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Solasodine Glycosides: A Topical Therapy for Actinic Keratosis. A Single-Blind, Randomized, Placebo-Controlled, Parallel Group Study with Curaderm<sup>BeC5</sup>

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Journal of Cancer Therapy 2013年第2期4卷 588-596页

作者： Bill e. Cham Australasian Institute of Medical Research Brisbane Australia.

Background: Untreated actinic keratosis can advance to squamous cell carcinoma, which in turn is associated with a risk of metastasis. Current treatments for actinic keratosis have many shortcomings. This communication describes the efficacy and safety of a topical cream therapy, CuradermBeC5, containing solasodine glycosides (0.005%) for actinic ***: Randomly assigned patients with actinic keratosis on the face, trunk or extremities received so-lasodine glycosides cream (CuradermBeC5) or placebo (vehicle) that was self-applied to the lesions and covered with an occlusive dressing (micropore) twice daily for 3 consecutive days. Complete clearance and local reactions were as-sessed at 56 days with follow-up periods of 6 months and 1 year. Results: The rate of complete clearance at day 56 was higher with solasodine glycosides than with placebo (92% vs. 38%, P 0.001). The absolute success rates after 1 year follow-up were 82% for solasodine glycosides and 18% for placebo. No differences in local reactions were obtained when solasodine glycosides and placebo were compared. Local reactions in both groups peaked at days 2 and 3 with local pain as the major event. The pain associated with treatments lasted approximately 10 minutes after application of solasodine glycosides and placebo. Complete reepithelialization occurred two weeks after treatment. Adverse events were generally mild to moderate in intensity and resolved without sequelae. Conclusions: Solasodine glycosides cream applied topically twice daily with a dressing for 3 days is effective for the treatment of actinic keratoses.

关键词： Solasodine Glycosides Solamargine Solasonine Actinic Keratosis Apoptosis Skin Cancer Clinical Trial CuradermBeC5

Correlates of Depression among Patients Diagnosed with Chronic Illnesses in Saudi Arabia

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Health 2014年第15期6卷 1895-1902页

作者： Ahmad e. Aboshaiqah College of Nursing King Saud University Riyadh KSA

Background: Depression contributes to an increased medical morbidity and mortality among patients with chronic medical illnesses. The purpose of this study was to investigate correlates of depression among patients diagnosed with chronic illnesses in Saudi Arabia. Methods: A cross sectional survey using 412 patients diagnosed with chronic illnesses has been used to collected data in regards to depressive symptoms, psychological distress, coping, and life satisfaction. Results: 25.2% of the patients reported that they had moderate to severe depressive symptoms, and about 13.8% of them had mild level of depression. Psychological distress and life satisfaction were significant correlates with depressive symptoms (r = 0.33, 0.54, p e coping strategies is not. The results also showed that there is a significant and negative correlation between patients’ age and depression score (r = 0.17, p ≤ 0.001). Regarding gender differences, the analysis showed that there was no significant difference between male and female patients in their depressive symptoms (t = ﹣0.69, p = 0.488). Conclusion: implication for clinical practice and research discussed.

关键词： Chronic Illness Depression Stress Life Satisfaction

Potential Correlation between Spontaneous emulsification and the Plait Point in the System Water/Benzene/ethanol: A Phase Diagram Approach

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Soft 2013年第1期2卷 1-6页

作者： Stig e. Friberg Ugelstad Laboratory Norwegian University of Science and Technology Trondheim Norway

The separation of phases after the stability composition at a plait point is exceeded has significant effect on the reactions during spontaneous emulsification, but experimental efforts to obtain accurate information are extremely difficult, because even the smallest scattering of the numbers has a large effect on the result. In the present contribution a model system was applied that closely mirrored experimental values and the mass ratio of the two phases could be calculated with high accuracy. extrapolation of the ratio between phase masses towards the critical composition showed the two phase masses each close to 0.5, while a composition with a miniscule difference from this composition extrapolated to 1.0. The results showed spontaneous emulsification between solutions at the plait point and water to consist of two processes;an initial extremely fast reaction and a slower process between the aqueous phase formed in the primary emulsification and water.

