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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

Assessing conservation practices in Amalacaxco Gorge (Izta-Popo National Park, Central mexico) using fallout 137Cs and Optically Stimulated Luminescence (OSL)

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Journal of mountain Science 2018年第3期15卷 447-460页

作者： mUNOZ-SALINAS e CASTILLO m Departamento de Geología Regional Universidad Nacional Autónoma de México Ciudad UniversitariaCiudad de MexicoMexico Laboratorio Nacional de Geoquimicay mineralogia Ciudad Universitaria Ciudad de Mexico Mexico

This study aims to assess conservation practices in Izta-Popo National Park(Central mexico) by evaluating the mechanisms of sediment transfer. We applied a methodology based on fallout ^(137)Cs and optically stimulated luminescence(OSL) analysis. This was tested in the upper catchment of Amalacaxco Gorge, selected for being one of the sectors of the park in which man-made actions have been implemented in last decades to favor forest growth in the alpine grassland and to reduce the effect of water runoff. We quantified the ^(137)Cs activity using gamma and beta spectrometry of fine sediment grains extracted from the surface of parcels of 0.4 m2 in areas of natural forest, natural alpine grassland, alpine grassland with conservation practices, ravines and trails. In general, ^(137)Cs values increases as local slope decreases as it was expected. The natural forest is the most stable area in terms of soil erosion and sediment accumulation and, mean ^(137)Cs activity was taken as reference to assess cumulative zones, with higher ^(137)Cs values and erosive, with lower. We found that trails are accumulative surfaces but in other areas, erosion predominates. man-made ditches, trenches and afforestation in the alpine grassland have higher ^(137)Cs values than thenatural grassland, which indicates that conservation practices are limiting the sediment transfer from hillslopes to channels, however, soil retention is less than in the natural grassland. Additionally, we evaluated the luminescence(OSL) values obtained from samples extracted from the sediment transported in ravines that are cutting into different sectors of the study area to assess the grade of resetting of fluvial materials. These luminescence results indicated that the sediment transported in ravines that are cutting into the natural forest and alpine grassland is bleached more efficiently than the sediment transported in the alpine grassland with conservation practices. Results of fallout ^(137)Cs and luminesce

关键词： Sediment transfer Soil erosion Natural protected areas Alpine grassland Caesium-137 Optically stimulated luminescence

Ion-acoustic waves at the night side of Titan's ionosphere:higher-order approximation

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Communications in Theoretical Physics 2020年第5期72卷 70-77页

作者： S m Ahmed e R Hassib U m Abdelsalam R e Tolba W m moslem Department of mathematics Faculty of ScienceSuez UniversitySuezEgypt Department of mathematics Faculty of ScienceFayoum UniversityFayoumEgypt Department of mathematics Rustaq College of EducationOman Centre for Theoretical Physics The British University in Egypt(BUE)El-Shorouk CityCairoEgypt Department of Physics Faculty of SciencePort Said UniversityPort Said 42521Egypt

Nonlinear solitary waves are investigated for a plasma system at the night side of Titan's *** plasma model consists of three positive ions,namely C2H5^+,HCNH^+,and C3H5^+,as well as maxwellian *** basic set of fluid equations is reduced to a Korteweg de-Vries(KdV)equation and linear inhomogeneous higher order KdV(LIHO-KdV)*** solitary wave solutions of both equations are obtained using a renormalization *** solitary waves'existence region and the wave profile are investigated,and their dependences on the plasma parameters at the night side of Titan's ionosphere are *** solitary waves'phase velocities are subsonic or supersonic,and the propagating pulses are usually *** effect of higher-order corrections on the perturbation theory is *** is found that the higher-order contribution makes the amplitude slightly taller,which is suitable for describing the solitary waves when the amplitude augments.

关键词： plasmas ion-acoustic waves planets and satellites:atmospheres

measurement of the pion form factor for m_(ππ)～2 between 0.1 and 0.85 GeV^2 with the KLOe detector

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Chinese Physics C 2010年第6期34卷 686-691页

作者： Stefan e.müller Institut für Kernphysik Johannes Gutenberg-Universitt

The KLOe experiment at the φ-factory DAФPNe has measured the pion form factor in the range between 0.1 〈 mππ^2 〈 0.85 GeV^2 using events taken at √s = 1 GeV with a photon emitted at large polar angles in the initial state. This measurement extends the mππ^2 region covered by KLOe ISR measurements of the pion form factor down to the two pion production threshold. The value obtained in this measurement of the dipion contribution to the muon anomalous magnetic moment of △αμ^ππ= （478.5±2-0stat±4.8syst±2.9theo）·10^-10 further confirms the discrepancy between the Standard model evaluation for αμ and the experimental value measured by the （g-2） collaboration at BNL.

