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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+t cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah e.est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes elana Ben-Akiva Randall A.Meyer Zoe t.Hsieh Simone Sidoli Stephany Y.tzeng Jonathan P.Schneck Jordan J.Green translational tissue engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACt)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACt,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+t cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo t-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate t-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific t cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo t cell activation and investigate possible mechanisms including the effects of aAPC elasticity on t cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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From Hölder Continuous Solutions of 3D Incompressible Navier-Stokes equations to No-Finite time Blowup on [ 0,∞ ]

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Advances in Pure Mathematics 2024年第9期14卷 695-743页

作者： terry e. Moschandreou tVDSB London Ontario London Canada

this article gives a general model using specific periodic special functions, that is, degenerate elliptic Weierstrass P functions composed with the LambertW function, whose presence in the governing equations through the forcing terms simplify the periodic Navier Stokes equations (PNS) at the centers of arbitrary r balls of the 3-torus. the continuity equation is satisfied together with spatially periodic boundary conditions. the yicomponent forcing terms consist of a function F as part of its expression that is arbitrarily small in an r ball where it is associated with a singular forcing expression both for inviscid and viscous cases. As a result, a significant simplification occurs with a v3(vifor all velocity components) only governing PDe resulting. the extension of three restricted subspaces in each of the principal directions in the Cartesian plane is shown as the Cartesian product ℋ=Jx,t×Jy,t×Jz,t. On each of these subspaces vi,i=1,2,3is continuous and there exists a linear independent subspace associated with the argument of the W function. Here the 3-torus is built up from each compact segment of length 2R on each of the axes on the 3 principal directions x, y, and z. the form of the scaled velocities for non zero scaled δis related to the definition of the W function such that e−W(ξ)=W(ξ)ξwhere ξdepends on t and proportional to δ→0for infinite time t. the ratio Wξis equal to 1, making the limit δ→0finite and well defined. Considering r balls where the function F=(x−ai)2+(y−bi)2+(z−ci)2−ηset equal to −1e+rwhere r>0. is such that the forcing is singular at every distance r of centres of cubes each containing an r-ball. At the centre of the balls, the forcing is infinite. the main idea is that a system of singular initial value problems with infinite forcing is to be solved for where the velocities are shown to be locally Hölder continuous. It is proven that the limit of these singular problems shifts the finite time blowup time ti∗for first and higher deriv

关键词： Navier-Stokes Periodic Navier-Stokes equations 3-torus Periodic Ball Sphere Hölder Continuous Functions Uniqueness Angular Velocity Velocity in terms of Vorticity

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Multisensor Data Fusion for High Quality Data Analysis and Processing in Measurement and Instrumentation

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Journal of Bionic engineering 2007年第1期4卷 53-62页

作者： Yan-bo Huang Yu-bin Lan W. C. hoffmann R. e. Lacey USDA ARS Agricultural engineer Areawide Pest Management Research Unit Texas 77845 USA Biological and A g ricultural engineering Department Texas A ＆M University Texas 77843-2117 USA

Multisensor data fusion （MDF） is an emerging technology to fuse data from multiple sensors in order to make a more accurate estimation of the environment through measurement and detection. Applications of MDF cross a wide spectrum in military and civilian areas. With the rapid evolution of computers and the proliferation of micro-mechanical/electrical systems sensors, the utilization of MDF is being popularized in research and applications. this paper focuses on application of MDF for high quality data analysis and processing in measurement and instrumentation. A practical, general data fusion scheme was established on the basis of feature extraction and merge of data from multiple sensors. this scheme integrates artificial neural networks for high performance pattern recognition. A number of successful applications in areas of NDI （Non-Destructive Inspection） corrosion detection, food quality and safety characterization, and precision agriculture are described and discussed in order to motivate new applications in these or other areas. this paper gives an overall picture of using the MDF method to increase the accuracy of data analysis and processing in measurement and instrumentation in different areas of applications.

