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Protein Kinase Activity Changes in the Aging Brain

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Biomedical and Environmental Sciences 1991年第Z1期 173-181页

作者： MICHAE LR.PISANO,HOAU-YAN WANG,eitan friedman Departments of Psychiatry and Pharmacology Medical College of Pennsylvania Departments of Psychiatry and Pharmacology Medical College of Pennsylvania Departments of Psychiatry and Pharmacology Medical College of Pennsylvania Philadelphia Pennsylvania 19129 Philadelphia Pennsylvania 19129 Philadelphia Pennsylvania 19129 To whom correspondence should be addressed

The aging process in mammals is correlated with changes in psychomotor performance, cognitive function, and ability to adapt to stress (Montgomery et al., 1982; Lorens et al., 1990). These changes may be related to alterations in neuronal tissue that occur during the aging process. The normal aging process may be conceived of as the neuronal cell's increasing inability to maintain normal cellular function which ultimately results in a number of morphological and biochemical changes. Morphologically, there is a loss of neuronal cells with increasing age (Brizzee and

关键词： Protein Kinase Activity Changes in the Aging Brain

GSK3β regulates D1 dopamine receptor phosphorylation and function

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GSK3β regulates D1 dopamine receptor phosphorylation and fu...

GSK3β regulates D1 dopamine receptor phosphorylation and function

第十二届全国神经精神药理学学术交流会

作者： friedman eitan Department of Physiology/Pharmacology CUNY Medical SchoolNew YorkNY 10031

Many protein kinases have been shown to regulate the phosphorylation of G - protein - coupled receptors. These kina-ses, together with associated protein phosphatases form complexes that regulate the function of G - protein - coupled receptors. In brain, protein phosphatasel ( PP1) exists as a complex with PP1 inhibitor - 2 (I - 2). Phosphorylation of I - 2 by cdk5 or GSK3β results in activation of PP1. The present study was designed to investigate the role of GSK3β in the regulation of D1 dopamine receptor function. In rat and rabbit frontal cortex ( FCX) , we found that GSK3β co - precipitates with

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中国药理通讯 2006年第4期23卷 26-26页

作者： Wang Jing- Ru Sun Pei -Hua friedman eitan Jin Guo -Zhang Zhen Xue -Chu Shanghai Institute of Materia Medica Chinese Academy of Science Shanghai 201203 Department of Physiology/Pharmacology CUNY Medical School New York NY 10031

Revisting High-Resolution Schemes with van Albada Slope Limiter

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1924-1953页

作者： Jingcheng Lu eitan Tadmor Department of Mathematics University of MarylandCollege ParkMDUSA School of Mathematics University of MinnesotaMinneapolisMNUSA Department of Mathematics and Institute for Physical Sciences and Technology University ofMarylandCollegeParkMDUSA

Slope limiters play an essential role in maintaining the non-oscillatory behavior of high-resolution methods for nonlinear conservation *** family of minmod limiters serves as the prototype ***,we revisit the question of non-oscillatory behavior of high-resolution central schemes in terms of the slope limiter proposed by van Albada et al.(Astron Astrophys 108:76–84,1982).The van Albada(vA)limiter is smoother near extrema,and consequently,in many cases,it outperforms the results obtained using the standard minmod *** particular,we prove that the vA limiter ensures the one-dimensional Total-Variation Diminishing(TVD)stability and demonstrate that it yields noticeable improvement in computation of one-and two-dimensional systems.

关键词： High resolution Limiters Total-Variation Diminishing(TVD)stability Central schemes

Constraint Preserving Schemes Using Potential-Based Fluxes *** Transport Equations

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Communications in Computational Physics 2011年第3期9卷 688-710页

作者： Siddhartha Mishra eitan Tadmor Centre of Mathematics for Applications(CMA) University of OsloP.O.Box 1053BlindernN-0316 OsloNorway Center of Scientific Computation and Mathematical Modeling(CSCAMM) and Department of Mathematicsand Institute for Physical Sciences and Technology(IPST)University of MarylandMD 20742-4015USA

We consider constraint preserving multidimensional evolution equations.A prototypical example is provided by the magnetic induction equation of plasma *** constraint of interest is the divergence of the magnetic *** design finite volume schemes which approximate these equations in a stable manner and preserve a discrete version of the *** schemes are based on reformulating standard edge centered finite volume fluxes in terms of vertex centered *** potential-based approach provides a general framework for faithful discretizations of constraint transport and we apply it to both divergence preserving as well as curl preserving *** present benchmark numerical tests which confirm that our potential-based schemes achieve high resolution,while being constraint preserving.

