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矿业工程 1979年第1期 1-7+17页

作者： H.P.Knudsen Y.C.Kim e.mueller 宋彦琦

本文叙述了地质统计学的矿石储量估算方法与其他三种传统方法——多边形法、距离倒数平方法(IDS)以及同距离倒数平方法相类似的一种修正法(eLIP)的对比研究结果。用上述各种方法对亚利桑那州图克逊市附近的碧玛铜矿在同一个阶段中的各... 详细信息

本文叙述了地质统计学的矿石储量估算方法与其他三种传统方法——多边形法、距离倒数平方法(IDS)以及同距离倒数平方法相类似的一种修正法(eLIP)的对比研究结果。用上述各种方法对亚利桑那州图克逊市附近的碧玛铜矿在同一个阶段中的各块段的品位子测结果,检验了每种方法的精确度。从碧玛铜矿的对比结果表明:在予测块段品位和矿石总吨量方面,地质统计学方法与eLIP法或IDS法相比较不差土下,而多边形法则显然最差。但如果在块段模型中已经考虑并包含了矿体的地质因素,则上述所有方法都能获得较好的结果,对于已经在生产的矿山来说,选用eLIP法或IDS法可能是比较好的,因为这两种方法占用电子计算机的时间较少,可以显著地节省运算费用。对于一个勘探的矿区或新矿区来说,由于地质统计学方法能够给出估算值的置信限,因而选用这种方法就具有更多的优越。

关键词：平均差平均绝对变率矿石储量地质统计学品位修正法权数

基于ReaxFF反应力场的多元金属氧化物（MMO）MoVNbTeO结构解析及丙烯氨氧化制丙烯腈的催化机理研究

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基于ReaxFF反应力场的多元金属氧化物（MMO）MoVNbTeO结构解析及...

The transcription factor HSFA7b controls thermomemory at the shoot apical meristem by regulating ethylene biosynthesis and signaling in Arabidopsis

第十六届全国分子筛大会

作者：刘连池孙淮 Jonathan e.mueller Robert J.Nielsen William A Goddard III 上海交通大学化学化工学院学院 Materials and Process Simulation Center California Institute of Technology

＜正＞多元金属氧化物（MMO）Mo VNb Te O是工业上丙烯制丙烯腈重要的催化剂。但是由于晶体结构中的多个位点由Mo,V,Nb混合占据,难以获得晶体结构中各金属的确切分布,从而难以对催化机理进行研究。我们运用Reax FF反应力场和蒙特卡洛-...

＜正＞多元金属氧化物（MMO）Mo VNb Te O是工业上丙烯制丙烯腈重要的催化剂。但是由于晶体结构中的多个位点由Mo,V,Nb混合占据,难以获得晶体结构中各金属的确切分布,从而难以对催化机理进行研究。我们运用Reax FF反应力场和蒙特卡洛-反应动力学（Reax FF-MC-RD）算法对多元金属氧化物Mo VNb Te O的结构进行了解析,并在此基础上对丙烯氨氧化制丙烯腈的催化反应机理做了初步探讨。

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Plant Communications 2024年第3期5卷 47-61页

作者： Sheeba John Federico Apelt Amit Kumar Ivan FAcosta Dominik Bents Maria Grazia Annunziata Franziska Fichtner Caroline Gutjahr Bernd mueller-Roeber Justyna J.Olas University of Potsdam Institute of Biochemistry and BiologyKarl-Liebknecht-Straße 24-25Haus 2014476 PotsdamGermany Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 114476 PotsdamGermany Laboratory of Molecular Biology Wageningen University6700 AP Wageningenthe Netherlands Center of Plant Systems Biology and Biotechnology(CPSBB) 14 St.Knyaz Boris 1 Pokrastitel Str.4023 PlovdivBulgaria Present address:Institute of Plant Biochemistry Heinrich Heine University DusseldorfUniversit€atsstr.140225 DusseldorfGermany Leibniz Institute of Vegetable and Ornamental Crops Theodor-Echtermeyer-Weg 114979 GroßbeerenGermany

