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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

Structural and Mechanistic Aspects of Mn-oxo and Co-based Compounds in Water Oxidation Catalysis and Potential Applications in Solar Fuel Production

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journal of Integrative Plant Biology 2010年第8期52卷 704-711页

作者： harvey j.M.Hou Department of Chemistry and Biochemistry University of Massachusetts Dartmouth North Dartmouth

To address the issues of energy crisis and global warming, novel renewable carbon-free or carbon-neutral energy sources must be identified and developed. A deeper understanding of photosynthesis is the key to provide a solid foundation to facilitate this transformation. To mimic the water oxidation of photosystem II oxygen evolving complex, Mn-oxo complexes and Co-phosphate catalytic material were discovered in solar energy storage. Building on these discoveries, recent advances in solar energy conversion showed a compelling working principle by combing the active Mn-oxo and Co-based catalysts in water splitting with semiconductor heteronanostructures for effective solar energy harnessing. In this review the appealing systems including Mn-oxo tetramer/Nafion, Mn-oxo dimer/TiO2, Mn-oxo oligomer/WO3, Co-Pi/Fe2O3, and Co-Pi/ZnO are summarized and discussed. These accomplishments offer a promising framework and have a profound impact in the field of solar fuel production.

关键词： Mn Structural and Mechanistic Aspects of Mn-oxo and Co-based Compounds in Water Oxidation Catalysis and Potential Applications in Solar Fuel Production II Figure

evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy

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World journal of Clinical Oncology 2014年第3期5卷 299-310页

作者： Haroon A Hussain Amanda j harvey Brunel Institute for Cancer Genetics and Pharmacogenomics Biosciences Brunel University (London)

There have been significant improvements in the detection and treatment of breast cancer in recent decades. However, there is still a need to develop more effective therapeutic techniques that are patient specific with reduced toxicity leading to further increases in patients' overall survival; the ongoing progress in understanding recurrence, resistant and spread also needs to be maintained. Better understanding of breast cancer pathology, molecular biology and progression as well as identification of some of the underlying factors involved in breast cancer tumourgenesis and metastasis has led to the identification of novel therapeutic targets. Over a number of years interest has risen in breast tumour kinase(Brk) also known as protein tyrosine kinase 6; the research field has grown and Brk has been described as a desirable therapeutic target in relation to tyrosine kinase inhibition as well as disruption of its kinase independent activity. This review will outline the current "state of play" with respect to targeted therapy for breast cancer, as well as discussing Brk's role in the processes underlying tumour development and metas-tasis and its potential as a therapeutic target in breast cancer.

关键词： Breast tumour kinase Protein tyrosine kinase 6 Breast neoplasms Targeted molecular therapy Intracellular signaling peptides and proteins Protein kinase inhibitors

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos j.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Generation and Regulation of CD8^+ Regulatory T Cells

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Cellular & Molecular Immunology 2008年第6期5卷 401-406页

作者： Linrong Lu harvey Cantor Department of Cancer Immunology ＆ AIDS Dana-Farber Cancer Instituteand Department of Pathology Harvard Medical School Boston MA 02115USA Institute of Immunology Zhejiang University School of MedicineHangzhou China Corresponding to： Dr. harvey Cantor Department of Cancer Immunology ＆ AIDS Dana-Farber Cancer Institute and Department of Pathology Harvard Medical School 44 Binney Street Boston MA 02115 USA

Research into the suppressive activity of CD4＋FoxP3＋ T regulatory cells （Treg） has defined a sublineage of CD4＋ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution of regulatory sublineages of CD8＋ cells. Analysis of a small fraction of CD8＋ cells that target autoreactive CD4＋ cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-e in human has revitalized interest in CD8＋ Treg. Here we summarize recent progress and future directions of research into the role of this CD8＋ sublineage in resistance to autoimmune disease. Cellular ＆ Molecular Immunology. 2008; 5（6）：401-406.

关键词： CD8+ regulatory T cell self-tolerance autoimmune disease eAe Qa-1 NKG2A

Roles of manganese in photosystem II dynamics to irradiations and temperatures

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Frontiers in Biology 2013年第3期8卷 312-322页

作者： Xuejing HOU harvey j. M. HOU Department of Chemistry and Biochemistry University of Massachusetts Dartmouth North Dartmouth MA 02747 USA Department of Physical Sciences Alabama State University Montgomery AL 36104 USA

The most amazing chemistry is the light-driven water splitting reaction occurred in the oxygen-evolving complex of phototsystem II in higher plants, green algae, and cyanobacteria. Mn, in the form of Mn4CaOs cluster in photosystem II, is responsible for the catalytic water splitting reaction as well as plays roles in photosystem II dynamics to irradiation and temperatures. Manganese hypothesis of UV-initiated photoinhibition as a direct target is established, and thermal inactivation of photosystem II involves the valence and structural changes of manganese. Recent progresses in understanding the roles of manganese in photoinhibition especially under UV light and in thermal inactivation including elevated temperatures using synthetic models and native PS II complexes are summarized and evaluated. Potential problems and possible solutions are discussed and presented.

关键词： photosynthesis manganese photosystem II irradiation temperature stress

Methane production from Sargassum muticum:effects of seasonality and of freshwater washes

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energy and Built environment 2021年第3期2卷 235-242页

作者： Supattra Maneein john j.Milledge Patricia j.harvey Birthe V.Nielsen Algae Biotechnology University of GreenwichChatham MaritimeME44TBUK

Biogas production from Sargassum muticum,an invasive seaweed species to europe,is hampered by low methane(CH_(4))yields during anaerobic digestion(AD),but causes are *** research is the first to demonstrate the impact of extensive freshwater washing of spring-and summer-harvested *** on the CH_(4)production rates and the biochemical methane potential(BMP).The findings reveal that the rate profile of CH_(4)production is affected by extensively washing the seaweed and is dependent on ***-harvested *** had higher initial CH_(4)production rates compared to summer-harvested *** spring-harvested ***,the initial rate of CH_(4)production was lowered by extensive *** contrast,extensively washed summer-harvested *** had a higher degradation rate and CH_(4)production rate relative to its non-extensively washed *** highest CH_(4)potentials accumulated by the treated and non-treated *** are,however,statistically similar and not influenced by seasonality or extensive washing(p>0.05).Potential causes for differences in the rate of CH_(4)production between summer-and spring-harvested *** are *** differences in CH_(4)production from treated summer-and spring-harvested *** acts as a stepping stone to understanding the causes for low CH_(4)yields,which could allow for further enhancements in CH_(4)production from ***.

关键词： Seaweed Biogas Biofuels Seasonality Washing

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António j.Salgado Nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Resolution beyond classical limits with spatial frequency heterodyning

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Chinese Optics Letters 2006年第3期4卷 148-151页

作者： A.Mudassar A.R.harvey A.H.Greenaway j.D.C.jones School of engineering and Physical Sciences Heriot-Watt UniversityUK

A technique for coherent imaging based on spatial frequency heterodyning is described. Three images corresponding to three physical measurements are recorded. For the first measurement, a scene is simply illuminated with a coherent beam and for measurements 2 and 3, the scene is projected with cosine and sine fringes, respectively. Due to spatial frequency heterodyning, upper and lower side hand information falls in the pass band of the imager. These bands are separated and correct phases and positions are assigned to these bands in the spatial frequency domain. An extension of bandwidth is achieved in the frequency domain and the inverse frequency domain data then give a high resolution coherent image.

关键词： Resolution beyond classical limits with spatial frequency heterodyning