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Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

World Journal of Gastroenterology 2015年第15期21卷 4599-4606页

作者： Soumana C Nasser Mahmoud Slim Jeanette G Nassif selim M Nasser School of Pharmacy Lebanese American University Institute of Neuroscience University of Granada Department of Pathology School of Medicine Lebanese American University

AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal ***: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney ***: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and le

关键词： Gastritis Diagnosis Helicobacter pylori Proton pump inhibitors Social factors

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Humidity and seasonality drives body size patterns in males of the bush cricket Isophya rizeensis Sevgili, 2003 （Orthoptera： Tettigoniidae： Phaneropterinae）

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Insect Science 2014年第2期21卷 213-226页

作者： selim S. Cagasan Cagasan Karacaoglu A. Cem Kuyucu ismail K. Saelam Department of Biology Ecological Sciences Research Laboratories Faculty of Science Hacettepe University Beytepe 06800 Ankara Turkey

Two primary patterns of body size variation have been recorded in ectotherms in relation to latitudinal/altitudinal shifts. In some, body size increases with increasing latitude/altitude whereas, in others, body size decreases with increasing latitude/altitude. This clinal variation is generally assumed to be caused by local adaptation to environmental conditions however the selective variable（s）（temperature, humidity, diet quality, etc.） is still heavily debated. Here we investigate geographic variation in body size of dark and pale color morphs of males of the bush-cricket lsophya rizeensis collected from 15 locations along an elevation gradient ranging from 350 to 2 500 m. Using an information theoretical approach we evaluate the relative support of four different hypotheses （the temperature size rule, the moisture gradient hypothesis, the seasonal constraint hypothesis, and the primary productivity hypothesis） explaining body size variation along the altitudinal gradient. Body size variation in pale color morphs showed a curvilinear relationship with altitude while dark color morphs showed no variation in body size. Body size variation in pale color morphs was highly correlated with precipitation and temperature seasonality values thus giving strong support for the moisture gradient and seasonal constraint hypothesis. Our results reinforce the importance of gradients in humidity and seasonality over temperature in the creation of altitudinal body size clines and the role of selection for resistance to stress factors in the establishment of these clines. Whether a body size cline is observed or not might also depend on the phenotypic properties of the individuals, like coloration.

关键词： altitude Bergmann's rule converse Bergmann's rule Flrtlna Valley,information-theoretic temperature size rule

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Ultrasound biomicroscopic evaluation of anterior segment cysts as a risk factor for ocular hypertension and closure angle glaucoma

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 515-520页

作者： Abdurrahim Dusak Mehmet Baykara Guven Ozkaya Cuneyt erdogan Hikmet Ozcetin Ercan Tuncel Department of Radiology School of MedicineUludag University Department of Ophthalmology School of MedicineUludag University Department of Statistics School of MedicineUludag University

AIMTo investigate the relationship between the ultrasound biomicroscopic (UBM) features of anterior-segment cysts (ASCs) and increased intraocular pressure (IOP) as a risk factor for closed-angle glaucoma (CAG).

关键词： anterior-segment cyst ocular hypertension closed-angle glaucoma intraocular pressure ultrasound biomicroscopy

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Effect of Boron and Heat Treatment on Mechanical Properties of White Cast Iron for Mining Application

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Journal of Iron and Steel Research International 2011年第11期18卷 31-39页

作者： Havva Kazdal Zeytin Hakan Yildirim Banu Berme selim Duduoglu Gürkan Kazdal Adem Deniz TUBITAK MRC Duduoglu Steel Casting Industry and Trade Inc Co TuBITAK MRC Materials Institute Chemistry Metallurgy Faculty Istanbul Technical University

Heat treatment methods were applied to white cast iron for improving the impact and wear resistance. Additionally, chemical composition optimization was made. Furthermore, the effect of boron addition on such applica- tions was investigated. Samples were investigated by using optical and electron microscope methods. Hardness, wear and impact tests were conducted. The results showed that the secondary carbides in the standard alloy were iron-enriched, needle-like carbides M3C when the boron-added alloy contained Fe23 （C, B）6 type, globular secondary carbides. It was concluded that heat treatment B provided higher wear and hardness properties, compared to the stand- ard heat treatment. Optimum mechanical properties were obtained by lower destabilisation temperatures and increasing temperature reduced the wear resistance and hardness.