The shoot apical meristem(SAM)is responsible for overall shoot growth by generating all aboveground *** research has revealed that the SAM displays an autonomous heat stress(HS)memory of a previous non-lethal HS *** the importance of the SAM for plant growth,it is essential to determine how its thermomemory is mechanistically ***,we report that HeAT SHOCK TRAN-SCRIPTION FACTOR A7b(HSFA7b)plays a crucial role in this process in Arabidopsis,as the absence of functional HSFA7b results in the temporal suppression of SAM activity after *** found that HSFA7b directly regulates ethylene response at the SAM by binding to the promoter of the key ethylene signaling gene eTHYLeNe-INSeNSITIVe 3 to establish ***,we demonstrated that HSFA7b regulates the expression of eTHYLeNe OVeRPRODUCeR 1(eTO1)and eTO1-LIKe 1,both of which encode ethylene biosynthesis repressors,thereby ensuring ethylene homeostasis at the *** together,these results reveal a crucial and tissue-specic role for HSFA7b in thermomemory at the Arabidopsis SAM.

关键词： ethylene response heat stress adaptation shoot apical meristem SAM thermopriming thermomemory

experimental Interactions Between Clay Minerals and Bacteria: A Review

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Pedosphere 2015年第6期25卷 799-810页

作者： Barbara mueller Clay Mineralogy Group Institute for Geotechnical EngineeringETH Zurich Plant Pathology Institute of Integrative BiologyETH Zurich

Interactions between microbes and minerals have the potential to contribute significantly to global cycles of various processes and serve as a link between the geosphere and life. Clays and clay minerals occur commonly in agriculturally utilized soils, are naturally grown underground （soil and rock） and are used in construction material. Clay minerals serve as natural, geological and technical barriers in geotechnics and environmental geotechnics. Bacteria in turn are ubiquitous in natural soils, subsoils and rocks and are in permanent contact with clay minerals. There are numerous ways in which bacteria can interact with clay minerals and alter them： dissolution, refinement and transformation, reduction of trace elements incorporated in the clay minerals and uptake of trace elements from these minerals, e.g., by the production of siderophores and chelators and enhancement or reduction of azisorbance of trace elements on clay minerals. In addition, bacteria can influence layer charge, cation exchange capacity （CeC）, exchangeable cations, Brunauer-emmett-Teller surface, swelling and the rheological properties of clay minerals. The field of clay mineral-microorganism interaction is still wide open because of the large potential that the interactions of bacteria with clay minerals in soils and sediments may result in changes in clay mineral properties and behaviors. Fhrther detailed studies on all these tentative changes and underlying mechanisms as well as broad surveys of quantifications of extents and rates of clay mineral-microorganism interactions, especially in mimicking natural systems, are highly required. This review summarizes the influences of various bacteria on the properties of different clay minerals as determined experimentally using viable bacteria.

关键词： bacterium dissolution microbes reduction trace elements

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Cachexia and pancreatic cancer: Are there treatment options?

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World Journal of Gastroenterology 2014年第28期20卷 9361-9373页

作者： Tara C mueller Marc A Burmeister Jeannine Bachmann Marc e Martignoni Department of Surgery University Hospital Rechts der IsarTechnical University of Munich Braun Melsungen AG/Department of Anesthesiology University Hospital Hamburg Eppendorf

Cachexia is frequently described in patients with pancreatic ductal adenocarcinoma (PDAC) and is associated with reduced survival and quality of life. Unfortunately, the therapeutic options of this multi-factorial and complex syndrome are limited. This is due to the fact that, despite extensive preclinical and clinical research, the underlying pathological mechanisms leading to PDAC-associated cachexia are still not fully understood. Furthermore, there is still a lack of consensus on the definition of cachexia, which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature. In order to provide an efficient therapy for cachexia, an early and reliable diagnosis and consistent monitoring is required, which can be challenging especially in obese patients. Although many substances have been tested in clinical and preclinical settings, so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia. However, recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancer-associated cachexia and ultimately improve patients’ outcome. In this current review, we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients. This strategy consists of nutritional, dietary, pharmacological, physical and psychological methods.

关键词： Cachexia Pancreatic neoplasms Nutritional support Gastrointestinal neoplasms

Pharmacological blockage of CYP2e1 and alcohol-mediated liver cancer: is the time ready?