关键词： multisensor data fusion artificial neural networks NDI food quality and safety characterization precision agriculture

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A Preliminary Comparative Study on the Centering Algorithms for CassiniISS NAC Images

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Research in Astronomy and Astrophysics 2024年第10期24卷 58-65页

作者： t.Liang Q.-F.Zhang G.-M.Liu W.-H.Zhu C.-S.Wang Department of Computer Science Jinan UniversityGuangzhou 510632China Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China School of Computer Science Guangdong University of EducationGuangzhou 510303China

Obtaining high precision is an important consideration for astrometric studies using images from the Narrow Angle Camera(NAC)of the Cassini Imaging Science Subsystem(ISS).Selecting the best centering algorithm is key to enhancing astrometric *** this study,we compared the accuracy of five centering algorithms:Gaussian fitting,the modified moments method,and three point-spread function(PSF)fitting methods(effective PSF(ePSF),PSFex,and extended PSF(x PSF)from the Cassini Imaging Central Laboratory for Operations(CICLOPS)).We assessed these algorithms using 70 ISS NAC star field images taken with CL1 and CL2 filters across different stellar *** ePSF method consistently demonstrated the highest accuracy,achieving precision below 0.03 pixels for stars of magnitude *** to the previously considered best,the modified moments method,the e PSF method improved overall accuracy by about 10%and 21%in the sample and line directions,***,the xPSF model provided by CICLOPS had lower precision than the ***,the ePSF exhibits an improvement in measurement precision of 23%and 17%in the sample and line directions,respectively,over the *** discrepancy might be attributed to the xPSF focusing on photometry rather than *** findings highlight the necessity of constructing PSF models specifically tailored for astrometric purposes in NAC images and provide guidance for enhancing astrometric measurements using these ISS NAC images.

关键词： methods:analytical techniques:image processing stars:imaging astrometry

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the proximity between hydroxyl and single atom determines the catalytic reactivity of Rh1/CeO_(2) single-atom catalysts

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Nano Research 2024年第1期17卷 397-406页

作者： Danfeng Wu Shuyun Zhou Congcong Du Juan Li Jianyu Huang Hong-xia Shen Abhaya K.Datye Shan Jiang Jeffrey t.Miller Sen Lin Haifeng Xiong State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Photocatalysis on energy and environment College of ChemistryFuzhou UniversityFuzhou 350002China Clean Nano energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China College of Biology and Chemical engineering Jiaxing UniversityJiaxing 314000China Department of Chemical&Biological engineering University of New MexicoAlbuquerqueNM 8731-0001USA Davidson School of Chemical engineering Purdue UniversityWest LafayetteIN 47907-2100USA Innovation Laboratory for Sciences and technologies of energy Materials of Fujian Province(IKKeM) Xiamen 361102China Fujian Key Laboratory of Rare-earth Functional Materials Fujian Shanhai Collaborative Innovation Center of Rare-earth Functional MaterialsLongyan 366300China

the local structure of the metal single-atom site is closely related to the catalytic activity of metal single-atom catalysts(SACs).However,constructing SACs with homogeneous metal active sites is a challenge due to the surface heterogeneity of the conventional ***,we prepared two Rh1/CeO_(2)SACs(0.5Rh1/r-CeO_(2)and 0.5Rh1/c-CeO_(2),respectively)using two shaped CeO_(2)(rod and cube)exposing different facets,i.e.,CeO_(2)(111)and CeO_(2)(100).In CO oxidation reaction,the t100 of 0.5Rh1/r-CeO_(2)SACs is 120°C,while the t100 of 0.5Rh1/c-CeO_(2)SACs is as high as 200°*** in-situ CO diffuse reflectance infrared Fourier transform spectroscopy(CO-DRIFtS),we found that the proximity between OH group and Rh single atom on the plane surface plays an important role in the catalytic activity of Rh1/CeO_(2)SAC system in CO *** Rh single atom trapped at the CeO_(2)(111)crystal surface forms the Rh1(OH)adjacent species,which is not found on the CeO_(2)(100)crystal surface at room ***,during CO oxidation,the OH group far from Rh single atom on the 0.5Rh1/c-CeO_(2)disappears and forms Rh1(OH)adjacent species when the temperature is above 150°*** formation of Rh1(OH)adjacentCO intermediate in the reaction is pivotal for the excellent catalytic activity,which explains the difference in the catalytic activity of Rh single atoms on two different CeO_(2)*** formed Rh1(OH)adjacent-O-Ce structure exhibits good stability in the reducing atmosphere,maintaining the Rh atomic dispersion after CO oxidation even when pre-reduced at high temperature of 500°*** functional theory(DFt)calculations validate the unique activity and reaction path of the intermediate Rh1(OH)adjacentCO species *** work demonstrates that the proximity between metal single atom and hydroxyl can determine the formation of active intermediates to affect the catalytic performances in catalysis.

