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Hypoglycemia Controlled by Prednisone in an Occult Insulinoma or a Nesidioblastosis

Open Journal of Endocrine and Metabolic Diseases 2019年第6期9卷 69-73页

作者： Annelie Kérékou Siham el Aziz Alihonou Dédjan Asma Chadli Ahmed Farouqi Endocrinology Metabolism and Nutrition Department CNHU-HKM Cotonou Benin Endocrinology Diabetology and Metabolic Diseases Department Ibn Rochd University Hospital Center Casablanca Morocco

Insulinoma is a pancreatic endocrine tumor lower in size than 20 mm in 80% of the cases and his treatment is chirurgical. However, in certain circumstances such as an occult location or circumstances of metastases, medical treatment is called for. Observation: A 29 years old patient with no specific pathological antecedents has presented severe hypoglycemia mainly in the morning. A patient was in a generally good condition. The fasting test revealed an inappropriate secretion of insulin at a venous glycemia of 0.35 g/l;which was corroborated by Turner index and altered glucose insulin index that we calculated. Moreover, the 8 h cortisolemia was normal at 90.13 ng/l, the TSH was normal at 1.44 μui/l, anti-insulin antibodies were negative at 6.7 U/l;the search of hypoglycemic sulfonamides was negative. Morphologically, she had three pancreatic tomodensitometry these were normal. She also had echo-endoscopy which showed a normal pancreas. The surgical exploration with preoperative echo is advised only after surgeon’s assessment when the technical conditions are not put together. The diagnosis of the occult insulinoma or of nesidioblastosis was retained. The medical treatment was retained. Due to the unavailability of diazoxide in our pharmacies and the high cost of analogs of somatostatine, she was provided with prednisone 0.5 mg/kg/24h which was 40 mg/day after common agreement. The evolution was favorable. Conclusion: It should be noticed that medical treatment can be suggested if insulinoma is not localized. This observation proves that the localization of the insulinoma can be unsuccessful. It should also be noticed that our experience is the fourth described in literature, where hypoglycemia in insulinomas is controlled by prednisone.

关键词： Hypoglycemia Insulinoma Nesidioblastosis Prednisone

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A comparison study of the nutritional, mineral and volatile compositions of three dry forms of ginger rhizomes, and antioxidant properties of their ethanolic and aqueous extracts

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Journal of Coastal Life Medicine 2017年第2期5卷 70-76页

作者： Aicha Jelled Hassiba Chahdoura Guido Flamini Amira Thouri Amira el Arem Khawla Adouni Zohra Haouas Isabel C.F.R.Ferreira Lotfi Achour Hassen Ben Cheikh Laboratory of Histology and Cytogenetics(UR12ES10) Faculty of MedicineUniversity of MonastirMonastirTunisia Laboratory of Bioressources Integrative Biology and Valorisation(LR14ES06)High Institute of BiotechnologyUniversity of MonastirMonastirTunisia Mountain Research Centre Higher Agricultural SchoolPolytechnic Institute of BragancaCampus of Santa Apolonia11725301-855 BragancaPortugal Interdepartmental Research Centre"Nutraceutical and Food for Health" University of PisaPisaItaly

Objective:To compare the most accessible dry forms of ginger rhizomes (Zingiber officinale) used as a spice and as a remedy in order to choose the best ginger for medicinal purpose. Methods:Freshly air dried ginger, commercially dry rhizomes and ginger available in powder form are investigated in terms of nutritional values (proximate and mineral compositions) and volatiles profile. Ethanolic and aqueous extracts (decoctions and infusions) were prepared for total phenolic, flavonoid and tannin contents determination. Also, three standard tests were established in order to estimate the best extract with the better antioxidant potential. Results:The results showed unlike proximate composition revealing different nutritional values. In fact, freshly dried ginger contained much ash, while already dry samples contained much protein. In addition, mineral contents of studied samples indicated their dissimilar richness especially in Ca, Mg, Na, K, Cu, Fe, and Mn. Solid phase micro-extraction gave volatile profiles with many interesting compounds, only 26 from the 51 identified components were common to studied samples with bioactive compounds predominance in freshly dried sample. Also, the antioxidant potential established by three different tests was higher in already dry samples and was positively correlated with their higher contents in the determined phytochemicals. The ethanolic extracts showed higher antioxidant activities than aqueous extracts. Decoctions and infusions were almost similar proving that long cooking time did not affect ginger antioxidant potential. Conclusions:This work highlighted the benefits of traditional preparations of ginger as sources of bioactive compounds, namely antioxidants, and proved that the available commercial samples are not identical and encouraged analyzing samples before uses depending on needs.

关键词： Zingiber officinale Dry forms Minerals Aroma volatiles Antioxidant properties

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