关键词： white cast iron mining application impact resistance wear toughness

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H pylori:Treatment for the patient only or the whole family?

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World Journal of Gastroenterology 2008年第8期14卷 1244-1247页

作者： Yavuz selim Sari Didem Can Vahit Tunali Orhan Sahin Oguz Koc Omer Bender SB Istanbul Training Hospital Istanbul Turkey SB Okmeydani Training Hospital Istanbul Turkey

AIM： To compare the effects of treatment of H pyloriinfected individuals with the effects of treatment of individuals as well as all Hpylori-infected family members.METHODS： H pylori-positive patients with similar demographic specifications were prospectively randomized with respect to treatment, with a triple regimen of either patients and all Hpylori-positive family members living together （group Ⅰ ） or patients only （group Ⅱ）. Nine months after treatment, all patients were assessed for H pylori positivity.RESULTS： There were 70 H pylori-positive patients in each group; patients in groups Ⅰ and Ⅱ lived with 175 and 190 Hpylori-positive relatives, respectively. Age, sex and Hpylori positivity rate were similar in both groups of relatives. Nine months after 14 d standard triple therapy, Hpylori positivity was 7.1% in group I patients and 38.6% in group 11 patients [P 〈 0.01, OR = 8.61 95% confidence interval （CI）： 2.91-22.84].CONCLUSION： The present results indicate bad environmental hygienic conditions and close intra-familial relationships are important in H pylori contamination. These findings indicate all family members of H pyloripositive individuals should be assessed for H pylori positivity, particularly in developing countries where H pylori prevalence is high; they also suggest patients, their spouses and all H pyloN-positive family members of H pylori-positive individuals should be treated for H pylori infection.

关键词： H pylori Gastric adenocarcinoma Intrafamilial infections Gastric lymphoma Peptic ulcerdisease Non-ulcer dyspepsia

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Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease

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World Journal of Hepatology 2015年第5期7卷 769-776页

作者： Mustafa Koplay Mesut Sivri Hasan erdogan Alaaddin Nayman Department of Radiology Medical Faculty of Selcuk University

Nonalcoholic fatty liver disease(NAFLD) is one of the most common causes of chronic liver disease and is a major public health problem *** is a spectrum that includes simple steatosis,nonalcoholic steatohepatitis(NASH),fibrosis and ***,NAFLD prevalence in children and adolescents has increased *** increasing prevalence has resulted in NASH-related chronic liver ***,early diagnosis and treatment is quite *** liver biopsy is still the gold standard for diagnosis and staging of NAFLD,particularly for the diagnosis of NASH,imaging methods such as ultrasonography,computed tomography,magnetic resonance imaging with chemical shift imaging and especially magnetic resonance spectroscopy and elastography have been increasingly approved as noninvasive alternative *** aim of this review is to analyze the diagnostic accuracy and limitations of the imaging methods and recent developments in the diagnosis of NAFLD.

关键词： Nonalcoholic fatty liver disease Imagingmethods Nonalcoholic steatohepatitis Elastography Magnetic resonance spectroscopy

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Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure

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World Journal of Gastroenterology 2005年第45期11卷 7183-7187页

作者： selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu Department of Gastroenterology Department of Pathology

AIM： To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure （CRF）. METHODS： Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori （H pylori） and CRF status. Groups were labeled as follows： la： normal renal function, H pylori negative （n = 12）, lb： normal renal function, H pylori positive （n = 11）, 2a： CRF, H pylori negative （n = 10）, 2b： CRF, H pylori positive （n = 11）. Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation, antral biopsy specimens were taken from each patient. In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen （PCNA） labeling indexes （LI） were assessed with immunohistochemical staining method. RESULTS： For groups la, lb, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5, 60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22, respectively. When the one-way ANOVA test was applied, statistically significant differences were detected between the groups for both Bax LI （P = 0.004 〈0.01） and PCNA LI （P = 0.009 〈0.01）. When groups were compared further in terms of Bax LI and PCNA LI with Tukey＇s HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups la and 2b （P = 0.006 〈0.01）.CONCLUSION： In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells.

