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Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang mu-Qi Wang Jiang Deng Ning Gao Mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu Shuang-Suo Dang Wen-Jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using eLISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the peGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin e1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with peGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

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Adalimumab in ulcerative colitis: Two cases of mucosal healing and clinical response at two years

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World Journal of Gastroenterology 2009年第30期15卷 3814-3816页

作者： Manuel Barreiro-de Acosta Aurelio Lorenzo Juan enrique Dominguez-muoz Department of Gastroenterology University Hospital of Santiago de CompostelaC/Choupanas/nE-15706-Santiago de CompostelaSpain

Infliximab (IFX) is currently the only biologic therapy used in the treatment of moderate-to-severe ulcerative colitis (UC). In the years to come, more biologic therapies will have a role in the management of moderate-to-severe UC. We report on two patients with steroid-dependent UC who, due to adverse reactions to IFX, have been under therapy with adalimumab for two years. Both patients received concomitant immunosuppressive treatment. Long term clinical remission and mucosal healing are described.

关键词： Adalimumab Ulcerative colitis mucosalhealing Maintenance treatment

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Colon capsule endoscopy

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World Journal of Gastroenterology 2008年第34期14卷 5265-5268页

作者： Ignacio Fernandez-Urien Cristina Carretero Ana Borda Miguel muoz-Navas Department of Gastroenterology University of Navarra

Wireless capsule endoscopy has become the first imaging tool for small bowel examination. Recently, new capsule endoscopy applications have been developed, such as esophageal capsule endoscopy and colon capsule endoscopy. Clinical trials results have shown that colon capsule endoscopy is feasible, accurate and safe in patients suffering from colonic diseases. It could be a good alternative in patients refusing conventional colonoscopy or when it is contraindicated. Upcoming studies are needed to demonstrate its utility for colon cancer screening and other indications such us ulcerative colitis. Comparative studies including both conventional and virtual colonoscopy are also required.

关键词： Capsule endoscopy Colon Polyp Colon cancer Screening Colonoscopy

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Intravenous iron in inflammatory bowel disease

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World Journal of Gastroenterology 2009年第37期15卷 4666-4674页

作者： Manuel muoz Susana Gómez-Ramírez José Antonio García-erce Transfusion Medicine School of Medicine University of Málaga Málaga 29071 Spain Department of Internal Medicine University Hospital Virgen de la Victoria Málaga 29010 Spain Department of Hematology and Hemoterapy University Hospital Miguel Servet Zaragoza 50008 Spain

The prevalence of anemia across studies on patients with inflammatory bowel disease (IBD) is high (30%). Both iron defi ciency (ID) and anemia of chronic disease contribute most to the development of anemia in IBD. The prevalence of ID is even higher (45%). Anemia and ID negatively impact the patient's quality of life. Therefore, together with an adequate control of disease activity, iron replacement therapy should start as soon as anemia or ID is detected to attain a normal hemoglobin (Hb) and iron status. Many patients will respond to oral iron, but compliance may be poor, whereas intravenous (IV) compounds are safe, provide a faster Hb increase and iron store repletion, and presents a lower rate of treatment discontinuation. Absolute indications for IV iron treatment should include severe anemia, intolerance or inappropriate response to oral iron, severe intestinal disease activity, or use of an erythropoietic stimulating agent. Four different products are principally used in clinical practice, which differ in their pharmacokinetic properties and safety profi les: iron gluconate and iron sucrose (lower single doses), and iron dextran and ferric carboxymaltose (higher single doses). After the initial resolution of anemia and the repletion of iron stores, the patient's hematological and iron parameters should be carefully and periodically monitored, and maintenance iron treatment should be provided as required. New IV preparations that allow for giving 1000-1500 mg in a single session, thus facilitating patient management,provide an excellent tool to prevent or treat anemia and ID in this patient population, which in turn avoids allogeneic blood transfusion and improves their quality of life.

