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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Relation between etching profile and voltage-current shape of sintered SiC etching by atmospheric pressure plasma

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Plasma Science and Technology 2019年第4期21卷 137-144页

作者： D C SeOK S R yOO K I Lee y S choi y H JUNG Plasma Technology Research Center National Fusion Research InstituteGunsan City 54004Republic of Korea

Sintered silicon carbide(SiC)was etched by a dielectric barrier discharge source.A high voltage bipolar pulse was used with helium gas for the plasma *** stable filament plasma was generated and could be used for SiC *** the processing gas(NF3)mixing rate increased,the width and depth of the etching profile became narrower and *** differentiated V-Q Lissajous method was used for measuring the capacitances(Ceq)of the electrode after the plasma turned *** width of the etching profile was proportional to *** the current peak value/smx of the substrate current in creased,the volume removal rate of SiC *** etch depth was proportional to the ratio of/smx to ***,because of the different characteristics of the plasma disks on SiC substrate by the voltage polarity,the etching profile was ***,in high NF3 mixing process,the etching profile became stable and deeper.

关键词： dielectric barrier discharge silicon carbide plasma etching、filament discharge,surface charge

A Hybrid Joining Technology for Aluminum/Zinc Coated Steels in Vehicles

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Journal of Materials Science & Technology 2010年第9期26卷 858-864页

作者： C.y.choi D.C.Kim D.G.Nam y.D.Kim y.D.Park School of Materials Science and engineering Pusan National UniversityBusan Advanced Welding & Joining R&D Division Institute of Industrial Technology Incheon Dongnam Technology Service Division Korea Institute of Industrial TechnologyBusan Department of Advanced Materials engineering Dong-Eui UniversityBusan

Currently,in the automotive industry,joining of the aluminum alloys with the steel is a crucial problem to be *** joining techniques including resistance spot and gas metal arc welding are not acceptable for those applications due to a number of metallurgical *** investigation was carried out to develop the hybrid joining process combining the resistance spot welding and *** this study,an attempt was made to apply hybrid process to the joining of dissimilar sheet metals,Al-Mg-Si（6000 series） alloy and low carbon steel *** process（resistance spot weld/brazing） using filler metal was found to be effective to overcome the incompatibility between aluminum alloy and *** hybrid joining process of Al alloy sheet and steel sheet did not produce acceptable bond strength,it was proved to have reasonable interfacial bond layer if the optimal process condition was applied.

关键词： Hybrid joining Aluminum alloy Steel Resistance welding Brazing

Creeping fat and gut microbiota in Crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana eV Quaglio Daniéla O Magro Marcello Imbrizi ellen CS De Oliveira Luiz C Di Stasi Ligia y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关键词： Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease

Giant magnetocaloric effect in the Gd_5 Ge_(2.025)Si_(1.925)In_(0.05) compound

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Chinese Physics B 2010年第3期19卷 517-522页

作者： e.yzak I.Dincer y.elerman Department of engineering Physics Faculty of EngineeringAnkara University06100 BesevlerAnkaraTurkey

The magnetocaloric properties of the GdsGe2.025Si1.925In0.05 compound have been studied by x-ray diffraction, magnetic and heat capacity measurements. Powder x-ray diffraction measurement shows that the compound has a dominant phase of monoclinic Cd5Ge2Si2-type structure and a small quantity of Gds（Ge,Si）3-type phase at room temperature. At about 270 K, this compound shows a first order phase transition. The isothermal magnetic entropy change （△SM） is calculated from the temperature and magnetic field dependences of the magnetization and the temperature dependence of MCe in terms of adiabatic temperature change （△Tad） is calculated from the isothermal magnetic entropy change and the temperature variation in zero-field heat-capacity data. The maximum △SM is -13.6 J·kg^-1.K^- 1 and maximum ATad is 13 K for the magnetic field change of 0 5 T. The Debye temperature （θD） of this compound is 149 K and the value of DOS at the Fermi level is 1.6 states/*** from the low temperature zero-field heat-capacity data. A considerable isothermal magnetic entropy change and adiabatic temperature change under a field change of 0-5 T jointly make the Gd5Ge2.025Si1.925In0.05 compound an attractive candidate for a magnetic refrigerant.

关键词： magnetic properties magnetocaloric effect isothermal magnetic entropy change adia-batic temperature change

Landslide disaster prevention and mitigation through works in Hong Kong

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Journal of Rock Mechanics and Geotechnical engineering 2013年第5期5卷 354-365页

作者： K.y.choi Raymond W.M.Cheung Geotechnical engineering Offce Civil Engineering and Development Department The Government of the Hong Kong SAR

Hong Kong has a high concentration of developments on hilly terrain in close proximity to man-made slopes and natural *** of the high seasonal rainfall,these man-made slopes and natural hillsides would pose a risk to the public as manifested by a death toll of 470 people due to landslides since the late *** 1977,the Government of the Hong Kong SAR embarked on a systematic programme,known as the Landslip Preventive Measure(LPM)Programme,to retroft substandard man-made *** 1977 to 2010,about 4500 substandard government man-made slopes have been upgraded through engineering *** the period,the Programme had evolved progressively in response to Government’s internal demand for continuous improvement and rising public expectation for slope *** 2010,the Government implemented the Landslip Prevention and Mitigation(LPMit)Programme to dovetail with the LPM Programme,with the focus on retroftting the remaining moderate-risk substandard man-made slopes and mitigating systematically the natural terrain landslide risk pursuant to the"react-to-known"hazard *** paper presents the evolution of the LPM and LPMit Programmes as well as the insight on landslide prevention and mitigation through engineering works.

关键词： Landslide Landslide prevention Landslide mitigation Landslide risk Man-made slopes Natural terrain

First-principles calculation on the electronic structures, phonon dynamics, and electrical conductivities of Pb_(10)(PO_(4))_(6O) and Pb_(9)Cu(PO_(4))_(6O) compounds

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Journal of Materials Science & Technology 2024年第6期173卷 218-224页

作者： L.y.Hao e.G.Fu State Key Laboratory of Nuclear Physics and Technology Department of Technical PhysicsSchool of PhysicsPeking UniversityBeijing 100871China

Superconducting materials with high critical temperature have the potential to revolutionize many fields,including military,electronic communications,and power ***,scientists around the world have been tirelessly working with the ultimate goal of achieving high-temperature *** 2023,a preprint by Lee et *** South Korea claimed the discovery of ultra-high-temperature superconductivity with a critical temperature of up to 423 K in Cu-doped lead-apatite(LK-99)(arXiv:2307.12008,arXiv:2307.12037),which caused a worldwide sensation and ***,the electronic structures,phonon dynamics,and electrical conductivities of LK-99 and its parent compound lead-apatite have been calculated using first-principles *** results show that the lead-apatite compound and the LK-99 compound are insulator and half-metal *** flat band characteristic is consistent with previous *** electrical conductivity of the LK-99 compound shows two extreme points,and the electrical conductivity along the C-axis increases significantly after 400 *** phonon dispersion spectra of the compounds were investigated,demonstrating their dynamic instability.

关键词： Superconductivity LK-99 Lead-apatite First-principles calculation

Perfluoroalkyl acid transformation and mitigation by nNiFe-activated carbon nanocomposites in steady-state flow column studies

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Journal of environmental Sciences 2023年第5期127卷 678-687页

作者： Mahsa Modiri-Gharehveran younjeong choi Jenny e.Zenobio Linda S.Lee Department of Agronomy Purdue UniversityWest LafayetteIN 47907USA Interdisciplinary ecological Sciences&engineering Purdue UniversityWest LafayetteIN 47907USA

