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Forging an easier path through graduation:Improving the patient transition from paediatric to adult critical care

World Journal of Critical Care Medicine 2025年第1期14卷 82-90页

作者： Stephen Warrillow ben Gelbart Jess Stevens Gordon Baikie Mark e Howard Department of Intensive Care Austin HealthHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneParkville 3010VictoriaAustralia Department of Intensive Care Royal Children’s HospitalParkville 3010VictoriaAustralia Living with Disability Research Centre La Trobe UniversityBundoora 3086VictoriaAustralia Department of Neurodevelopment&Disability Royal Children’s HospitalParkville 3010VictoriaAustralia Department of Paediatrics The University of MelbourneParkville 3010VictoriaAustralia Department of Respiratory and Sleep Medicine Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine Austin HealthThe University of MelbourneHeidelberg 3084VictoriaAustralia

Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing *** normal experiences are potentially magnified for teenagers living with chronic illness or disability and their *** in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing *** those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of *** the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general *** there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive *** patients may encounter considerable challenges during this *** may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric *** addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health *** challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.

关键词： Paediatric intensive care Disability Adult intensive care Transition Critical care

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AVirtual Cloud Storage Architecture for enhanced Data Security

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Computer Systems Science & engineering 2023年第2期44卷 1735-1747页

作者： M.Antony Joans Kumar C.Christopher Columbus e.ben George T.Ajith Bosco Raj Department of Information Technology St.Xavier’s Catholic College of EngineeringNagercoil629003Tamil NaduIndia Department of Computer Science engineering PSN College of Engineering and TechnologyTirunelveli627152India Department of Computer Science engineering University of Technology and Applied SciencesMuscat112Oman Department of electronics and Communications engineering PSN College of Engineering and TechnologyTirunelveli627152India

The sensitive data stored in the public cloud by privileged users,such as corporate companies and government agencies are highly vulnerable in the hands of cloud providers and *** proposed Virtual Cloud Storage Archi-tecture is primarily concerned with data integrity and conﬁdentiality,as well as *** provide conﬁdentiality and availability,theﬁle to be stored in cloud storage should be encrypted using an auto-generated key and then encoded into distinct *** the encoded chunks ensured theﬁle integrity,and a newly proposed Circular Shift Chunk Allocation technique was used to determine the order of chunk ***ﬁle could be retrieved by performing the opera-tions in *** the regenerating code,the model could regenerate the missing and corrupted chunks from the *** proposed architecture adds an extra layer of security while maintaining a reasonable response time and sto-rage *** results analysis show that the proposed model has been tested with storage space and response time for storage and *** VCSA model consumes 1.5x(150%)storage *** was found that total storage required for the VCSA model is very low when compared with 2x Replication and completely satisﬁes the CIA *** response time VCSA model was tested with different sizedﬁles starting from 2 to 16 *** response time for storing and retrieving a 2 MBﬁle is 4.96 and 3.77 s respectively,and for a 16 MBﬁle,the response times are 11.06 s for storage and 5.6 s for retrieval.

关键词： erasure code regenerating code cryptography virtual cloud storage architecture circular shift chunk allocation algorithm

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Geometric phase opens new frontiers in nonlinear frequency conversion of light

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Frontiers of physics 2022年第1期17卷 1-5页

作者： Mai Tal Danielle.ben haim Tal ellenbogen Department of Physical electronics Faculty of EngineeringTel-Aviv UniversityTel-Aviv6779801Israel Raymond and Beverly Sackler School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv6779801Israel Center for Light-Matter Interaction Tel-Aviv UniversityTel-Aviv6779801Israel

Nonlinear frequency conversion of light involves in-teraction of photons through the nonlinear dielec-tric response of mat erials to genera te light at new *** first demonstration of nonlinear optical frequency conver... 详细信息

关键词： nonlinear light frontier

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Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara e Agko Marina N Kouliou Konstantinos e Koumarelas Dimitris Zacharoulis Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIe)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIe include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIe’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIe.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

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Accelerating CFD–DeM simulation of processes with wide particle size distributions

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Particuology 2014年第1期12卷 113-121页

作者： Tamir Brosh haim Kalman Avi Levy Pearlstone Centre for Aeronautical engineering Studies Department of Mechanical Engineering Ben-Gurion University of the Negev School of Mechanical and Systems engineering Stephenson Building Claremont Road Newcastle University

Sizereduction systems have been extensively used in industry for many years. Nevertheless, reliable engi neering tools to be used to predict the comminution of particles are scarce. Computational fluid dynamics （CFD）discrete element model （DeM） numerical simulation may be used to predict such a complex phe nomenon and therefore establish a proper design and optimization model for comminution systems, They may also be used to predict attrition in systems where particle attrition is significant. Therefore, empirical comminution functions （which are applicable for any attrition/comminution process）, such as： strength distribution, selection, equivalence, breakage, and fatigue, have been integrated into the three dimensional CFDDeM simulation tool. The main drawback of such a design tool is the long computational time required owing to the large number of particles and the minute timestep required to maintain a steady solution while simulating the flow of particulate materials with very fine particles. The present study developed several methods to accelerate CFDDeM simulations： reducing the num ber of operations carried out at the singleparticle level, constructing a DeM grid detached from the CFD grid enabling a no binary search, generating a subgrid within the DeM grid to enable a no binary search for fine particles, and increasing the computational timestep and eliminating the finest particles in the simulation while still tracking their contribution to the process. The total speedup of the simulation process without the elimination of the finest particles was a factor of about 17. The elimination of the finest particles gave additional speedup of a factor of at least 18. Therefore, the simulation of a grinding process can run at least 300 times faster than the conventional method in which a standard no binary search is employed and the smallest particles are tracked.