关键词： Inflammatory bowel disease Anemia Iron deficiency Functional iron deficiency erythropoiesisstimulating agents Oral iron Intravenous iron

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Role of videocapsule endoscopy for gastrointestinal bleeding

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World Journal of Gastroenterology 2008年第34期14卷 5261-5264页

作者： Cristina Carretero Ignacio Fernandez-Urien Maite Betes Miguel muoz-Navas Department of Gastroenterology University of Navarra

Obscure gastrointestinal bleeding (OGIB) is defi ned as bleeding of an unknown origin that persists or recurs after negative initial upper and lower endoscopies. Several techniques, such as endoscopy, arteriography, scintigraphy and barium radiology are helpful for recognizing the bleeding source; nevertheless, in about 5%-10% of cases the bleeding lesion cannot be determined. The development of videocapsule endoscopy (VCe) has permitted a direct visualization of the small intestine.mucosa. We will analyze those techniques in more detail. The diagnostic yield of Ce for OGIB varies from 38% to 93%, being in the higher range in those cases with obscure-overt bleeding.

关键词： Capsule endoscopy Bleeding Small bowel Obscure Hemorrhage

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[As_(3)M(As_(3)Pb_(3))]^(3−)(M=Nb,Ta):Ternary Heterometallic Clusters with early Transition Metal Atoms and Aromatic[Pb_(3)]^(2−)

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Chinese Journal of Chemistry 2021年第7期39卷 1953-1957页

作者： Cong-Cong Shu Lei Qiao Alvaro muñoz-Castro Zhong-Ming Sun Tianjin Key Lab for Rare earth Materials and Applications State Key Laboratory of Elemento-Organic ChemistrySchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Grupo de Química Inorgánicay Materiales Moleculares Facultad de IngenieriaUniversidad Autonoma de ChileEl Llano SubercaseauxSantiago2801 Chile

Main observation and conclusion Two ternary clusters,[As_(3)Nb(As_(3)Pb_(3))]^(3−)1 and[As_(3)Ta(As_(3)Pb_(3))]^(3−)2,were directly extracted from“K_(8)NbPbAs_(5)”and“K_(8)TaPbAs_(5)”intermetallic solid in the presence of ethylenediamine and 2.2.2-crypt,*** 1 and 2,comprising an electron-poor early transition metal-atom Nb or Ta coordinated to a As3 triangle and a bowl-like As_(3)Pb_(3).

关键词： Cluster compounds Aromaticity Zintl anions DFT calculation Sandwich structure

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Profibrotic role of the SOX9-MMP10-eCM biosynthesis axis in the tracheal fibrosis after injury and repair

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Genes & Diseases 2024年第5期11卷 360-373页

作者： Lei Gu Anmao Li Chunyan He Rui Xiao Jiaxin Liao Li Xu Junhao mu Xiaohui Wang Mingjin Yang Jinyue Jiang Yang Bai Xingxing Jin Meiling Xiao Xia Zhang Tairong Tan Yang Xiao Jing Lin Yishi Li Shuliang Guo Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Fibroblast activation and extracellular matrix(eCM)deposition play an important role in the tracheal abnormal repair process and *** a transcription factor,SOX9 is involved in fibroblast activation and eCM ***,the mechanism of how SOX9 regulates fibrosis after tracheal injury remains *** investigated the role of SOX9 in TGF-b1-induced fibroblast activation and eCM deposition in rat tracheal fibroblast(RTF)***9 overexpression adenovirus(Ad-SOX9)and siRNA were transfected into RTF *** found that SOX9 expression was up-regulated in RTF cells treated with ***9 overexpression activated fibroblasts and promoted eCM *** SOX9 inhibited cell proliferation,migration,and eCM deposition,induced G2 arrest,and increased apoptosis in RTF ***-seq and chromatin immunoprecipitation sequencing(ChIP-seq)assays identified MMP10,a matrix metalloproteinase involved in eCM deposition,as a direct target of SOX9,which promotes eCM degradation by increasing MMP10 expression through the Wnt/b-catenin signaling ***,in vivo,SOX9 knockdown ameliorated granulation proliferation and tracheal fibrosis,as manifested by reduced tracheal *** conclusion,our findings indicate that SOX9 can drive fibroblast activation,cell proliferation,and apoptosis resistance in tracheal fibrosis via the Wnt/b-catenin signaling *** SOX9eMMP10 eeCM biosynthesis axis plays an important role in tracheal injury and *** SOX9 and its downstream target MMP10 may represent a promising therapeutic approach for tracheal fibrosis.

