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Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor

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Journal of Pharmaceutical Analysis 2017年第5期7卷 324-331页

作者： Gema M.Durán Tomás e.Benavidez Ana M.Contento Angel Ríos Carlos D.García Department of Analytical Chemistry and Food Technology University of Castilla-La Mancha IRICA (Regional Institute of Applied Scientific Research) Department of Chemistry Clemson University219 Hunter Laboratories

A simple methodology was developed to quantify penicillamine(PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots(Cu-GQDs). The proposed strategy combines the advantages of carbon dots(over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response(in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.

关键词： Graphene quantum dots One-step synthesis Fluorescence quenching Penicillamine Pharmaceutical preparations

在1例先天性眼外肌纤维化伴Marcus-gunn现象患者发现一种新型KIF21A突变

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 31-31页

作者： Yamada K. hunter D.G. Andrews C. engle e.C. 王海燕 Division of Genetics Children' s Hospital Boston 300 Longwood Ave Boston MA 02115 United States Dr

Objective: To determine whether congenital fibrosis of the extraocular muscles (CFeOM) with Marcus Gunn jaw-wink-ing phenomenon (MG) can result from mutations in the KIF21A gene encoding a kinesinmotor protein. Methods: An individual with CFeOM1 (classic autosomal dominant CFeOM) and MG underwent a comprehensive ophthalmic examination. He and his healthy parents underwent screening for mutations in the KIF21A gene by direct DNA sequencing. The clinical records of our previously described patients with CFeOM and KIF21A mutations were reviewed for evidence of more extensive dysinnervation. Results: A de novo and novel KIF21A mutation 2840T.C (M947T) was present in the proband. In addition, among our previously described patients with CFeOM and KIF21A mutations, 3 individuals had MG and 1 had hypertropia during toothbrushing. Conclusions: This report introduces a new CFeOM1 KIF21A mutation and is, to our knowledge, the first report of a genetic defect associated with MG. The combination of CFeOM1 with MG supports a primary neurogenic etiology of CFeOM resulting from KIF21A mutations. Clinical Relevance: These findings will increase understanding of the etiology of CFeOM and increase awareness of the affiliation of CFeOM with MG.

关键词： KIF21A 患者先天性眼外肌纤维化 Marcus-gunn

Color of Vertically-Suspended Structure Does Not Impact the Growth of Rainbow Trout Reared in Circular Tanks

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Open Journal of Animal Sciences 2020年第4期10卷 706-713页

作者： edgar Meza Misty D. Jones Nathan Huysman Jill M. Voorhees Michael e. Barnes Department of Game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA

This study examined the effects of five different colors of vertically-suspended environmental enrichment on the growth of juvenile Shasta strain rainbow trout (Oncorhynchus mykiss) during hatchery rearing in circular tanks. The colors used were silver (unpainted aluminum—control), safety red, semi-gloss black, hunter green, and safety blue. After 86 days, total tank weight, weight gain, and feed conversion ration were not significantly different among any of the color treatments. Individual fish weights, lengths, and condition factors were also not significantly different among the treatments. The results of this study indicate that the relatively small amount of color present on the suspended structure did not affect rainbow trout growth. Thus, the inherent silver color of the aluminum angles does not need to be changed.

关键词： environmental enrichment Oncorhynchus mykiss Salmonids Color

Identification and optimization of a potent and highly selective D3 dopamine receptor agonist

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中国药理学与毒理学杂志 2017年第10期31卷 950-951页

作者： Amy e MORITZ R Benjamin FRee Warren WeINeR Muzna BACHANI Trevor DOYLe Noel SOUTHALL Marc FeRReR Jonathan A JAVITCH Joseph STeINeR Ara ABRAMYAN Lei SHI Jeffrey AUBé Kevin FRANKOWSKI David R SIBLeY Molecular Neuropharmacology Section National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 University of North Carolina Chapel Hill NC27599 Neurotherapeutic Development Unit National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 National Center for Advancing Translational Sciences Rockville MD 20892 Columbia University New York NY 10032 Computational Chemistry and Molecular Biophysics Unit Molecular Targets and Medications Discovery Branch National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224

