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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina p.Bracho-Rincon Luis H.pagan Rivera Jorge D.Miranda Department of physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María norte-Muñoz María portela-Lomba paloma Sobrado-Calvo Diana Simón Johnny Di pierdomenico Alejandro Gallego-Ortega Mar pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TeG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TeG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TeG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TeG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Study of the e^+e^- to hadrons via ISR at BABAR

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Chinese physics C 2010年第6期34卷 660-668页

作者： e.p.Solodov Budker Institute of nuclear physics

experimental data from the pep-II B-factory at 10.6 GeV center-of-mass （c.m.） energy, obtained via initial-state radiation （ISR） with the BABAR detector, are presented. The cross sections for many hadronic processes have been measured from the production threshold to 4-5 GeV of the e^＋e^- c.m. energy. The obtained data allow to study a number of intermediate states and determine the parameters of known resonances and their branching fractions. The exclusive cross section for some number of hadronic sub-processes are presented.

关键词： ISR e^+e^- hadrons BABAR

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protection of Maternity in Greece and the e.U.——A Comparison Analysis

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Journal of Reproduction and Contraception 2007年第1期18卷 49-60页

作者： n.Salakos p.Christopoulos e.Deligeoroglou Z.Roupa p.Sotiropoulou p.papadimitriou Division of Family planning 2nd Dept of Obstetrics and GynaecologyUniversity of AthensMedical SchoolAretaieion Hospital14564 AthensGreece Dept of Health Visitors Technological Institute of AthensGreece

pregnancy and motherhood are two situations which impose on the special regulation of the working conditions in order to secure the protection of the physical and psychological health of woman. Furthermore, the disproportion between woman＇s and man＇s work and the mentality that labour and the raising of child is a burden that only woman has to bear, needs to be eliminated. This burden is softened by the protection provided to pregnant women by the state. This way, a great effort is made to promote the equality in working relations between men and women. This kind of protection is realized through the national Health and Social Care by giving economical provisions and through legislative regulations in order to harmonize work and parental role. In this study, regulations and services along with their health care personnel, referring to motherhood＇s protection in Greece, are presented and related data concerning other eU countries are given. Until now, the existing system of maternity of the ＂Social State＂ has not reached yet the desired goal.

关键词： protection of motherhood Health care personnel Social Care System Greece eU

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Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

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World Journal of Gastroenterology 2005年第28期11卷 4375-4381页

作者： n pallotta p pezzotti e Calabrese F Baccini e Corazziari Dpt Scienze Cliniche Università degli Studi di Roma "La Sapienza" Reparto AIDS e Malattie Sessualmente Trasmesse Istituto Superiore di Sanità Rome Italy Dpt Scienze Cliniche

AIM: Delayed gastric emptying and an enlarged fasting gastric antrum are common findings in functional dyspepsia but their relationship with gastrointestinal (GI), and the frequently associated extra-GI symptoms remains *** study evaluated the relationship between GI and extra-GI symptoms, fasting antral volume and delayed gastric emptying in functional ***: In 108 functional dyspeptic patients antral volume and gastric emptying were assessed with ultrasonography (US). Symptoms were assessed with standardized questionnaire. The association of symptoms and fasting antral volume with delayed gastric emptying was estimated with logistic regression ***: Delayed gastric emptying was detected in 39.8% of the patients. postprandial drowsiness (AOR 11.25; 95%CI 2.75-45.93), nausea (AOR 3.51; 95%CI 1.19-10.32), fasting antral volume (AOR 1.93; 95%CI 1.22-3.05), were significantly associated with delayed gastric emptying. Symptoms, mainly the extra-GI ones as postprandial drowsiness and nausea, combined with fasting antral volume predicted the modality of gastric emptying with a sensitivity and specificity of 78%.COnCLUSIOn: In functional dyspeptic patients, (1) an analysis of fasting antral volume and of symptoms can offer valuable indication on the modality of gastric emptying,and (2) it seems appropriate to inquire on postprandial drowsiness that showed the best correlation with delayed gastric emptying.

关键词： Functional dyspepsia Gastric emptying Ultrasonography

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Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： Sheharyar S.Baig Ali n.Ali Arshad Majid Sheffield Institute for Translational neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VnS)and stroke:Stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VnS paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,STOp-AUST,and TRAIGe did not show improvements in functional outcomes(puy et al.,2023).

