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A generalized approach for implicit time integration of piecewise linear/nonlinear systems

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International Journal of Mechanical System Dynamics 2021年第1期1卷 108-120页

作者： Huimin Zhang Runsen Zhang Andrea zanoni Pierangelo Masarati School of Aeronautic Science and engineering Beihang UniversityBeijingChina Dipartimento di Scienze e Tecnologie Aerospaziali Politecnico di MilanoMilanoItaly

A generalized solution scheme using implicit time integrators for piecewise linear and nonlinear systems is developed.The piecewise linear characteristic has been well‐discussed in previous studies,in which the original problem has been transformed into linear complementarity problems(LCPs)and then solved via the Lemke algorithm for each time step.The proposed scheme,instead,uses the projection function to describe the discontinuity in the dynamics equations,and solves for each step the nonlinear equations obtained from the implicit integrator by the semismooth Newton iteration.Compared with the LCP‐based scheme,the new scheme offers a more general choice by allowing other nonlinearities in the governing equations.To assess its performances,several illustrative examples are solved.The numerical solutions demonstrate that the new scheme can not only predict satisfactory results for piecewise nonlinear systems,but also exhibits substantial efficiency advantages over the LCP‐based scheme when applied to piecewise linear systems.

关键词： implicit time integrator piecewise linear and nonlinear systems projection function

palliative care and end-stage colorectal cancer management:The surgeon meets the oncologist

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World Journal of Gastroenterology 2014年第24期20卷 7602-7621页

作者： Renato Costi Francesco Leonardi DanielE.Zanoni Vincenzo Violi Luigi Roncoroni Istituto di Clinica Chirurgica Generale e Terapia Chirurgica Dipartimento di Scienze ChirurgicheUniversità di ParmaAzienda Ospedaliero-Universitaria di Parma43126 ParmaItaly Dipartimento Polispecialistico 1 Unità Operativa di Oncologia MedicaAzienda Ospedaliero-Universitaria di Parma43126 ParmaItaly Dipartimento di Chirurgia Generale e Specialistica Ospedale di VaioAzienda Unità Sanitaria Locale di Parma43036 Fidenza (Parma)Italy

Colorectal cancer(CRC)is a common neoplasia in the Western countries,with considerable morbidity and mortality.every fifth patient with CRC presents with metastatic disease,which is not curable with radical intent in roughly 80%of cases.Traditionally approached surgically,by resection of the primitive tumor or stoma,the management to incurable stageⅣCRC patients has significantly changed over the last three decades and is nowadays multidisciplinary,with a pivotal role played by chemotherapy(CHT).This latter have allowed for a dramatic increase in survival,whereas the role of colonic and liver surgery is nowadays matter of debate.Although any generalization is difficult,two main situations are considered,asymptomatic(or minimally symptomatic)and severely symptomatic patients needing aggressive management,including emergency cases.In asymptomatic patients,new CHT regimens allow today long survival in selected patients,also exceeding two years.The role of colonic resection in this group has been challenged in recent years,as it is not clear whether the resection of primary CRC may imply a further increase in survival,thus justifying surgeryrelated morbidity/mortality in such a class of shortliving patients.Secondary surgery of liver metastasis is gaining acceptance since,under new generation CHT regimens,an increasing amount of patients with distant metastasis initially considered non resectable become resectable,with a significant increase in long term survival.The management of CRC emergency patients still represents a major issue in Western countries,and is associated to high morbidity/mortality.Obstruction is traditionally approached surgically by colonic resection,stoma or internal by-pass,although nowadays CRC stenting is a feasible option.Nevertheless,CRC stent has peculiar contraindications and complications,and its long-term cost-effectiveness is questionable,especially in the light of recently increased survival.Perforation is associated with the highest mortality and remains mostly matter for surgeons,by

关键词： Colorectal cancer Palliative care Multimodal treat

Toxoplasma gondii causes death and plastic alteration in the jejunal myenteric plexus

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World Journal of Gastroenterology 2015年第16期21卷 4829-4839页