OBJeCTIVe Dopamine receptors(DRs) are involved in the development and treatment of many neuropsychiatric *** available dopaminergic drugs modulate both DRD2 and DRD3,leading to side effects and uncertainty as to the roles each DR subtype plays *** lab employed high throughput screening paradigms to discover highly selective modulators for the *** The NIH Molecular Libraries Program 400,000 + small molecule library was screened using the Discove Rx Path hunter?β-arrestin assay for compounds that activate the DRD3 without effects on the *** and counter-screens assessed selectivity and mechanisms of *** identified 62 potential agonists,and chose the most promising to perform a structure-activity relationship(SAR) study to increase potency while maintaining *** lead compound identified through this process,ML417,was also characterized using bioluminescence resonance energy transfer(BReT)-based β-arrestin recruitment and G-protein activation assays as well as p-eRK *** neuroprotective properties of this compound were assessed using a SHSY5 Y neuronal cell *** ML417 displays potent,DRD3-selective agonist activity in multiple functional *** and functional GPCR screens(>165 receptors) show ML417 has limited cross-reactivity with other ***417 also displays superior(compared to the reference compound pramipexole),dose-dependent protection against a decrease in neurite length induced by 10 μmol·L^(-1) of the neurotoxin,6-hydroxydopamine,in the SHSY5 Y cell *** We have discovered and characterized ML417,a potent and highly selective DRD3 *** compound will be useful as a research tool,and may prove useful as a therapeutic drug lead.

关键词： Dopamine receptor high throughput screening subtype selectivity neuroprotection

examination of care processes and treatment optimization for head and neck cancer patients in a community setting"hub and hub"model

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 152-157页

作者： Harleen K.Sethi elijah Walker Travis Weinsheim Matthew J.Brennan Christopher e.Fundakowski Department of Otolaryngology-Head and Neck Surgery Sidney Kimmel Cancer Center at Abington—Jefferson HealthWillow GrovePennsylvaniaUSA Department of Otolaryngology-Head and Neck Surgery Philadelphia College of Osteopathic MedicinePhiladelphiaPennsylvaniaUSA College of Applied Health Science University of Illinois at Urbana-ChampaignUrbanaIllinoisUSA Department of Otolaryngology-Head and Neck Surgery Thomas Jefferson University HospitalPhiladelphiaPennsylvaniaUSA

Objective:To examine referral pattern,the timing of diagnostic/staging processes,and treatment initiation for new head and neck cancer patients in a community ***:Patients with a newly diagnosed previously untreated diagnosis of head neck cancer managed at Asplundh Cancer Pavilion/Abington Memorial Hospital from October 2018 to March *** of referral and preceding workup were examined as well as intervals between initial head and neck consult and various timepoints of treatment ***:One hundred and five patients were included in the *** primary referral sources were external general otolaryngology(56.3%).Oral surgery and dermatology obtained tissue biopsy approximately 80%of the time before *** average time from the ordering of initial staging positron emission tomography/computed tomography to finalized results was 14 days(range:10-25 days).Patients referred from dermatology and oral surgery were more likely to require single modality care,namely definitive surgical *** to treatment initiation average was 37 days(range:29-41 days).Patients with longer treatment times noted significantly higher times to both radiation and medical oncology consults(48.42 vs.18.13 days;Pe differences in treatment initiation times were identified based on referral source or extent of workup performed before head/neck surgery *** appears the largest opportunities for improvement in terms of reducing overall treatment length exist in the optimization of radiation initiation time.

关键词： head and neck cancer package time referral source time to treatment initiation total treatment length

应用4DCT扫描获得的组织固有密度与血管信息而建立的多项式logistic回归模型对甲状旁腺腺瘤与其他组织鉴别

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国际医学放射学杂志 2014年第2期 164-164页

作者： G.J.hunter D.T.Ginat H.R.Kelly e.F.Halpern L.M.Hamberg 朱晓明 Department of Neuroradiology Massachusetts General-Hospital

目的由4D CT标准三期扫描的组织增强及其碘含量所获得的一系列参数建立起多项式logistic回归模型,并用于鉴别甲状旁腺腺瘤与甲状腺结节或淋巴结。材料与方

关键词：甲状旁腺腺瘤甲状腺粒子肉内分泌腺 logistic 多项式回归模型

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受控的空气污染物暴露与心律失常风险

环境与职业医学 2014年第10期31卷 787-787页

作者： Jeremy P.Langrish Simon J.Watts Amanda J.hunter Anoop S.V.Shah Jenny A.Bosson Jon Unosson Stefan Barath Magnus Lundbck Flemming R.Cassee Ken Donaldson Thomas Sandstrm Anders Blomberg David e.Newby Nicholas L.Mills