关键词： Computational fluid dynamicsDiscrete element modelSearch algorithmIncreased time-step

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Mid/far-infrared photo-detectors based on graphene asymmetric quantum wells

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Chinese Physics B 2016年第9期25卷 573-580页

作者： e.ben Salem R Chaabani S Jaziri Institut Preparatoire aux etudes d'Ingenieurs de Tunis 2 Rue Jawaher Lel Nahrou Monfleury 1089 Tunisie Laboratoire de Physique de la Matiere Condensee Departement de Physique Faculte des Sciences de Tunis Campus Universitaire 2092 Tunisie Departement de Physique Faculte des Sciences de Bizerte Jarzouna 7021 Bizerte

We conducted a theoretical study on the electronic properties of a single-layer graphene asymmetric quantum *** of energy levels is limited by electron–hole conversion at the barrier interfaces and free-electron ***–hole conversion at the barrier interfaces can be controlled by introducing an asymmetry between barriers and taking into account the effect of the interactions of the graphene sheet with the *** interaction with the substrate induces an effective mass to carriers,allowing observation of Fabry–P′erot resonances under normal incidence and extinction of Klein *** asymmetry,between barriers creates a transmission gap between confined states and free-electron continuum,allowing the large graphene asymmetric quantum well to be exploited as a photo-detector operating at mid-and far-infrared frequency regimes.

关键词： graphene quantum wells reflection coefficient photo-detector

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苏云金芽胞杆菌以色列亚种20kDa蛋白质对CytA蛋白溶细胞作用的影响

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Acta Genetica Sinica 1999年第1期26卷 81-86页

作者：刘子铎孙明陈亚华喻子牛 R.Manassherob e.ben-Dov A.Zaritsky 华中农业大学农业微生物农业部重点实验室微生物科学技术系武汉430070 Dept ofLifeSciencesBen-GurionUniversityoftheNegev Israel

为了证明苏云金芽胞杆菌以色列亚种２０ｋＤｅ蛋白质对ＣｙｔＡ蛋白溶细胞作用的影响，根据２０ｋＤｅ蛋白质和ｃｙｔＡ蛋白基因的核苷酸序列，用ＡＭＰＬＩＦＹ程序设计了一套带有酶切位点的引物，经ＰＣＲ扩增分别获得了２０ｋＤｅ... 详细信息

为了证明苏云金芽胞杆菌以色列亚种２０ｋＤｅ蛋白质对ＣｙｔＡ蛋白溶细胞作用的影响，根据２０ｋＤｅ蛋白质和ｃｙｔＡ蛋白基因的核苷酸序列，用ＡＭＰＬＩＦＹ程序设计了一套带有酶切位点的引物，经ＰＣＲ扩增分别获得了２０ｋＤｅ蛋白质和ｃｙｔＡ蛋白基因。将其基因与表达载体ｐＵＨＥ２４连接并转化到大肠杆菌ＸＬＩ和ＤＨＳ分别获得含２０ｋＤａ蛋白质基因的克隆子ＬＺ２９；含ｃｙｔＡ基因的克隆子ＬＺｃｙｔＡ和含有二者基因的重组子ＬＺ２０Ａ．在ＩＰＴＧ诱导下，测定了不同克隆株基因表达产物对大肠杆菌细胞生长的影响。结果表明：ＬＺ２０的细胞生长不受影响；ＬＺｃｙｔＡ的细胞被杀死；ＬＺ２０Ａ的细胞生长也不受影响。这表明２０ｋＤａ蛋白质基因与ｃｙｔＡ蛋白基因重组后，２０ｋＤａ蛋白质基因表达产物可保护ＣｙｔＡ蛋白对大肠杆菌的溶细胞作用，而巳这种作用并不因不同大肠杆菌受体而改变。

关键词：苏云金芽胞杆菌 20kDa蛋白质 cytA蛋白

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Aphid populations showing differential levels of virulence on Capsicum accessions

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Insect Science 2020年第2期27卷 336-348页

作者： Mengjing Sun Roeland e.Voorrips ben Vosman Plant Breeding Wageningen University&ResearchWageningenThe Netherlands

