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Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation

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World journal of Cardiology 2025年第1期17卷 22-27页

作者： Alexander e Berezin Department of Internal Medicine-II Paracelsus Medical University SalzburgSalzburg 5020Austria

the recurrence of atrial fibrillation(AF)in patients after successful radiofrequency catheter ablation(RFCA)appears to be an unresolved clinical issue and needs to be clearly *** are many factors associated with AF recurrence,such as duration of AF,male sex,concomitant heart failure,hemodynamic parameters,chronic obstructive pulmonary disease,hypertension,obstructive sleep apnea,hyperthyroidism,smoking and ***,the inflammatory changes are strongly associated with electrical and structural cardiac remodeling,cardiac damage,myocardial fibrotic changes,microvascular dysfunction and altered reparative *** this context,biomarkers reflecting the different stages of AF pathogenesis deserve thorough *** authors of the retrospective study revealed that one-year recurrence rate of non-valvular AF in the high systemic immune inflammation(SII)index group was significantly increased compared to that of the low SII index group and provided additional predictive value to the ***,the authors suggest that this biomarker may help physicians to optimize the selection of AF patients and to develop a personalized treatment *** conclusion,the SII index may serve as a valuable indicator of recurrent AF in patients after RFCA and may be a biomarker with plausible predictive value for poor clinical outcomes.

关键词： Systemic immune inflammation index Recurrent atrial fibrillation Radiofrequency catheter ablation Biomarkers APPLe score Prediction

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

traumatic brain injury(tBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).tBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 177-192页

作者： M.NAVeeD M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDes)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

Analyzing the Cytotoxic and Genetic Impact of Datura stramonium extract on MCF7 and Ht29 Cancer Cells:A Metabolite and Gene expression Study

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Phyton-International journal of experimental Botany 2025年第1期94卷 181-198页

作者： Fayez Althobaiti Hadeer Darwish Raghad Alruqayb Saqer S.Alotaibi Fahad e.Alharthi Ibrahim jafri Sarah Awwadh Altalhi Ghadi Alsharif Hussam Awwadh e Althagafi Hesham Noureldeen Sarah Alharthi jawaher Albaqami Najla Amin t.Al Kashgry Ahmed Noureldeen Department of Biotechnology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Saud Bin Abdulaziz University for Health SciencesJeddah21423Saudi Arabia Department of Biomedical Research King Abdullah International Medical Research CenterJeddah21423Saudi Arabia Biology Department Faculty of Science and ArtsAl-Baha UniversityAl-Mikhwah65731Saudi Arebia Faculty of Medicine Mansoura UniversityMansoura35516Egypt Department of Chemistry Collage of ScienceTaif UniversityTaif21944Saudi Arabia

the interest in using the Datura stramonium plant is due to its natural products,which are used in many pharmaceutical *** objective of the current study was to assess the therapeutic and cytotoxic effects of the *** plant on two types of human cancer cell models(MCF7 and Ht29)in vitro.A soxhlet apparatus was used to obtain methanolic extract from dried plant *** recovered crude,after the solvent had evaporated,was then dispersed at varied concentrations of extract 100,50,20,and 0.0µg/mL and tested to see how the cells ***,the cancer-testis antigen(CtA)gene transcription in the two cell types exposed to the plant extract was examined using a semi-quantitative real-time polymerase chain *** chromatography–mass spectrometry(GC-MS)results produced the significant main metabolites Nonanoic acid,tropine N-Oxide,3,6-Ditigloyloxy-7-hydroxytropane,Hexadecanoic acid,2-Pentadecanone,6,10,14-trimethyl-,Carvenone,methyl ester,Phytol,Aposcopolamine,Hyoscyamine,4,8,12,16-tetramethylheptadecan-4-olide,Scopolamine,Alpha.-tocospiro A,1,2-Cycloheptanedione,3,3,7,7-tetramethyl-,dihydrazone,Campesterol,Stigmasterol,Gamma-Sitosterol and dl-.alpha.-*** results showed that the two types of cell lines impacted by *** extract,through untreated type 1 cells(MCF7)gave a highly significant transcription according to all applicable *** implemented analyses cleared the strong genetic impacts of Datura extract on cancer cells’***2LY and C2orf63 transcript accumulation were also significantly elevated when exposed to plant extract at a level of 50µg/mL in cell line type 2(Ht29),but tGIF2LY and P53 had the lowest relative expression at a level of 100µg/mL when treated the same cell line type.

