检索结果-南通市图书馆

NeCAB family of neuronal calcium-binding proteins in health and disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Functional responses to deforestation in fish communities inhabiting neotropical streams and rivers

在线全文

学校读者我要写书评

暂无评论

ecological Processes 2023年第1期12卷 716-732页

作者： Isabel Cantera Céline jézéquel Tony Dejean jérôme Murienne Régis Vigouroux Alice Valentini Sébastien Brosse Department of environmental Science and Policy Universitàdegli Studi di MilanoVia Celoria 2620133 MilanItaly Laboratoire evolution et DiversitéBiologique UMR5174-UniversitéPaul SabatierCNRSIRD118 Route de Narbonne31062 ToulouseFrance SPYGeN Savoie Technolac-BP 27417 Rue du Lac Saint-André73375 Le Bourget-du-Lac CedexFrance HYDReCO Laboratoire Environnement de Petit SautB.P 82397388 Kourou CedexFrench GuianaFrance

Background Deforestation is a widespread disturbance for neotropical freshwater *** biodiversity declines have been associated with deforestation,its functional consequences for stream and river fish faunas remain poorly *** this study,we explored how deforestation affects the different facets of the functional structure of fish communities inventoried using environmental DNA metabarcoding in 64 river and 35 stream sites of French ***,we investigated how functional richness,divergence,evenness and identity of fish faunas are affected by *** We showed that anthropogenic disturbances in French Guiana are modifying the functional diversity of freshwater fish *** disturbances not only affected the amount of functional traits held by the communities but also the identity of the traits and the internal structure of the functional ***,different facets of the functional diversity supported by fish assemblages were *** streams,deforestation did not affect the overall diversity of traits but reduced functional redundancy,underlined by a shift in functional identity towards assemblages dominated by pelagic *** contrast,river fish faunas experienced a decline in functional richness,paired with shifts in functional identity and a loss of fish species with extreme *** The response to deforestation differed between streams and rivers,but it supports the hypothesis that deforestation is linked to functional changes in fish *** diminishing the range of the functions in rivers or by jeopardizing the redundancy of functions in streams,deforestation could severely hamper the functioning and stability of neotropical freshwater ecosystems.

关键词： eDNA Traits Functional space Richness Divergence evenness Identity Gold mining

同方期刊数据库

effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

在线全文

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2024年第1期13卷 90-98页

作者： Tania Pinto-escalona erica Gobbi Pedro L.Valenzuela Simon j.Bennett Pierluigi Aschieri Manuel Martin-Loeches Antonio Paoli Oscar Martinez-de-quel Faculty of education Complutense University of MadridMadrid 28040Spain Department of Biomolecular Sciences University of Urbino“Carlo Bo”Urbino 61029Italy Department of Systems Biology University of AlcaláMadrid 28805Spain Research Institute for Sport and exercise Sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for the Behavioural Sciences Department Complutense University of MadridMadrid 28040Spain Department of Biomedical Sciences University of PaduaPadua 35122Italy

Purpose:To examine the effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness in children aged 7-8 ***:Twenty schools in 5 different european countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(Sport at School trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an intervention group,which replaced these lessons with a 1-year karate intervention(Karate Mind and Movement program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±SD)completed the study,of which 333 and 388 were assigned to the control group and intervention group,*** included academic performance(average grade),psychosocial functioning(Strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The intervention provided small but significant benefits compared to the control group for academic achievement(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;pe(d=0.24;p=0.015).There was a trend towards significant benefits for flexibility(d=0.24;p=0.056).No significant benefits were observed for other variables,including psychosocial difficulties,emotional symptoms,hyperactivity/inattention,peer problems,or prosocial behaviour(all p>0.05).Conclusion:A 1-year school-based karate intervention was effective in improving academic achievement,conduct problems,and physical fitness in primary school *** results support the inclusion of karate during physical education lessons.