关键词： stimulation acute

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effect of local environment in resonant domains of polydisperse plasmonic nanoparticle aggregates on optodynamic processes in pulsed laser fields

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Chinese physics B 2015年第4期24卷 467-474页

作者： A.e.ershov A.p.Gavrilyuk S.V.Karpov p.n.Semina L.V.Kirensky Institute of physics Russian Academy of Sciences Institute of Computational Modeling Russian Academy of Sciences Siberian State Aerospace University Siberian Federal University

Interactions of pulsed laser radiation with resonance domains of multiparticle colloidal aggregates having an increasingly complex local environment are studied via an optodynamic model. The model is applied to the simplest configurations, such as single particles, dimers, and trimers consisting of mono- and polydisperse Ag nanoparticles. We analyze how the local environment and the associated local feld enhancement by surrounding particles affect the optodynamic processes in domains, including their photomodification and optical properties.

关键词： nanoparticle surface plasmon colloid aggregate optodynarnics

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neCAB family of neuronal calcium-binding proteins in health and disease

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neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The n-terminal eF-hand calcium-binding proteins 1–3(neCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. neCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. neCAB2 interacts with predominantly striatal G-protein-coupled receptors, while neCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. neCAB proteins exhibit distinct subcellular localizations: neCAB1 is found in the nucleus and cytosol, neCAB2 resides in endosomes and the plasma membrane, and neCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in neCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of neCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Structure and magnetic properties of YCo5 compound at high pressures

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Journal of Materials Science & Technology 2020年第7期42卷 106-112页

作者： e.Burzo p.Vlaic D.p.Kozlenko n.O.Golosova S.e.Kichanov B.n.Savenko A.Ostlin L.Chioncel Faculty of physics Babes-Bolyai University 40084 Cluj-NapocaRomania Romanian Academy of Science Cluj-Napoca BranchCluj-Napoca 400015Romania University of Medicine and pharmacy“Iuliu Hatieganu” Physics and Biophysics Department Cluj-NapocaRomania Frank Laboratory of neutron physics Joint Institute for Nuclear Research141980 DubnaRussia Theoretical physics III Center for Electronic Correlations and MagnetismInstitute of PhysicsUniversity of AugsburgD-86135 AugsburgGermany Augsburg Center for Innovative Technologies(ACIT) D-86135 AugsburgGermany

The crystal structure and magnetic properties of YCo5 compound have been studied by neutron diffraction,in the pressure range 0≤p≤7.2 *** cobalt moments decrease with pressure,parallelly with anisotropic changes of lattice *** experimental data are analyzed together with results from the combined Density Functional and Dynamical Mean-Field Theory.A rather good agreement between the experimentally determined and calculated values of cobalt moments is *** scenario for the behavior of YCo5 under pressure,is the combined action of the Lifshitz transition with a strong local electron-electron interaction.

关键词： Internetallic compound pressure study Magnetic properties Band structure

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Free Oxide Distribution in poorly and Well drained Soils Developed on Calcareous Alluvial Deposits

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pedosphere 2003年第4期13卷 345-351页

作者： n. K. MOUSTAKAS p. e. BAROUCHAS Agricultural University of Athens Laboratory of Soil Science and Agricultural Chemistry 75 /era Odos Botanikos 11855Agricultural University of Athens Laboratory of Soil Science and Agricultural Chemistry 75 /era Odos Botanikos 11855

A study on the distribution of free iron and manganese oxides was conducted in soils developed on calcareous alluvial deposits under subhumid climatic conditions, in Western Greece. Soil samples from two well drained soils and from two poorly drained soils, classified as Alfisols, were collected and used in this study. After certification of soil homogeneity the acid ammonium oxalate and dithionite-citrate-bicarbonate methods were used to extract free iron and manganese oxides from the samples. Iron oxides extracted by the dithionite-citrate-bicarbonate method (Fed) were significantly higher than the iron oxides extracted by the ammonium oxalate method (Feo), indicating that a considerable fraction is present in crystalline forms,independent of drainage status. A confirmation of free iron oxides and fine clay was detected. The ratios Feo/Fed and (Fed-Feo)/total Fe (Fet) could not be used to distinguish the well drained soils from the poorly drained soils. Manganese movement in a soluble form is independent of the fine clay.

关键词： argillic horizon calcareous alluvial deposits iron oxides manganeseoxides soil homogeneity

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