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The computerized LASSI-BC Test versus the Standard LASSI-L Paper-and-Pencil Version in Community-Based-Samples

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Advances in Alzheimer's Disease 2024年第1期13卷 11-25页

作者： Rosie e. Curiel Cid Alexandra Ortega Ubbo Visser Marcela Kitaigorodsky D. Diane Zheng Diana Hincapie Kirsten Horne crenshaw Ashleigh Beaulieu Brooke Bosworth Liz Gallardo emory Neer Sofia Ramirez elizabeth A. Crocco Mike Georgiou efrosyni Sfakianaki David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami FL USA Department of Computer Sciences University of Miami Coral Gables FL USA Nova Southeastern University Fort Lauderdale FL USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami FL USA

Proactive Semantic Interference (PSI) and failure to recover from PSI (frPSI), are novel constructs assessed by the LASSI-L. These measures are sensitive to cognitive changes in early Mild Cognitive Impairment (MCI) and preclinical AD determined by Aβ load using PeT. The goal of this study was to compare a new computerized version of the LASSI-L (LASSI-Brief Computerized) to the standard paper-and-pencil version of the test. In this study, we examined 110 cognitively unimpaired (CU) older adults and 79 with amnestic MCI (aMCI) who were administered the paper-and-pencil form of the LASSI-L. Their performance was compared with 62 CU older adults and 52 aMCI participants examined using the LASSI-BC. After adjustment for covariates (degree of initial learning, sex, education, and language of evaluation) both the standard and computerized versions distinguished between aMCI and CU participants. The performance of CU and aMCI groups using either form was relatively commensurate. Importantly, an optimal combination of Cued B2 recall and Cued B1 intrusions on the LASSI-BC yielded an area under the ROC curve of .927, a sensitivity of 92.3% and specificity of 88.1%, relative to an area under the ROC curve of .815, a sensitivity of 72.5%, and a specificity of 79.1% obtained for the paper-and-pencil LASSI-L. Overall, the LASSI-BC was comparable, and in some ways, superior to the paper-and-pencil LASSI-L. Advantages of the LASSI-BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built-in audio recording of responses.

关键词： Mild Cognitive Impairment Proactive Semantic Interference LASSI-L Computerized Cognitive Assessment

骨形态发生蛋白对鼠小脑浦肯野细胞发育的重要性

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中国临床康复 2006年第26期10卷 92-94,i0002页

作者：秦丽华 e. bryan crenshaw Ⅲ 雷季良周长满北京大学医学部解剖学与组织胚胎学系北京市100083 费城儿童医院耳鼻喉科儿童感染中心神经遗传学组

目的:观察骨形态发生蛋白通过Ⅰ型受体传导信号在小脑浦肯野细胞发育中的作用。为揭示临床有关骨形态发生蛋白引起的遗传病发病及治疗提供有力的依据。方法:实验于2004-03/2005-08在美国费城儿童医院crenshaw实验室和北京大学医学部解... 详细信息

目的:观察骨形态发生蛋白通过Ⅰ型受体传导信号在小脑浦肯野细胞发育中的作用。为揭示临床有关骨形态发生蛋白引起的遗传病发病及治疗提供有力的依据。方法:实验于2004-03/2005-08在美国费城儿童医院crenshaw实验室和北京大学医学部解剖学神经研究实验室完成。小鼠种类为C57Bl/6J,敲除了骨形态发生蛋白Ⅰ型受体的Bmpr1a和Bmpr1b两个亚型基因,产生了条件性的BMPR-ⅠA和经典性的BMPR-ⅠB受体敲除鼠,破坏了在小脑内的骨形态发生蛋白信号转导。并使用免疫双标calbindin,Tuj1估计小鼠胚胎13.5d和新生幼鼠的浦肯野细胞发育分化情况。结果:①在小鼠刚出生时,正常组鼠的浦肯野细胞都迁移到了小脑,并形成浦肯野细胞层;但在Bmpr1a/Bmpr1b双敲除鼠的浦肯野细胞迁移明显异常,大部分Calbindin阳性的浦肯野细胞呈簇状位于小脑深部,另有部分细胞迁移到了中脑下丘。②免疫双标显示在正常组双标的细胞位于小脑的腹侧缘;但在Bmpr1a/Bmpr1b双敲除组,双标记的浦肯野细胞数量明显减少,并且浦肯野细胞排列紊乱,说明浦肯野细胞的分化受到影响。结论:①骨形态发生蛋白信号对浦肯野细胞的作用可能不是直接的,或许是经过一些中间环节来完成的。②只有两受体基因Bmpr1a和Bm-pr1b同时敲除才能影响骨形态发生蛋白信号对小脑浦肯野细胞发育的作用。