The green peach aphid,Myzus persicae,is one of the most threatening pests in pepper cultivation and growers would benefit from resistant ***,we identified two Capsicum acessions as susceptible and three as resistant to *** using an aphid population originating from the Netherlands(NL).Later on we identified an aphid population originating from a diferent gcographical region(Switserland,SW)that was virulent on all tested Capsicum *** objeetive of the current work is to describe in detail diferent aspects of the interaction between two aphid populations and two sclected Capsicum acessions(one that was susceptible[PB2013046]and one that was resistant[PB2013071]to population NL),including biochemical processes *** penetration graph(ePG)recordings showed similar feeding activities for both aphid populations on *** acession PB2013071 the aphid population sw was able to devote significantly more time to phloem ingestion than population *** also studied plant defense response and found that plants of acession PB2013046 could not induce an accumulation of reactive oxygen species and callose formation after infestation with either aphid ***,plants of PB2013071 induced a stronger defense response after infestation by population NL than after infestation by population *** on these results,population SW of *** seems to have overcome the resistance of PB2013071 that prevented feeding of aphids from NL *** potential mechanism by which SW population overcomes the resistance is discussed.

关键词： callose deposition ePG plant aphid interaction plant immunity ROS accumulation virulence

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Numerical Analysis of the Behavior of A New Aeronautical Alloy (Ti555-03) Under the effect of A High-Speed Water Jet

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China Ocean engineering 2019年第1期33卷 114-126页

作者： I.ben Belgacem L.Cheikh e.M.Barhoumi W.Khan W.ben Salem Laboratoire de Génie Mécanique Ecole Nationale d’Ingénieurs de MonastirUniversité de Monastir Institut Préparatoire aux etudes d’Ingénieur de Monastir Université de Monastir Department of electrical and Computer engineering College of EngineeringDhofar University University of Waterloo Institut Supérieur des Arts et Métiers de Mahdia Université de Monastir

In this paper, we present a numerical simulation of a water jet impacting a new aeronautical material Ti555-03 *** Computational Fluid Dynamics(CFD) behavior of the jet is investigated using a FV(Finite Volume) *** Fluid–Structure Interaction(FSI) is studied using a coupled SPH(Smoothed Particle Hydrodynamics)-Fe(Finite element) method. The jets hit the metal sheet with an initial velocity 500 m/s. Two configurations which differ from each other by the position(angle of inclination) of the plate relatively to the axis of revolution of the jet inlet are investigated in this study. The objective of this study is to predict the impact of the fluid produced at high pressure and high speed especially at the first moment of impact. Numerical simulations are carried out under ABAQUS. We have shown in this study that the inclination of the titanium alloy plate by 45° stimulates the phenomenon of recirculation of water. This affects the velocity profile, turbulence and boundary layers in the impact zone. The stagnation zone and the phenomenon of water recirculation are strongly influenced by the slope of the plate which gives a pressure gradient and displacement very important between the two configurations. Fluctuations of physical variables(displacement and pressure) prove the need for a noise and vibratory study. These predictions will subsequently be used for the modeling of the problem of an orthogonal cut in a high-speed machining process assisted by high-pressure water jet.

关键词： Titanium alloy(Ti555-03) CFD turbulence ABAQUS Smoothed Particle Hydrodynamics(SPH) Fluid Structure Interaction(FSI)

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Preservation of sperm of cancer patients： extent of use and pregnancy outcome in a tertiary infertility center

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Asian Journal of Andrology 2013年第3期15卷 382-386页

作者： Amnon Botchan Shiri Karpol Ofer Lehavi Gedalia Paz Sandra e Kleiman LeahYogev haim Yavetz Ron Hauser The Institute for the Study of Fertility Lis Maternity Hospital Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine Tel-Aviv U niversity TeI-Aviv 6423906 Israel

Sperm cryopreservation is the best modality to ensure future fertility for males diagnosed with cancer. The extent to which cryopreserved sperm is actually used for impregnation, the fertility treatment options that are available and the success rates of these treatments have not been investigated in depth. The medical records of 682 patients who cryopreserved sperm cells due to cancer treatment were analyzed. Seventy of these patients withdrew their frozen sperm for fertility treatments over a 20-year period （most within the first 4 years after cryopreservation）. Sperm quality of different malignancies and outcomes of assisted reproduction treatment （ART） for pregnancy achievement in relation to the type of treatment and the type of malignancy were evaluated. The results showed that the rate of using cryo-thawed sperm from cancer patients for fertility treatments in our unit was 10.3%. Sperm quality indices differed between different types of malignancies, with the poorest quality measured in testicular cancer. Conception was achieved in 46 of the 184 ART cycles （25%）, and resulted in 36 deliveries. The use of intracytoplasmic sperm injection （ICSI） methodology yielded a significantly higher pregnancy rate （37.4%） than intrauterine insemination （IUI; 11.5%） and was similar to other groups of infertile couples using these modalities. In vitro fertilization （IVF） failed to produce pregnancies. In conclusion, the rate of use of cryopresseved sperm in cancer patients is relatively low （10.3%）. Achievement of pregnancies by ICSI presents the best option but when there are enough stored sperm samples and adequate quality, I UI can be employed. Cryopreservation is nevertheless the best option to preserve future fertility potential and hope for cancer patients.

关键词： assisted reproduction treatment (ART) cancer pregnancy outcome sperm cryopreservation

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