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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

BSeC Method for Unveiling Open Clusters and its Application to Gaia DR3:83 New Clusters

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Research in Astronomy and Astrophysics 2024年第5期24卷 169-184页

作者： Zhong-mu Li Cai-Yan Mao Institute of Astronomy and Information Dali UniversityDali 671003China

Open clusters(OCs) are common in the Milky Way, but most of them remain undiscovered. There are numerous techniques, including some machine-learning algorithms, available for the exploration of OCs. However, each method has its limitations and therefore, different approaches to discovering OCs hold significant values. We develop a comprehensive approach method to automatically explore the data space and identify potential OC candidates with relatively reliable membership determination. This approach combines the techniques of Hierarchical Density-Based Spatial Clustering of Applications with Noise, Gaussian mixture model, and a novel cluster member identification technique, color excess constraint. The new method exhibits efficiency in detecting OCs while ensuring precise determination of cluster memberships. Because the main feature of this technique is to add an extra constraint(eC) for the members of cluster candidates using the homogeneity of color excess,compared to typical blind search codes, it is called Blind Search-extra Constraint(BSeC) method. It is successfully applied to the Gaia Data Release 3, and 83 new OCs are found, whose color–magnitude diagrams(CMDs) are fitted well to the isochrones. In addition, this study reports 621 new OC candidates with discernible main sequence or red giant branch. It is shown that BSeC technique can discard some false negatives of previous works, which takes about three percentage of known clusters. It shows that as an eC, the color excess(or twocolor) constraint is useful for removing fake cluster member stars from the clusters that are identified from the positions and proper motions of stars, and getting more precise CMDs, when differential reddening of member stars of a cluster is not large(e.g., Δe(G_(BP)-G_(RP)) es the CMDs of 15% clusters clearer(in particular for the region near turnoff) and therefore is helpful for CMD and stellar population studies. Our result suggests that the color excess con

关键词： Galaxy stellar content-(Galaxy:)open clusters and associations general-stars fundamental parameters

Thermal conductivity of iron under the earth’s inner core pressure

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Chinese Physics B 2024年第10期33卷 343-348页

作者： Cui-e Hu mu-Xin Jiao Xue-Nan Yang Zhao-Yi Zeng Jun Chen College of Physics and electronic engineering Chongqing Normal UniversityChongqing 400047China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Center for Applied Physics and Technology Peking UniversityBeijing 100071China

The thermal conductivity ofε-iron at high pressure and high temperature is a key parameter to constrain the dynamics and thermal evolution of the earth’s *** this work,we use first-principles calculations to study the Hugoniot sound velocity and the thermal transport properties ofε-*** total thermal conductivity considering lattice vibration is 200 W/mK at the earth’s inner core *** suppressed anharmonic interactions can significantly enhance the lattice thermal conductivity under high pressure,and the contribution of the lattice thermal conductivity should not be ignored under the earth’s core conditions.

关键词： thermal conductivity first-principles high pressure and high temperature

Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHeIA-SeOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHeIA-Spanish Society of Medical Oncology(SeOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SeOM Real World-evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRIents with>5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

High-Order Two-Scale Asymptotic Paradigm for the elastodynamic Homogenization of Periodic Composites

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Acta Mechanica Solida Sinica 2024年第1期37卷 124-138页

作者： Wei-Zhi Luo mu He Liang Xia Qi-Chang He State Key Laboratory of Intelligent Manufacturing equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Laboratoire Modélisation et Simulation multi-echelle MSME UMR 8208 CNRSUniversite Gustave Eiffel77454 Marne-la-ValléeFrance

The classical two-scale asymptotic paradigm provides macroscopic and microscopic analyses for the elastodynamic homogenization of periodic composites based on the spatial or/and temporal variable,which offers an approximate framework for the asymptotic homogenization analysis of the motion ***,in this framework,the growing complexity of the homogenization formulation gradually becomes an obstacle as the asymptotic order *** such a context,a compact,fast,and accurate asymptotic paradigm is *** work reviews the high-order spatial two-scale asymptotic paradigm with the effective displacement field representation and optimizes the implementation by symmetrizing the tensor to be ***,the modified implementation gets rid of the excessive memory consumption required for computing the high-order tensor,which is demonstrated by representative one-and two-dimensional *** numerical results show that(1)the contrast of the material parameters between media in composites directly affects the convergence rate of the asymptotic results for the homogenization of periodic composites,(2)the convergence error of the asymptotic results mainly comes from the truncation error of the modified asymptotic homogenized motion equation,and(3)the excessive norm of the normalized wavenumber vector in the two-dimensional inclusion case may lead to a non-convergence of the asymptotic results.

