Ds*→Dsγ,for which a recent prediction based on light-cone sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattice QcD result|gDs*Dsγ|=0.11(2)at nearly3σ.Our calculation yields|gDs*Dsγ|=0.29(6),which falls somehow between the two mentioned results,although it is larger than those predicted in other studies using quark models or QcD sum rules.

关键词： covariant quark model radiative decay charmed meson

Seasonal changes in Hermit Thrush (catharus guttatus) song syntax

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Avian Research 2024年第2期15卷 172-179页

作者： Sean p.Roach Luke c.McLean Jeff W.MacLeod Leslie S.phillmore psychology Department University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Department of psychology and Neuroscience Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In many songbird species,birdsong features phonological syntax,meaning that the units within their vocal se-quences are ordered in a non-random way that adheres to a rule.While such syntactical patterns have been richly described in many species,comparatively little is known about how those patterns contribute to song achieving its important functions.For each of song’s main functions,territorial defense and mate attraction,evidence of a role for syntax is limited.One species for which syntax has been thoroughly described is the Hermit Thrush(catharus guttatus),which presents song types from their repertoires in a semi-predictable order and,in doing so,rapidly cycle up and down the frequency spectrum.The objective of the present study was to explore the importance of song syntax in the Hermit Thrush through a within-subject examination of how measures of syntax,such as the predictability of song type order within song sequences,shift over the breeding season.We hypothesized that,if such syntactical characteristics are important to breeding behaviour,they would be most prominent at the start of the breeding season when activity associated with territory establishment and mate attraction is most intense.Analysis revealed that,as predicted,the rigidness of song type ordering within se-quences was highest at the start of the season and declined thereafter.That song type sequences were most predictable at the vitally important early part of the breeding season fit our hypothesis that this aspect of song syntax is important to song’s functions related to territory establishment and/or mate attraction.Future work will clarify whether that role relates to one of song’s two main functions or serves song transmission in some broader way.

关键词： Birdsong Hermit Thrush Seasonal change Stereotypy Syntax

Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthopedics 2024年第6期15卷 585-592页

作者： Katherine Esser James J Butler Mackenzie Roof Nathaniel p Mercer Michael c Harrington Alan p Samsonov Andrew J Rosenbaum John G Kennedy Department of Orthopaedic Surgery University of Toledo Medical center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Department of Orthopedic Surgery NYU Langone HealthNew YorkNY 10002United States Department of Orthopedic Surgery Albany Medical CenterAlbanyNY 12208United States

BAcKGROUND cheilectomy of the 1^(st)metatarsophalangeal joint(MTpJ)is one of the most common procedures for the management of hallux rigidus.However,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDc)for the management of hallux rigidus.AIM To evaluate outcomes following MIDc for the management of hallux rigidus.METHODS During November 2023,the pubMed,EMBASE and cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDc for the management of hallux rigidus.RESULTS Six studies were included.In total,348 patients(370 feet)underwent MIDc for hallux rigidus at a weighted mean follow-up of 37.9±16.5 months.The distribution of patients by coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 patients,27.1%),Ⅱ(112 patients,52.3%),Ⅲ(44 patients,20.6%).Three studies performed an additional 1^(st)MTpJ arthroscopy and debridement following MIDc.Retained intra-articular bone debris was observed in 100%of patients in 1 study.The weighted mean American orthopedic foot and ankle society score improved from a preoperative score of 68.9±3.2 to a postoperative score of 87.1.The complication rate was 8.4%,the most common of which was persistent joint pain and stiffness.Thirty-two failures(8.7%)were observed.Thirty-three secondary procedures(8.9%)were performed at a weighted mean time of 8.6±3.2 months following the index procedure.cONcLUSION This systematic review demonstrated improvements in subjective clinical outcomes together with a moderate complication rate following MIDc for the management of hallux rigidus at short-term follow-up.A moderate reoperation rate at short-term follow-up was recorded.The marked heterogeneity between included studies and paucity of high quality comparative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsophalangeal joint cheilectomy Minimally invasive surgery

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抗肥胖症药物市场需求旺盛

Engineering 2024年第1期32卷 4-6页

作者： Sarah c.p.Williams Senior Technology Writer

In early September 2023,when its market cap jumped to 428 billion USD,a valuation topping the estimated 2022 gross domestic product of its Scandinavian home country,the drugmaker Novo Nordisk(Bagsværd,Denmark)briefly eclipsed the French luxury brand conglomerateLMVH(paris,France)as Europe's most valuable company[1].The reason for the company's soaring worth?Its already best-selling weight loss drug Wegovy was being released to patients in the United Kingdom.

关键词： market French briefly