关键词： Multidimensional evolution equations magnetohydrodynamics finite-difference finite volume schemes constraint transport potential-based schemes

Geometric Counting on Wavefront Real Spherical Spaces

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Acta Mathematica Sinica,English Series 2018年第3期34卷 488-531页

作者： Bernhard KROTZ eitan SAYAG Henrik SCHLICHTKRULL Universitat Paderborn Institut Jur MathematikWarburger Strafle 10033098 PaderbornDeutschland Department of Mathematics Ben Gurion University of the NegevP.O.B.653Be'er Sheva 84105Israel Department of Mathematics University of CopenhagenUniversitetsparken 5DK-2100 Copenhagen ODenmark

We provide L^p-versus L~∞-bounds for eigenfunctions on a real spherical space Z of wavefront type. It is shown that these bounds imply a non-trivial error term estimate for lattice counting on Z. The paper also serve... 详细信息

关键词： Homogeneous spaces real spherical spaces lattice counting error term wavefront lemma spectral analysis norm comparison of eigenfunctions

Improving localization precision of Brillouin measurements using spectral autocorre lation analysis

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 35-42页

作者： eitan Edrei Milos Nikolic Giuliano Scarcelli Fischell Department of Bioengineering University of Maryland College ParkMaryland 20742USA

Brillouin spectroscopy is a powerful tool for measuring the mechanical properties of materials without *** sensitivity to mechanical changes that a Brillouin spectrometer can detect is determined by the precision to which a spectral peak can be *** localization precision is however fundamentally limited by the low mumber of photons within a Brillouin measurement,as wel as by intrinsic noise of the ***,we present a method to improve the spectral sensitivity of Brillouin measurements by exploiting the autocorelation function of the *** show that by performing a localization process on the autocorrelation function nearly 20%increase in localizat ion precision can be *** result is consistent bet ween our theoretical treatment,numerical simulation and experimental *** further study the efect of back-ground noise on the precision im provement for realistic scenarios.

关键词： Brillouin microscopy localization

Differentiation of murine male germ cells to spermatozoa n a soft agar culture system

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Asian Journal of Andrology 2012年第2期14卷 285-293页

作者： Mahmoud Abu Elhija eitan Lunenfeld Stefan Schlatt Mahmoud Huleihel The Shraga Segal Department of Microbiology and Immunology Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva 84105 Israel Department of Obstetrics and Gynecology Soroka University Medical Center and Faculty of Health Sciences Ben-Gurion University of the Negev Beer-Sheva 84105 Israel Centre of Reproductive Medicine and Andrology of the University of Menster Menster 84149 Germany

Establishment of an in vitro system that allows the development of testicular germ cells to sperm will be valuable for studies of spermatogenesis and future treatments for male infertility. In the present study, we developed in vitro culture conditions using three-dimensional agar culture system （SACS）, which has the capacity to induce testicular germ cells to reach the final stages of spermatogenesis, including spermatozoa generation. Seminiferous tubules from testes of 7-day-old mice were enzymatically dissociated, and intratubular cells were cultured in the upper layer of the SACS in RPMI medium supplemented with fetal calf serum （FCS）. The lower layer of the SACS contained only RPMI medium supplemented with FCS. Colonies in the upper layer were isolated after 14 and 28 days of culture and were classified according to their size. Immunofluorescence and real-time PCR were used to analyse specific markers expressed in undifferentiated and differentiated spermatogonia （Vasa, Dazl, OCT-4, C-Kit, GFR- a-l, CD9 and a-6-integrin）, meiotic cells （LDH, Crem-1 and Boule） and post-meiotic cells （Protamine-1, Acrosin and SP-IO）. Our results reveal that it is possible to induce mouse testicular pre-meiotic germ cell expansion and induce their differentiation to spermatozoa in SACS. The spermatozoa showed normal morphology and contained acrosomes. Thus, our results demonstrate that SACS could be used as a novel in vitro system for the maturation of pre-meiotic mouse germ cells to post-meiotic stages and morphologically-normal spermatozoa.

关键词： acrosome agar in vitro culture meiosis spermatogenesis spermatogonia spermatozoa testis

Regulation of spermatogenesis by paracrine/autocrine testicular factors

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Asian Journal of Andrology 2004年第3期6卷 259-268页

作者： Mahmoud Huleihel eitan Lunenfeld Department of Microbiology and Immunology and BGU Cancer Research Center Faculty of Health Sciences Ben-Gurion University of the NegevBeer-ShevaIsraelDepartment of Obstetrics and GynecologySoroka University Medical Center Faculty of Health SciencesBen-Gurion University of the NegevBeer-ShevaIsrael

Spermatogenesis is a complex process regulated by endocrine and testicular paracrine/autocrine factors. Gonadotropins are involved in the regulation of several testicular paracrine factors, mainly of the IL-1 family and testicular hormones. Testicular cytokines and growth factors (such as IL-1, IL-6, TNF, IFN-γ, LIF and SCF) were shown to affect both the germ cell proliferation and the Leydig and Sertoli cells functions and secretion. Cytokines and growth factors are produced by immune cells and in the interstitial and seminiferous tubular compartments by various testicular cells, including Sertoli, Leydig, peritubular cells, spermatogonia, differentiated spermatogonia and even spermatozoa. Corresponding cytokine and growth factor receptors were demonstrated on some of the testicular cells. These cytokines also control the secretion of the gonadotropins and testosterone in the testis. Under pathological conditions the levels of pro-inflammatory cytokines are increased and negatively affected spermatogenesis. Thus, the expression levels and the mechanisms involved in the regulation of testicular paracrine/autocrine factors should be considered in future therapeutic strategies for male infertility.

关键词： spermatogenesis paracrine autocrine cytokine growth factor