检索结果-南通市图书馆

Animal models of hepatitis e infection: Advances and challenges

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze Xiang Xiang-Lin He Chuan-Wu Zhu Jia-Jia Yang Lan Huang Chun Jiang Jian Wu Chinese Consortium for the Study of Hepatitis e(CCSHe) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

Hepatitis e virus(hev)is one of the leading causes of acute viral hepatitis worldwide.Although most of hev infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and jaundice.hev infection may become chronic in immunosuppressed individuals.In addition,hev infection can also cause several extrahepatic manifestations.hev exists in a wide range of hosts in nature and can be transmitted across species.Hence,animals susceptible to hev can be used as models.The establishment of animal models is of great significance for studying hev transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis e.This review summarized the animal models of hev,including pigs,monkeys,rabbits,mice,rats,and other animals.For each animal species,we provided a concise summary of the hev genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of hev infection.The advantages and disadvantages of these animal models were also emphasized.This review offers new perspectives to enhance the current understanding of the research landscape surrounding hev animal models.

关键词： Hepatitis e virus Animal models Pathogenesis Prevention Treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Breeding for FHB Resistance via Fusarium Damaged Kernels and Deoxynivalenol Accumulation as Well as Inoculation Methods in Winter Wheat

引用

Agricultural Sciences 2015年第9期6卷 970-1002页

作者： Akos Mesterházy Szabolcs Lehoczki-Krsjak Mónika Varga ágnes Szabó-hevér Beata Tóth Marc Lemmens Cereal Research non-Profit Ltd Szeged Hungary University of Life Sciences-BOKU IFA Tulln Austria

FHB is one of the most destructive diseases of wheat. Resistance testing depends strongly on inoculation methods, and on measured traits. Therefore a four-year (2009-2012) study was performed using spray inoculation + polyethylene (Pe) bag cover, spray inoculation + mist irrigation, and spawn method supported by mist irrigation on 40 genotypes, 20 from Hungary and 20 from IFA Tulln, Austria. each year four isolates were used in artificial inoculations except the spawn method where stalk debris served the inoculum. Visual Fusarium head blight (FHB) scores, Fusarium damaged kernels (FDK) and deoxynivalenol (DOn) contamination were checked. 7680 FHB and FDK, as well as 3840 DOn analyses served as the background for the statistical evaluation. The most reliable method used was the spray + polyethylene (Pe) bag;the other two were significantly poorer being valid for all traits. The FHB scores were the least reliable, whereas the FDK was much more consequent and the DOn gave the best results. The FDK gave much better predictions for DOn contamination than FHB. The cultivars responses correlated well at different epidemic severities. The presence of the kernel resistance was confirmed and a new trait as extra kernel susceptibility was described. Presence of DOn resistance was confirmed again, and extra DOn susceptibility was described as a new trait. DOn performance varied on the most sensitive cultivar between 0.32 and 143 mg/kg (mean 17.52 mg/kg) and on the most resistant genotype between 0.00 and 18.19 mg/kg (mean 1.87 mg/kg). Correlations between stability and resistance level are r = 0.85 for FHB, 0.78 for FDK, and 0.88 for DOn, all at a significance level of p = 0.001. The very close correlation between FDK and DOn contamination (r = 0.81, p = 0.001) proves that control of DOn contamination needs appropriate resistance. In the breeding program evaluation of FDK is the most important, and then DOn will be decided. Variety registration must be updated;otherwise no improvement on the field will occur.

关键词： FHB Resistance Kernel Resistance Kernel Susceptibility DOn Resistance DOn Susceptibility Inoculation Techniques Breeding Aspects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece

引用

World Journal of Gastroenterology 2010年第2期16卷 225-231页

作者： Paraskevi Mina Sarah P Georgiadou Christos Rizos George n Dalekos eirini I Rigopoulou Department of Medicine and Research Laboratory of Internal Medicine Medical School University of Thessaly41110 LarissaThessalyGreece Research Group of Investigational Medicine Institute of Biomedical Research and TechnologyCentre for Research and Technology-Thessaly(CE.RE.TE.TH)41222 LarissaThessalyGreece RE.TE.TH)41222 LarissaThessalyGreece Research Group of Investigational Medicine Institute of Biomedical Research and TechnologyCentre for Research and Technology-Thessaly(CE.RE.TE.TH)41222 LarissaThessalyGreece

AIM:To assess the hepatitis B virus(HBV)-DnA and the prevalence of occult HBV infection in end-stage renal failure(eSRF)patients from Central Greece. MeTHODS:Sera from 366 eSRF patients attending five out of six dialysis units from Central Greece were investigated for HBV-DnA by real-time polymerase chain reaction.Only serum samples with repeatedly detectable HBV-DnA were considered positive.IgG antibodies to hepatitis C virus(anti-HCV)were tested by a third generation enzyme linked immunosorbent assay(eLISA),while IgG antibodies to hepatitis e virus (anti-hev)were tested by two commercially available eLISAs.ReSULTS:HBV-DnA was detected in 15/366 patient (4.1%)and HBsAg in 20/366(5.5%).The prevalenc of occult HBV infection was 0.9%(3/346 HBsAg negative patients).Occult HBV was not associate with a specific marker of HBV infection or anti-HCV o anti-hev reactivity.There was no significant differenc in HBV-DnA titres,demographic and biochemica features,between patients with occult HBV infectio and those with HBsAg-positive chronic HBV infection. COnCLUSIOn:In central Greece,4%of eSRF patient had detectable HBV-DnA,though in this setting,th prevalence of occult HBV seems to be very low(0.9%).

关键词： Hepatitis B virus-DnA Occult hepatitis B virus infection Haemodialysis Hepatitis B Real-time polymerase chain reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

功率分流式混动汽车发动机转矩故障诊断及容错控制

引用

机械设计与制造工程 2020年第5期49卷 97-101页

作者：周文太王晨赵治国王博于海生张彤科力远混合动力技术有限公司上海201501 同济大学汽车学院上海201804 上海理工大学汽车工程研究所上海200093

发动机转矩不足、不出转矩等发动机转矩故障可造成车辆驱动能力急剧恶化,有必要对其实施诊断并妥善处理。针对功率分流式混合动力汽车,提出基于行星齿轮转矩平衡数学模型的诊断方法,并提出了分级容错控制策略,最后对诊断及容错控制策略... 详细信息

发动机转矩不足、不出转矩等发动机转矩故障可造成车辆驱动能力急剧恶化,有必要对其实施诊断并妥善处理。针对功率分流式混合动力汽车,提出基于行星齿轮转矩平衡数学模型的诊断方法,并提出了分级容错控制策略,最后对诊断及容错控制策略进行了仿真验证。结果表明,该控制策略能够在预期的时间内诊断出故障,并能够进行妥善处理。

关键词：功率分流混合动力故障诊断容错控制发动机转矩故障

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于中药整合药理学平台的泽泻汤治疗高血压作用机制研究

引用

亚太传统医药 2020年第5期16卷 138-141页

作者：吴萍张震何益锋彭学清刘义钊张涛周覃郭爱枝常德市第一人民医院湖南常德415700

目的:利用中药整合药理学探讨经典名方泽泻汤治疗高血压的分子机制。方法:借助整合药理学平台V1.0版软件的分析功能,构建经典名方泽泻汤治疗高血压的多维网络,探索泽泻汤治疗高血压潜在的分子机制。结果:泽泻汤对高血压的干预作用可能... 详细信息

目的:利用中药整合药理学探讨经典名方泽泻汤治疗高血压的分子机制。方法:借助整合药理学平台V1.0版软件的分析功能,构建经典名方泽泻汤治疗高血压的多维网络,探索泽泻汤治疗高血压潜在的分子机制。结果:泽泻汤对高血压的干预作用可能与神经系统、循环系统、神经退行性疾病、内分泌系统、神经营养因子信号通路等有关。结论:该研究为经典名方泽泻汤治疗高血压的作用机制提供了理论依据。

