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Weight loss increases skeletal muscle mitochondrial energy efficiency in obese mice

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Life Metabolism 2023年第2期2卷 23-34页

作者： Patrick J.Ferrara Marisa J.Lang Jordan M.Johnson Shinya Watanabe Kelsey L.McLaughlin John Alan Maschek Anthony R.P.verkerke Piyarat Siripoksup Amandine Chaix James e.Cox Kelsey H.Fisher-Wellman Katsuhiko Funai Diabetes&Metabolism Research Center University of UtahSalt Lake CityUtah 84112United States Department of Nutrition&Integrative Physiology University of UtahSalt Lake CityUtah 84112United States east Carolina Diabetes&Obesity Institute East Carolina UniversityGreenvilleNorth Carolina 27834United States Department of Physiology East Carolina UniversityGreenvilleNorth Carolina 27834United States Metabolomics Core Research Facility University of UtahSalt Lake CityUtah 84112United States Molecular Medicine Program University of UtahSalt Lake CityUtah 84112United States Department of Biochemistry University of UtahSalt Lake CityUtah 84112United States

Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight *** suggests that this energetic mismatch originates from lean *** this phenomenon is well documented,the mechanisms have remained *** hypothesized that increased mitochondrial energy efficiency in skeletal muscle is associated with reduced expenditure under weight ***(WT)male C57BL6/N mice were fed with high-fat diet for 10 weeks,followed by a subset of mice that were maintained on the obesogenic diet(OB)or switched to standard chow to promote weight loss(WL)for additional 6 *** energy efficiency was evaluated using high-resolution respirometry and *** spectrometric analyses were employed to describe the mitochondrial proteome and *** loss promoted~50%increase in the efficiency of oxidative phosphorylation(ATP produced per O_(2) consumed,or P/O)in skeletal ***,Weight loss did not appear to induce significant changes in mitochondrial proteome,nor any changes in respiratory supercomplex ***,it accelerated the remodeling of mitochondrial cardiolipin(CL)acyl-chains to increase tetralinoleoyl CL(TLCL)content,a species of lipids thought to be functionally critical for the respiratory *** further show that lowering TLCL by deleting the CL transacylase tafazzin was sufficient to reduce skeletal muscle P/O and protect mice from diet-induced weight *** findings implicate skeletal muscle mitochondrial efficiency as a novel mechanism by which weight loss reduces energy expenditure in obesity.

关键词： energy efficiency energy expenditure mitochondria oxidative phosphorylation phospholipids weight loss

Notes for genera:Ascomycota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiraman C.Rajeshkumar David L.hawksworth Hugo Madrid Paul M.Kirk Uwe Braun Rajshree v.Singh Pedro W.Crous Martin Kukwa Robert Lücking Cletus P.Kurtzman Andrey Yurkov Danny haelewaters Andre´Aptroot H.Thorsten Lumbsch einar Timdal Damien ertz Javier etayo Alan J.L.Phillips Johannes Z.Groenewald Moslem Papizadeh Laura Selbmann Monika C.Dayarathne Gothamie Weerakoon e.B.Gareth Jones Satinee Suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj Martina Hujslová Lorenzo Lombard Belle D.Shenoy Ave Suija Sajeewa S.N.Maharachchikumbura Kasun M.Thambugala Dhanushka N.Wanasinghe Bharati O.Sharma Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri eleonora egidi Huzefa A.Raja Rampai Kodsueb Marcela e.S.Caceres Sergio Perez-Ortega Patrícia O.Fiuza Josiane Santana Monteiro Larissa N.vasilyeva Roger G.Shivas Maria Prieto Mats Wedin Ibai Olariaga Adebola Azeez Lateef Yamini Agrawal Seyed Abolhassan Shahzadeh Fazeli Mohammad Ali Amoozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharma Magdalena Oset Mohamed A.Abdel-Wahab Susumu Takamatsu Konstanze Bensch Nimali Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonmee Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagama Indunil C.senanayake Subashini C.Jayasiri Milan C.Samarakoon Xiang-Yu Zeng Mingkwan Doilom Luis Quijada Sillma Rampadarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukhamsakda Margarita Hernańdez-Restrepo Xiaoya Ma Saowaluck Tibpromma Luis F.P.Gusmao Darshani Weerahewa Samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of east Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Department of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica y Bioinforma´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Martin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of Plant Taxonomy and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention and Applied Microbiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany Farlow Reference Library and Herbarium of Cryptogamic Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Department of Organismic and evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of molecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** names have thus been introduced for species which are phylogenetically distinct from the type species of particular *** ending of the separate naming of morphs of the same species in 2011,has also caused changes in fungal generic *** order to facilitate access to all important changes,it was desirable to compile these in a single *** present article provides a list of generic names of Ascomycota(approximately 6500 accepted names published to the end of 2016),including those which are *** and summaries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are *** notes include the number of accepted species,classification,type species(with location of the type material),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascomycete component of the"Without prejudice list of generic names of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a modification in the rules relating to protected lists,and scrutiny by procedures determined by the Nomenclature Committee for Fungi(NCF).The previously invalidly published generic names Barriopsis,Collophora(as Collophorina),Cryomyces,Dematiopleospora,Heterospora(as Heterosporicola),Lithophila,Palmomyces(as Palmaria)and Saxomyces are validated,as are two previously invalid family names,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One name Pleomorphic fungi Taxonomy

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鄂尔多斯盆地上古生界天然气生成

天然气工业 2000年第6期20卷 19-23页

作者：刘新社席胜利付金华王涛王欣长庆油田公司勘探开发研究院

鄂尔多斯盆地上古生界有石炭—二叠系煤系和石炭系碳酸盐岩两套气源岩 ,其中前者对天然气的生成贡献最大。古地质温度计测温和古地温场模拟计算结果显示出 ,在晚侏罗世—早白垩世存在异常高地温场 ,使盆地古地温场和热流值均远高于现今... 详细信息

鄂尔多斯盆地上古生界有石炭—二叠系煤系和石炭系碳酸盐岩两套气源岩 ,其中前者对天然气的生成贡献最大。古地质温度计测温和古地温场模拟计算结果显示出 ,在晚侏罗世—早白垩世存在异常高地温场 ,使盆地古地温场和热流值均远高于现今值。受古地温场演化史的控制 ,天然气的生成具有侏罗纪之前深成变质作用控制下的生烃演化 ,早、中侏罗世深成变质作用和局部热异常控制下的生烃演化 ,晚侏罗世—早白垩世深成变质作用和区域热变质共同控制下的生烃演化及早白垩世之后降温过程下的生烃演化 4个阶段 ;相应的烃源岩在晚三叠世局部开始进入生烃门限 ,之后随生气量的逐渐增加 ,生烃范围不断扩大 ,至早中侏罗世开始有少量天然气的排出 ,晚侏罗世受燕山中期异常热事件的强烈影响 ,在晚侏罗世—早白垩世达到生排气高峰期。并最终形成以东部为主、西部次之的广覆式资源分布特征。

关键词：鄂尔多斯盆地晚古生代气源岩热演化天然气成因

丰中子核^(63,65,67)Mn的在束γ谱学研究

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原子核物理评论 2020年第3期37卷 548-553页

作者：卢洪洋刘小雨丁兵刘忠 P.Doornenbal A.Obertelli S.MLenzi P.M.Walker L.X.Chung B.D.Linh G.Authelet H.Baba D.Calvet F.Chateau A.Corsi A.Delbart J.M.Gheller A.Gillibert T.Isobe v.Lapoux M.Matsushita S.Momiyama T.Motobayashi M.Niikura F.Nowacki H.Otsu C.Peron A.Peyaud e.C.Pollacco J.Y.Rousse H.Sakurai M.Sasano Y.Shiga S.Takeuchi R.Taniuchi T.Uesaka H.Wang K.Yoneda 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 RIKeN Nishina Center 2-1 HirosawaWakoSaitama 351-0198Japan IRFU CEAUniversitéParis-SaclayF-91191Gif-sur-YvetteFrance Institut für Kernphysik Technische Universität Darmstadt64289DarmstadtGermany Universitádi Padova and INFN Sezione di PadovaI-35131PadovaItaly Department of Physics University of SurreyGuildford GU27XHUnited Kingdom Institute for Nuclear Science&Technology VINATOM179Hoang Quoc VietCau GiayHanoiVietnam Center for Nuclear Study University of TokyoRIKEN campusWakoSaitama 351-0198Japan Department of Physics University of Tokyo7-3-1 HongoBunkyoTokyo 113-0033Japan IPHC CNRS/IN2P3Universitéde StrasbourgF-67037StrasbourgFrance Department of Physics Rikkyo University3-34-1 Nishi-IkebukuroToshimaTokyo 172-8501Japan

利用放射性束68Fe轰击液氢靶引起的敲出反应,研究了极端丰中子核^(63,65,67)Mn的激发态,指认了它们的自旋宇称,建立了这三个原子核的能级纲图。纲图包含11/2^(-)、9/2^(-)和7/2^(-)三个激发态以及5/2^(-)_(g.s.)基态,它们由三条ΔI=1的... 详细信息

利用放射性束68Fe轰击液氢靶引起的敲出反应,研究了极端丰中子核^(63,65,67)Mn的激发态,指认了它们的自旋宇称,建立了这三个原子核的能级纲图。纲图包含11/2^(-)、9/2^(-)和7/2^(-)三个激发态以及5/2^(-)_(g.s.)基态,它们由三条ΔI=1的γ跃迁连接。这种能级结构与K=5/2时强耦合转动带的特征一致。使用改进的LNPS有效相互作用(LNPSm)的大规模壳模型计算能很好地重现观测到的能级。计算表明,^(65,67)Mn的低位激发态都主要包含处于4p-4h的中子组态和1p-1h的质子组态。基于实验结果发现,在吸积中子星壳中,与质量数A=63相关的Urea中微子冷却效果比预期的要强很多,而A=65,67的冷却效果比预期的更弱。

关键词：在束γ谱学翻转岛丰中子核壳演化

基于多参数MRI的形态和功能学评估区分非肌层浸润性和肌层浸润性膀胱癌

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国际医学放射学杂志 2017年第6期 735-735页

作者： v.Panebianco e.De Berardinis G.Barchetti G.Simone C.Leonardo M.D.Grompone 宋瑞瑞 Department of Radiological Sciences Oncology and Pathology Sapienza University of Rome Viale Regina Elena

摘要目的本研究旨在确定多参数MRI(mp MRI)对肌层浸润性膀胱癌(MIBC)和非肌层浸润性膀胱癌(NMIBC)的鉴别能力。方法肿瘤切除之前,病人均行mp MRI检查。2名放

关键词： MRI DTI PWI 多参数 DWI 浸润性膀胱癌

应用多参数MRI进行前列腺癌分期并包膜外侵犯风险评分:与组织病理学的相关性分析

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国际医学放射学杂志 2015年第4期 406-406页

作者： L.Boesen e.Chabanova v.LФgager I.Balslev K.Mikines H.S.Thomsel 王凤丽 Department of Urology Herlev University Hospital

摘要目的评价多参数MRI在前列腺癌术前肿瘤分期(T分期)中评估包膜外侵犯(eCe)风险积分的效能,并评价eCe预测最终病理结果的能力。材料与方法前瞻性纳入78

关键词：前列腺癌肿瘤分期多参数组织病理学病理组织学组织学风险评分 MRI 包膜病毒结构

乳腺断层融合摄影+数字乳腺摄影与单纯数字乳腺摄影对乳腺癌筛查的比较研究

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国际医学放射学杂志 2014年第1期 73-73页

作者： B.M.haas v.Kalra J.Geisel M.Raghu M.Durand L.e.Philpotts 杨迎迎 Department of Diagnostic Radiology Yale University School of Medicine PO Box 208042 New Haven CT 06520-8042

目的比较断层融合+数字X线乳腺摄影与单纯数字X线乳腺摄影的筛查召回率与乳腺癌检出率。方法本研究经伦理委员会批准,获得了知情同意,并遵循HIPAA。对

关键词：乳腺摄影筛查乳腺癌检出率召回率乳腺肿瘤乳房乳腺乳腺密度地质构造断层

辐射暴露:通过对核医学报告自动数据挖掘进行质量控制和器官剂量监测的方法来加强病人安全性

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国际医学放射学杂志 2012年第5期 483-483页

作者： I. Ikuta A. Sodickson e.J. Wasser G.I. Warden v.H. Gerbaudo R. Khorasani 胡裕效 Department of Radiology and Center for evidence-Based Imaging Brigham and Women's HospitalHarvard Medical School75 Francis StBostonMA 02115

摘要目的开发和验证一个开放源代码信息工具包,它可以从现有的核医学报告档案中创建一个放射辐射数据储存库,阐明这些数据在质量保证和病人个性辐射剂量纵向监测方面的潜在应用价值。材料与方法这项研究已被伦理审查委员会批准并被HIPA... 详细信息

摘要目的开发和验证一个开放源代码信息工具包,它可以从现有的核医学报告档案中创建一个放射辐射数据储存库,阐明这些数据在质量保证和病人个性辐射剂量纵向监测方面的潜在应用价值。材料与方法这项研究已被伦理审查委员会批准并被HIPAA认可。(由于是回顾性研究的原因)未签署知情同意书。开发了一个开放源代码信息工具包,它可以从核医学报告中自动提取有关放射性药物种类及给药活度的相关信息。

关键词：核医学原子医学器官剂量病人质量

X线容积成像系统的辐射剂量和图像质量:锥形束CT、DSA和数字荧光透视

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国际医学放射学杂志 2013年第4期 403-403页

作者： J. Paul v. Jacobi M. Farhang B. Bazrafshan T.J. vogl e.C. Mbalisike 杨淑杰 Department of Diagnostic and Interventional Radiology J.W.Goethe University Hospital -Frankfurt/MainTheodor -Stern -Kai 760590 Frankfurt/Main Germany

目的评估3种X线容积成像(XvI)系统的辐射剂量和图像质量。方法回顾性分析2007年—2012年间应用3种XvI系统(组1～3)接受检查的126例病人的数据。每组包括42例病人,每例病人均行锥形束计算机体层摄影术(CBCT)、数字减影血管造影(DSA)和数... 详细信息

目的评估3种X线容积成像(XvI)系统的辐射剂量和图像质量。方法回顾性分析2007年—2012年间应用3种XvI系统(组1～3)接受检查的126例病人的数据。每组包括42例病人,每例病人均行锥形束计算机体层摄影术(CBCT)、数字减影血管造影(DSA)和数字荧光透视检查(DF)。评估剂量参数,如剂量面积乘积(DAP)、入射表面剂量(SeD)和图像质量参数,如霍斯菲尔德单位(HU)、噪声、信噪比(SNR)、对比噪声比(CNR),并采用适当的统计检验方法进行比较。结果近期XvI的平均DAP和SeD值较先前CBCT、DSA、DF的低。除了肝动脉,所有测量部位的HU组间差异不显著。各组间的噪声具有显著差异(PvI与之前的版本间显示具有更高和显著的差异。定性地讲,与DSA和DF的先后版本间无差异,CBCT的不同版本之间存在显著差异。结论 CBCT、DSA、DF的新一代XvI系统的辐射剂量是降低的。影像噪声明显更低;SNR和CNR较之前的版本更高。新一代XvI系统的技术进步和帧数的减少使剂量明显降低、图像质量提高。要点①X线容积成像系统越来越多地用于介入放射学手术。②与之前的版本相比,更多现代的XvI系统的辐射剂量更低。③而且更现代的XvI系统可提供更高的影像质量。④技术进步可降低辐射剂量并提高影像质量。

关键词：锥形束CT 数字减影血管造影数字荧光透视辐射剂量影像质量