作者： eduardo Joséde Almeida Araújo Larissa Marchi Zaniolo Suellen Laís Vicentino Marcelo Biondaro Góis Jacqueline Nelisis zanoni Aristeu Vieira da Silva Débora de Mello Goncales Sant'Ana Departamento de Histologia Centro de Ciencias BiológicasUniversidade Estadual de Londrina Programa de Pós-graduacao em Ciencia Animal Universidade Paranaense Departamento de Ciencias Morfológicas.Universidade estadual de Maringa Departamento de Biologia Universidade Estadual de Feira de Santana

AIM:To assess the effects of Me-49 Toxoplasma gondii(T.gondii) strain infection on the myenteric plexus and external muscle of the jejunum in rats.MeTHODS:Thirty rats were distributed into two groups:the control group(CG)(n = 15) received 1 m L of saline solution orally, and the infected group(IG)(n=15)inoculated with 1 m L of saline solution containing500 oocysts of M-49 T.gondii strain orally.After 36 d of infection,the rats were euthanized.Infection with T.gondii was confirmed by blood samples collected from all rats at the beginning and end of the experiment.The jejunum of five animals was removed and submitted to routine histological processing(paraffin)for analysis of external muscle thickness.The remaining jejunum from the others animals was used to analyze the general population and the NADH-diaphorase,VIPergic and nitrergic subpopulations of myenteric neurons;and the enteric glial cells(S100-IR).ReSULTS:Serological analysis showed that animals from the IG were infected with the parasite.Hypertrophy affecting jejunal muscle thickness was observed in the IG rats(77.02±42.71)in relation to the CG(51.40±12.34),Pe total number of myenteric neurons died(CG:39839.3±5362.3;IG:26766.6±2177.6;Perplasia of nitrergic myenteric neurons was observed(CG:7959.0±1290.4;IG:10893.0±1156.3;Peneral hypertrophy of the cell body in the remaining myenteric neurons was noted[CG:232.5(187.2-286.0);IG:248.2(204.4-293.0);Pertrophy of the smallest varicosities containing VIP neurotransmitter was seen(CG:0.46±0.10;IG:0.80±0.16;Peduction of 25.3%in enteric glia cells(CG:12.64±1.27;IG:10.09±2.10;Perved in the infected rats.CONCLUSION:It was concluded that infection with oocysts of Me-49 T.gondii strain caused quantitative and plastic alterations in the myenteric plexus of the jejunum in rats.

关键词： enteric nervous system Infectious diseases Glial cells Nitric oxide Neuronal plasticity Smallintestine Toxoplasmosis Vasoactive intestinal peptide

Photoelectrocatalytic Oxidation of ethinylestradiol on a Ti/TiO<sub>2</sub>electrode: Degradation efficiency and Search for By-Products

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Green and Sustainable Chemistry 2014年第3期4卷 151-161页

作者： Karla Moreira Vieira Fabiana Maria Monteiro Paschoal Maria Valnice Boldrin zanoni Clésia Cristina Nascentes Rodinei Augusti Departamento de Ciências exatas e Aplicadas Universidade Federal de Ouro Preto Loanda Brazil Departamento de Química Universidade Federal de Minas Gerais Belo Horizonte Brazil Instituto de Química Universidade Estadual Paulista Araraquara Brazil

The degradation of ethinylestradiol (ee, an orally bio-active estrogen) in an aqueous-methanolic solution using a Ti/TiO2 thin-film electrode and UV radiation (a photoelectrocatalytic system) was evaluated. Hence, HPLC/UV analysis shows that ee (at 0.34 mmol) is totally consumed after 30 minutes of exposure to the photoelectrocatalytic system in the presence of Na2SO4 (0.1 mol·L-1) and with an applied bias potential of +1.0 V versus the Ag/AgCl reference electrode. Moreover, monitoring by direct infusion electrospray ionization mass spectrometry (eSI-MS) and SPMe-GC/ MS (solid phase microextraction coupled with gas chromatography-mass spectrometry) reveals that apparently no degradation products are formed under these conditions. Hence, this study demonstrates that the photoelectrocatalytic system can be efficiently used to promote the complete degradation (and likely mineralization) of this hormone under these conditions.

关键词： Photoelectrocatalytic Oxidation ethinylestradiol Ti/TiO2 Thin-Film electrode Degradation efficiency Search for By-Products