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neurocircuit regeneration by extracellular matrix reprogramming

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neural Regeneration Research 2025年第8期20卷 2300-2301页

作者： Shengzhang Su Ian n.Levasseur Kimberly M.Alonge department of Medicinal Chemistry University of WashingtonSeattleWAUSA department of Chemistry University of WashingtonSeattleWAUSA department of Medicine University of Washington Medicine Diabetes InstituteSeattleWAUSA

The brain's extracellular matrix(eCM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's eCM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's eCM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.

关键词： matrix programming

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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neural Regeneration Research 2025年第3期20卷 660-670页

作者： ernesto doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for neurological diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Improvement of True Green Porosity, Sinterability and Microstructure in Alumina Ceramics by Filter Pressing

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Journal of Materials Science & Technology 2005年第1期21卷 105-108页

作者： RenjieZenG B.rand dept.ofMaterialsScience&engineering XiamenUniversityXiamen361005China dept.ofProcess Environment&MaterialsEngineeringLeedsUniversityLeedsLS29JTUK

Comparison between filter pressing and isostatic pressing for submicrometer alumina powder has been systematically made. Obvious improvements in true porosity, sintering behaviour, and microstructure of green compacts... 详细信息

关键词： Porosimetry Agglomerate Sintering dilatometry pH PeG

electrochemical power sources:key agents for energy sustainability(Ⅱ)

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电池 2006年第1期36卷 111-117页

作者： d.A.J.rand CSIRO energy Technology Box 312 Clayton SouthVictoria 3169Australia

There is mounting concern over the sustainability of global energy supplies. Among the key drivers are：（ Ⅰ ） global warming, ocean surface acidification and air pollution, which imply the need to control and reduce anthropogenie emissions of greenhouse gases （especially carbon dioxide）, nitrogen oxides, sulfur oxides, unburnt hydrocarbons and fine particles; （ Ⅱ ）the low estimated reserves of oil and natural gas; （ Ⅲ ） the need for energy security adapted to each country, such as decreasing the dependence on fossil-furl imports （in particular, the vulnerability to volatile oil prices） from regions where there is political or economic instability; （ Ⅳ ） the expected growth in world population with the ever-increasing aspiration for an improved standard-of- living for all. Hydrogen is being promoted world-wide as a total panacea for energy problems. As a versatile carder for storing and transporting energy from any one of a myriad of sources to an dectricity generator, it is ＇argued that hydrogen will eventually replace （or at least greatly reduce） the reliance on fossil fuels and thereby also avoid/decrease emissions of carbon dioxide. not unexpectedly, the building of a ＇Hydrogen economy＇ presents great scientific and technological challenges in the production, delivery, storage, conversion and end-use of this energy vector. In addition, there ate many policy, regulatory, economic, financial, investment, environmental and safety questions to be addressed. notwithstanding these obstacles, it is indeed plausible that hydrogen will become inereasingiy deployed and win compete with traditional systems of energy storage and supply. Future roles for electrochemical power sources hatteries, supercapacitors, photoelectrochemical cells and fuel cells on the pathway to universal energy sustainability in stationary, mobile-power and road transportation applications are examined.

关键词：蓄电池电化学氢分配电极材料

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Performance of Text-Independent Automatic Speaker Recognition on a Multicore System

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Tsinghua Science and Technology 2024年第2期29卷 447-456页

作者： rand Kouatly Talha Ali Khan Faculty of Tech and Software engineering University of Europe for Applied SciencesPotsdam 14469Germany

This paper studies a high-speed text-independent Automatic Speaker Recognition(ASR)algorithm based on a multicore system's Gaussian Mixture Model(GMM).The high speech is achieved using parallel implementation of the feature's extraction and aggregation methods during training and testing *** memory parallel programming techniques using both OpenMP and PThreads libraries are developed to accelerate the code and improve the performance of the ASR *** experimental results show speed-up improvements of around 3.2 on a personal laptop with Intel i5-6300HQ(2.3 GHz,four cores without hyper-threading,and 8 GB of RAM).In addition,a remarkable 100%speaker recognition accuracy is achieved.

关键词： Automatic Speaker Recognition(ASR) Gaussian Mixture Model(GMM) shared memory parallel programming PThreads OpenMP

Long-wave instabilities

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Science China Mathematics 2024年第8期67卷 1761-1776页

作者： dongfen Bian emmanuel grenier School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China Unité de Mathématiques Pures et Appliquées CNRS UMR 5669Ecole Normale Supérieure de LyonLyon 69007France

This paper aims to give a detailed presentation of long-wave instabilities of shear layers for navierStokes equations,and in particular to give a simple and easy-to-read presentation of the study of the OrrSommerfeld equation and to detail the analysis of its *** these analyses,we prove the existence of long-wave instabilities in the cases of slowly rotating fuids,slightly compressible fuids,or fuids with navier boundary conditions,under smallness conditions.

关键词： navier-Stokes equations boundary layers Prandtl equations

5dGWO-GAn:A novel Five-dimensional Gray Wolf Optimizer for Generative Adversarial network-enabled Intrusion detection in IoT Systems

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Computers, Materials & Continua 2025年第1期82卷 881-911页

作者： Sarvenaz Sadat Khatami Mehrdad Shoeibi Anita ershadi Oskouei diego Martín Maral Keramat dashliboroun department of data Science engineering University of HoustonHoustonTX 77204USA The WPI Business School Worcester Polytechnic InstituteWorcesterMA 01609USA School of Systems and enterprises Stevens Institute of TechnologyHobokenNJ 07030USA department of Computer Science Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain ernest G.Welch School of Art&design Georgia State UniversityAtlantaGA 30303USA

The Internet of Things(IoT)is integral to modern infrastructure,enabling connectivity among a wide range of devices from home automation to industrial control *** the exponential increase in data generated by these interconnected devices,robust anomaly detection mechanisms are *** detection in this dynamic environment necessitates methods that can accurately distinguish between normal and anomalous behavior by learning intricate *** paper presents a novel approach utilizing generative adversarial networks(GAns)for anomaly detection in IoT ***,optimizing GAns involves tuning hyper-parameters such as learning rate,batch size,and optimization algorithms,which can be challenging due to the non-convex nature of GAn loss *** address this,we propose a five-dimensional Gray wolf optimizer(5dGWO)to optimize GAn *** 5dGWO introduces two new types of wolves:gamma(γ)for improved exploitation and convergence,and theta(θ)for enhanced exploration and escaping local *** proposed system framework comprises four key stages:1)preprocessing,2)generative model training,3)autoencoder(Ae)training,and 4)predictive model *** generative models are utilized to assist the Ae training,and the final predictive models(including convolutional neural network(Cnn),deep belief network(dBn),recurrent neural network(Rnn),random forest(RF),and extreme gradient boosting(XGBoost))are trained using the generated data and Ae-encoded *** evaluated the system on three benchmark datasets:nSL-Kdd,UnSW-nB15,and *** conducted on diverse IoT datasets show that our method outperforms existing anomaly detection strategies and significantly reduces false *** 5dGWO-GAn-CnnAe exhibits superior performance in various metrics,including accuracy,recall,precision,root mean square error(RMSe),and convergence *** proposed 5dGWO-GAn-CnnAe achieved the lowest RMSe values across the nSL-Kdd,UnSW-nB15,and

关键词： Internet of things intrusion detection generative adversarial networks five-dimensional binary gray wolf optimizer deep learning

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis