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“Sitting-up vertigo as an expression of posterior semicircular canal heavy cupula and posterior semicircular canal short arm canalolithiasis”

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Journal of Otology 2022年第2期17卷 101-106页

作者： Darío H.Scocco María A.Barreiro Ivan e.garcía Institute of Neuroscience Favaloro Foundation University HospitalBuenos AiresArgentina

Background:Vestibular symptoms on sitting-up are frequent on patients seen by vestibular ***,a benign paroxysmal positional vertigo(BPPV)variant which elicits vestibular symptoms with oculomotor evidence of posterior semicircular canal(P-SCC)cupula stimulation on sitting-up was described and named sitting-up vertigo BPPV.A periampullar restricted P-SCC canalolithiasis was proposed as a causal ***:To describe new mechanisms of action for the sitting-up vertigo BPPV ***:eighteen patients with sitting-up vertigo BPPV were examined with a pre-established set of positional maneuvers and follow-up until they resolved their symptoms and clinical ***:All patients showed up-beating torsional nystagmus(UBTN)and vestibular symptoms on coming up from either Dix-Hallpike(DHM)or straight head-hanging *** out of 18 patients presented a sustained UBTN with an ipsitorsional component to the tested side on half-Hallpike maneuver(HH).A slower persistent contratorsional down-beating nystagmus was found in eleven out18 patients tested on nose down position(ND).Conclusions:Persistent direction changing positional nystagmus on HH and ND positions indicative of PSCC heavy cupula was found in 11 patients.A sustained UBTN on HH with the absence of findings on ND,which is suggestive of the presence of P-SCC short arm canalolithiasis,was found on 5 *** patients were treated with canalith repositioning maneuvers without success,but they resolved their findings by means of Brandt-Daroff *** propose P-SCC heavy cupula and P-SCC short arm canalolithiasis as two new putative mechanisms for the sitting-up vertigo BPPV variant.

关键词： BPPV Benign paroxysmal positional vertigo Vertigo Residual dizziness Subjective BPPV Sitting up vertigo Heavy cupula Short arm canalolithiasis

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3D printing of patient-specific 316L–stainless–steel medical implants using fused filament fabrication technology: two veterinary case studies

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Bio-Design and Manufacturing 2022年第4期5卷 808-815页

作者： J.M.Chacón P.J.Núñez M.A.Caminero e.garcía-Plaza J.Vallejo M.Blanco escuela Técnica Superior de Ingeniería Industrial Universidad de Castilla-La ManchaAvdaCamilo JoséCela213071 Ciudad RealSpain Protresde Ingeniería y Soluciones C/Solana 60nave 313005 Ciudad RealSpain

Biomedical fracture fixation implants have complex sculptured geometries to adapt perfectly to fractured bones,making them difficult and expensive to manufacture with conventional machining methods. Fused filament fabrication(FFF) is a very popular Additive Manufacturing technology that simplifies the manufacture of parts with complex geometries, making it ideal for the manufacture of customized medical implants.

关键词： steel fracture fused

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Heterostructures of Ni(II)-doped CdS quantum dots andβ-Pb_(0.33)V_(2)O_(5)nanowires:enhanced charge separation and redox photocatalysis via doping of QDs

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Nano Research 2024年第12期17卷 10279-10291页

作者： Karoline e.garcía-Pedraza Jaime R.Ayala Udani Wijethunga Alice R.Giem George Agbeworvi Sarbajit Banerjee David F.Watson Department of Chemistry University at BuffaloThe State University of New YorkBuffaloNew York 14260-3000USA Department of Chemistry Texas A&M UniversityCollege StationTexas 77843USA Department of Materials Science and engineering Texas A&M UniversityCollege StationTexas 77843USA

We synthesized heterostructures by tethering Ni(II)-doped CdS(Ni:CdS)quantum dots(QDs)toβ-Pb_(0.33)V_(2)O_(5)nanowires(NWs)using L-cysteine as a molecular linker,and we evaluated the influence of doping on their redox photocatalytic *** initially hypothesized that incorporating Ni:CdS QDs into heterostructures could alter excited-state dynamics and mechanisms,and that the localization of excited electrons on Ni 3d states could promote redox photocatalytic mechanisms including reduction of CO_(2).Isolated Ni:CdS QDs were ferromagnetic,and they exhibited enhanced photocatalytic hydrogen evolution and photostability relative to undoped CdS *** Pb_(0.33)V_(2)O_(5)/CdS heterostructures(with undoped QDs)and Pb_(0.33)V_(2)O_(5)/Ni:CdS heterostructures(with Ni(II)-doped QDs)exhibited substantial energetic overlap between valence-band states of QDs and intercalative mid-gap states ofβ-Pb_(0.33)V_(2)O_(5)*** Pb_(0.33)V_(2)O_(5)/CdS heterostructures,photoexcitation of CdS QDs was followed by rapid(50-100 ps)transfer of both holes and electrons toβ-Pb_(0.33)V_(2)O_(5)*** contrast,within Pb_(0.33)V_(2)O_(5)/Ni:CdS heterostructures,holes were transferred from Ni:CdS QDs toβ-Pb_(0.33)V_(2)O_(5)NWs within 100 ps,but electrons were transferred approximately 20-fold more *** difference in electron-and hole-transfer kinetics promoted charge separation across the Pb_(0.33)V_(2)O_(5)/Ni:CdS interface and enabled the photocatalytic reduction of CO_(2)to CO,CH_(4),and HCO_(2)H with>99.9%selectivity relative to the reduction of H+to *** results highlight the opportunity to fine-tune dynamics and mechanisms of excitedstate charge-transfer,and mechanisms of subsequent redox half-reactions,by doping QDs within ***,they reveal the promise of heterostructures comprising QDs and MxVyO5 materials as CO_(2)-reduction photocatalysts.

