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New direction for surgery:super minimally invasive surgery

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World Journal of Gastroenterology 2024年第12期30卷 1676-1679页

作者： en-Qiang Linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their *** invasive surgery(MIs)has dominated the surgical realm because of its lesser ***,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIs,decreasing the quality of life of patients ***,I propose a new treatment mode,super MIs(sMIs),which is defined as“curing a disease or lesion which used to be treated by MIs while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of sMIs.

关键词： super minimally invasive surgery Minimally invasive surgery Treatment mode Traditional surgery New direction for surgery

All-electron basis sets for H to Xe specific for ZORA calculations:Applications in atoms and molecules

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chinese Physics B 2024年第8期33卷 238-246页

作者： c.s.Gomes F.e.Jorge A.canal Neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-ccsD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–Hess Hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe ccsD(T)method atomic and molecular properties

Improved segmented Belief Propagation List Decoding for Polar codes with Bit-Flipping

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china communications 2024年第3期21卷 19-36页

作者： Mao Yinyou Yang Dong Liu Xingcheng Zou en school of electronics and Information Technology(seIT) Sun Yat-sen University(SYSU)Guangzhou 510006China school of Information science Guangzhou Xinhua UniversityGuangzhou 510520China southern Marine science and engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Belief propagation list(BPL) decoding for polar codes has attracted more attention due to its inherent parallel nature. However, a large gap still exists with cRc-aided scL(cA-scL) *** this work, an improved segmented belief propagation list decoding based on bit flipping(sBPL-BF) is proposed. On the one hand, the proposed algorithm makes use of the cooperative characteristic in BPL decoding such that the codeword is decoded in different BP decoders. Based on this characteristic, the unreliable bits for flipping could be split into multiple subblocks and could be flipped in different decoders simultaneously. On the other hand, a more flexible and effective processing strategy for the priori information of the unfrozen bits that do not need to be flipped is designed to improve the decoding convergence. In addition, this is the first proposal in BPL decoding which jointly optimizes the bit flipping of the information bits and the code bits. In particular, for bit flipping of the code bits, a H-matrix aided bit-flipping algorithm is designed to enhance the accuracy in identifying erroneous code bits. The simulation results show that the proposed algorithm significantly improves the errorcorrection performance of BPL decoding for medium and long codes. It is more than 0.25 d B better than the state-of-the-art BPL decoding at a block error rate(BLeR) of 10^(-5), and outperforms cA-scL decoding in the low signal-to-noise(sNR) region for(1024, 0.5)polar codes.

关键词： belief propagation list(BPL)decoding bit-flipping polar codes segmented cRc

Melt flow,heat transfer and solidification in a flexible thin slab continuous casting mold with vertical-combined electromagnetic braking

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Journal of Iron and steel Research International 2024年第2期31卷 401-415页

作者： Lin Xu Ze-feng Han christian Karcher en-gang Wang Key Laboratory of electromagnetic Processing of Materials(Ministry of education) Northeastern UniversityShenyang110819LiaoningChina Key Laboratory of Liaoning Province for clean combustion Power Generation and Heating Technology Shenyang Institute of EngineeringShenyang110136LiaoningChina Institute of Thermodynamics and Fluid Mechanics Technische Universität IlmenauIlmenau98684Germany

During continuous casting of steel slabs,the application of electromagnetic braking technology(eMBr)provides an effective tool to influence solidification by controlling the pattern of melt flow in the ***,the quality of the final product can be improved considerably.A new electromagnetic braking(eMBr)method,named vertical-combined electromagnetic braking(Vc-eMBr),is proposed to be applied to a flexible thin slab casting(FTsc)*** evaluate the beneficial effects of the Vc-eMBr,the melt flow,heat transfer,and solidification processes in the FTsc mold are studied by means of numerical *** detail,a Reynolds-averaged Navier–stokes turbulence model together with an enthalpy-porosity approach was *** numerical findings are compared with respective simulations using the traditional *** results demonstrate that the application of the Vc-eMBr contributes significantly to preventing relative slab *** contrast to the Ruler-eMBr,the additional vertical magnetic poles of the Vc-eMBr preferentially suppress the direct impact of jet flow on the narrow face of FsTc mold and considerably diminish the level fluctuation near the meniscus *** instance,by applying a magnetic flux density of 0.3 T,the maximum amplitude of meniscus deflection reduces by about 80%.Moreover,the braking effect of the Vc-eMBr effectively improves the homogeneity of temperature distribution in the upper recirculation region and increases the solidified shell thickness along the casting *** this basis,the newly proposed Vc-eMBr shows a beneficial effect in preventing relative slab defects for FTsc thin slab continuous casting.

