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New trends in diagnosis and management of gallbladder carcinoma

World Journal of Gastrointestinal Oncology 2024年第1期16卷 13-29页

作者： efstathios T Pavlidis Ioannis N Galanis Theodoros e Pavlidis ^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Gallbladder(GB)carcinoma,although relatively rare,is the most common biliary tree cholangiocarcinoma with aggressiveness and poor *** is closely associated with cholelithiasis and long-standing large(>3 cm)gallstones in up to 90%of *** other main predisposing factors for GB carcinoma include molecular factors such as mutated genes,GB wall calcification(porcelain)or mainly mucosal microcalcifications,and GB polyps≥1 cm in *** is made by ultrasound,computed tomography(CT),and,more precisely,magnetic resonance imaging(MRI).Preoperative staging is of great importance in decisionmaking regarding therapeutic *** staging is based on MRI findings,the leading technique for liver metastasis imaging,enhanced three-phase CT angiography,or magnetic resonance angiography for major vessel *** is also necessary to use positron emission tomography(PeT)-CT or ^(18)F-FDG PeT-MRI to more accurately detect metastases and any other occult deposits with active metabolic *** laparoscopy may detect dissemination not otherwise found in 20%-28.6%of *** treatment is needed,including surgical resection,targeted therapy by biological agents according to molecular testing gene mapping,chemotherapy,radiation therapy,and *** is of great importance to understand the updated guidelines and current treatment *** extent of surgical intervention depends on the disease stage,ranging from simple cholecystectomy(T1a)to extended resections and including extended cholecystectomy(T1b),with wide lymph node resection in every case or Iv-v segmentectomy(T2),hepatic trisegmentectomy or major hepatectomy accompanied by hepaticojejunostomy Roux-Y,and adjacent organ resection if necessary(T3).Laparoscopic or robotic surgery shows fewer postoperative complications and equivalent oncological outcomes when compared to open surgery,but much attention must be paid to avoiding *** addition to surgery,novel targe

关键词： Biliary tract neoplasms extrahepatic cholangiocarcinoma Gallbladder carcinoma Gallbladder diseases Biliary tree diseases Gastrointestinal malignancies

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exploring one material for dual applications:A red-emitting Mg2GeO4:eu3+ nanophosphor for future generation energy efficient WLeDs and dosimetric applications

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Journal of Rare earths 2024年第10期42卷 1835-1845页

作者： Akshay Arjun G.P.Darshan S.C.Sharma H.Nagabhushana D.v.Sunitha H.B.Premkumar Department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied Sciences Jain University C.N.R.Rao Centre for Advanced Materials Tumkur University School of Applied Sciences (Physics) REVA University

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg2GeO4:eu3+（1 mol%-9 mol%） nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg2GeO4:eu3+（1 mol%-9 mol%） nanophosphors was estimated and obtained to be～4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at ～579,589,610,661,and 707 nm,which are due to characteristic5D0→7F0,5D0→7F1,5Do→7F2,5D0→7F3and5D0→7F4transitions of eu3+ions,*** Commission International de L'eclairage color coordinates are gradually tuned from pale red（0.5980,0.4012） to a pure red（0.6385,0.3611） *** glow peaks showcase excellent super-linear response at low doses of γ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared Mg2GeO4:eu3+（1 mol%-9 mol%） nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes（WLeDs） and personal dosimetric applications.

关键词： Dosimetry Nanophosphors Photoluminescence Photometric properties Rare earths Thermoluminescence

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Fluoride contamination in groundwater:A global review of the status,processes,challenges,and remedial measures

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Geoscience Frontiers 2024年第2期15卷 1-29页

作者： e.Shaji K.v.Sarath M.Santosh P.K.Krishnaprasad B.K.Arya Manisha S.Babu Department of Geology University of KeralaKariavattom CampusThiruvananthapuramKerala 695581India School of earth Sciences and Resources China University of Geosciences(Beijing)29 Xueyuan RoadBeijing 100083China Department of earth Science University of AdelaideAdelaideSA 5005Australia Department of Geology Central University of KeralaTejaswini HillsPeriyeKasaragodKerala 671316India

