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Histone Acetylation, VeRNALIZATION INSeNSITIVe 3, FLOWeRING LOCUS C, and the Vernalization Response

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Molecular Plant 2009年第4期2卷 724-737页

作者： Donna M. Bond elizabeth S. Dennis Barry J. Pogson e. jean finnegan CSIRO Plant Industry Canberra Australia ARC Centre of excellence in Plant energy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The quantitative induction of VIN3 by low temperatures is required for PRC2 repression of FLC and promotion of flowering （vernalization） in Arabidopsis. Histone acetylation, a chromatin modification commonly associated with gene transcription, increased on VIN3 chromatin in two spatially and temporally distinct phases in response to low temperatures. During short-term cold exposure, histone H3 acetylation at the transcription start site rapidly increased, implying that it is required for VlN3 induction. Subsequent changes in histone H3 and H4 acetylation occurred following continued VIN3 transcription during prolonged cold exposure. Members of the SAGA-like transcriptional adaptor complex, including the histone acetyltransferase GCNS, which induces expression of the cold acclimation pathway genes, do not regulate VlN3 induction during cold exposure, indicating that the cold acclimation pathway and the cold-induction of VlN3 are regulated by different transcriptional mechanisms. Mutations in the other 11 histone acetyltransferase genes did not affect VlN3 induction. However, nicotinamide, a histone deacetyiase inhibitor, induced VIN3 and altered histone acetylation at the VIN3 locus. VIN3 induction was proportional to the length of nicotinamide treatment, which was associated with an early-flowering phenotype and repression of FLC. However, unlike vernalization, the repression of FLC was independent of VIN3 activity. Nicotinamide treatment did not cause a change in the expression of any genes in the autonomous pathway or members of the PRC2 complex, the well characterized repressors of FLC. Our data suggest that FLC is repressed via a novel pathway involving the SIR2 class of histone deacetylases.

关键词： Cold acclimation histone acetyltransferase histone deacetylase SIR2 nicotinamide.

WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder

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Neural Regeneration Research 2022年第10期17卷 2126-2130页

作者： Alexandre Vallée Yves Lecarpentier jean-Noël Vallée Department of Clinical Research and Innovation(DRCI) Foch HospitalSuresnesFrance Centre de Recherche Clinique Grand Hôpital de l’Est Francilien(GHEF)MeauxFrance Laboratoire de Mathématiques et Applications(LMA) Universitéde PoitiersPoitiersFrance Centre Hospitalier Universitaire(CHU)Amiens Picardie UniversitéPicardie Jules Verne(UPJV)AmiensFrance

The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or ***-compulsive disorder etiologies are ***,numerous mechanisms in several localizations are *** studies showed that both glutamate,inflammatory factors and oxidative stress could have main functions in obsessive-compulsive *** synthase kinase-3β,the major negative controller of the WNT/β-catenin pathway is upregulated in obsessive-compulsive *** obsessive-compulsive disorder,some studies presented the actions of the different circadian clock ***/β-catenin pathway and circadian clock genes appear to be ***,this review focuses on the interaction between circadian clock genes and the WNT/β-catenin pathway in obsessive-compulsive disorder.

关键词： circadian rhythms glutamatergic pathway inflammation obsessive-compulsive disorder oxidative stress WNT/β-catenin pathway

Scanning transmission electron microscopy and atom probe tomography analysis of non-stoichiometry long-period-stacking-ordered structures in Mg-Ni-Y/Sm alloys

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Journal of Magnesium and Alloys 2024年第3期12卷 954-965页

作者： Yimeng Chen Manuel Legrée.jean-Louis Bobet Alexander Kvit CAMeCA Instruments Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Materials Science Department University of WisconsinMadisonWI 53706USA

The long-period-stacking-ordered(LPSO)structure affects the mechanical,corrosion and hydrolysis properties of Mg *** current work employs high angle annular dark field-scanning transmission electron microscopy(HAADF-STeM)and atom probe tomography(APT)to investigate the structural and local chemical information of LPSO phases formed in Mg-Ni-Y/Sm ternary alloys after extended isothermal *** on the alloying elements and their concentrations,Mg-Ni-Y/Sm develops a two-phase LPSO+α-Mg structure in which the LPSO phase contains defects,hybrid LPSO structure,and Mg ***-STeM and APT indicate non-stoichiometric LPSO with incomplete Ni_(6)(Y/Sm)_(8) *** addition,the APT quantitatively determines the local composition of LPSO and confirms the presence of Ni within the Mg bonding *** results provide insight into a better understanding of the structure and hydrolysis properties of LPSO-Mg alloys.

