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Hepatic artery reconstruction technique in liver transplantation:experience with 3,000 cases

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 281-283页

作者： sami Akbulut Koray Kutluturk Sezai Yilmaz Department of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatyaTurkey

Hepatic artery reconstruction(HAR)is the most valuable step in correcting graft and recipient survival after liver transplantation(LT).Hepatic artery thrombosis(HAT)in immediate postoperative period may lead to fatal *** allograft is partial in a living donor liver transplantation(LDLT),and HAR is technically much more difficult than deceased donor liver transplantation(DDLT).The likelihood of HAT in LDLT is higher due to the narrower diameters of arterial vessels.

关键词： Hepatic donor narrow

In memoriam of Thomas Earl Starzl,the pioneer of liver transplantation

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World Journal of Transplantation 2022年第3期12卷 55-58页

作者： Sezai Yilmaz sami Akbulut Surgery and Liver Transplant Institute Inonu UniversityMalatya 44280Turkey

Starzl’s nearly 3000 publications that contribute to the science of transplantation in every field have been the most important resources for every scientist working in this *** those of us who work in the liver transplant field,his contributions throughout his life have shaped our career and passion,even for those who have never met,spoken to,or worked with *** we are able to help patients with liver failure today by offering them the chance of transplantation,it is because of Starzl’s passionate work and *** to Starzl’s scientific legacy,hundreds of scientists serve humanity and thousands of patients can hold on to *** has been an honor for us to write this article about Professor Starzl.

关键词： Liver transplantation Thomas Earl Starzl Pioneer of liver transplantation

Liver transplantation for hepatocellular carcinoma:Historical evolution of transplantation criteria

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World Journal of Clinical Cases 2022年第29期10卷 10413-10427页

作者： Volkan Ince Tevfik Tolga Sahin sami Akbulut Sezai Yilmaz Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey

Liver transplantation(LT) for hepatocellular carcinoma is still a hot topic,and the main factor that is associated with the success of treatment is to determine the patients who will benefit from *** criteria have been defined 25 years ago and still is being used for patient selection for ***,in living donor LT,the Milan criteria is being *** criteria for patient selection do not only consider morphologic characteristics such as tumor size and number of tumor nodules but also biologic markers that show tumor aggressiveness is also being *** the present review article,we have summarized all the criteria and scoring systems regarding LT for hepatocellular *** criteria have 5-year overall survival rates that were comparable to the Milan Criteria and ranged between 60%-85%.On the other hand,it was seen that the recurrence rates had increased as the Milan criteria were exceeded;the 5-year recurrence rates ranged between 4.9% to 39.9%.Treatment of hepatocellular carcinoma needs a multidisciplinary *** selection criteria are yet to be *** same is true for treatment *** goal will be achieved by a harmonic interplay between basic science researchers and clinicians.

关键词： Liver transplantation Hepatocellular carcinoma Milan criteria Expanded Malatya criteria

Impact of COVID-19 pandemic on clinicopathological features of transplant recipients with hepatocellular carcinoma:A case-control study

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World Journal of Clinical Cases 2022年第15期10卷 4785-4798页

作者： sami Akbulut Tevfik Tolga Sahin Volkan Ince Sezai Yilmaz Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic had a significant impact on the management of all *** diseases such as cancer have a higher risk of COVID-19-related *** this fact,any delay or alteration in treatment of cancer may have fatal *** carcinoma(HCC)is an aggressive liver cancer that requires multimodality treatment to improve *** To evaluate the impact of COVID-19 on the management of patients with HCC by determining changes in demographic,clinical and histopathological *** Demographic,clinical and pathological variables of patients with HCC who had undergone liver transplantation between March 2020 and June 2021(Pandemic group,n=48)were retrospectively compared with that of the patients with HCC transplanted between November 2018 and March 2020(Pre-pandemic group,n=61).RESULTS The median age of the patients in the study was 56(interquartile range=15).Ninety-seven patients(89%)were male and 12 were female(11%).The most common etiology of liver disease was hepatitis B virus(n=52,47.7%).According to our results,there was a 21.3% drop in the number of patients transplanted for *** was no difference in the demographic,clinical and pathological characteristics of the patients except blood alkaline phosphatase levels(P=0.029),lymphovascular invasion(P=0.019)and type of the liver graft that was transplanted(P=0.017).CONCLUSION It is important to develop a surveillance strategy for liver transplant *** liver transplantation for HCC is justified and safe provided that strict surveillance protocols are applied.