关键词： heterostructures photocatalysis CO_(2)reduction quantum dots metal vanadates charge transfer

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Release of interleukin-10 and neurotrophic factors in the choroid plexus：possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia

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Neural Regeneration Research 2018年第10期13卷 1743-1752页

作者： Yolanda Cruz edna e.garcía Jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-garcía Herlinda Bonilla-Jaime Julio Rojas-Castaneda Antonio Ibarra Centro de Investigación en Ciencias de la Salud (CICSA) FCSUniversidad Anáhuac México Norte Huixquilucan Estado de México México Lab. De Biologia de la reproducción UAMI. Ciudad de México México Hospital de Pediatría CMN Siglo XXI. Ciudad de México México Subdirección de Medicina experimental Instituto Nacional de PediatríaCiudad de México México Doctorado en Ciencias Biológicas División de Ciencias Biológicas y de la SaludUniversidad Autónoma MetropolitanaUnidad Iztapalapa.Ciudad de México México

Copolymer-1（Cop-1） is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus（CP） is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors（brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3） and cytokines（tumor necrosis factor alpha, interferon-gamma, interleukin-4（IL-4）, IL-10 and IL-17）, in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and IL-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of IL-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and IL-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1.

关键词： choroid plexus growth factors immunomodulation protective autoimmunity Cop-1 Copaxone stroke glatiramer acetate t MCAo focal cerebral ischemia

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Potential anti neuro-inflammatory effect of BioCen-128 in animal models of dementia

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Animal Models and experimental Medicine 2022年第4期5卷 369-376页

作者： Nashelly esquivel Yenela garcía Roberto Menéndez Teidy egarcía Ana RMorales Claudio Rodríguez National Center for Bioproducts(BIOCeN) BejucalCuba Center for Neurosciences(CNeURO) PlayaCuba Department of Pharmacology Institute of Marine Sciences(ICIMAR)HavanaCuba

Background:BioCen-128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide *** results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging,immunosenescence and Alzheimer’s disease(AD),where the inflammation plays an important *** of the anti-i nflammatory potential of BioCen-128,the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular(ICV)administration of streptozotocin(STZ).Method:The experiment was carried out using male OF-1mice weighing 20±2 ***:Mice administered BioCen-128 in via the IP route at 5,10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma,providing evidence of a systemic anti-i nflammatory *** the ICV model of STZ,the administration of BioCen-128 improved cognitive ***:These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosinβ4 and thymosin alfa *** results suggested that BioCen-128 could be used in the prevention and treatment of some diseases,for example AD,where neuroinflammation is one of the biological events that take place.

关键词： BioCen-128 cotton pellet mice neuroinflammation

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DIGeSTIVe GLAND AS A FeeD INDeX FOR JUVeNILeS OF QUeeN CONCH STROMBUS GIGAS ReAReD WITH FORMULATeD FOODS

DIGESTIVE GLAND AS A FEED INDEX FOR JUVENILES OF QUEEN CONCH...

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Ⅸ International Congress on Medical and Applied Malacology

作者： D.Aldana Aranda A..Zetina Zárate R.Moreno e.garcía Santaella L.Frenkiel CINVeSTAV IPN unidad Mérida Laboratorio de Biología y Cultivo de Moluscos Km.6 carretera antigua a Progreso Mérida YucatánMéxico CINVeSTAV IPN unidad Mérida Laboratorio de Biología y Cultivo de Moluscos Km.6 carretera antigua a Progreso Mérida YucatánMéxico CINVeSTAV IPN unidad Mérida Laboratorio de Biología y Cultivo de Moluscos Km.6 carretera antigua a Progreso Mérida YucatánMéxico CINVeSTAV IPN unidad Mérida Laboratorio de Biología y Cultivo de Moluscos Km.6 carretera antigua a Progreso Mérida YucatánMéxico Archipel des Sciences French West Indies

＜正＞The queen conch Strombus gigas is a marine resource of ecological and economical importance in the Caribbean *** of queen conch suffer a severe reduction in most Caribbean countries due to over-fishing,forcing t... 详细信息

关键词： Strombus gigas culture digestive gland index feeding

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Temperature Inversions,Meteorological Variables and Air Pollutants and Their Influence on Acute Respiratory Disease in the Guadalajara Metropolitan Zone,Jalisco,Mexico