关键词： Magnesium alloys Long-range ordering Atom probe tomography(APT) STeM HAADF Hydrolysis properties.

Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma： A Potential Therapeutic Target in Gliomas

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Neuroscience Bulletin 2018年第3期34卷 573-588页

作者： AlexANDre Vallée Yves Lecarpentier Rémy Guillevin jean-Noёl Vallée Laboratory of Mathematics and Applications Unites Mixtes de Recherche (UMR) Centre National de la Recherche Scientifique (CNRS) 7348 University of Poitiers PoitiersFrance Delegation a la Recherche Clinique et a l'Innovation (DRCI) Hopital Foch Suresnes France Centre de Recherche Clinique Grand Hopital de l'EstFrancilien Meaux France DACTIM UMR CNRS 7348 University of Poitiers et CHU de Poitiers Poitiers France CHU Amiens Picardie University of Picardie Jules VerneAmiens France

In gliomas, the canonical Wingless/Int（WNT）/b-catenin pathway is increased while peroxisome proliferator-activated receptor gamma（PPAR-c） is *** two systems act in an opposite manner. This review focuses on the interplay between WNT/b-catenin signaling and PPAR-c and their metabolic implications as potential therapeutic target in gliomas. Activation of the WNT/bcatenin pathway stimulates the transcription of genes involved in proliferation, invasion, nucleotide synthesis,tumor growth, and angiogenesis. Activation of PPAR-c agonists inhibits various signaling pathways such as the JAK/STAT, WNT/b-catenin, and PI3 K/Akt pathways,which reduces tumor growth, cell proliferation, cell invasiveness, and angiogenesis. Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin,and sulforaphane downregulate the WNT/b-catenin pathway through the upregulation of PPAR-c and thus appear to provide an interesting therapeutic approach for ***（TMZ） is an antiangiogenic agent. The downstream action of this opposite interplay may explain the TMZ-resistance often reported in gliomas.

关键词： WNT/beta-catenin pathway PPAR gamma Glioma STAT3 pathway PI3K/Akt pathway NSAID Curcumin

Mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： jean-David M.Gothié Timothy e.Kennedy Department of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

Mosaic theory revised:inflammation and salt play central roles in arterial hypertension

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Cellular & Molecular Immunology 2022年第5期19卷 561-576页

作者： Felicitas e.Hengel jean-Pierre Benitah Ulrich O.Wenzel Ⅲ.Department of Medicine University Hospital Hamburg-EppendorfHamburgGermany Inserm UMR-S 1180 Faculty of PharmacyUniversity Paris SaclayGif-sur-YvetteFrance

The mosaic theory of hypertension was advocated by Irvine Page~80 years ago and suggested that hypertension resulted from the close interactions of different *** evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic *** plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial *** intake is indispensable for normal body function but can be detrimental when it exceeds dietary *** data show that sodium levels also modulate the function of monocytes/macrophages,dendritic cells,and different T-cell *** of these effects are mediated by changes in the microbiome and metabolome due to high-salt *** purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt,immunity,and hypertension *** and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces.

