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Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children

World Journal of Gastroenterology 2012年第40期18卷 5729-5733页

作者： Salvatore Leonardi Andrea Domenico Praticò elena Lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa Department of Pediatrics University of Catania

AIM:To compare intradermal(ID) and intramuscular(IM) booster doses,which have been used in healthy and high risk subjects,such as healthcare workers,haemodialysis patients,human immunodeficiency virus patients,and renal transplant recipients unresponsive to initial hepatitis B vaccination,in celiac ***:We conducted our study on 58 celiac patients,vaccinated in the first year of life,whose blood analysis had showed the absence of protective hepatitis B virus(HBV) *** patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 *** all patients we randomly performed an HBV vaccine booster dose by ID or IM *** celiac patients were revaccinated with recombinant hepatitis B vaccine(Engerix B) 2 g by the ID route,while 28 celiac patients were revaccinated with Engerix B 10 g by the IM *** weeks after every booster dose,the anti-hepatitis B surface(HBs) antibody titer was measured by an enzyme-linked immuneadsorbent *** performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine *** cut off value for a negative anti-HBs antibody titer was 10 IU/*** with values between 10 and 100 IU/L were considered "low responders" while patients with an antibody titer higher than 1000 IU/L were considered "high responders".RESULTS:No significant difference in age,gender,duration of illness,and years of gluten intake was found between the two *** found a high percentage of "responders" after the first booster dose(ID = 76.7%,IM = 78.6%) and a greater increase after the third dose(ID = 90%,IM = 96.4%) of vaccine in both *** we found a significantly higher number of high responders(with an anti-HBs antibody titer > 1000 IU/L) in the ID(40%) than in the IM(7.1%) group,and this difference was evident after the first booster dose of vaccination(P < 0.01).No side effects

关键词：乙肝疫苗助推器皮内注射腹腔人类免疫缺陷病毒乙型肝炎病毒酶联免疫吸附法抗体滴度

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