关键词： crystal plane Rh1/CeO_(2)single-atom catalyst proximity of Rh and hydroxyl coordination structure CO oxidation

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Searching for ductile superconducting Heusler X_(2)YZ compounds

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npj Computational Materials 2023年第1期9卷 919-927页

作者： Noah hoffmann tiago F.t.Cerqueira Pedro Borlido Antonio Sanna Jonathan Schmidt Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of t_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

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Quality evaluation of Nothofagus pumilio seeds linked to forest management and climatic events

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ecological Processes 2024年第1期13卷 98-107页

作者： Julian Rodríguez-Souilla Jimena e.Chaves María Vanessa Lencinas Juan Manuel Cellini Fidel A.Roig Pablo L.Peri Guillermo Martinez Pastur Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) Laboratorio de Investigaciones en Maderas (LIMAD) Universidad Nacional de la Plata (UNLP) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IAN-IGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Nacional de tecnología Agropecuaria (INtA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background Forest ecosystems undergo significant transformations due to harvesting and climate fluctuations, emphasizing the critical role of seeding in natural regeneration and long-term structural preservation. Climate change further amplifies these dynamics, affecting phenology across species and regions. In tierra del Fuego(Argentina), Nothofagus pumilio(lenga) forests represent the most important timber resource, and it is managed through different silvicultural strategies. this species demonstrates notable post-disturbance regeneration, yet seed fall exhibits signifi-cant variability, leading to variations in seed quality(e.g., viability). this study aims to assess fluctuations in N. pumilio seed quality, determine how it varies concerning forest management strategies, annual productivity, and the co-occurrence of climatic phenomena including el Ni?o-Southern Oscillation(eNSO) and the Southern Annular Mode(SAM).Results Viable seeds represented 18.4% of the total, notably higher in unharvested than in managed areas. Con-versely, empty seeds were more prevalent in harvested areas(> 75%). Seed quality exhibited significant differences across silvicultural treatments, except for insect-predated seeds, which had similar proportions across all areas, though dispersed retention showed higher predation. When considering years with varying production levels, high-production years favoured full and viable seeds, particularly in unharvested forests and aggregated retention, while low-production years saw reduced viability across all treatments. Quadratic models revealed that viability increased with seed production, where unharvested forests achieved the highest values. Climate variability influenced seed proportions, where eNSO+/SAM+ promoting more full and viable seeds, while eNSO–/SAM+ favoured non-predated seeds, especially in unharvested *** Seed quality varies among treatments and years with different levels of seeding. Variations in seed qual-ity, l

关键词： Forest management Seeding Climate change extreme event Patagonia

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exploring trees Diversity and ecological Value of Mountain Forests in the Blue Nile Region of Sudan

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Open Journal of ecology 2024年第3期14卷 245-256页

作者： Dafa-Alla M. Dafa-Alla Haytham H. Gibreel Ahmed A. H. Siddig Yousif e. Yagoub Hashim A. Abdelkarim Khatir H.t. Saeed Ahmed I. Abuelbashar Faculty of Forestry-Shambat University of Khartoum Khartoum Sudan Harvard Forest Harvard University Petersham MA USA Faculty of Forest Science and Wood technology University of Gezira Wad-Medani Sudan Department of Forestry and Range Sciences Faculty of Natural Resources and Environmental Studies Alsalam University Alfula Sudan Forest Research and Gum Arabic Centre Agricultural Research Corporation Khartoum-Soba Sudan