关键词：高血压泽泻汤整合药理学平台作用机制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hepatitis e Virus Infection in HIV Positive ART naive and experienced Individuals in nigeria

引用

World Journal of AIDS 2013年第3期3卷 216-220页

作者： Georgina n. Odaibo David O. Olaleye Department of Virology College of Medicine University of Ibadan Ibadan Nigeria

Background: Studies have shown Hepatitis e Virus to be a causative agent of acute and chronic hepatitis in severely immunocompromised patients such as organ transplant recipients and person with HIV infection. This study was designed to determine the burden of hev infection among HIV positive individuals in nigeria and the effect of HIV treatment on the burden of hev infection among this group of patients. Methods: Aliquot of plasma samples collected for laboratory investigations such as CD4 enumeration, blood chemistry (AST, ALT, Creatine, Urea) were used to determine the presence of hev IgG and IgM antibodies using commercially available eLISA. Samples analysed in the study were collected from 180 HIV positive individuals (90 ART naive and 90 ART experienced) attending the ART clinic at the University College Hospital, Ibadan, nigeria. Results: Twenty two of the 180 (12.2%) samples were positive for either hev IgG (20/180) or IgM (2/180). The rate of hev IgG was higher among ART naive individuals and the two IgM positive persons were ART naive. There was no significant difference in the mean CD4 count and mean ALT between hev seronegative and seropositive individuals (P = 0.8 and 0.2 respectively). Conclusions: The results of this study suggest the need to test for hev infection in HIV positive individuals for the early diagnosis and proper management since hev is known to be fulminant in the presence of underlying liver disease that is common among HIV infected persons. In addition, the use of ART may reduce the incidence of hev infection in HIV positive persons.

关键词： hev Infection HIV Positive ART nigeria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

eV和hev的爪形离合器变速器

引用

汽车零部件 2012年第10期 25-26页

作者： Markus Schnablerhofer f&e

电动汽车是在减少对化石燃料依赖和环境污染的同时，确保人类移动灵活性和实现汽车产业可持续发展的有效路径。在中国，通过”九五”、“十五”和”十一五”期间国家科技计划的持续支持和能源基金组织等国际社会的帮助，电动汽车技术的... 详细信息

电动汽车是在减少对化石燃料依赖和环境污染的同时，确保人类移动灵活性和实现汽车产业可持续发展的有效路径。在中国，通过”九五”、“十五”和”十一五”期间国家科技计划的持续支持和能源基金组织等国际社会的帮助，电动汽车技术的开发及产业化工作得以不断深入，并得到国际社会的广泛认可。

关键词：电动汽车汽车发展 hev 变速器离合器借鉴国家科技计划汽车产业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于模拟退火粒子群算法的混合动力车参数优化

引用

汽车工程 2012年第7期34卷 580-584页

作者：邓元望陈可亮鄂加强湖南大学机械与运载工程学院长沙410082

分别采用多层次参数扫描(MLPS)算法和模拟退火粒子群优化(SAPSO)算法对并联式混合动力车逻辑门限控制策略的参数进行优化。将优化后的车辆以TeST-CITY-HWY测试循环进行仿真,并将结果与优化前的车辆的仿真结果进行对比。结果表明,经MLPS... 详细信息

分别采用多层次参数扫描(MLPS)算法和模拟退火粒子群优化(SAPSO)算法对并联式混合动力车逻辑门限控制策略的参数进行优化。将优化后的车辆以TeST-CITY-HWY测试循环进行仿真,并将结果与优化前的车辆的仿真结果进行对比。结果表明,经MLPS算法优化后,燃油消耗和HC与nOx排放分别下降了11.98%、6.01%和4.03%,但CO排放增加了25.18%;经SAPSO算法优化后,燃油消耗和HC、CO与nOx排放分别下降了13.61%、9.57%、27.78%和18.53%,且电池荷电状态(SOC)比MLPS优化略高。说明SAPSO算法在混合动力车控制参数优化效果上明显优于MLPS算法。

关键词：模拟退火粒子群算法控制策略参数优化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Screening Outcomes of Hepatitis B and e among HIV Patients on HAART in Osogbo, South Western nigeria

引用

World Journal of AIDS 2016年第4期6卷 205-217页

作者： Bolaji e. egbewale Victor O. Mabayoje M. A. Muhibi A. F. Mustapha Calistus A. Akinleye Department of Community Health College of Health Sciences Ladoke Akintola University of Technology Osogbo Nigeria Department of Haematology and Blood Transfusion College of Health Sciences Ladoke Akintola University of Technology Osogbo Nigeria Department of Haematology LAUTECH Teaching Hospital Osogbo Nigeria Department of Medicine LAUTECH Teaching Hospital Osogbo Nigeria

Background: The lives of patients living with HIV/AIDs have improved in terms of longer life expectancy and quality. This has seen the emergence of complications of the disease and the drugs such as metabolic syndrome and re-emergence of tuberculosis. Co-infection with other viruses especially the hepatic viruses has also become a major source of concern. The aim of this research is to determine the incidence of hepatitis B and e among this group of patients. Methods and Findings: Blood samples were collected from 156 consecutive HIV positive patients on HAART, informed consent having been obtained previously. The patients were screened both for hepatitis B and e using standard procedures. A questionnaire was administered to all participants. The results are illustrated with tables following analysis with SPSS version 10. It was found that 24.5% were positive for hepatitis e while 7.8% were positive for hepatitis B. It was also found that educational status was the only statistical significant variable for hev co-infection. Taking the value of alanine transaminase to be 12 U/L as upper limit of normal, the mean value for hev positive patients obtained was 13.8U/L while for those HBV positive was 10U/L. Conclusion: From the findings, more emphasis should be placed on improving education of the populace. More research should be carried out to determine what subtypes of the viruses are present and their effects on the hepatic system using preferably non-invasive techniques. Also the variability of hepatic enzymatic activity needs more analysis.

关键词： Aids Transmission Viral HAART Hepatic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混合电动车辆复式电力机械无级变速器的控制策略

引用

传动技术 2010年第2期24卷 20-32页

作者： n-D Kim J-M Kim H-S Kim 谷雨 School of Mechanical engineering Sungkyunkwan University Suwon

本文为双型电力机械无级变速器(eVT)混合电动车辆推荐了一个操纵策略,首先,进行网络分析估算复式eVT与速比有关的效率,由网络分析发现,当功率循坏发生在电驱动变速器时,eVT效率降低,而eVT在速比范围内工作时,可提供相对高的系统的效率,... 详细信息

本文为双型电力机械无级变速器(eVT)混合电动车辆推荐了一个操纵策略,首先,进行网络分析估算复式eVT与速比有关的效率,由网络分析发现,当功率循坏发生在电驱动变速器时,eVT效率降低,而eVT在速比范围内工作时,可提供相对高的系统的效率,这就要求操纵策略应从动力系总效率观点出发而不只是内燃机的热效率。为了开发复式eVT的操纵策略,采用反向基础控制求出包括eVT的hev动力系的动力学方程式,以及指定马达转矩控制算法。在hev动力系动态模型的基础上,采用Cruise和MAT-LAB/Simulink开发了一个hev模拟器。该模拟结果指出,本文推荐的操纵策略可以操纵发动机在预定速比范围内具有相对高的效率,它比常规控制方法提供的燃油经济性有所改进。这是基于变速器效率可以用于hev复式eVT设计要求的操纵策略。

关键词：电力机械无级变速器复式混合电动车辆网络分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：