关键词：骨形态发生蛋白质类小鼠,基因敲除浦肯野细胞

Dietary supplementation of sulfur amino acids improves intestinal immunity to eimeria in broilers treated with anti-interleukin-10 antibody

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Animal Nutrition 2022年第3期10卷 382-389页

作者： Zhouzheng Ren Jiakun Yan Rose Whelan Xujie Liao Daniel e.Bütz Maria K.Arendt Mark e.Cook Xiaojun Yang Thomas D.crenshaw College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxiChina Department of Animal Sciences University of WisconsinMadisonWIUSA evonik Operations GmbH Hanau-WolfgangGermany

Oral antibody to interleukin-10(anti-IL-10)enhances the intestinal immune defense against *** sulfur amino acids methionine and cysteine(MtC)play essential roles in inducing and maintaining protective immune responses during intestinal ***,increased dietary MtC may support the anti-IL-10-induced intestinal immunity to ***(n=640)were arranged in a 2×2×2 factorial design with 2 levels of each of the 3 main factors:dietary standardized ileal digestible(SID)MtC levels(0.6%or 0.8%),dietary anti-IL-10 supplementation(with or without),and coccidiosis challenge(control or challenge).Briefly,the broilers were supplied with either 0.6%or 0.8%SID MtC,each with or without anti-IL-10(300 mg/kg),from d 10 to *** d 14,broilers from each diet were gavaged with either PBS or *** resulting eimeria infection induced fecal oocyst shedding and intestinal *** fed 0.8%SID MtC(main effects,P≤0.05)had decreased feed-to-gain ratio,increased duodenum and cecum luminal anti-eimeria IgA titers,and decreased fecal oocyst counts,when compared to 0.6%SID *** supplementation of anti-IL-10(main effects,P≤0.05)increased cecum luminal total IgA concentration and decreased cecum ***(P≤0.05)were detected for growth performance and cecum luminal IFN-γ.Briefly,the highest body weight gain and feed intake were reached in PBS-gavaged broilers fed 0.8%SID MtC with no anti-IL-10 and in eimeria-challenged broilers fed 0.8%SID MtC with *** eimeria-infected broilers,anti-IL-10 increased intestinal luminal IFN-γ and body weight gain only at 0.8%SID ***,anti-IL-10 increased intestinal luminal IFN-γ levels,decreased cecum lesions and restored growth only when fed with adequate amounts of sulfur amino *** findings underscore the importance of providing sufficient essential nutrients to support the anti-IL-10 induced immunity against coccidiosis.

关键词： Chicken Coccidiosis egg yolk antibody Interleukin-10 Sulfur amino acid

A simple daily dynamic feeding regimen for reducing phosphorus consumption and excretion in laying hens

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Animal Nutrition 2022年第4期11卷 132-141页

作者： Xujie Liao Jiakun Yan Jionghao Chen Zhenyu Huang Tianshuai Xiao Changqing Li Chong Pan Xin Yang Yanli Liu Thomas D.crenshaw Xiaojun Yang Zhouzheng Ren College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Department of Animal Sciences University of Wisconsin-MadisonMadisonWI 53706USA

Phosphorus metabolism in laying hens is a highly dynamic process over the course of the 24 h egg-laying *** the phosphorus feeding regimen according to the daily egg-laying cycle may help to improve phosphorus utilization ***-Line Brown layers(n=120;70 wk old)were offered 4different phosphorus daily regimens:(1)RR,fed regular phosphorus at both 09:00 and 17:00;(2)RL,fed regular phosphorus at 09:00 and low phosphorus at 17:00;(3)LR,fed low phosphorus at 09:00 and regular phosphorus at 17:00;(4)LL,fed low phosphorus at both 09:00 and 17:*** regular and low phosphorus diets contained 0.32% and 0.14% non-phytate phosphorus,*** feeding trial lasted for 12 *** a result,layers on the RL regimen had decreased laying rate(Pen compared to all other *** on the LL regimen had decreased eggshell thickness and specific gravity(Pen compared to all other regimens,and had decreased egg shell strength(Pen compared to RL and LR *** compared to the RR regimen(a common practice in the industry),layers on the LR regimen had:(1)identical laying performance and egg quality(P>0.05);(2)decreased phosphorus excretion(Pe period of09:00 to 17:00;(3)increased jejunal calbindin D28k protein expression(Per feeding in the morning;(4)decreased serum fibroblast growth factor 23 and calcitriol levels(Pecreased jejunal type Ⅲ sodium-phosphate cotransporter 2 gene and protein expression(Pecreased renal type Ⅲ sodium-phosphate cotransporter 1 protein expression(Per feeding in the *** summary,when dietary phosphorus was supplemented in accordance with daily serum phosphorus rhythms(i.e.,the LR regimen),laying performance and egg quality were well supported whilst significantly decreasing phosphorus consumption and ***,serum phosphorus rhythms will need to be carefully maintained when developing dietar