关键词： Arterial hypertension salt innate and adaptive immunity renin angiotensin aldosterone system mineralocorticoid receptor angiotensinⅡreceptor

用XPS和SeM研究低温条件下金在硫化矿物表面的沉淀作用:利用吸收/还原浓缩金

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世界核地质科学 1988年第2期 24-29页

作者： GilleS e.jean G.Michael Bancroft 郭虹

利用X射线光电光谱（XPS或eSCA）和扫描电镜（SeM）,我们对溶液中的金在硫化物表面上的吸收和还原机理进行了详细的研究。KAuIIICl4溶液迅速地为硫化物表面吸收,Au（III）立即被还原为Au（0）。1 min之内就形成了单分子Au层。还原作用... 详细信息

利用X射线光电光谱（XPS或eSCA）和扫描电镜（SeM）,我们对溶液中的金在硫化物表面上的吸收和还原机理进行了详细的研究。KAuIIICl4溶液迅速地为硫化物表面吸收,Au（III）立即被还原为Au（0）。1 min之内就形成了单分子Au层。还原作用被自动催化,金属Au在表面生长。SeM照片清楚地表明,Au团块不规则地分布于表面。发现了异常高浓度Au存在的特定位置。提出了吸收和还原作用的可能机理。结果表明,Au（III）和Au（I）在硫化矿物上被吸收,随即还原。这一过程在天然体系金的沉淀中特别是低温,低浓度的金溶液中起着十分重要的作用。

关键词：硫化矿物硫化物矿物 XPS SeM

engaging diverse community members to enhance analysis and interpretation:processing qualitative interview data

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Family Medicine and Community Health 2022年第1期10卷 10-14页

作者： Sarah e Brewer jean Scandlyn Family Medicine University of Colorado-Anschutz Medical CampusAuroraColoradoUSA ACCORDS University of Colorado-Anschutz Medical CampusAuroraColoradoUSA Health and Behavioral Sciences University of Colorado DenverDenverColoradoUSA Anthropology University of Colorado DenverDenverColoradoUSA

As the USA becomes more diverse,the inclusion of patients from diverse backgrounds in research becomes ever more important to ensuring a complete understanding of the patient experience in primary *** and cultural barriers are important areas in which researchers face substantial *** care researchers need tools and approaches to include diverse communities in qualitative ***,we describe one way primary care researchers can apply an adapted,engaged transcription and interpretation method in qualitative research to improve retention of nuance and meaning across language and cultures,specifically with non-english,non-Spanish speaking resettled *** also discuss how the approach provided additional information that increased the validity of interpretation and analysis and improved the retention of nuance in a qualitative primary care *** methodological and practical value,scope of application and potential limitations and improvements of this method through future research are addressed.

关键词： interview qualitative retention

What is artificial meat and what does it mean for the future of the meat industry?

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Journal of Integrative Agriculture 2015年第2期14卷 255-263页

作者： Sarah P F Bonny Graham e Gardner David W Pethick jean-Franois Hocquette School of Veterinary and Life Sciences Murdoch UniversityMurdoch W.A. 6150 Australia INRA UMR1213 Recherches sur les HerbivoresSaint-Genès Champanelle F-63122 France Clermont Université Vet Agro Sup UMR1213 Recherches sur les HerbivoresSaint-Genès Champanelle F-63122 France

The meat industry cannot respond to increases in demand by ever increasing resource use. The industry must find solutions to issues regarding animal welfare, health and sustainability and will have to do so in the face of competition from emerging non-traditional meat and protein products in an increasingly complex regulatory environment. These novel meat and protein products, otherwise known as ‘artificial meat＇ are utilising ground breaking technologies designed to meet the issues facing the conventional meat industry. These artificial meats, in vitro or cultured meat and meat from genetically modified organisms have no real capacity to compete with conventional meat production in the present environment. However, meat replacements manufactured from plant proteins and mycoproteins are currently the biggest competitors and are gaining a small percentage of the market. Manufactured meats may push conventional meat into the premium end of the market, and supply the bulk, cheap end of the market if conventional meat products become more expensive and the palatability and versatility of manufactured meats improve. In time the technology for other artificial meats such as meat from genetic modified organisms or cultured meat may become sufficiently developed for these products to enter the market with no complexity of the competition between meat products. Conventional meat producers can assimilate agroecology ecology concepts in order to develop sustainable animal production systems. The conventional meat industry can also benefit from assimilating biotechnologies such as cloning and genetic modification technologies, using the technology to adapt to the changing environment and respond to the increasing competition from artificial meats. Although it will depend at least partly on the evolution of conventional meat production, the future of artificial meat produced from stem cells appears uncertain at this time.

关键词： artificial meat in vitro meat meat industry consumer satisfaction sustainable production