关键词： extracellular matrix deposition Fibroblast activation MMP10 SOX9 Tracheal fibrosis

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基于PLUS-InVeST模型的天山北坡生态系统碳储量时空变化与预测

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干旱区研究 2024年第7期41卷 1228-1237页

作者：张顺鑫吴子豪闫庆武李桂娥牟守国中国矿业大学公共管理学院江苏徐州221116

土地利用变化作为影响陆地生态系统碳储量的重要因素,研究两者间的关系对维持区域碳平衡和实现双碳目标具有重要意义。基于第三次新疆综合科学考察背景,分析天山北坡1990年、2000年、2010年、2020年土地利用变化与碳储量的定量关系,结合... 详细信息

土地利用变化作为影响陆地生态系统碳储量的重要因素,研究两者间的关系对维持区域碳平衡和实现双碳目标具有重要意义。基于第三次新疆综合科学考察背景,分析天山北坡1990年、2000年、2010年、2020年土地利用变化与碳储量的定量关系,结合PLUS和InVeST模型,模拟在历史趋势、水资源保护和经济发展3种情景下2030年区域碳储量的空间格局。结果表明:(1)草地和裸地是天山北坡主要土地覆被类型,1990—2020年耕地、林地、水域、建设用地和湿地面积增加,耕地面积增加最多,其余土地利用类型面积减少,草地减少最多。(2)1990—2020年天山北坡碳储量呈“先升后降”趋势,草地、裸地、耕地和林地间的转化是总碳储量变化的主要成因。(3)3种情景下碳储量均低于2020年水平,经济发展情景减幅最为显著,草地减少、裸地增加是碳损失的主要原因。

关键词：土地利用变化碳储量 PLUS模型 InVeST模型天山北坡

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Role of cytokines in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第27期14卷 4280-4288页

作者： Fausto Sanchez-muoz Aaron Dominguez-Lopez Jesus K Yamamoto-Furusho Inflammatory Bowel Disease Clinic Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 colonia Sección XVI

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), rep- resents a group of chronic disorders characterized by inflammation of the gastrointestinal tract, typically with a relapsing and remitting clinical course. mucosal mac- rophages play an important role in the.mucosal im- mune system, and an increase in the number of newly recruited monocytes and activated macrophages has been noted in the inflamed gut of patients with IBD. Activated macrophages are thought to be major con- tributors to the production of inflammatory cytokines in the gut, and imbalance of cytokines is contributing to the pathogenesis of IBD. The intestinal inflammation in IBD is controlled by a complex interplay of innate and adaptive immune mechanisms. Cytokines play a key role in IBD that determine T cell differentiation of Th1, Th2, T regulatory and newly described Th17 cells. Cytokines levels in time and space orchestrate the development, recurrence and exacerbation of the inflammatory process in IBD. Therefore, several cyto- kine therapies have been developed and tested for the treatment of IBD patients.

关键词： Cytokines Inflammatory bowel disease Crohn's disease Ulcerative colitis Inflammation

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Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity

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Neural Regeneration Research 2022年第9期17卷 1861-1866页

作者： Juan Segura-Aguilar Bengt Mannervik JoséInzunza mukesh Varshney Ivan Nalvarte Patricia muñoz Molecular and Clinical Pharmacology ICBM Faculty of Medicine University of Chile SantiagoChile Department of Biochemistry and Biophysics Arrhenius LaboratoriesStockholm UniversityStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetStockholmSweden Nucleo de Química y Bioquímica Facultad de Estudios InterdisciplinariosUniversidad MayorSantiagoChile

Astrocytes protect neurons by modulating neuronal function and *** support neurons in several *** provide energy through the astrocyte-neuron lactate shuttle,protect neurons from excitotoxicity,and internalize neuronal lipid droplets to degrade fatty acids for neuronal metabolic and synaptic support,as well as by their high capacity for glutamate uptake and the conversion of glutamate to glutamine.A recent reported astrocyte system for protection of dopamine neurons against the neurotoxic products of dopamine,such as aminochrome and other o-quinones,were generated under neuromelanin synthesis by oxidizing dopamine catechol *** secrete glutathione transferase M2-2 through exosomes that transport this enzyme into dopaminergic neurons to protect these neurons against aminochrome *** role of this new astrocyte protective mechanism in Parkinson´s disease is discussed.

关键词： aminochrome astrocytes dopamine dopaminergic neurons exosomes glutathione transferase M2-2 neuroprotection Parkinson’s disease

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