关键词： COVID-19 pandemic Liver transplantation Hepatocellular carcinoma Biological behavior

Prediction of Vibration Characteristics in Beam Structure Using Sub-Scale Modeling with Experimental Validation

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Chinese Journal of Mechanical Engineering 2015年第5期28卷 928-934页

作者： ZAI Behzad Ahmed sami Saad KHAN M Amir AHMAD Furqan PARK Myung Kyun Structure Design and Development Directorate Institute of Space Technology Department of Civil and Environmental Engineering KAIST Department of Mechanical Engineering Myongji University

Geometric or sub-scale modeling techniques are used for the evaluation of large and complex dynamic structures to ensure accurate reproduction of load path and thus leading to true dynamic characteristics of such structures. The sub-scale modeling technique is very effective in the prediction of vibration characteristics of original large structure when the experimental testing is not feasible due to the absence of a large testing facility. Previous researches were more focused on free and harmonic vibration case with little or no consideration for readily encountered random vibration. A sub-scale modeling technique is proposed for estimating the vibration characteristics of any large scale structure such as Launch vehicles, Mega structures, etc., under various vibration load cases by utilizing precise scaled-down model of that dynamic structure. In order to establish an analytical correlation between the original structure and its scaled models, different scale models of isotropic cantilever beam are selected and analyzed under various vibration conditions（ i.e. free, harmonic and random） using finite element package ANSYS. The developed correlations are also validated through experimental testing The prediction made from the vibratory response of the scaled-down beam through the established sets of correlation are found similar to the response measured from the testing of original beam structure. The established correlations are equally applicable in the prediction of dynamic characteristics of any complex structure through its scaled-down models. This paper presents modified sub-scale modeling technique that enables accurate prediction of vibration characteristics of large and complex structure under not only sinusoidal but also for random vibrations.

关键词： sub-scale modeling resonance frequency vibration characteristics scale factors power spectral density

Traditional Healer’s Medicinal Practice Survey and Clinical Evidence Assessment of “YIKI”: An Antimalarial Phytomedicine Recipe from Bobo-Dioulasso, Burkina Faso

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Pharmacology & Pharmacy 2024年第7期15卷 248-267页

作者： Zachari Kabre Rakiswende Serge Yerbanga Aminata Fofana Roland Nâg-Tiero Meda Anyirekun Fabrice Some Alassane Haro Natacha A. J. A. Boro Fazhira B. Ye Benjamin Kouliga Koama sami Eric Kam Eliasse Zongo Hadidjatou Belèm Windmi Kagambèga Florence Fournet Georges A. Ouedraogo Jean-Bosco Ouedraogo Institut de Recherche en Sciences de la Sant Direction Rgionale de lOuest Bobo-Dioulasso Burkina Faso Laboratoire de Recherche et dEnseignement en Sant et Biotechnologies Animales Universit Nazi BONI Bobo-Dioulasso Burkina Faso Institut des Sciences et Techniques Bobo-Dioulasso Burkina Faso Laboratoire de Recherche en Bactriologie INSP/Centre MURAZ Bobo-Dioulasso Burkina Faso Maladies Infectueuses et Vecteurs: Ecologie Gntique Evolution et Contrle (MIVEGEC) Institut de Recherche pour le Dveloppement Universit de Monpellier Montpellier France

YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to identify the medicinal practices of the healer holder of YIKI and assess the clinical evidence of its phytomedicine in the uncomplicated malaria treatment. Ethnomedical survey based on a semi-structured and open questionnaire was conducted from October to December 2019 with the healer. Malaria knowledge and diagnosis methods, patient treatment and monitoring, and recipe formulation steps were surveyed. Moreover, thick and thin blood smears were taken, haemoglobin levels and temperature of consenting patients were measured before treatment, mid-treatment and at the end of treatment. The survey revealed that the healer has a good knowledge of malaria symptoms and his diagnosis is based on observation and physical examination of patients. The healer’s malaria diagnosis was rudimentary and had accuracy problems, with only 62.79% of malaria cases confirmed by microscopy. The formulation of YIKI and its use to treat malaria follow a standard process for plant harvesting, powder quantities and posology, but do not use any reproducible parameters for dose adjustment. Forty-three patients diagnosed and treated by the healer participated in the study. Laboratory results revealed 27 Plasmodium falciparum infection cases, including 2 with parasitaemia ≥ 200,000 p/µl blood. 25 patients were selected for therapeutic evidence assessment. There was a 48% elimination of parasites, a 28% parasitaemia decrease without complete cure, with gametocytogenesis in some patients, and a 24% parasitaemia increase. Haemoglobin and temperature results suggested that YIKI was not cytotoxic and reduced fever. Encouraging preliminary results have been obtained, but in view of the low number of patients, further YIKI efficacy and toxicity studies will be necessary for patient safety.

