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Gastrointestinal disorders associated with migraine: A comprehensive review

World Journal of Gastroenterology 2016年第36期22卷 8149-8160页

作者： Carlos R Cámara-Lemarroy rene Rodriguez-Gutierrez Roberto Monreal-Robles Alejandro Marfil-Rivera Servicio de Neurología Hospital Universitario "Dr. José E. González" Universidad Autónoma de Nuevo León Servicio de endocrinología Hospital Universitario "Dr. José E. González" Universidad Autónoma de Nuevo León Servicio de Gastroenterología Hospital Universitario "Dr. José E. González" Universidad Autónoma de Nuevo León

Migraine is a recurrent and commonly disabling primary headache disorder that affects over 17% of women and 5%-8% of men. Migraine susceptibility is multifactorial with genetic, hormonal and environmental factors all playing an important role. The physiopathology of migraine is complex and still not fully understood. Many different neuropeptides, neurotransmitters and brain pathways have been implicated. In connection with the myriad mechanisms and pathways implicated in migraine, a variety of multisystemic comorbidities(e.g., cardiovascular, psychiatric and other neurological conditions) have been found to be closely associated with migraine. Recent reports demonstrate an increased frequency of gastrointestinal(GI) disorders in patients with migraine compared with the general population. Helicobacter pylori infection, irritable bowel syndrome, gastroparesis, hepatobiliary disorders, celiac disease and alterations in the microbiota have been linked to the occurrence of migraine. Several mechanisms involving the gut-brain axis, such as a chronic inflammatory response with inflammatory and vasoactive mediators passing to the circulatory system, intestinal microbiota modulation of the enteric immunological milieu and dysfunction of the autonomic and enteric nervous system, have been postulated to explain these associations. However, the precise mechanisms and pathways related to the gut-brain axis in migraine need to be fully elucidated. In this review, we survey the available literature linking migraine with GI disorders. We discuss the possible physiopathological mechanisms, and clinical implications as well as several future areas of interest for research.

关键词： Migraine Headache Microbiota Review Gastrointestinal diseases

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Rapid preparation of carbon-supported ruthenium nanoparticles by magnetic induction heating for efficient hydrogen evolution reaction in both acidic and alkalinemedia

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SusMat 2022年第3期2卷 335-346页

作者： Qiming Liu Bingzhang Lu Forrest Nichols Jeffrey Ko rene Mercado Frank Bridges Shaowei Chen Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCaliforniaUSA Department of Physics University of CaliforniaSanta CruzCaliforniaUSA

Ruthenium has been hailed as a competitive alternative for platinum toward hydrogen evolution reaction(HeR),a critical process in electrochemical water *** this study,we successfully prepare metallic Ru nanoparticles supported on carbon paper by utilizing a novel magnetic induction heating(MIH)*** samples are obtained within seconds,featuring a Cl-enriched surface that is unattainable via conventional thermal *** best sample within the series shows a remarkable HeR activity in both acidic and alkaline media with an overpotential of only-23 and-12 mV to reach the current density of 10 mA/cm^(2),highly comparable to that of the Pt/C *** studies based on density functional theory show that the excellent electrocatalytic activity is accounted by the surface metal-Cl species that facilitate charge transfer and downshift the d-band *** from this study highlight the unique advantages of MIH in rapid sample preparation,where residual anion ligands play a critical role in manipulating the electronic properties of the metal surfaces and the eventual electrocatalytic activity.

关键词： Cl-enriched surface density functional theory hydrogen evolution reaction magnetic induction heating ruthenium

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Direct quantification of topological protection in symmetry-protected photonic edge states at telecom wavelengths

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Light(Science & Applications) 2021年第1期10卷 5-11页

作者： Sonakshi Arora Thomas Bauer rene Barczyk ewold Verhagen L.Kuipers Kavli Institute of Nanoscience Delft University of Technology2600 GA DelftThe Netherlands Center for Nanophotonics AMOLFScience Park 1041098 XG AmsterdamThe Netherlands

Topological on-chip photonics based on tailored photonic crystals(PhCs)that emulate quantum valley-Hall effeas has recently gained widespread interest owing to its promise of robust unidirectional transport of classical and quantum *** present a direct quantitative evaluation of topological photonic edge eigenstates and their transport properties in the telecom wavelength range using phase-resolved near-field optical *** visualizing the detailed sub-wavelength structure of these modes propagating along the interface between two topologically non-trivial mirror-symmetric lattices allows us to map their dispersion relation and differentiate between the contributions of several higher-order Bloch *** probing of forward-and backward-propagating modes as defined by their phase velocities enables direct quantification of topological *** near-field propagation in controlled defects allows us to extract upper limits of topological protection in on-chip photonic systems in comparison with conventional PhC *** find that protected edge states are two orders of magnitude more robust than modes of conventional PhC *** direct experimental quantification of topological robustness comprises a crucial step toward the application of topologically protected guiding in integrated photonics,allowing for unprecedented error-free photonic quantum networks。

关键词： protected quantum symmetry

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Treatment of colonic varices and gastrointestinal bleeding by recanalization and stenting of splenic-vein-thrombosis:A case report and literature review

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World Journal of Gastroenterology 2023年第24期29卷 3922-3931页

作者： Lisa-Michaela Füssel rene Müller-Wille Patrick Dinkhauser Walter Schauer Harald Hofer Department of Internal Medicine Ⅰ Gastroenterology and HepatologyKlinikum Wels-GrieskirchenWels 4600Austria Department of Radiology Klinikum Wels-GrieskirchenWels 4600Austria Department of Abdominal Surgery Klinikum Wels-GrieskirchenWels 4600Austria

BACKGROUND Splenic vein thrombosis is a known complication of *** can lead to increased blood flow through mesenteric *** segmental hypertension may result in the development of colonic varices(CV)with a high risk of severe gastrointestinal *** clear guidelines for treatment are lacking,splenectomy or splenic artery embolization are often used to treat *** vein stenting has been shown to be a safe *** SUMMARY A 45-year-old female patient was admitted due to recurrent gastrointestinal *** was anemic with a hemoglobin of 8.0 g/*** a source of bleeding,CV were *** tomography scans revealed thrombotic occlusion of the splenic vein,presumably as a result of a severe acute pancreatitis 8 years *** a selective angiography,a dilated mesenterial collateral leading from the spleen to enlarged vessels in the right colonic flexure and draining into the superior mesenteric vein could be *** hepatic venous pressure gradient was within normal *** an interdisciplinary board,transhepatic recanalization of the splenic vein via balloon dilatation and consecutive stenting,as well as coiling of the aberrant veins was discussed and successfully *** evaluation revealed complete regression of CV and splenomegaly as well as normalization of the red blood cell count during *** Recanalization and stenting of splenic vein thrombosis might be considered in patients with gastrointestinal bleeding due to ***,a multidisciplinary approach with a thorough workup and discussion of individualized therapeutic strategies is crucial in these difficult to treat patients.

关键词： Pancreatitis-induced splenic vein thrombosis Gastrointestinal hemorrhage Colonic varices Splenic vein stenting Segmental/sinistral hypertension Case report

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Modelling potential distribution of a pine bark beetle in Mexican temperate forests using forecast data and spatial analysis tools

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Journal of Forestry Research 2020年第2期31卷 649-659页

作者： Antonio Gonzalez-Hernandez rene Morales-Villafana Martin enrique Romero-Sanchez Brenda Islas-Trejo Ramiro Perez-Miranda Conservation and enhancement of Forest ecosystems National Institute of ForestryAgriculture and Livestock ResearchProgreso 504010 Coyoacan Mexico CityMexico Geography Department The National Autonomous University of MexicoUniversidad 300004010 Coyoacan Mexico CityMexico

Accurate and reliable predictions of pest species distributions in forest ecosystems are urgently needed by forest managers to develop management plans and monitor new areas of potential ***-only species distribution models are commonly used in these *** maximum entropy algorithm(Maxent)has gained popularity for modelling species ***,Maxent was used to model the spatial distribution of the Mexican pine bark beetle(Dendroctonus mexicanus)in a daily fashion by using forecast data from the Weather Research and Forecasting *** study aimed to exploit freely available geographic and environmental data and software and thus provide a pathway to overcome the lack of costly data and technical guidance that are a challenge to implementing national monitoring and management strategies in developing *** results showed overall agreement values between 60 and 87%.The results of this research can be used for *** monitoring and management and may aid as a model to monitor similar species.

