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Relationship between PON-1 enzymatic activity and risk factors for pesticide poisoning in farmers from the Cienega,Jalisco,Mexico

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BIOCELL 2021年第5期45卷 1241-1250页

作者： HAZAEL RAMIRO CEJA-GALVEZ erandis dheni torres-sánchez JUAN HERIBERTO torres-JAssO EMMANUEL REYEsURIBE JOEL sALAZAR-FLOREs Department of Medical and Life sciences University Center of La CienegaUniversity of Guadalajara(CUCI-UdeG)OcotlánCP 47810Mexico Department of Biological sciences University Center of the CoastUniversity of Guadalajara(CUCosta-UdeG)Puerto VallartaCP 48280Mexico

Paraoxonase-1(PON-1)is an enzyme that hydrolyzes organophosphate *** presence of polymorphisms in PON-1(L55M and Q192R)decreases its enzyme activity and increases the risk of central nervous system(CNs)toxicity in occupationally exposed farmers,leading to chronic degenerative diseases and *** studied 103 farmers in the region of Cienega Jalisco,Mexico,which were exposed mainly to organophosphate *** used serum and plasma samples to assay PON-1 activity and perform polymorphism analysis(L55M and Q192R)using qPCR and TaqMan probes,*** both polymorphisms,there was high percentage of heterozygosity(55 LL=0.19,LM=0.75,MM=0.06;192 QQ=0.12,QR=0.72,RR=0.16),while the allelic frequencies were more balanced(L=0.56,M=0.44;Q=0.48,R=0.52).There were no significant differences in enzyme activity of L55M polymorphism genotypes(LL=179.27;LM=192.11;MM=122.11;QQ=135.74;QR=187.90;RR=209;p>0.05).But there was a slight decrease in enzyme activity for the Q192R polymorphism *** genotype and alcohol consumption associated with slight increases in enzyme ***,genotype and tobacco consumption did not have a significant effect on PON-1 activity(μU/mL)(p>0.05).Overall,alcohol and tobacco consumption affected PON-1 enzyme activity(μU/mL)up to 21.1%.The data obtained in this study reveal that PON-1 activity is affected by genetic variants such as Q192R and alcohol *** may influence the susceptibility of populations to organophosphate poisoning.

关键词： Paraoxonase-1 Pesticides Organophosphates Polymorphisms

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Effect of structure and function of paraoxonase-1(PON-1)on organophosphate pesticides metabolism

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BIOCELL 2020年第3期44卷 363-370页

作者： HAZAEL RAMIRO CEJA-GÁLVEZ erandis dheni torres-sánchez JUAN HERIBERTO torres-JAssO ARTURO VILLALOBOs ORNELAs JOEL sALAZAR-FLOREs Department of Medical and Life sciences University Center of La CiénegaUniversity of Guadalajara(CUCI-UdeG)OcotlánCP 47810Mexico Department of Biological sciences University Center of the CoastUniversity of Guadalajara(CUCosta-UdeG)Puerto VallartaCP 48280Mexico

Paraoxonase-1(PON1)is an important enzyme in various pathologies such as pesticide poisoning,diabetes,atherosclerosis,neuronal disorders,and cancer,due to its multifunctional activity since it acts on different ***,one of its main functions is the hydrolysis of organophosphate(OP)compounds from pesticides that cause fatal poisoning at the level of the central nervous system(CNs).The objective of this review was to investigate whether the structure,genetics,and function of PON1 affect the metabolism of organophosphate pesticides or other *** was selected from articles in the database PubMed–NCBI(https://***/pubmed/)with a publication date between 2011 and *** enzymatic activity of PON1 can be modified depending on its chemical structure since there are different genetic polymorphisms that change PONI morphologies or the levels of expression in the *** leads to differences in susceptibilities to organophosphate pesticide *** results of this review reveal that phenotypic variants of PON1 have differences in affinities for OP substrates.

关键词： PON1 Pesticides Organophosphorus toxicity

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Effect of pesticides on phosphorylation of tau protein,and its influence on Alzheimer’s disease

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世界临床病例杂志 2023年第24期11卷 5628-5642页

作者： erandis D torres-sánchez Genaro G Ortiz Emmanuel Reyes-Uribe Juan H torres-Jasso Joel salazar-Flores Department of Medical and Life sciences University Center of la CienegaUniversity of GuadalajaraOcotlan 47820JaliscoMexico Department of Philosophical and Methodological Disciplines and service of Molecular Biology in Medicine Hospital Civil University of GuadalajaraGuadalajara 44340JaliscoMexico Department of Biological sciences CUCOSTAUniversity of GuadalajaraPuerto Vallarta 48280JaliscoMexico

Alzheimer’s disease(AD)is a progressive and neurodegenerative illness which results in alterations in cognitive *** is characterized by loss/dysfunction of cholinergic neurons,and formation of amyloid plaques,and formation of neurofibrillary tangles,among other changes,due to hyperphosphorylation of *** to pesticides in humans occurs frequently due to contact with contaminated food,water,or ***,organophosphates,carbamates,pyrethroids and neonicotinoids are associated with the most diagnosed incidents of severe cognitive *** aim of this study was to determine the effects of these pesticides on the phosphorylation of tau protein,and its cognitive implications in the development of *** was found that exposure to pesticides increased the phosphorylation of tau protein at sites ser198,ser199,ser202,Thr205,ser396 and *** with these chemicals altered the enzymatic activities of cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta,and protein ***,it altered the expression of the microtubule associated protein tau gene,and changed levels of intracellular *** changes affected tau protein phosphorylation and neuroinflammation,and also increased oxidative *** addition,the exposed subjects had poor level of performance in tests that involved evaluation of novelty,as test on verbal,non-verbal,spatial memory,attention,and problem-solving skills.

关键词： Organochlorines Organophosphates Carbamates Pyrethroids Neonicotinoids Tau protein

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Cognitive disorder and dementia in type 2 diabetes mellitus

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World Journal of Diabetes 2022年第4期13卷 319-337页

作者： Genaro G Ortiz Miguel Huerta Héctor A González-Usigli erandis D torres-sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela Department of Philosophical and Methodological Disciplines University Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Department of Neurology Movement Disorders ClinicSub-Specialty Medical UnitNational Western Medical CenterMexican Social Security Institute(IMSS)Guadalajara 44340JaliscoMexico University Biomedical Research Center University of ColimaColima 28040Mexico Department of Medical and Life sciences University Center of‘La Ciénega’University of GuadalajaraOcotlán 47810JaliscoMexico Department of Chemistry University Center of Exact Sciences and EngineeringUniversity of GuadalajaraGuadalajara 44340JaliscoMexico Division of Neurosciences Western Biomedical Research CenterMexican Social Security Institute(IMSS)Guadalajara 44340JaliscoMexico Gerontology Postgraduate Program Public Health DepartmentUniversity Health Sciences CenterUniversity of GuadalajaraGuadalajara 44340JaliscoMexico

Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and *** the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative *** the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are *** and animal model studies suggest that memory improvements are due to changes in insulin ***,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis ***, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, a

关键词： Alzheimer´s disease Diabetes mellitus Insulin Vascular dementia Cognitive decline

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