关键词： Antimalarial-Phytomedicine Efficacy Traditional Practices Bobo-Dioulasso

How to reduce and manage hepatic arterial complications in living and deceased donor liver transplantations

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 731-733页

作者： Emrah Otan sami Akbulut Sezai Yilmaz Department of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatyaTurkey

Hepatic arterial complications include hepatic artery thrombosis(HAT),stenosis,and *** may occur in the early as well as the late *** HAT has typically been associated with less severe complications and may even be **... 详细信息

关键词： hepatic complications arterial

Management of pancreatic head adenocarcinoma: From where to where?

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World Journal of Gastrointestinal Surgery 2019年第3期11卷 143-154页

作者： Kemal Dolay Fatma Umit Malya sami Akbulut Department of Surgery Division of Hepato-Pancreato-Biliary Surgery Istinye University Liv Hospital Department of Surgery Bezmialem Vakif University Faculty of Medicine Department of Surgery and Liver Transplant Institute Inonu University Faculty of Medicine

Pancreatic head adenocarcinoma(PHAC) is one of the most aggressive malignancies, and it has low long-term survival rates. Surgery is the only option for long-term survival. The difficulties associated with PHAC include higher frequencies of regional or distant lymph node metastases and vascular involvement, and positive resection margins in pancreatic and retroperitoneal tissues. Radical resections increase margin negativity and life expectancy;however, the extend of the surgery applied is controversial. Thus, western and eastern centers may use different approaches. Multiorgan, peripancreatic nerve plexus, and vascular resections have been discussed in relation to radical surgery for pancreatic cancer as have the roles of neoadjuvant and adjuvant therapy regimens. Determining the appropriate limits for surgery, standardizing definitions and surgical techniques according to guidelines, and centralizing pancreatic surgery within high-volume institutions to reduce mortality and morbidity rates are among the most important issues to consider. In this review,we evaluate the basic concepts underlying and the roles of radical surgery for PHAC, and lymphadenectomy, nerve plexus, retroperitoneal tissue, vascular,and multivisceral resections, total pancreatectomy, and liver metastases are discussed.

关键词： Pancreatic head cancer Standard pancreatectomy Extended pancreatectomy Regional lymphadenectomy Extended lymphadenectomy

Giant vesical diverticulum:A rare cause of defecation disturbance

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World Journal of Gastroenterology 2009年第31期15卷 3957-3959页

作者： sami Akbulut Bahri Cakabay Arsenal Sezgin Kenan Isen Ayhan Senol Department of Surgery Diyarbakir Education and Research Hospital Department of Pathology Diyarbakir Education and Research Hospital Department of Urology Diyarbakir Education and Research Hospital Department of Radiology Diyarbakir Education and Research Hospital

Vesical diverticula frequently result from bladder outlet obstructions. However, giant vesical diverticula which cause acute abdomen or intestinal obstruction are very rare. Our review of the English medical literature found 3 cases of bladder diverticula which caused gastrointestinal symptoms. Here, we present a 57-yearold man with a giant diverticulum of the urinary bladder who complained of abdominal pain, nausea and vomiting, constipation, no passage of gas or feces, and abdominal distension for 3 d. A 20 cm x 15 cm diverticulum was observed upon laparotomy. The colonic obstruction was secondary to external compression of the rectum against the sacrum by a distended vesical diverticulum. We performed a diverticulectomy and primary closure. Twelve months postoperatively, the patient had no difficulty with voiding or defecation.

关键词： Colonic obstruction Defecation Diverticulectomy Urinary bladder Vesical diverticulum