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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Recent Advancements in the Optimization Capacity Configuration and Coordination Operation Strategy of Wind-Solar Hybrid Storage System

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energy engineering 2025年第1期122卷 285-306页

作者： Hongliang Hao Caifeng Wen Feifei Xue HaoQiu Ning Yang Yuwen Zhang Chaoyu Wang edwin e.Nyakilla Department of New energy Storage Peking University Ordos Research Institute of EnergyOrdos017010China School of energy and Power engineering Inner Mongolia University of TechnologyHohhot010080China Key Laboratory of Wind energy and Solar energy Utilization Technology Inner Mongolia University of TechnologyHohhot010051China

Present of wind power is sporadically and cannot be utilized as the only fundamental load of energy *** paper proposes a wind-solar hybrid energy storage system(HeSS)to ensure a stable supply grid for a longer period.A multi-objective genetic algorithm(MOGA)and state of charge(SOC)region division for the batteries are introduced to solve the objective function and configuration of the system capacity,***/Simulink was used for simulation *** optimization results show that for a 0.5 MW wind power and 0.5 MW photovoltaic system,with a combination of a 300 Ah lithium battery,a 200 Ah lead-acid battery,and a water storage tank,the proposed strategy reduces the system construction cost by approximately 18,000 ***,the cycle count of the electrochemical energy storage systemincreases from4515 to 4660,while the depth of discharge decreases from 55.37%to 53.65%,achieving shallow charging and discharging,thereby extending battery life and reducing grid voltage fluctuations *** proposed strategy is a guide for stabilizing the grid connection of wind and solar power generation,capability allocation,and energy management of energy conservation systems.

关键词： electric-thermal hybrid storage modal decomposition multi-objective genetic algorithm capacity optimization allocation operation strategy

Heterosis and combining ability in cucumber(Cucumis sativus L.)

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Information Processing in Agriculture 2019年第1期6卷 150-157页

作者： Chikezie Onuora ene Peter ejimofor Ogbonna Christian Ugwu Agbo Uchechukwu Paschal Chukwudi Department of Crop Science University of NigeriaNsukka 410001Nigeria

The objective of this work was to evaluate four parental lines of cucumber which included:‘Zeina’(Zna),‘Beit Alpha’(BA),‘Straight 8’(Strght 8)and‘Calypso’(Capso)and six F1s generated by diallel cross,using randomized complete block design with three replications to study heterosis and combining ability for yield and yield component *** heterosis showed that cross‘ZnaCapso’had the highest Better Parent(BP)heterosis in total fruit yield/ha while‘BACapso’had the highest Mid Parent(MP)heterosis in the same *** general(GCA)and specific(SCA)combining ability variances were obtained in all the traits implying that both the additive and non-additive gene effects operated in the genetic expression of the *** magnitude of GCA and SCA variances indicated preponderance of additive gene action for all the traits.‘Beit Alpha’and‘Straight 8’are best general combiners while‘BACapso’and‘CapsoStrght 8’were the best specific combiners for total fruit yield.

关键词： Cucumber Hybrid vigour Half diallel crosses GCA SCA

ethiopian Trade Relations with China: Achievement, Challenges and Prospects

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Ethiopian Trade Relations with China: Achievement, Challenge...

作者： DeMeKe ZeM ene SHI FeRAW 外交学院

学位级别：硕士

The main objective of this study was to examine post1991ethiopian trade relationswith China, the main focus being on achievements, challenges and *** needs China for economic cooperation including trade relation. It cannot allin all depend on the western countries. China’s development experience is generallyconsidered as a role model for ethiopia to adopt. Moreover, China supports ethiopiaon different economic issues like aid and soft loan. On the other hand, there are alsoseveral factors pushing China to look towards ethiopia especially in terms ofethiopia’s strategic importance and market potential. After the critical analysis oftrade data between ethiopia and China, this paper empirically proved that ethiopiaincurs huge deficit in its trade balance with China in the period *** result from cross sectional data sources, i.e. secondary sources, and officialreports, reveal that ethiopia’s export to China is much less than its imports fromChina. Although trade figures show that there are improvements in the ethiopia’sexport, the trade balance is still largely in favor of China. Dependence on the exportof few unprocessed agricultural products, weak export performance and geographicfactors are among the reasons for the ethiopia’s trade deficit. The researcher also provides practical policy recommendations such as: preferentialtreatment to be fully exploited by ethiopia;leveraging China’s investment in Specialeconomic Zones;encouraging joint venture between Chinese and ethiopian firmsamong others.

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sadreev Yong Li Andrey e.Miroshnichenko School of Physics and electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

An efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng e Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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Toward development of ecosystem asset accounts at the national level

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ecosystem Health and Sustainability 2019年第1期5卷 36-46,I0022页

作者： Dava vačkářů Ioanna Grammatikopoulou Department of Human Dimensions of Global Change Global Change Research Institute of the Czech Academy of SciencesBrnoCzech Republic

ecosystem accounting has become one of the key components in the revision of international statistical *** of the System of environmental-economic Accounting for ecosystem services follows the rapid progress of science in this area as well as expanding applications to sustainability *** this contribution,we discuss approaches to accounting of ecosystem assets as a natural capital basis that is critical for ecosystem service *** on examples from the Czech Republic,a Central european country,we illustrate the construction of ecosystem extent accounts based on the methodology of Land and ecosystem *** analysis is complemented by monetary ecosystem asset accounting through quantification of the present value of future ecosystem service *** condition is represented by the Mean Species Abundance indicator,which gauges the direction of ecosystem *** on the demonstration of approaches to ecosystem asset accounting,we discuss selected aspects of ecosystem condition measurements,valuation,and policy implications of ecosystem asset accounting at the national level.

关键词： ecosystem accounting ecosystem services land cover change Mean Species Abundance value transfer Czech Republic

Correlation and path coefficient analyses of yield and yield components of eggplant (Solanum melongena) in a coarse-textured Ultisol

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Information Processing in Agriculture 2020年第1期7卷 173-181页

作者： Vincent NOnyia Uchechukwu Paschal Chukwudi Augustus Chika ezea Agatha I.Atugwu Chikezie O.ene Department of Crop Science University of NigeriaNsukkaNigeria Department of Agriculture Alex Ekwueme Federal University Ndufu-AlikeNigeria Department of Crop Science North-West UniversityMmabathoSouth Africa

Assessment of variability and understanding of traits relationship in eggplant species are vital pre-requisite for formulating an effective breeding *** studied 23 genotypes of eggplants in a coarse-textured Ultisol using a randomized complete block design experiment with three *** were collected on number of branches,number of leaves,number of nodes and internodes,stem diameter,plant height,floral and yield *** revealed significant(p=0.05)variation in the flowering and fruiting pattern of the genotypes.‘Yalo x K3BC2P10 gave the highest individual fruit weight of 80.8 *** fruit weight contributed the highest direct positive effect on the fruit *** acted majorly through plant height,number of branches,number of leaves and number of days to first fruit set as revealed in the path coefficient *** fruit weight,number of fruits per plant,plant height,number of days to 50%flowering,number of branches,numbers of days to first flowering and 50%fruit set had positive direct effect on *** traits should be considered in developing high yielding eggplant breeding programme.

关键词： Correlation Genetic improvement Path coefficient Solanum melongena Ultisol Yield