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Cancer-associated fibroblasts of colorectal cancer: Translationalprospects in liquid biopsy and targeted therapy

BIOCELL 2023年第10期47卷 2233-2244页

作者： elyn amiela salleh YEONG YEH LEE ANDEE DZULKARNAEN ZAKARIA NUR ASYILLA CHE JALIL MARAHAINI MUSA Human Genome Centre School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Internal Medicine School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Surgery School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKubang Kerian16150Malaysia

Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts(CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component ofthe tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectalcarcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patientsurvival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinicalapplications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected inblood samples, have been proposed to help in determining patient prognosis and enables the detection of cancerthrough liquid biopsy. Liquid biopsy is gaining traction as it is non-invasive, allows frequent and easy sampling, andshows concordance to tissue biopsy analysis. In addition, CAF-targeted therapy is currently being studied extensivelyto be used as one of the treatment avenues for CRC. Various mechanisms of CAF-targeted therapy have beenreported, including blocking the signaling pathways involving CAFs and cancer cells, thus abolishing the CAF-tumorcell crosstalk and subsequently hindering tumorigenesis. These translational applications of cCAFs and utilization ofCAFs as key targets for CRC therapy, although still in the early phases of development, will potentially improve CRCpatient management in the future.

关键词： Activated fibroblast Colon cancer Liquid biopsy Precision medicine

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