The ongoing contamination of groundwater with per-and polyfluoroalkyl substances(PFAS)has resulted in a global and rapidly growing interest in PFAS groundwater *** technologies that lead to PFAS destruction are often limited by not addressing all PFAS,being energy-intensive or not being suited for in-situ *** developed nNiFeactivated carbon(AC)nanocomposites and demonstrated varying degrees of PFAS reduction and fluoride generation with these nanocomposites in batch reactors for several *** we explore nNiFe-AC’s effectiveness to transform perfluoroalkyl acid acids(PFAAs)under steady-state flow(0.0044 to 0.15 mL/min)in nNiFe-AC:sand packed *** experiments included,two perfluorooctane sulfonate(PFOS)in deionized water and two PFAA mixtures in deionized water or bicarbonate buffer containing five perfluoroalkyl carboxylates(PFCAs,C5-C9)and three perfluoroalkyl sulfonates(PFSAs,C4,C6 and C8)at temperatures of 50 or 60℃ were *** transformation was similar in PFOS-only and PFAA mixture column ***,%PFAA transformation under flow conditions exceeded what we observed previously in batch reactors with up to 53%transformation of a PFAA mixture with∼8%*** chain PFAS dominated the PFAAs transformed and a bicarbonate matrix appeared to reduce overall *** breakthrough was slower than predicted from only sorption due to transformation;some longer chain PFAS like PFOS did not ***,nNiFe-AC technology with both in-situ and ex-situ potential application was shown to be a plausible part of a treatment train needed to address the ongoing challenge for cleaning up PFAS-contaminated waters.

关键词： PFAAs PFAS Zero valent iron Nanoparticles Remediation Groundwater

effects of manganese doping on magnetocaloric effect in Ge-rich Gd_5Ge_(2.05)Si_(1.95) alloy

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Journal of Rare earths 2012年第3期30卷 217-221页

作者： e.yüzüak I.Dincer y.elerman Department of engineering Physics Faculty of EngineeringAnkara University

The structure, magnetic and magnetocaloric properties of the Ge-rich Gd5Ge2.05-xSi1.95-xMn2x （x=0.01 and 0.03） alloys were investigated by scanning electron microscopy, X-ray powder diffraction, differential scanning calorimeter （DSC） and magnetization measurements. The results of energy dispersive X-ray analysis （eDX） and X-ray diffraction analyses showed that the composition and crystal structure of the alloys were desired. DSC measurements were performed to determine the transformation temperatures for each alloy. Both alloys exhibited the first order phase transition around room temperature. The alloys showed an anti-ferromagnetic transition around 60 K. The isothermal magnetic entropy changes of the alloys were determined from the isothermal magnetization measurements by using the Maxwell relation. The maximum values of isothermal magnetic entropy change of the Gd5Ge2.05-xSi1.95-xMn2x alloy with x=0.01 was found to be -12.1 and -19.8 J/（kg·K） using Maxwell equation around 268 K in applied fields of 2 and 5 T, respectively.

关键词： magnetocaloric effect entropy change magnetic materials rare earths

Low temperature oxidation of Cr-alloyed MoSi_2

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中国有色金属学会会刊：英文版 2007年第6期17卷 1282-1286页

作者： e. Strom y. Cao y. M. yao Kanthal AB Box 502 SE-734 27 Hallstahammar Sweden Department of Materials and Manufacturing Technology Chalmers University Technology SE-412 96 Gothenburg Sweden

Cr-alloyed MoSi2 was compared with monolithic MoSi2 with respect to oxidation at 450 ℃ for 456 h. Phases formed on Cr-alloyed MoSi2 after exposure are Cr2(MoO4)3, MoO3, and cristobalite (SiO2) according to X-ray diffraction results. Monolithic MoSi2 forms MoO3 and mainly amorphous SiO2. X-ray photoelectron spectroscopy indicates that the main oxidation product on the outermost surface is SiO2 for all studied samples. The samples form a relatively loose oxide but the oxide adherence improves with increasing Cr content. It is indicated that Cr addition can benefit pesting control in MoSi2.

关键词：钼硅化合物合金有害物氧化作用