关键词： Helicobacter pylori Chronic renal failure Bax Proliferating cell nuclear antigen

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Role of Infographics in Healthcare

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Chinese Medical Journal 2018年第20期131卷 2514-2517页

作者： Melisa Balkac erdogan Ergun Faculty of Fine Arts and Design Near East University Nicosia North Cyprus

＂You have read a newspaper or blog, flipped through a magazine, or used social media recently; you have likely come across infographics- those self-contained pictorials that tell you about the gist of the story or co...

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Non-alcoholic steatohepatitis with normal aminotransferase values

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World Journal of Gastroenterology 2009年第15期15卷 1863-1868页

作者： Hüseyin Saadettin Uslusoy selim Giray Nak Macit Gülten Zeynep B|y|kl| Department of Gastrenterology Uludag University Medical School Department of Biostatistics Ankara University School of Medicine

AIM： To investigate the aspects of liver histology in patients with non-alcoholic steatohepatitis （NASH） who had normal aminotransferase levels. METHODS： Thirty-four patients diagnosed with liver steatosis by ultrasonographic examination participated in the study. We compared all non- alcoholic fatty liver disease and NASH cases, according to aminotransferase level, aspartate aminotransferase （AST）/alanine aminotransferase （ALT） ratio and presence of metabolic syndrome. RESULTS： Sixteen of 25 patients with high aminotransferase levels were diagnosed with NASH and nine with simple fatty liver according to liver histology. Among the nine patients with normal aminotransferase levels, seven had NASH and two had simple fatty liver. The patients with normal and high liver enzyme levels had almost the same prevalence of NASH and metabolic syndrome. Liver histology did not reveal any difference according to aminotransferase levels and AST/ALT ratio. CONCLUSION： Aminotransferase levels and AST/AIT ratio do not seem to be reliable predictors for NASH. Despite numerous non-invasive biomarkers, all patients with fatty liver should undergo liver biopsy.

关键词： Non-alcoholic steatohepatitis, Liverenzymes Liver histology

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The aggregate and sectoral time‑varying market efficiency during crisis periods in Turkey:a comparative analysis with COVID‑19 outbreak and the global financial crisis

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Financial Innovation 2023年第1期9卷 2165-2189页

作者： Deniz Erer Elif Erer selim Güngör School of Applied Sciences Manisa Celal Bayar UniversityManisaTurkey Independent Researcher IzmirTurkey Resadiye Vocational School Tokat Gaziosmanpasa UniversityTokatTurkey

This study aims to examine the time-varying efficiency of the Turkish stock market’s major stock index and eight sectoral indices,including the industrial,financial,service,information technology,basic metals,tourism,real estate investment,and chemical petrol plastic,during the COVID-19 outbreak and the global financial crisis(GFC)within the framework of the adaptive market *** study employs multifractal detrended fluctuation analysis to illustrate these sectors’multifractality and short-and long-term *** results show that all sectoral returns have greater persis-tence during the COVID-19 outbreak than during the ***,the real estate and information technology industries had the lowest levels of efficiency during the GFC and the COVID-19 ***,the fat-tailed distribution has a greater effect on multifractality in these *** results validate the conclusions of the adaptive market hypothesis,according to which arbitrage opportunities vary over time,and contribute to policy formulation for future outbreak-induced economic crises.

关键词： MF-DFA Adaptive market hypothesis Global financial crisis COVID-19 outbreak Sectoral indices

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