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Chinese Journal of Cancer Research 2013年第3期25卷 269-271页

作者： Sebastian mueller Department of Medicine and Alcohol Research Center Salem Medical Center University of Heidelberg

Chronic alcohol consumption is a major risk factor worldwide affecting significantly both mortality and years of life lost （YLL）（1）. Ca. 5% of the western world show risky alcohol consumption and in some countries such as China a regional yearly increase of alcohol consumption of over 400% has been observed recently （2,3）. The liver is the major target organ of alcohol. According to the recently published ＇Global Burden of Disease Study 2010, liver cirrhosis and liver cancer are ranked at position 12 and 16 in the global deaths statistics （1）. Thus, in 2010, ca. 1 million people died from liver cirrhosis with one third directly attributable to alcohol. This is a considerable number when comparing with coronary heart disease with 7 million deaths and the leading cause of mortality. In central europe, liver cirrhosis even ranks at the fourth position in YLL. Hepatocellular cancer （HCC） is now the most common fatal complication of patients with alcoholic cirrhosis. Moreover, it shows the second fastest increase of all tumors worldwide after kidney tumors and alcohol-associated HCC ranks on third position after HCCs caused by viral hepatitis B and C.

关键词： CYP Pharmacological blockage of CYP2e1 and alcohol-mediated liver cancer is the time ready time

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Friction predication on pin-to-plate interface of PTFe material and steel

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Friction 2019年第3期7卷 268-281页

作者： Zhuming BI Donald W.mueller Depatment of Civil and Mechnical engineering Purdue University Fort WayneFort Wayne2101EUSA School of Mechanical and electrical engineering GuangDong University of TechnologyGuangzhou510006China

In this paper,the friction behavior at a pin-to-plate interface is *** pin and plate are made of Polytetrafluoroethylene(PTFe) and steel,respectively,and there is a reciprocating motion at the *** mathematical models for the relations of design variables and frictions are investigated,and a general procedure is proposed to solve the developed models and predict the friction forces at the interface subjected to given test *** models have been developed to represent intrigued friction behaviors affected by various factors such as pin geometrics and finishes,lubrication conditions,and reciprocating *** test data from experiments is used to verify the effectiveness of the proposed models.

关键词： pin-to-plate friction wear coefficient of frictions PTFe sealing finite element analysis

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Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?

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World Journal of Gastroenterology 2012年第26期18卷 3379-3388页

作者： Sophia Fu Albert Stanek Cathy M mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael e Zenilman Department of Surgery SUNY Downstate Medical SchoolBrooklynNY 11203United States Department of Pathology Wayne State UniversityDetroitMI 48202United States Department of Surgery Johns Hopkins School of Medicine and SUNY Downstate School of Public HealthBethesdaMD 20814United States

AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).MeTHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old *** and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal ***:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± Se histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P ecreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P eased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P ecreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical *** were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 ***,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P er animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course.

关键词： Acute pancreatitis Aging Rats Pancreati-tis-associated protein Molecular biology

Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with electrical excitability

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Molecular Plant 2016年第3期9卷 428-436页

作者： J. Bohm S. Scherzer S. Shabala e. Krol e. Neher T.D. mueller R. Hedrich Julius-yon-Sachs Institute Department for Molecular Plant Physiology and Biophysics University of Wurzburg Julius-von-Sachs Platz 2 97082 Wurzburg Germany School of Land and Food University of Tasmania Hobart TAS 7001 Australia Zoology Department College of Science King Saud University PO Box 2455 Riyadh 11451 Saudi Arabia Department for Membrane Biophysics Max Planck Institute for Biophysical Chemistry 37077 Goettingen Germany

The animal diet of the carnivorous Venus flytrap, Dionaea muscipula, contains a sodium load that enters the capture organ via an HKT1-type sodium channel, expressed in special epithelia cells on the inner trap lobe surface. DmHKT1 expression and sodium uptake activity is induced upon prey contact. Here, we analyzed the HKT1 properties required for prey sodium osmolyte management of carnivorous Dionaea. Analyses were based on homology modeling, generation of model-derived point mutants, and their functional testing in Xenopus oocytes. We showed that the wild-type HKT1 and its Na^＋- and K^＋-permeable mutants function as ion channels rather than K^＋ transporters driven by proton or sodium gradients. These structural and biophysical features of a high-capacity, Na^＋-selective ion channel enable Dionaea glands to manage prey-derived sodium loads without confounding the action potential-based information management of the flytrap.

关键词： sodium channel HKT1 Dionaea muscipula action potential glands sodium uptake