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Reproductive fluids,used for the in vitro production of pig embryos,result in healthy offspring and avoid aberrant placental expression of PeG3 and LUM

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Journal of Animal science and Biotechnology 2021年第3期12卷 972-983页

作者： e.parís-ol.er s.Navarro-serna C.soriano-Úbeda J.s.Lopes C.Matás s.Ruiz R.Latorre O.López-Albors R.Romar s.Cánovas P.Coy Department of Physiology-Faculty of Veterinary University of Murcia-Campus Mare Nostrum30100 MurciaSpain Institute for Biomedical Research of Murcia IMIB-ArrixacaMurciaSpain Department of Anatomy and Comparartive Pathology Faculty of Veterinary MedicineUniversity of Murcia-Campus Mare Nostrum30100 MurciaSpain

Background:In vitro embryo production(IVP)and embryo transfer(eT)are two very common assisted reproductive technologies(ART)in human and ***,in pig,the combination of either procedures,or even their use separately,is still considered suboptimal due to the low efficiency of IVP plus the difficulty of performing eT in the long and contorted uterus of the *** addition,the potential impact of these two ART on the health of the offspring is *** investigated here if the use of a modified IVP system,with natural reproductive fluids(RF)as supplements to the culture media,combined with a minimally invasive surgery to perform eT,affects the output of the own IVP system as well as the reproductive performance of the mother and placental molecular ***:The blastocyst rates obtained by both in vitro systems,conventional(C-IVP)and modified(RF-IVP),were *** and farrowing rates were also ***,when compared to in vivo control(artificial insemination,AI),litter sizes of both IVP groups were lower,while placental efficiency was higher in AI than in *** expression studies revealed aberrant expression levels for PeG3 and LUM in placental tissue for C-IVP group when compared to AI,but not for RF-IVP ***:The use of reproductive fluids as additives for the culture media in pig IVP does not improve reproductive performance of recipient mothers but could mitigate the impact of artificial procedures in the offspring.

关键词： Assisted reproductive technologies embryo transfer In vitro embryo production Placenta Reproductive fluids

Metal-organic frameworks (MOFs) in aqueous batteries (ABs):unlocking potential through innovative materials design

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science China Chemistry 2025年

作者： Bo Han erhai Hu Bei-er Jia Ziyang Liu shuen Tso Afriyanti sumboja Ivandini T.Anggraningrum Anne Zulfia syahrial Qingyu Yan sCARCe Laboratory Energy Research Institute NTU (ERIN) Nanyang Technological University school of Materials science and engineering Nanyang Technological University Material science and engineering Research Group Faculty of Mechanical and Aerospace Engineering Institut Teknologi Bandung Department of Chemistry University of Indonesia Metallurgical & Materials engineering Department Fakultas Teknik Universitas Indonesia

Metal-organic frameworks (MOFs) represent a revolutionary class of materials in the field of energy storage.particularly for aqueous batteries (ABs).Distinguished by their large surface area,tuneable porosity,and adaptable chemical activity,MOFs offer significant advantages over conventional materials in battery *** article provides a thorough analysis of the crucial role that MOFs play in improving the efficiency of *** includes a concise review of the current research progress,emphasizing the fundamental processes by which MOFs enhance electrochemical ***,the review examines the synthesis and design strategies for the structure of MOFs to maximize ion transport,improve conductivity,and enhance *** structural advantages,chemical versatility,stability,durability and functionalization potential of MOFs are comprehensively ***,we explore the distinct advantages of MOFs in overcoming common challenges encountered in ABs,such as declining capacity,inadequate cycling stability,and limited energy *** paper also highlights the future research directions needed to fully harness their *** goal is to develop a fundamental understanding and stimulate further progress in the use of MOFs for advanced energy storage solutions.

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKolAeI H.GHANDVAR e.JUMAeV s.KHATIR T.CUONG-Le school of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and science Center for engineering Application and Technology solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANsYs, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

关键词： Kinetic energy

extracorporeal liver support in severe alcoholic hepatitis

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World Journal of Gastroenterology 2014年第25期20卷 8011-8017页

作者： Albert parés Antoni Mas Liver Unit Hospital ClínicUniversity of BarcelonaIDIBAPSCIBERehd08036 BarcelonaSpain

The severity of alcoholic hepatitis(AH) which may coexist with cirrhosis varies greatly, from asymptomatic forms which are detected in alcoholic patients without any sign of liver disease, except laboratory abnormalities, to severe forms characterised by deep jaundice, ascites, hepatic encephalopathy and low prothrombin index. In hospitalized patients the mortality could be as high as 75%. The elevated number of therapeutic proposals reported for more than forty years reveals the lack of efficacy of a particular modality. even in the most favorable trials, the survival is already very poor and in some cases related to the development of renal failure or hepatorenal syndrome. There are some motivating reports concerning albumin dialysis as a support treatment in patients with severe AH, either alone or in combination with other pharmacological therapies. The favorable effects of albumin dialysis in patients with severe AH suggest that the procedure used alone or in combination with other therapies may have a role in this clinical condition. This will be.particularly relevant to offer an alternative therapy in these patients, thus being a potential bridge to recovery or to be listed for liver transplantation.

关键词： Acute alcoholic hepatitis Alcoholic liver disease extracorporeal liver support Molecular Adsorbents Recirculating system Hepatorenal syndrome Treatment of alcoholic hepatitis

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the.parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the.parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these.parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged fromells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-eM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating