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国际医学放射学杂志 2015年第4期 399-400页

作者： e.savarino V.savarino M.Fox G.D.Leo M.Furnari e.Marabotto 刘春明 Division of Gastroenterology Department of SurgicalOncological and Gastroenterological Sciences

摘要目的前瞻性地评估乳果糖氢呼气试验(LHBT)和MRI测量健康个体口腔-盲肠通过时间(OCTT)的一致性。方法所有志愿者均行空腹及摄入乳果糖(10 g/125 m L)后的

关键词：乳果糖 MRI测量呼气试验扫描序列呼气相末端回肠权序列分割法四分位间距团注

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超声引导下经皮注射曲安奈德对隆胸和乳房再造术后病人乳房纤维包膜挛缩的治疗

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国际医学放射学杂志 2011年第3期 296-296页

作者： L.M.Sconfienza C.Murolo S.Callegari M.Calabrese e.savarino P.Santi 郭丽君 Unità di Radiologia IRCCS Policlinico San DonatoVia Morandi 3020097 San Donato MilaneseMilanoItaly

目的评价隆胸/乳房再造术后病人经超声(US)引导治疗乳房纤维包膜挛缩(CC)的效果。材料与方法 25例4级CC病人经US引导下植入体周围注射曲安奈德治疗。US

关键词：超声引导包膜萎缩乳腺曲安奈德

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Alginate controls heartburn in patients with erosive and nonerosive reflux disease

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World Journal of Gastroenterology 2012年第32期18卷 4371-4378页

作者： edoardo savarino Nicola de Bortoli Patrizia Zentilin Irene Martinucci Luca Bruzzone Manuele Furnari Santino Marchi Vincenzo savarino Division of Gastroenterology Department of Internal MedicineUniversity of Genoa16126 GenoaItaly Division of Gastroenterology Department of SurgicalOncological and Gastroenterological SciencesUniversity of Padua35128 PaduaItaly Division of Gastroenterology Department of Internal MedicineUniversity of Pisa56100 PisaItaly

AIM:To evaluate the effect of a novel alginate-based compound,Faringel,in modifying reflux characteristics and controlling ***:In this prospective,open-label study,40 patients reporting heartburn and regurgitation with proven reflux disease(i.e.,positive impedance-pH test/evidence of erosive esophagitis at upper endoscopy) underwent 2 h impedance-pH testing after eating a refluxogenic *** were studied for 1 h under basal conditions and 1 h after taking 10 mL *** both sessions,measurements were obtained in right lateral and supine decubitus *** also completed a validated questionnaire consisting of a 2-item 5-point(0-4) Likert scale and a 10-cm visual analogue scale(VAS) in order to evaluate the efficacy of Faringel in symptom *** of the treatment was assessed using a 6-point Likert scale ranging from very good(1) to very poor(6).ReSULTS:Faringel decreased significantly(P e right lateral and supine decubitus positions,esophageal acid exposure time [median 10(25th75th percentil 6-16) vs 5.8(4-10) and 16(11-19) vs 7.5(5-11),respectively] and acid refluxes [5(3-8) vs 1(1-1) and 6(4-8) vs 2(1-2),respectively],but increased significantly(P e number of nonacid reflux events compared with baseline [2(1-3)vs 3(2-5) and 3(2-4) vs 6(3-8),respectively].Percentage of proximal migration decreased in both decubitus positions(60% vs 32% and 64% vs 35%,respectively;P el was significantly effective in controlling heartburn,based on both the Likert scale [3.1(range 1-4) vs 0.9(0-2);P e [7.1(3-9.8) vs 2(0.1-4.8);P ess success against regurgitation,based on both the Likert scale [2.6(1-4) vs 2.2(1-4);P = not significant(NS)] and VAS score [5.6(2-9.6) vs 3.9(1-8.8);P = NS].Overall,the tolerability of Faringel was very good 5(2-6),with only two patients reporting modest adverse events(i.e.,nausea and bloating).CONCLUSION:Our findings demonstrate t

关键词：反流糜烂控制海藻酸钠患者胃暴露时间 VAS

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Outcome of nonerosive gastro-esophageal reflux disease patients with pathological acid exposure

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World Journal of Gastroenterology 2009年第45期15卷 5700-5705页

作者： Fabio Pace Stefano Pallotta Gianpiero Manes Annalisa de Leone Patrizia Zentilin Luigi Russo Vincenzo savarino Matteo Neri enzo Grossi Rosario Cuomo Division of Gastroenterology Department of Clinical Sciences "L. Sacco" University HospitalVia G. B. Grassi 74-20157 MilanoItaly Gastroenterology Unit D.I.M.I University of GenovaViale Benedetto XV 6 16132 Genova Italy Gastroenterology Unit Dip. Med. Clin e Sper. AOU Federico ⅡVia S. Pansini 5 80131 Napoli Italy Department of Medicine and Aging Sciences and Ce.S.I "G. D'Annunzio" University & FoundationVia dei Vestini 31 66013 Chieti Italy Department of Medical Bracco Imaging SpAVia XXV Aprile 4 20097 San Donato Milanese Milano Italy

AIM: To assess the management and outcome of nonerosive gastro-esophageal reflux disease (NeRD) patients who were identified retrospectively, after a 5-year ***: We included patients with gastro-esophageal reflux disease (GeRD) symptoms who had a negative endoscopy result and pathological 24-h esophageal pH-monitoring while off therapy. We interviewed them after an average period of 5 years (range 3.5-7 years) by means of a structured questionnaire to assess presence of GeRD symptoms, related therapy, updated en-doscopic data and other features. We assessed predictors of esophagitis development by means of univariate and multivariate statistical ***: 260 patients (137 women) were included. Predominant GeRD symptoms were heartburn andregurgitation in 103/260 (40%). 70% received a maintenance treatment, which was proton pump inhibitor (PPI) in 55% of cases. An average number of 1.5 symptomatic relapses per patient/year of follow-up were observed. A progression to erosive gastro-esophageal reflux disease (eRD) was found in 58/193 (30.0%) of patients undergoing repeat endoscopy; 72% of these were Los Angeles grade A-B. CONCLUSION: This study shows that progression to eRD occurs in about 5% of NeRD cases per year, despite therapy. Only two factors consistently and independently influence progression: smoking and absence of PPI therapy.

关键词：病理性食管胃病反流患者疾病质子泵抑制剂 pH监测

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