关键词： Spatial analysis Dendroctonus mexicanus Geodatabases Maxent Forest modelling

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丹酰-L-苯丙氨酸和L-苯丙氨酸对小牛肠碱性磷酸酶抑制作用动力学的比较性研究

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光谱学与光谱分析 2009年第10期29卷 2820-2823页

作者：李丽娜吴玉清 rene Buchet 吉林大学超分子结构与材料国家重点实验室吉林长春130012 Universite de Lyon VilleurbanneF-69622FranceCNRS UMR 5246 ICBMSViileurbanneF-69622France

利用紫外分光光度法揭示了丹酰-L-苯丙氨酸对小牛肠碱性磷酸酶的选择性抑制作用,并比较性地研究了丹酰-L-苯丙氨酸和L-苯丙氨酸对小牛肠碱性磷酸酶的动力学抑制过程。结果表明在37℃和碱性磷酸酶工作的最佳pH值(pH10.4)的条件下,丹酰-L... 详细信息

利用紫外分光光度法揭示了丹酰-L-苯丙氨酸对小牛肠碱性磷酸酶的选择性抑制作用,并比较性地研究了丹酰-L-苯丙氨酸和L-苯丙氨酸对小牛肠碱性磷酸酶的动力学抑制过程。结果表明在37℃和碱性磷酸酶工作的最佳pH值(pH10.4)的条件下,丹酰-L-苯丙氨酸与L-苯丙氨酸类似,能够有效抑制小牛肠碱性磷酸酶的活性;利用双倒数曲线拟合,判定丹酰-L-苯丙氨酸与L-苯丙氨酸的抑制类型均为反竞争性抑制,两者的抑制常数Ki均为mmol级。对丹酰-L-苯丙氨酸抑制小牛肠碱性磷酸酶的作用研究,不仅有助于进一步阐明L-苯丙氨酸对组织特异性碱性磷酸酶的选择性抑制机理,而且丹酰基团的存在也为荧光标定碱性磷酸酶的特效抑制剂提供了可能。

关键词：碱性磷酸酶丹酰 L-苯丙氨酸抑制反竞争性

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Dynamical Analysis of A Class of Rotation-theta-equation

Dynamical Analysis of A Class of Rotation-theta-equation

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作者： N'gbo Paul-rene Marie N'GBO 浙江师范大学

学位级别：硕士

In this dissertation,we analyze the rotation-θ equation,which is the theta equation augmented with the Coriolis effect,induced by the earth *** Rotation-θ equation is a generalization of a family of models(including the Rotation-CamassaHolm equation and the Rotation-Degasperis-Procesi).Our study is conducted via the bifurcation method and qualitative theory of dynamical *** existence of not only smooth solitary wave solution,periodic wave solution,but also peakon and periodic peakon solutions are given.

关键词： Rotation-θ-equation solitary wave solution periodic wave solution peakon solution periodic peakon solution

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Harnessing the synergy of perfusable muscle flap matrix and adipose-derived stem cells for prevascularization and macrophage polarization to reconstruct volumetric muscle loss

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Bioactive Materials 2023年第4期22卷 588-614页

作者： Qixu Zhang Yulun Chiu Youbai Chen Yewen Wu Lina W.Dunne.rene D.Largo edward I.Chang David M.Adelman Mark V.Schaverien Charles e.Butler Department of Plastic Surgery The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Department of Plastic Surgery Chinese PLA General HospitalBeijing100853China

Muscle flaps must have a strong vascular network to support a large tissue volume and ensure successful *** developed porcine stomach musculofascial flap matrix(PDSF)comprising extracellular matrix(eCM)and intact *** had a dominant vascular pedicle,microcirculatory vessels,a nerve network,well-retained 3-dimensional(3D)nanofibrous eCM structures,and no allo-or ***-depth proteomic analysis demonstrated that PDSF was composed of core matrisome proteins(e.g.,collagens,glycoproteins,proteoglycans,and eCM regulators)that,as shown by Gene Ontology term enrichment analysis,are functionally related to musculofascial biological ***,PDSF􀀀human adipose-derived stem cell(hASC)synergy not only induced monocytes towards IL-10􀀀producing M2 macrophage polarization through the enhancement of hASCs’paracrine effect but also promoted the proliferation and interconnection of both human skeletal muscle myoblasts(HSMMs)and human umbilical vein endothelial cells(HUVeCs)in static triculture ***,PDSF was successfully prevascularized through a dynamic perfusion coculture of hASCs and HUVeCs,which integrated with PDSF and induced the maturation of vascular networks in *** a xenotransplantation model,PDSF demonstrated myoconductive and immunomodulatory properties associated with the predominance of M2 macrophages and regulatory T *** a volumetric muscle loss(VML)model,prevascularized PDSF augmented neovascularization and constructive remodeling,which was characterized by the predominant infiltration of M2 macrophages and significant musculofascial tissue *** results indicate that hASCs’integration with PDSF enhances the cells’dual function in immunomodulation and *** in part to this PDSF-hASC synergy,our platform shows promise for vascularized muscle flap engineering for VML reconstruction.

关键词： Muscle flap fabrication extracellular matrix Decellularization Vascularization Macrophage polarization Volumetric muscle loss

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Noise Reduction in Industry Based on Virtual Instrumentation

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Computers, Materials & Continua 2021年第10期69卷 1073-1096页

作者： Radek Martinek rene Jaros Jan Baros Lukas Danys Aleksandra Kawala-Sterniuk Jan Nedoma Zdenek Machacek Jiri Koziorek Faculty of electrical engineering and Computer Science Department of Cybernetics and Biomedical EngineeringVSB–Technical University of Ostrava70800Ostrava-PorubaCzechia Faculty of electrical engineering Automatic Control and InformaticsOpole University of TechnologyOpolePoland Faculty of electrical engineering and Computer Science Department of TelecommunicationsVSB–Technical University of Ostrava70800Ostrava-PorubaCzechia

This paper discusses the reduction of background noise in an industrial environment to extend *** the Industry 4.0 era,the mass development of voice control(speech recognition)in various industrial applications is possible,especially as related to augmented reality(such as hands-free control via voice commands).As Industry 4.0 relies heavily on radiofrequency technologies,some brief insight into this problem is provided,including the Internet of things(IoT)and 5G *** study was carried out in cooperation with the industrial partner Brose CZ spol.s.r.o.,where sound recordings were made to produce a *** experimental environment comprised three workplaces with background noise above 100 dB,consisting of a laser/magnetic welder and a press.A virtual device was developed from a given dataset in order to test selected commands from a commercial speech recognizer from *** tested a hybrid algorithm for noise reduction and its impact on voice command recognition *** virtual devices,the study was carried out on large speakers with 20 participants(10 men and 10 women).The experiments included a large number of repetitions(100 times for each command under different noise conditions).Statistical results confirmed the efficiency of the tested *** welding environment efficiency was 27%before applied filtering,76%using the least mean square(LMS)algorithm,and 79%using LMS+independent component analysis(ICA).Magnetic welding environment efficiency was 24%before applied filtering,70%with LMS,and 75%with LMS+*** workplace environment efficiency showed no success before applied filtering,was 52%with LMS,and was 54%with LMS+ICA.

关键词： 5G hybrid algorithms signal processing speech recognition

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A Novel Technique for Detecting Various Thyroid Diseases Using Deep Learning

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Intelligent Automation & Soft Computing 2023年第1期35卷 199-214页

作者： Soma Prathibha Deepak Dahiya C.R.rene Robin Cherukuru Venkata Nishkala S.Swedha Department of Information Technology Sri Sai Ram Engineering CollegeChennai600044India College of Computer and Information Sciences(CCIS) Majmaah UniversityMajmaah11952Kingdom of Saudi Arabia Department of Computer Science and engineering Sri Sai Ram Engineering CollegeChennai602109India Associate Solutions engineer PegasystemsChennai600044India Systems engineer Infosys Ltd.Chennai600119India

Thyroid disease is a medical condition caused due to the excess release of thyroid *** is released by the thyroid gland which is in front of the neck just below the *** pictures such as X-rays and CT scans can,however,be used to diagnose *** this proposed model,Deep Learning technology is used to detect thyroid diseases.A Convolution Neural Network(CNN)based modified ResNet architecture is employed to detectfive different types of thyroid diseases namely *** *** *** cancer *** *** *** the proposed work,the training method is enhanced using dual optimizers for better accuracy and ***,a Python library that is high level runs as the main part of the Tensor Flow *** is used in the proposed work to implement deep learning *** comparative analysis of the proposed model and the existing work helps to show that there is a great improvement in the performance metrics in classifying the type of thyroid *** applying Adam and SGD(Stochastic Gradient Descent)optimizers in the training phase of the proposed model it was identified that these increase the operational efficiency of the modified ResNet *** retraining the model with SGD,the modified ResNet provides more accuracy of about 97%whereas the basic ResNet architecture attains 94%accuracy.A web-based frame-work is also developed which yields the type of thyroid disease as the output for a given input scanned image of the system.

关键词： Thyroid deep learning convolution neural network modified ResNet dual optimizer

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