Groundwater pollution by fluoride is one of the prime concerns of the world population due to its toxicity,which results in adverse health *** this paper,we review the current scenario of the fluoride contamination of groundwater in various countries across the globe and its impact on human *** the last decade,several newly affected regions have been reported all over the world,with more than 100 countries affected by fluoride contamination in groundwater(concentration exceeding the acceptable limit of 1.5 mg/L defined by the World Health Organization).Fluoride poisoning is mainly due to the unsupervised ingestion of products for dental and oral hygiene and over-fluoridated drinking *** is estimated that more than 200 million people from different countries are affected by fluoriderelated groundwater issues and health *** highest among these are from the countries in Africa(38),Asia(28),and europe(24),followed by countries like South America(5),North America(3),and Australia(2).The source of fluoride in drinking water is primarily geogenic,together with forage,grasses and grains,tea,and anthropogenic *** countries affected were correlated with climatic zones and geological factors to gain insights into geospatial *** analyses show that most of the fluoride pollution-prone zones are located in high-grade metamorphic terranes with granitoid or alkaline intrusions,geothermal hot springs,and volcanic regions with arid or semi-arid climatic *** study also finds that children across the globe are more vulnerable than adults to fluoride *** review finds that,although there are efficient fluoride removal techniques,including filters with next-generation nanomaterials,to date,there has not been a single technique developed that can claim to be a practically robust solution for fluoride removal from drinking ***,we suggest developing next-generation filters that can retain essential miner

关键词： Fluoride Groundwater Water contamination WHO standards Climate zones Remediation Sustainable Development Goals

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Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li eline H.van den Berg Alexander Kurilshikov Dasha v.Zhernakova Ranko Gacesa Shixian Hu esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study vincent e.de Meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl eleonora A.M.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(UK)Biobank(UKBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in UKBB revealed five statistically significant loci,including two novel genomic loci harboring CReB3L1(rs72910057-T,P=5.40e−09)and GCM1(rs1491489378-T,P=3.16e−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in UKBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35e−13)and FTO(P=2.11e−09).Statistically significant genetic correlation(rg)between MRI-PDFF(UKBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45e−03).Novel MRI-PDFF genetic signals(CReB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction

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expanded Porphyrin exhibiting Off-Centered Out-of-Plane Coordination to Dysprosium

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CCS Chemistry 2024年第7期6卷 1731-1738页

作者： Dmitry I.Nazarov Jorge Labella Alexey v.Kuzmin Maxim A.Faraonov evgenii N.Ivanov Salavat S.Khasanov Tomas Torres Mikhail K.Islyaikin Dmitri v.Konarev Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS 142432 Chernogolovka Department of Organic Chemistry Universidad Autonoma de Madrid28049 Madrid Institute of Solid-State Physics RAS 142432 Chernogolovka Research Institute of Macroheterocycles Ivanovo State University of Chemistry and Technology15300 Ivanovo G.A.Krestov Institute of Solution Chemistry of the Russian Academy of Sciences 153045 Ivanovo Institute for Advanced Research in Chemical Sciences Universidad Autonoma de Madrid28049 Madrid IMDeA-Nanociencia 28049 Madrid

The complexation of high-spin lanthanides to porphyrinoids is a powerful strategy for the development of advanced molecular *** this context,the use of expanded porphyrinoids remains elusive since their coordination chemistry is challenging to ***,taking inspiration from on-surface chemistry,we explored the coordination of Dy^(3+)to a six-membered porphyrinoid,namely,the hemihexaphyrazine ***,we observed the selective formation of a mono-nuclear off-centered,out-of-plane H_(2)Hhp-Dy^(3+)complex when performing the complexation under reductive *** this reaction,the oxidation state of the macrocycle did not *** X-ray diffraction analysis,we found that the coordination number of Dy in this complex was *** macrocycle cocrystallized with decamethylcobaltocene(Cp_(2)^(*)Co)molecules,giving rise to a wellordered solid-state packing,governed byπ-π*** a result of this organization,a small magnetic coupling between the neighboring molecules was *** in all,this work provides key insights into the coordination of magnetically active metals with expanded porphyrinoids,thus motivating the development of advanced spintronic devices.

关键词： porphyrins dysprosium macrocycle coordination chemistry magnetism

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Rigidity Symmetry Line for Thermodynamic Fluid equations-of-State

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Journal of Modern Physics 2024年第5期15卷 613-633页

作者： Leslie v. Woodcock Department of Physics University of Algarve Faro Portugal

We report progress towards a modern scientific description of thermodynamic properties of fluids following the discovery (in 2012) of a coexisting critical density hiatus and a supercritical mesophase defined by percolation transitions. The state functions density ρ(p,T), and Gibbs energy G(p,T), of fluids, e.g. CO2, H2O and argon exhibit a symmetry characterised by the rigidity, ω = (dp/dρ)T, between gaseous and liquid states along any isotherm from critical (Tc) to Boyle (TB) temperatures, on either side of the supercritical mesophase. Here, using experimental data for fluid argon, we investigate the low-density cluster physics description of an ideal dilute gas that obeys Dalton’s partial pressure law. Cluster expansions in powers of density relate to a supercritical liquid-phase rigidity symmetry (RS) line (ω = ρrs(T) = RT) to gas phase virial coefficients. We show that it is continuous in all derivatives, linear within stable fluid phase, and relates analytically to the Boyle-work line (BW) (w = (p/ρ)T = RT), and to percolation lines of gas (PB) and liquid (PA) phases by: ρBW(T) = 2ρPA(T) = 3ρPB(T) = 3ρRS(T)/2 for T TB. These simple relationships arise, because the higher virial coefficients (bn, n ≥ 4) cancel due to clustering equilibria, or become negligible at all temperatures (0 T TB) within the gas phase. The Boyle-work line (p/ρBW)T is related exactly at lower densities as T → TB, and accurately for liquid densities, by ρBW(T) = −(b2/b3)T. The RS line, ω(T) = RT, defines a new liquid-density ground-state physical constant (ρRS(0) = (2/3)ρBW(0) for argon). Given the gas-liquid rigidity symmetry, the entire thermodynamic state functions below TB are obtainable from b2(T). A BW

关键词： Liquid-State Theory Cluster Physics Percolation Lines Fluid Thermodynamics Boyle Line Rigidity-Symmetry Line

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About the Features of Transient to Steady State Deformation of Solids

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Journal of Materials Science & Technology 1997年第1期13卷 69-72页

作者： S. G.Psakhie A. YU.Smolin e. v.shilko S.Yu.Korostelev, A.I.Dmitriev and S. v.Alekseev (Institute of Strength Physics and Materials Science of the Russian Academy of Sciences,Siberian Branch 634055, Tomsk, Russia) Institute of Strength Physics and Materials Science Russian Academy of Sciences Siberian Branch 634055 Tomsk Russian Federation

The features of transient to steady state deformation of solids are theoretically *** of various types of loading was carried out by the Movable Cellular Automata method.A stress state of material at the stage of transient to a steady state is shown to be essentially non-uniform, that may in its turn result in stable structures in velocity field of particles of the material. It may also influence development of deformation at the further stages.

关键词： About the Features of Transient to Steady State Deformation of Solids

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Management of early oesophageal cancer:An overview

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1255-1258页

作者： Gavin G Calpin Matthew G Davey Noel e Donlon Department of Surgery Royal College of Surgeons in IrelandDublin D2Ireland Department of Upper Gastrointestinal Surgery Beaumont HospitalDublin D09V2N0Ireland

The incidence of esophageal cancer,namely the adenocarcinoma subtype,continues to increase exponentially on an annual *** indolent nature of the disease renders a significant proportion inoperable at first presentation,however,with the increased utilisation of endoscopy,many early lesions are now being identified which are suitable for endotherapeutic *** article details the options available for dealing with early esophageal cancer by endoscopic mean obviating the need for surgery thereby avoiding the potential morbidity and mortality of such intervention.

关键词： esophageal cancer endotherapy endoscopic submucosal resection endoscopic mucosal resection endoscopy

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Associations between parental adherence to healthy lifestyles and cognitive performance in offspring:A prospective cohort study in China

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Chinese Medical Journal 2024年第6期137卷 683-693页

作者： Rongxia Lv Yuhui Huang Siyi Huang Shiyi Wu Siwen Wang Guangyu Hu Yanan Ma Peige Song Jorge e.Chavarro S.v.Subramanian Chunling Lu Zhihui Li Changzheng Yuan School of Public Health the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310058China Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Institute of Medical Information/Center for Health Policy and Management Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Biostatistics and epidemiology School of Public HealthChina Medical UniversityShenyangLiaoning 110122China Department of Social and Behavioral Sciences Harvard T.H.Chan School of Public HealthBostonMA 02115USA Division of Global Health equity Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Global Health and Social Medicine Harvard Medical SchoolBostonMA 02115USA vanke School of Public Health Tsinghua UniversityBeijing 100084China Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMA 02115USA

Background:Previous studies have reported associations of specific maternal and paternal lifestyle factors with offspring’s cognitive development during early *** study aimed to investigate the prospective associations between overall parental lifestyle and offspring’s cognitive performance during adolescence and young adulthood in ***:We included 2531 adolescents aged 10-15 years at baseline in 2010 from the China Family Panel Studies.A healthy parental lifestyle score(ranged 0-5)was constructed based on the following five modifiable lifestyle factors:Smoking,drinking,exercise,sleep,and *** estimating equation models were used to examine the association between baseline parental healthy lifestyle scores and offspring’s fluid and crystallized intelligence in subsequent years(2012,2014,2016,and 2018).Results:Offspring in the top tertile of parental healthy lifestyle scores performed better in overall fluid intelligence(multivariable-adjusted β=0.53,95%confidence interval[CI]:0.29-0.77)and overall crystallized intelligence(multivariable-adjusted β=0.35,95%CI:0.16-0.54)than those in the bottom tertile of parental healthy lifestyle *** results were similar after further adjustment for the offspring’s healthy lifestyle scores and persisted across the subgroups of parental socioeconomic ***,maternal and paternal healthy lifestyle scores were independently associated with better offspring’s cognitive performance,with significant contribution observed for paternal never-smoking,weekly exercise,and diversified *** both parents and offspring adhered to a healthier lifestyle,we observed the highest level of the offspring’s overall crystallized ***:Our study indicates that parental adherence to a healthier lifestyle is associated with significantly better offspring’s cognitive performance during adolescence and early adulthood,regardless of socioeconomic *** findings highlight the poten

关键词： Cohort study Parental healthy lifestyle Offspring Cognitive performance Intelligence Adolescence

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CCD/eMCCD光电参数测试系统的设计与应用

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中国光学（中英文） 2024年第3期17卷 693-703页

作者：沈吉 vIACHeSLAv v.Zabudsky 常维静那启跃简云飞 OLeG v.Rikhalsky OLeKSANDR G.Golenkov vOLODYMYR P.Reva 华东光电集成器件研究所江苏苏州215263 乌克兰科学院v.e.Lashkaryov半导体物理研究所乌克兰基辅01001 乌克兰科学院Bogomoletz生理学研究所乌克兰基辅01001

本文开发了一种用于测量CCD和eMCCD(电子倍增CCD)芯片光电参数的测试系统。该测试系统通过自动模式或手动模式间的切换,测量器件的暗电流、读出放大器的响应度、电荷转移效率、电荷容量和其他参数。该测试系统可以针对不同规格和结构的C... 详细信息

本文开发了一种用于测量CCD和eMCCD(电子倍增CCD)芯片光电参数的测试系统。该测试系统通过自动模式或手动模式间的切换,测量器件的暗电流、读出放大器的响应度、电荷转移效率、电荷容量和其他参数。该测试系统可以针对不同规格和结构的CCD/eMCCD器件,实现CCD晶圆或封装好的成品的参数测试,实现576×288、640×512、768×576、1024×1024、1280×1024 CCD/eMCCD的测试和筛选。

关键词： CCD eMCCD 测试系统光电参数

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