We carried out this research at Abu-Gaddaf Natural Forest Reserve (ANFR) which is located east of Blue Nile River, in Blue Nile State, Sudan. It aims at exploring tree composition assessing their diversity indices, and ecological importance values. For survey of types and estimation of density of tree species in the forest, we randomly distributed 97 circular sample plots (0.1 hectare (ha)). In each sample plot we identified all trees to the species level, recorded their frequencies and computed species diversity and importance value indices (IVI). A total of 13 tree species, which belong to 12 genera and nine families, were identified in the tree layer of the forest. Mean tree density in ANFR was 116 trees/ha, composed mainly of Boswellia papyrifera (Del.) Hochst. (48), followed by Combretum hartmannianu (19) and Lannea fruticosa (18). Fabaceae was the most common family followed by Combretaceae and Malvaceae. B. papyrifera Delile Hochst was the most abundant while Acacia seyal was the least abundant species. Species richness (R = 1.71), evenness (e = 0.69), dominance (0.24) indices and Simpson’s Index of Diversity (D' = 0.76) suggest a moderate diversity, moderate numbers of individuals in each species and a moderate community stability. the research provides empirical results on diversity and ecological importance value of species, signifies the urging need to safeguard threatened species and to prioritize them for conservation, as well as the need to promote management of abundant species to provide multiple forest ecosystem services.

关键词： tree Species Diversity Dry-Land Forest Sudan

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treatment technologies for aqueous perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA)

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Frontiers of environmental Science & engineering 2009年第2期3卷 129-151页

作者： Chad D.VeCItIS Hyunwoong PARK Jie CHeNG Brian t.MADeR Michael R.hoffmann W.M.Keck Laboratories California Institute of TechnologyPasadenaCalifornia 91125USA 3M environmental Laboratory 3M CenterBuilding 260-05-N-17MaplewoodMN 55144-1000USA

Fluorochemicals(FCs)are oxidatively recalcitrant,environmentally persistent,and resistant to most conventional treatment *** have unique physiochemical properties derived from fluorine which is the most electronegative ***(PFOS),and perfluorooctanoate(PFOA)have been detected globally in the hydrosphere,atmosphere and *** treatment technologies such as reverses osmosis,nano-filtration and activated carbon can remove FCs from ***,incineration of the concentrated waste is required for complete FC ***,a number of alternative technologies for FC decomposition have been *** FC degradation technologies span a wide range of chemical processes including direct photolysis,photocatalytic oxidation,photochemical oxidation,photochemical reduction,thermally-induced reduction,and sonochemical *** paper reviews these FC degradation technologies in terms of kinetics,mechanism,energetic cost,and *** optimal PFOS/PFOA treatment method is strongly dependent upon the FC concentration,background organic and metal concentration,and available degradation time.

关键词： fluorochemical(FC)degradation technologies perfluoroctanesulfonate(PFOS) perfluorooctanoate (PFOA) oxidation reduction photolysis thermolysis review

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Auxin-Oxylipin Crosstalk:Relationship of Antagonists

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Journal of Integrative Plant Biology 2011年第6期53卷 429-445页

作者： Maik hoffmann Mathias Hentrich Stephan Pollmann Centro de Biotecnología y Genómica de Plantas(U.P.M.-I.N.I.A.) Parque Científico y tecnológico de la U.P.M. Campus de Montegancedo Ruhr-Universitt Bochum Lehrstuhl fr PflanzenphysiologieUniversittsstrasse

Phytohormones regulate a wide array of developmental processes throughout the life cycle of plants. Herein, the various plant hormones may interact additively, synergistically, or antagonistically. By their cooperation they create a delicate regulatory network whose net output largely depends on the action of specific phytohormone combinations rather than on the independent activities of separate hormones. While most classical studies of plant hormonal control have focused mainly on the action of single hormones or on the synergistic interaction of hormones in regulating various developmental processes, recent work is beginning to shed light on the crosstalk of nominally antagonistic plant hormones, such as gibberellins and auxins with oxylipins or abscisic acid. In this review, we summarize our current understanding of how two of the first sight antagonistic plant hormones, i.e. auxins and oxylipins, interact in controlling plant responses and development.

关键词： Auxin biosynthesis crosstalk hormone jasmonic acid.

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