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Journal of environmental Protection 2013年第8期4卷 142-153页

作者： Hermes U.Ramirez-Sanchez Mario e.garcía-Guadalupe Hector H.Ulloa-Godinez Angel R.Meulenert-Pena Omar garcia-Concepcion Jaime Alcala Gutierrez Sarahi J.Lizarraga Brito Department of Physics Institute of Astronomy and MeteorologyUniversity Center of Exact Sciences and Engineering(CUCEI)University of GuadalajaraGuadalajaraMexico

The presence of temperature inversions (TI), concentration of air pollutants (AP) and meteorological variables (MV) affect the welfare of the population, creating public health problems (acute respiratory diseases ARDs, among others). The Guadalajara Metropolitan Zone (GMZ) experiences high levels of air pollution, which associated with the presence of temperature inversions and meteorological variations is conducive to the incidence of ARDs in children. The aim of this work is to evaluate the TI, MV, AP and their influence on the ARDs in children under five years in the GMZ from 2003 to 2007. In this period, the moderate and strong TI are the most frequent presenting from November to May. The AP shows a variable behavior during the year and between years, with the highest concentration of particles less than 10 microns (PM10), followed by ozone (O3), nitrogen dioxide (NO2), nitrogen oxides (NOX), carbon monoxide (CO) and sulfur dioxide (SO2), the most affected areas are the southeast of the GMZ. Annual arithmetic mean is 213,510 ± 41,209 ARDs consultations. The most important diseases are acute respiratory infections (98.0%), followed by pneumonia and bronchopneumonia (1.1%), asthma and status asthmaticus (0.5%) and streptococcal pharyngitis and tonsillitis (0.4%). Months with most inquiries were from October to March, mainly in the southeast, south and center of the city, coinciding with high levels of AP. Statistical analysis shows that the TI have significant correlation with ARDs in three years, temperature (Temp) in two, relative humidity (RH) in two, wind speed (WS) in three, wind direction (WD) in two, while that air pollutants NOX and NO2 showed significant correlation with ARDs throughout the period. CO and SO2 showed significance in two years, while the PM10 and O3 in one.

关键词： Temperature Inversions Meteorological Variables Air Pollutants Acute Respiratory Diseases

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Generation of high energy laser-driven electron and proton sources with the 200 TW system VeGA 2 at the Centro de Laseres Pulsados

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High Power Laser Science and engineering 2019年第2期7卷 34-39页

作者： L.Volpe R.Fedosejevs G.Gatti J.A.Pérez-Hernández C.Méndez J.Apinaniz X.Vaisseau C.Salgado M.Huault S.Malko G.Zeraouli V.Ospina A.Longman D.De Luis K.Li O.Varela e.garcía I.Hernandez J.D.Pisonero J.garcia Ajates J.M.Alvarez C.garcía M.Rico D.Arana J.Hernandez-Toro L.Roso Centro de Laseres Pulsados(CLPU) Edicio M5.Parque Cientco.C/Adaja&37185VillamayorSalamancaSpain Laser-Plasma Chair at the University of Salamanca SalamancaSpain Department of electrical and Computer engineering University of AlbertaEdmontonAlberta T6G2V4Canada University of Salamanca SalamancaSpain

The Centro de Laseres Pulsados in Salamanca,Spain has recently started operation phase and the first user access period on the 6 J 30 fs 200 TW system(VeGA 2)already started at the beginning of *** this paper we report on two commissioning experiments recently performed on the VeGA 2 system in preparation for the user *** 2 system has been tested in different configurations depending on the focusing optics and targets *** configuration(long focal length F=130 cm)is for underdense laser-matter interaction where VeGA 2 is focused onto a low density gas-jet generating electron beams(via laser wake field acceleration mechanism)with maximum energy up to 500 MeV and an X-ray betatron source with a 10 keV critical energy.A second configuration(short focal length F= 40 cm)is for overdense laser-matter interaction where VeGA 2 is focused onto a 5 μm thick Al target generating a proton beam with a maximum energy of 10 MeV and temperature of 2.5 *** this paper we present preliminary experimental results.

关键词： high power laser laser-plasma particle acceleration

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco garcía-garcía Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-eVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived eVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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腹壁下动脉穿支皮瓣行乳房再造的术前计划优化

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国际医学放射学杂志 2014年第6期 594-594页

作者： M.C.Santiago e.garcía-Tutor G.R.Caravaca J.del Cerro González L.M.Klein A.Alonso-Burgos 惠东明 Department of Radiology Hospital Universitario de TorrejonC/Mateo Inurria s/n.C.P.28550Torrejon de ArdozMadridSpain

摘要目的腹壁下动脉穿支(DIeP)皮瓣术前计划首选多层螺旋CT血管成像(CTA)已经成为一项越来越重要的放射科业务。本文旨在优化流程,验证"Navarra准则"的价值,

关键词：术前计划皮瓣 DIeP 阅读时间穿支

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