关键词： Datura stramonium secondary metabolites GC-MS analysis cytotoxicity breast and colon cancer cell lines Mtt assay

Protective activity of adipose-derived stem cell extracellular vesicles in ischemia and/or reperfusion

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World journal of Stem Cells 2025年第1期17卷 1-5页

作者： Alexander e Berezin Internal Medicine-II Paracelsus Medical University SalzburgSalzburg 5020Austria

Increasing evidence of the significant clinical value of protection against ischemia/reperfusion injury has contributed to the realization of the independent importance of this approach in improving prognosis and reducing cardiovascular *** vesicles(eVs)derived by adipose mesenchymal stem cells may mediate the paracrine effects of stem cells and provide regenerative and anti-inflammatory properties,which are enhanced byγ-aminobutyric *** protective effects on cardiac myocytes may result from the eV embarked by miR-21-5p,which is a target for thioredoxin-interacting protein,regulating the formation of thioredoxin-interacting protein-thioredoxin complexes and subsequently enhancing the antioxidant activity of *** has been found thatγ-aminobutyric acid governs myocardial bioenergetics through suppressing inflammation and supporting mitochondrial ***,stem cell-based cell-free therapy based on adipose-derived stem cell eVs is considered a promising approach to individualized management of ischemia-induced cardiomyopathy.

关键词： extracellular vesicles Adipose mesenchymal stem cells MicroRNA-21-5p Cardiac protection Ischemia Reperfusion

Altered microRNA composition in the uterine lumen fluid in cattle(Bos taurus)pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo

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journal of Animal Science and Biotechnology 2025年第1期16卷 76-91页

作者： Fernando H.Biase Sarah e.Moorey julie G.Schnuelle Soren Rodning Martha Sofia Ortega thomas e.Spencer School of Animal Sciences Virginia Polytechnic Institute and State University175 W Campus DrBlacksburgVA 24061USA Department of Animal Science University of TennesseeKnoxvilleTN 37996USA Department of Clinical Sciences Auburn UniversityAuburnAL 36849USA Department of Animal Science Auburn UniversityAuburnAL 36849USA Department of Animal and Dairy Sciences University of Wisconsin MadisonMadisonWI 53706USA Division of Animal Sciences University of MissouriColumbiaMO 65211USA

Background MicroRNAs(miRNAs)are presented in the uterine lumen of many mammals,and in vitro experiments have determined that several miRNAs are important for the regulation of endometrial and trophoblast *** aim was to identify and contrast the miRNAs present in extracellular vesicles(eVs)in the uterine lumen fluid(ULF)at the onset of attachment in cattle pregnancies(gestation d 18)initiated by artificial insemination(AI)or by the trans-fer of an in vitro-produced blastocyst(IVP-et).A third group had no conceptus after the transfer of an IVP *** the abundance of 263 annotated miRNAs was quantified in the eVs collected from *** was an increase in the transcript abundance of 20 miRNAs in the ULF eVs from the AI pregnant group,while 4 miRNAs had a lower abundance relative to the group not containing a ***,4 miRNAs were more abun-dant in ULF eVs in the AI pregnant group relative to IVP-et group(bta-mir-17,bta-mir-7-3,MIR7-1,MIR18A).Specific miRNAs in the ULF eVs were co-expressed with messenger RNAs expressed in extra-embryonic tissues and endome-trium,including genes that are known to be their *** the results provide biological insights into the participation of miRNAs in the regulation of trophoblast proliferation and differentiation,as well as in endometrium *** knowledge that in vitro cultured embryos can contribute to the altered abundance of specific miRNAs in the uterine lumen can lead to the development of cor-rective approaches to reduce conceptus losses during the first month of pregnancy in cattle.

关键词： Artificial reproductive technology Cattle Conceptus embryos endometrium Small RNA

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Abrasive wear behavior of functionally graded Al_(3)ti reinforced aluminum matrix composite

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China Foundry 2025年第1期22卷 45-54页

作者： eylül tuğçe Yaman Yildiz Ömer Savaş Muhammed Soner Başer engin Kocaman Ince Shipping Group 34724IstanbulTurkey Yildiz technical University Faculty of Naval Architecture and Maritime34349IstanbulTurkey Ministry of transport and Infrastructure General Directorate of Marine Affairs06338AnkaraTurkey Zonguldak Bulent ecevit University Faculty of EngineeringDepartment of Aerospace Engineering67100ZonguldakTurkey

Aluminum alloys are widely used in industry due to their light *** alloys are generally exposed to abrasive wear,which diminishes their effective *** wear resistance of these alloys is enhanced by adding various reinforcements,however,this enhancement comes at the cost of reduced fracture *** paradox of increased wear resistance versus decreased fracture toughness in aluminum alloys can be resolved by using functionally graded materials (FGMs).this study focuses on the abrasive wear behavior of functional graded aluminum matrix composites reinforced with Al_(3)ti *** wear properties of the composites were investigated by considering the characteristics of the composite such as matrix type and various composite zones,as well as the wear parameters such as abrasive particle diameter,load,sliding speed and *** method was used in the abrasive wear tests in order to get more reliable results in a timeefficient *** recipes were created based on the L_(27)(3^(6)) orthogonal *** a result of the study,it is observed that the wear resistance of the composites increases with an increase in Al_(3)ti reinforcement content and hardness of the *** addition,the size of abrasive particles and the applied load are significant factors affecting abrasive wear.

关键词： functionally graded Al_(3)ti taguchi abrasive wear

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Improving gastrointestinal scoring systems for predicting short-term mortality in critically ill patients

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World journal of Gastroenterology 2025年第5期31卷 137-139页

作者： Shane Moore Noel e Donlon Department of Anaesthesia and Critical Care University Hospital LimerickLimerick V94MunsterIreland Department of Upper Gastrointestinal Surgery St James HospitalDublin D09LeinsterIreland

Shen et al’s retrospective study aims to compare the utility of two separate scoring systems for predicting mortality attributable to gastrointestinal(GI)injury in critically ill patients[the GI Dysfunction Score(GIDS)and the Acute Gastroin-testinal Injury(AGI)grade].the authors note that this study is the first proposal that suggests an equivalence between the ability of both scores to predict mor-tality at 28 days from intensive care unit(ICU)*** et al retrospec-tively analysed an ICU cohort of patients utilising two physicians administering both the AGI grade and GIDS score,using electronic healthcare records and ICU *** these physicians disagreed about the scores,the final decision as to the scores was made by an associate chief physician,or chief *** note that the primary reason for the development of GIDS was to create a clear score for GI dysfunction,with minimal subjectivity or inter-operator *** subjectivity inherent to the older AGI grading system is what ultimately led to the development of GIDS in *** ensuring consensus between physicians administering the AGI,Shen et al have controlled for one of this grading systems biggest *** have concerns,however,that this does not represent the real-world challenges associated with applying the AGI compared to the newer GIDS,and wonder if this arbitration process had not been instituted,would the two scoring systems remain equivalent in terms of predicted mortality?

关键词： Gastrointestinal injury Critical care Patient mortality prediction Gastrointe-stinal Dysfunction Score Acute Gastrointestinal Injury grade Intensive care unit scoring systems

Circadian nutrition:is meal timing an elixir for fatigue?

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Science Bulletin 2025年第3期70卷 309-312页

作者： Zhihui Zhang Lu Yan jonas t.treebak Min-Dian Li Department of Cardiovascular Medicine Center for Circadian Metabolism and Cardiovascular DiseaseSouthwest HospitalArmy Medical UniversityChongqing 400038China Ministry of education(MOe)Key Laboratory of Geriatric Cardiovascular and Cerebrovascular Disease Chongqing 400038China Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen 2200Denmark

Fatigue is increasingly prevalent in industrialized societies,highlighting an urgent need for effective clinical and lifestyle *** manifests as reduced muscle endurance,strength and a persistent sensation of exhaustio... 详细信息

关键词： fatigue strength sensation