关键词： Academic performance Cardiorespiratory fitness Conduct problems Karate Physical fitness

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Combinatorial therapies for spinal cord injury repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Hybrid silicon modulators

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2009年第4期7卷 280-285页

作者： j.e.Bowers Department of electrical and Computer engineering University of California Santa Barbara

A number of active elements have been demonstrated using the hybrid silicon evanescent platform, including lasers, amplifiers, and detectors. In this letter, two types of hybrid silicon modulators, flflfilling the building blocks in optical communication on this platform, are presented. A hybrid silicon electroabsorp- tion modulator, suitable for high speed interconnects, with 10-dB extinction ratio at -5 V and 16-GHz modulation bandwidth is demonstrated. In addition, a hybrid silicon Mach-Zehnder modulator utilizing carrier depletion in multiple quantum wells is proved with 2 *** voltage-length product, 150-nm optical bandwidth, and a large signal modulation up to 10 Gb/s.

关键词： Bandwidth electroabsorption modulators Modulation Modulators Optical communication Quantum well lasers Semiconducting indium compounds Semiconductor quantum wells Silicon Silicon detectors

Approximate ballistics formulas for spherical pellets in free flight

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2018年第1期14卷 1-11页

作者： e.j.Allen Department of Mathematics and Statistics Texas Tech University

The ballistics equations for spherical pellets in free flight are simplified through appropriate scaling of the pellet velocity and pellet distance. Two different drag coefficient curves are averaged to yield a single curve applicable to shot pellets and round balls. The resulting S-shaped drag coefficient curve is approximated by three straight-line segments. The scaled ballistics equations are then solved exactly and simple formulas are found for the velocity and flight time with respect to trajectory distance. The formulas are applicable to spherical shot pellets and round balls of any composition under any atmospheric conditions. The formulas are amenable to quick and easy computation and may also serve as an aid in understanding and comparing black-box ballistics calculators. For shotshell ballistics, an important assumption in the present investigation is that the pellets are moving as single, free spheres and not as a dense cloud or in a shot column, in particular, the pellets are not interacting during flight. Therefore, the formulas are most appropriate for single round balls, for large shot sizes, and for pellets of small shot size fired from open chokes. The formulas are clear and accessible, and can be implemented by military or law enforcement personnel as well as hunters and shooters. This work differs from previous investigations in that accurate ballistics formulas are derived for spherical projectiles of shotguns and muzzleloaders using realistic drag coefficients.

关键词： Ballistics Sphere Drag Shotgun Muzzleloader Nondimensionalization

Stress waves propagation in solids under high-speed liquid impact

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2004年第6期47卷 752-766页

作者： j.e.Field Cavendish Laboratory Cambridge UniversityMadingly RoadCambridge CB3 0HEUK

An experiment of impact between 450 m/s water jets and polymethylme- thacrylate (PMMA) materials with complex surface geometry was conducted. The testing surfaces were a corner, step change, surface-breaking notch, inclined surface, etc. Stress waves propagation in the solid such as reflection, interference and diffraction was observed using polarized optics and an Imacon high speed camera (operating at both of 106 and 5×105 framing rates per second, fps). A damage test by the impact of the side jetting of an 850 m/s water jet was also carried out. It was found that stress waves propagation in solids depends not only on the surface geometry but also on the contact situation between liquid and solid. It was shown that the side jetting has sufficient damage potential although its head may consist of finer droplets. The results of this paper are useful to further analyze the dynamic stress state of solids under high-speed liquid impact.

关键词： high-speed liquid/solid impact, stress waves, mechanical property of solid, high-speed photography.

Faulty evidence for superconductivity in ac magnetic susceptibility of sulfur hydride under pressure

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第6期9卷 43-44页

作者： j.e.Hirsch Department of Physics University of California

Sulfur hydride was reported to become superconducting at high pressure and temperature [1]. Posteriorly, Huang and coworkers measured its ac magnetic susceptibility [2], reportedly confirming that finding. According to Semenok and Oganov [3], their work ‘sets a new standard for experimental studies of superconductivity at high pressure’.Instead I argue here that the ac susceptibility measurements of Huang et al.

关键词：