关键词： Phosphorus-calcium homeostasis Dynamic feeding regimen egg production Laying hen Phosphorus excretion

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喷雾干燥血浆蛋白在仔猪日粮中的应用

中国饲料 2015年第10期 40-42页

作者： J.D.crenshaw APC Inc.2425 S.e.Oak Tree Ct.Ankeny IAUSA 50021

喷雾干燥血浆蛋白粉是动物血液分离出红细胞后经喷雾干燥而制成的粉状产品，具有一定生物安全性、研究证明喷雾干燥血制品是猪日粮中安全高效的蛋白原料。

关键词：喷雾干燥血浆蛋白粉仔猪日粮生物安全性应用动物血液蛋白原料红细胞

母仔猪出生后的营养模式对其日后的生长和繁殖性能的影响

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河南科技大学学报（农学版） 1990年第3期14卷 86-89页

作者： R.e.Martin T.D.crenshaw 洪子燕

128头母仔猪在其出生后的头28天,以两组不同的营养模式处理,确定它对母仔猪日后的生长和繁殖的影响。营养模式是将刚出生的母仔猪调整为每窝6头或12头;哺乳期为13日或28日。13日龄断奶的仔猪在这28天期间内,或任意采食基础日粮,或任意... 详细信息

128头母仔猪在其出生后的头28天,以两组不同的营养模式处理,确定它对母仔猪日后的生长和繁殖的影响。营养模式是将刚出生的母仔猪调整为每窝6头或12头;哺乳期为13日或28日。13日龄断奶的仔猪在这28天期间内,或任意采食基础日粮,或任意采食基础日粮的50％。28天后,所有的猪均喂以相同的日粮。仔猪在出生的早期遭受到不利条件而抑制增长的体重,到154天出售时得到恢复。出生后的营养模式不影响其初的情期。28日龄断奶的猪,窝养6头的比窝养12头的猪,多产卵2.4个(P<0.05);13日龄断奶的猪,窝养6头的比窝养12头的少产卵2.3个。对于断奶后限制饲料15天的仔猪,并不影响其排卵率。尽管仔猪在出生后的头28天遭受窝养头数、哺乳期限和饲料限制等强制处理,使其生长率和排卵率出现变化,然而并不影响母猪日后的产仔数。以上的资料表明,对仔猪在其出生后期进行限制窝仔猪数等抑制因素的处理,达性成熟后可使其卵子死亡;当这些影响繁殖性能的抑制因素排除,则其产仔数(出生率)不变。

关键词：繁殖性能窝仔猪数出生后排卵率哺乳期早期断奶日龄饲料利用率体重营养

Nanotechnology-based approach for safer enrichment of semen with best spermatozoa

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Journal of Animal Science and Biotechnology 2019年第2期10卷 390-401页

作者： Casey L.Durfey Sabrina e.Swistek Shengfa F.Liao Mark A.crenshaw Henry J.Clemente Rooban V.K.G.Thirumalai Christy S.Steadman Peter L.Ryan Scott T.Willard Jean M.Feugang Department of Animal and Dairy Sciences Mississippi State UniversityMississippi StateMSUSA Department of Biochemistry Molecular BiologyEntomology and Plant PathologyMississippi StateMSUSA Clemente Associates MadisonCTUSA Institute of Imaging and Analytic Technology(I2AT) Mississippi State UniversityMississippi StateMSUSA Department of Pathobiology and Population Medicine Biochemistry Mississippi State UniversityMississippi StateMSUSA.