关键词： emulsions Spontaneous emulsification Phase Diagrams Plait Point

Subcutaneous or Transvenous Defibrillator Therapy

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四川生理科学杂志 2021年第1期43卷 125-125页

作者： Reinoud e Knops From the Heart Center Department of Clinical and Experimental Cardiology Amsterdam Cardiovascular Sciences Amsterdam University Medical Centers University of Amsterdam (R.E.K. L.R.A.O.N. L.V.A.B. T.F.B. A.-F.B.E.Q. L.S. W.S. A.W. K.C.W. J.R.G. K.M.K. M.C.B. J.G.P.T. A.A.M.W.) ERN GUARD-Heart (E.R.B. P.D.L. A.A.M.W.) and the Department of Cardiology OLVG (J.S.S.G.J.) Amsterdam the Department of Cardiology Isala Heart Centre Zwolle (P.-P.H.M.D.) the Department of Cardiology St. Antonius Hospital Nieuwegein (L.V.A.B.) the Department of Cardiology Flevoziekenhuis Almere (N.R.B.) the Department of Cardiology Radboud University Medical Center Nijmegen (M.A.B.) the Department of Cardiology Cardiovascular Research Institute Maastricht Maastricht University Medical Center Maastricht (K.V.) the Department of Cardiology Amphia Hospital Breda (M.A.) Werkgroep Cardiologische Centra Nederland Utrecht (M.A.) and the Department of Electrophysiology Catharina Hospital Eindhoven (F.A.L.E.B.) — all in the Netherlands the First Department of Medicine-Cardiology University Medical Center Mannheim and the German Center for Cardiovascular Research Partner Site Heidelberg-Mannheim Mannheim (J.K.) Klinik für Innere Medizin III Schwerpunkt Kardiologie und Angiologie Universitätsklinikum Schleswig-Holstein Campus Kiel Kiel (H.B.) the Department of Medicine I Ludwig-Maximilians University Hospital and the German Center for Cardiovascular Research Munich Heart Alliance Munich (S.K.) and the Department of Electrophysiology Heart Center at University of Leipzig Leipzig (S.R.) — all in Germany the Division of Cardiology Section of electrophysiology Emory University Atlanta (M.F.E.-C.) the Cardiology Clinical Academic Group St. George’s University of London and St. George’s University Hospitals NHS Foundation Trust London (E.R.B.) and Office of the Director of Clinical Electrophysiology Research and Lead for Inherited Arrhythmia Specialist Services University College London and

Background:The subcutaneous implantable cardioverter-defibrillator(ICD)was designed to avoid complications related to the transvenous ICD lead by using an entirely extrathoracic *** comparing these systems has been based primarily on observational ***:We conducted a noninferiority trial in which patients with an indication for an ICD but no indication for pacing were assigned to receive a subcutaneous ICD or transvenous *** primary end point was the composite of device-related complications and inappropriate shocks;the noninferiority margin for the upper boundary of the 95%confidence interval for the hazard ratio(subcutaneous ICD *** ICD)was 1.45.A superiority analysis was prespecified if noninferiority was established.

关键词： venous Therapy entirely

The Murmur of Dynamic Subortic Stenosis Recognition Through A Novel Graphic Display

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International Journal of Clinical Medicine 2012年第5期3卷 419-425页

作者： Morton e. Tavel St. Vincent Hospital Indiana University School of Medicine Indianapolis USA

Background: Dynamic subaortic stenosis occurs in differing situations, commonly with hypertrophic cardiomyopathy. Regardless of the underlying cause, the resulting murmurs usually possess a characteristic sound spectral pattern, manifesting a sharp and high frequency peak occurring late in systole, often bearing a striking resemblance to the subaortic Doppler flow pattern. Methods: Murmurs found in thirty one subjects with dynamic subaortic stenosis were analyzed after having been recorded with a novel portable device capable of spectral and waveform sound displays. Results: All subjects manifested characteristic frequency patterns, consisting of high and sharp peaks occurring in late systole. With significant subaortic stenosis (resting subaortic flow velocity > 2 m/sec) this pattern was evident at rest. In the presence of little or no resting subaortic obstruction (ec) this pattern was produced regularly by the Valsalva maneuver. Conclusions: Dynamic subaortic stenosis produces a specific sound spectral pattern that may provide a basis for clinical evaluation, especially in early detection of this disorder and in screening situations.

关键词： Hypertrophic Cardiomyopathy Cardiac Physical Diagnosis Subaortic Stenosis Heart Murmurs Computer Analysis of Heart Sounds

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L'Homme des herbes

法语国家与地区研究 2003年第3期 21-25页

作者： Andre Clair

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TC4钛合金室温滞后回弹研究

稀有金属材料与工程 2017年第11期46卷 3267-3271页

作者：孙帅鄂大辛北京理工大学北京100081

为了探明TC4钛合金室温下的滞后回弹效应,采用万能试验机进行了不同预应变和不同加载速率的滞后回弹实验;为了揭示滞后回弹变化规律的微观机理,采用OM和TeM对微观组织进行表征。结果表明:TC4钛合金经过室温塑性变形卸载后尺寸继续变化,... 详细信息

为了探明TC4钛合金室温下的滞后回弹效应,采用万能试验机进行了不同预应变和不同加载速率的滞后回弹实验;为了揭示滞后回弹变化规律的微观机理,采用OM和TeM对微观组织进行表征。结果表明:TC4钛合金经过室温塑性变形卸载后尺寸继续变化,具有明显的滞后回弹效应。随着预应变以及加载应变率的提高,滞后回弹应变(TDSS)的绝对值均呈现指数增长。组织分析表明,"流线型"光镜组织、位错塞积以及孪晶组织的演变与滞后回弹变化规律正相关。

关键词： TC4钛合金拉伸变形滞后回弹变形孪晶

维普期刊数据库

Multifractal Decomposition of Statistically Self-Similar Sets

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Acta Mathematica Sinica,english Series 2001年第3期17卷 507-516页

作者： Jing Hu YU Wuhan Institute of Physics and Mathematics,The Chinese Academy of Sciences,Wuhan 430071,P.R.China e-mail:ding@wipm.whcnc.ac.cnDi He HU College of Mathematics and Statistics.Wuhan University,Wuhan 430072,P.R.China e-mail:dhhu@*** Wuhan Institute of Physics and Mathematics The Chinese Academy of Sciences Wuhan 430071 P. R. China College of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China

Let K be a statistically self-similar set defined by *** this paper,we construct a random measure ρ which is supported by K and study the multifractal decomposition for K with p. Under such a decomposition,we obtain ... 详细信息

关键词： Statistically self-similar sets Multifractal decomposition Spectrum function

维普期刊数据库

Delayed gastric emptying following pancreaticoduodenectomy:Incidence,risk factors,and healthcare utilization

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World Journal of Gastrointestinal Surgery 2017年第3期9卷 73-81页

作者： Somala Mohammed George Van Buren II Amy Mc elhany eric J Silberfein William e Fisher elkins Pancreas Center Michael E DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030United States

AIM To characterize incidence and risk factors for delayed gastric emptying(DGe) following pancreaticoduodenectomy and examine its implications on healthcare utilization. MeTHODS A prospectively-maintained database was reviewed. DGe was classified using International Study Group of Pancreatic Surgery criteria. Patients who developed DGe and those who did not were compared. ReSULTS Two hundred and seventy-six patients underwent pancreaticoduodenectomy(PD)(> 80% pyloruspreserving, antecolic-reconstruction). DGe developed in 49 patients(17.8%): 5.1% grade B, 3.6% grade C. Demographic, clinical, and operative variables were similar between patients with DGe and those without. DGe patients were more likely to present multiplecomplications(32.6% vs 4.4%, ≥ 3 complications, P erative pancreatic fistula(POPF)(42.9% vs 18.9%, P = 0.001) and intra-abdominal abscess(IAA)(16.3% vs 4.0%, P = 0.012). Patients with DGe had longer hospital stay(median, 12 d vs 7 d, P ere more likely to require transitional care upon discharge(24.5% vs 6.6%, P e analysis, predictors for DGe included POPF [OR = 3.39(1.35-8.52), P = 0.009] and IAA [OR = 1.51(1.03-2.22), P = 0.035].CONCLUSION Although DGe occurred in ents after PD, it was associated with increased healthcare utilization. Patients with POPF and IAA were at risk for DGe. Anticipating DGe can help individualize care and allocate resources to high-risk patients.

关键词： Delayed gastric emptying Pancreaticoduodenectomy Post-operative pancreatic fistula