关键词： hadronic cross section initial state radiation pion form factor muon anomaly

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

many Families of exact Solutions for Nonlinear System of Partial Differential equations Describing the Dynamics of DNA

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Journal of Partial Differential equations 2013年第4期26卷 373-384页

作者： zayed elsayed m. e. ARNOUS Ahmed H. mathematics Department Faculty of Science Zagazig University Zagazig Egypt. Department of engineering mathematics and Physics Higher Institute of Engineering El Shorouk Egypt.

The objective of this paper is to apply the improved generalized Riccati equation mapping method to find many families of exact traveling wave solutions for the general nonlinear dynamic system in a new double-chain model of DNA. This model consists of two long elastic homogeneous strands connected with each other by an elastic membrane. Hyperbolic and trigonometric function solutions of this model are obtained. Comparison between our results and the well-known results are given.

关键词： Nonlinear dynamics of DNA model exact solutions improved generalized Riccatiequation mapping method double-chain model of DNA.

Aspect of the specialty metals potentials of pegmatites in western Oban massif,Se Nigeria:A preliminary geochemical approach

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Chinese Journal Of Geochemistry 2012年第4期31卷 355-361页

作者： Oden m.I. Igonor e.e. Department of Geology University of CalabarP.M.B.1115 CalabarNigeria Petra Prospectors Limited Nigeria

minerals in general and rare-metals in particular are of invaluable importance in the development and industrialization of any *** is true as they could affect a nation's national income,employment ratio,Gross National Product,and its entire *** study area(western Oban massif-Se Nigeria) was investigated for its specialty metals bearing potentials because of(1) its geology,which is similar to other specialty metals bearing areas of the world;(2) past works,which points to the area as a likely source of economic deposit of such metals;and(3) the soaring cost of these rare metals in the light of recent upsurge in global information/telecommunication *** from the study,show that only cesium(Cs) and beryllium(Be) show minute signs or indications of enrichment if properly *** these metals should be studied in details to ascertain their economic *** rocks are too deficient in the other rare-metals(lithium,zirconium,strontium,tantalite,niobium,tungsten,gallium,and chromium) to warrant further analysis.

关键词：特种金属尼日利亚地球化学方法电位伟晶岩稀有金属矿地块国民生产总值

Faddeev calculations on lambda hypertriton with potentials from Gel'fand–Levitan–marchenko theory

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Communications in Theoretical Physics 2020年第10期72卷 119-124页

作者： e F meoto m L Lekala Department of Physics University of South AfricaPrivate Bag X61710 JohannesburgSouth Africa

effective lambda-proton and lambda-neutron potentials,restored from theoretical scattering phases through Gel'fand–Levitan–marchenko theory,are tested on a lambda hypertriton through three-body *** lambda hypertriton is treated as a three-body system consisting of lambda-proton,lambda-neutron and proton–neutron *** energy and root mean square radius are computed for the ground state of lambda hypertriton(Jp=12+).In coordinate space,the dynamics of the system is described using a set of coupled hyperradial equations obtained from the differential Faddeev *** solving the eigenvalue problem derived from this set of coupled hyperradial equations,the binding energy and root mean square matter radius computed are found to be-2.462 meV and 7.00 fm,*** potentials are also shown to display a satisfactory convergence behaviour.

关键词： lambda-nucleon potential lambda-proton potential lambda-neutron potential lambda hypertriton Faddeev equations hyperspherical method

Review of analytical methods for stress and deformation analysis of buried water pipes considering pipe-soil interaction

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Underground Space 2023年第6期13卷 205-227页

作者： Yingxu Huo Sherif mohsen mohamed Hassan Gomaa Tarek zayed mohamed meguid Department of Civil and environmental engineering The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Department of Building and Real estate The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China Structural engineering Department Faculty of EngineeringMansoura UniversityMansoura 35516Egypt Department of Civil engineering McGill UniversityMontrealQuebec H3A 0G4Canada

Buried water pipelines are vulnerable to fail or break due to excessive loading or ground *** evaluation of pipe performance and serviceability relies on the proper understanding of pipe-soil interactions(PSI).Analytical methods are important approaches to studying ***,a systematic and thorough literature review to analyze the existing research trends,technological achievements and future research opportunities is not *** work investigates analytical methods that analyze the stress and deformation of pipes in terms of cross-sectional,transverse and longitudinal PSI ***,scientometric analysis is performed to acquire relevant research works from online databases and analyze the existing data of influential authors,productive research sources and frequent key word occurrence in the fields of ***,a qualitative discussion is performed in the three categories of PSI:(1)cross-sectional,including ovalization and circumferential behaviours;(2)transverse,including seismic fault crossing,weak soil zones,ground settlement and pipe uplift;and(3)***,six research opportunities are discussed,including the role of friction in cross-sectional deformation,combined effects of bending and compression,choice of soil reaction models and calibration of key parameters,effect of pipe flaws,soil spatial variability and behaviours of curved *** study helps beginners familiarize themselves with PSI analytical methods and provides experienced researchers with ideas for future research directions.

关键词： Pipeline Analytical methods Pipe-soil interactions Seismic fault Settlement Uplift Buckling Tunnelling