[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露... 详细信息

[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露期间和之后,统计分析了健康志愿者和冠状动脉心脏疾病患者的心律失常发生率。[方法]分析数据来自13个随机双盲交叉研究,包括282名参加者(140名健康志愿者和142例稳定性冠状动脉心脏疾病患者)的连续心电图记录。记录研究人群每次暴露时发生心律失常的情况。[结果]在稀释的柴油车尾气、木材烟雾、臭氧、浓缩的环境颗粒物、工程碳纳米颗粒或空气污染高环境水平的暴露期间或者之后,无论在健康志愿者或冠状动脉心脏疾病患者中,任何形式心律失常的发生均没有增加。[结论]急性、可控制的空气污染物暴露不增加受试者发生心律失常的短期风险。研究中所采用的这些技术,对于确定涉及空气污染不利影响的重要病理生理途径依然至关重要,并且在为环境和公共卫生政策决策提供信息中也起着重要的作用。

关键词：空气污染物心律失常短期风险健康志愿者患者群体摘要心脏自主神经心脏疾病

Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data:a multi-phased study of prostate cancer

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Cancer Communications 2021年第12期41卷 1387-1397页

作者： Chong Wu Jingjing Zhu Austin King Xiaoran Tong Qing Lu Jong Y.Park Liang Wang Guimin Gao Hong-Wen Deng Yaohua Yang Karen e.Knudsen Timothy R.Rebbeck Jirong Long Wei Zheng Wei Pan David V.Conti Christopher A Haiman Lang Wu Department of Statistics Florida State UniversityTallahasseeFL 32304USA Cancer epidemiology Division Population Sciences in the Pacific ProgramUniversity of Hawaii Cancer CenterUniversity of Hawaii at ManoaHonoluluHI 96813USA Department of epidemiology and Biostatistics Michigan State UniversityEast LansingMI 48824USA Department of Biostatistics University of FloridaGainesvilleFL 32603USA Department of Cancer epidemiology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612USA Department of Tumor Biology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612USA Department of Public Health Sciences University of ChicagoChicagoIL 60637USA Center of Bioinformatics and Genomics Department of Global Biostatistics and Data ScienceTulane UniversityNew OrleansLA 70112USA Division of epidemiology Department of MedicineVanderbilt Epidemiology CenterVanderbilt-Ingram Cancer CenterVanderbilt University Medical CenterNashvilleTN 37203USA Department of Cancer Biology Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaPA 19107USA Department of Medical Oncology Dana-Farber Cancer InstituteBostonMA 02215USA Department of epidemiology Harvard TH Chan School of Public HealthBostonMA 02115USA Division of Biostatistics University of MinnesotaMinneapolisMN 55455USA Department of Preventive Medicine Keck School of MedicineUniversity of Southern California/Norris Comprehensive Cancer CenterLos AngelesCA 90033USA

Background:DNA methylation and gene expression are known to play important roles in the etiology of human diseases such as prostate cancer(PCa).However,it has not yet been possible to incorporate information of DNA methylation and gene expression into polygenic risk scores(PRSs).Here,we aimed to develop and validate an improved PRS for PCa risk by incorporating genetically predicted gene expression and DNA methylation,and other genomic information using an integrative ***:Using data from the PRACTICAL consortium,we derived multiple sets of genetic scores,including those based on available single-nucleotide polymorphisms through widely used methods of pruning and thresholding,LDpred,LDpred-funt,AnnoPred,and eBPRS,as well as PRS constructed using the genetically predicted gene expression and DNA methylation through a revised pruning and thresholding *** the tuning step,using the UK Biobank data(1458 prevalent cases and 1467 controls),we selected PRSs with the best *** an independent set of data from the UK Biobank,we developed an integrative PRS combining information from individual ***,in the testing step,we tested the performance of the integrative PRS in another independent set of UK Biobank data of incident cases and ***:Our constructed PRS had improved performance(C statistics:76.1%)over PRSs constructed by individual benchmark methods(from 69.6%to 74.7%).Furthermore,our new PRS had much higher risk assessment power than family *** overall net reclassification improvement was 69.0%by adding PRS to the baseline model compared with 12.5%by adding family ***:We developed and validated a new PRS which may improve the utility in predicting the risk of developing *** innovative method can also be applied to other human diseases to improve risk prediction across multiple outcomes.

关键词： risk prediction polygenic risk scores predicted gene expression predicted DNA methylation integrative models prostate cancer

Differences in nutrient intakes between Australia-and Asia-born women living in Australia

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Differences in nutrient intakes between Australia-and Asia-b...