Background: Advances in nanotechnology have permitted molecular-based targeting of cells through safe and biocompatible magnetic nanoparticles(MNP). Their use to detect and remove damaged spermatozoa from semen doses could be of great interest. Here, MNP were synthesized and tested for their ability to target apoptotic(annexin V) and acrosome-reacted(lectin) boar spermatozoa, for high-throughout retrieval in a magnetic field(nanoselection). The potential impacts of nanoselection on sperm functions and performance of offspring sired by sperm subjected to nanoselection were determined. Fresh harvested and extended boar semen was mixed with various amounts(0, 87.5, and 175 μg) of MNP-conjugates(Annexin V-MNP or Lectin-MNP) and incubated(10 to15 min) for 37 °C in exp. 1. In exp. 2, extended semen was mixed with optimal concentrations of MNP-conjugates and incubated(0, 30, 90, or 120 min). In exp. 3, the synergistic effects of both MNP-conjugates(87.5 μg– 30 min)on spermatozoa was evaluated, followed by sperm fertility assessments through pregnancy of inseminated gilts and performance of neonatal offspring. Sperm motion, viability, and morphology characteristics were evaluated in all ***: Transmission electron microscopy, atomic force microscopy, and hyperspectral imaging techniques were used to confirm attachment of MNP-conjugates to damaged spermatozoa. The motility of nanoselected spermatozoa was improved(P e viability of boar sperm, as assessed by the abundance of reactive oxygen species and the integrity of the acrosome, plasma membrane, and mitochondrial membrane was not different between nanoselected and control spermatozoa. The fertility of gilts inseminated with control or nanoselected spermatozoa, as well as growth and health of their offspring were not different between(P > 0.05).Conclusions: The findings revealed the benefit of magnetic nanoselection for high-throughput targeting of damaged sperm, for removal and rapid and effortles

关键词： Acrosome reaction Apoptosis Artificial insemination Boar Iron oxide nanoparticles Nanopurification Nanoselection Nanotechnology Reproduction Swine

日粮中添加喷雾血浆蛋白粉对哺乳母猪生产性能的影响

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饲料与畜牧（新饲料） 2009年第3期 59-59页

作者：刘冰 e.D.Frugé M.L.Roux R.D.Lirette T.D.Bidner L.L.Southern J.D.crenshaw

72头初产母猪和经产母猪（每种et粮处理为36头）分成4组，研究在泌乳期日粮中添加喷雾血浆蛋白粉（SDP）对哺乳母猪和仔猪生产性能的影响。泌乳期日粮组成如下：对照组为玉米-豆粕型日粮，试验组为玉米-豆粕型日粮＋0．5％SDP。两种日... 详细信息

72头初产母猪和经产母猪（每种et粮处理为36头）分成4组，研究在泌乳期日粮中添加喷雾血浆蛋白粉（SDP）对哺乳母猪和仔猪生产性能的影响。泌乳期日粮组成如下：对照组为玉米-豆粕型日粮，试验组为玉米-豆粕型日粮＋0．5％SDP。两种日粮配方含有1．0％总赖氨酸，消化能为14．46MJ／kg，试验期从妊娠（107±1．2）d开始到断奶结束。根据母猪的品种、胎次和妊娠天数将其分配到不同的口粮处理组。仔猪出生后（19±2．1）d断奶。母猪泌乳期每天饲喂三次。

关键词：饲料摄入量母猪喷雾干燥血浆蛋白粉

饲喂生大豆对肥育猪生长、饲料效率和胴体品质的影响

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国外畜牧学(饲料) 1988年第4期 3-4页

作者： J·e·Pontif 冯立志

猪饲粮中生大豆的应用是多年来的研究课题。人们设想,如果生大豆能直接用于猪饲粮中,将会减少或免除大豆和豆饼粉的运输费和加工费,这对养猪生产者和大豆生产者都有利。通常认为,猪利用生大豆的效率不如豆饼粉。然而 crenshaw 和 Daniel... 详细信息

猪饲粮中生大豆的应用是多年来的研究课题。人们设想,如果生大豆能直接用于猪饲粮中,将会减少或免除大豆和豆饼粉的运输费和加工费,这对养猪生产者和大豆生产者都有利。通常认为,猪利用生大豆的效率不如豆饼粉。然而 crenshaw 和 Danielson(1985a)报道,怀孕的幼母猪(8月龄,体重130公斤)采食由生大豆作为唯一蛋白质补充饲料的饲粮时,其增重和繁殖效率与饲喂豆饼粉的幼母猪一样。他们的另一个研究(1985b)报道指出,肥育猪(3.2～4.2月龄,体重68～85公斤)利用生大豆的效率不如豆饼粉。

关键词：肥育猪饲料效率生大豆饲粮饲喂饲养