关键词： electromagnetic braking Mold Melt flow Heat transfer solidification

Investigations of nuclear chirality at iThemba LABs

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Frontiers of physics 2024年第2期19卷 7-38页

作者： R.A.Bark e.A.Lawrie c.Liu s.Y.Wang iThemba Laboratory for Accelerator Based sciences National Research FoundationP.O.Box 722Somerset-West 7129South Africa Department of Physics University of the Western CapePrivate Bag X177535BellvilleSouth Africa shandong Provincial Key Laboratory of Optical Astronomy and solar-Terrestrial environment Institute of Space SciencesShandong UniversityWeihai 264209China

Progress in the studies of chirality in atomic nuclei at iThemba LABs is *** regions of chirality,around mass 80 and 190 have been discovered using the AFRODITe array,specifically in the nuclei^(74)As,^(78,80,82)Br,^(81)Kr,and^(193,194,198)*** phenomena have been observed,including multiple chiral bands in the same nucleus,the coexistence of octupole correlations and nuclear chirality,and the coexistence of pseudo spin and nuclear *** best example of chiral degeneracy to date was found in ^(194)*** level scheme of ^(106)Ag has been revisited and interpreted in terms of two-and four-quasiparticle *** using the particle-rotor model have shown that the fingerprints of chirality in the two-quasiparticle system only can occur in an idealised model *** systems with a higher number of quasiparticles,the calculations showed that nuclear chirality can persist.

关键词： chirality high-spin states particle-rotor model

The Perturbed compound Poisson Risk Model with Proportional Investment

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Acta Mathematicae Applicatae sinica 2024年第1期40卷 109-128页

作者： Nai-dan Deng chun-wei Wang Jia-en Xu school of Mathematics and statistics Henan University of Science and TechnologyLuoyang471023China

In this paper, the insurance company considers venture capital and risk-free investment in a constant proportion. The surplus process is perturbed by diffusion. At first, the integro-differential equations satisfied by the expected discounted dividend payments and the Gerber-shiu function are derived. Then, the approximate solutions of the integro-differential equations are obtained through the sinc method. Finally, the numerical examples are given when the claim sizes follow different distributions. Furthermore, the errors between the explicit solution and the numerical solution are discussed in a special case.

关键词： expected discounted dividend payments lognormal distribution proportional investment perturbed risk model sinc numerical method

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen Huang Lining Ke en Huang Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina scientific Research center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

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science china(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-Yu chen Xiang-Yu Lyu en-Kun Li Yi-Ming Hu MOe Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F cells by Reversing ADAMTs18 Gene Methylation

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chinese Journal of Integrative Medicine 2024年第7期30卷 600-607页

作者： XU Ben ZHANG Jia-en Ye Lin YUAN chang-wei Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis(RIF)progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18(ADAMTs18)*** NRK-49F cells RIF model were induced with transforming growth factorβ1(TGF-β1).effects of different concentrations of curcumin(0,10,20,and 30μmol/L)on cell proliferation,cell cycle,cell apoptosis as well as cyclin D1 expression were analyzed by cell counting kit-8,flow cytometry and Western blot,***18 methylation levels were determined by methylation-specific polymerase chain ***18,fibronectin(FN),type I collagen(col-I)and alpha-smooth muscle actin(α-sMA)mRNA and protein expressions were analyzed by real-time PcR(RT-PcR)and Western blot,***,cells were treated with 50 mmol/L 5-aza-2′-deoxycytidine(5-aza-dc,demethylation agent)for 72 *** of curcumin on extracellular matrix(ecM)deposition was evaluated by immunochemical staining and Western ***-49F cells were transfected with ADAMTs18 small interfering RNA and grouped into a normal control,ADAMTs18-knock-out(KO),and ADAMTs18-KO+30μmol/L curcumin groups,and whether curcumin can reverse the effect of ADAMTs18 knockdown on RIF was *** compared with the control group,TGF-β1 significantly inhibited the proliferation of NRK-49F cells,blocked the G1/G0 phase,promoted cell apoptosis and inhibited cyclin D1 expression(Pe different concentrations of curcumin,30μmol/L curcumin significantly reversed these processes(Pchemical staining and Western blot results showed that curcumin significantly inhibited the deposition of FN,col-I andα-sMA(Pcurcumin and 5-zaz-dc had synergistic effects,promoting ADAMTs18 expression,removing ADAMTs18 methylation,and reducing ecM ***18 knockdown promoted ecM accumulation,and curcumin reversed this process(Pconclusion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal fibrosis curcumin chinese medicine ADAMTs18 methylation modification