关键词： Composites Homogenization Asymptotic analysis Dynamics Dispersion

Vermicompost:In situ retardant of antibiotic resistome accumulation in cropland soils

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Journal of environmental Sciences 2024年第7期141卷 277-286页

作者： Meirui mu Fengxia Yang Bingjun Han Guisheng Tian Keqiang Zhang Agro-environmental Protection Institute Ministry of Agriculture and Rural AffairsTianjin 300191China Key Laboratory of Low-carbon Green Agriculture in North China Ministry of Agriculture and Rural Affairs P.R.ChinaBeijing 10083China Wuxue City Agriculture and Rural Bureau Wuhan 435400China

The dissemination of antibiotic resistance genes(ARGs)in soil has become a global environmental *** is gaining prominence in agricultural practices as a soil amendment to improve soil ***,its impact on soil ARGs remains unclear when it occurs in *** comprehensively explored the evolution and fate of ARGs and their hosts in the field soil profiles under vermicompost application for more than *** application increased several ARG loads in soil environment but decreased the high-risk bla-ARGs(bla_(ampC),bla_(NDM),and bla_(GeS-1))by log(0.04-0.43).ARGs in soil amended with vermicompost primarily occurred in topsoil(approximately 1.04-fold of unfertilized soil),but it is worth noting that their levels in the 40-60 cm soil layer were the same or even less than in the unfertilized *** microbial community structure changed in soil profiles after vermicompost *** application altered the microbial community structure in soil profiles,showing that the dominant bacteria(i.e.,Proteobacteria,Actinobacteriota,Firmicutes)were decreased 2.62%-5.48%with the increase of soil depth.A network analysis further revealed that most of ARG dominant host bacteria did not migrate from surface soil to deep *** particular,those host bacteria harboring high-risk bla-ARGs were primarily concentrated in the surface *** study highlights a lower risk of the propagation of ARGs caused by vermicompost application and provides a novel approach to reduce and relieve the dissemination of ARGs derived from animals in agricultural production.

关键词： Vermicompost application Antibiotic resistance genes Vertical migration Soil profile Agricultural soils

BACNN: multi-scale feature fusion-based bilinear attention convolutional neural network for wood NIR classification

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Journal of Forestry Research 2024年第4期35卷 202-214页

作者： Zihao Wan Hong Yang Jipan Xu Hongbo mu Dawei Qi College of Science Northeast Forestry UniversityHarbin 150040People’s Republic of China

effective development and utilization of wood resources is *** modification research has become an integral dimension of wood science research,however,the similarities between modified wood and original wood render it challenging for accurate identification and classification using conventional image classification ***,the development of efficient and accurate wood classification techniques is *** paper presents a one-dimensional,convolutional neural network(i.e.,BACNN)that combines near-infrared spectroscopy and deep learning techniques to classify poplar,tung,and balsa woods,and PVA,nano-silica-sol and PVA-nano silica sol modified woods of *** results show that BACNN achieves an accuracy of 99.3%on the test set,higher than the 52.9%of the BP neural network and 98.7%of Support Vector Machine compared with traditional machine learning methods and deep learning based methods;it is also higher than the 97.6%of LeNet,98.7%of AlexNet and 99.1%of ***,the classification method proposed offers potential applications in wood classification,especially with homogeneous modified wood,and it also provides a basis for subsequent wood properties studies.

关键词： Wood classification Near infrared spectroscopy Bilinear network Se module Anti-noise algorithm

Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

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World Journal of Diabetes 2024年第4期15卷 758-768页

作者： enriqueta muñoz-Islas edgar David Santiago-SanMartin eduardo Mendoza-Sánchez Héctor Fabián Torres-Rodríguez Laura Yanneth Ramírez-Quintanilla Christopher Michael Peters Juan Miguel Jiménez-Andrade Unidad Académica multidisciplinaria Reynosa-Aztlán Universidad Autónoma de TamaulipasReynosa 88740TamaulipasMexico Department of Anesthesiology Wake Forest University School of MedicineWinston SalemNC 27101United States

BACKGROUND Prolonged fetal exposure to hyperglycemia may increase the risk of developing abnormal glucose metabolism and type-2 diabetes during childhood,adolescence,and adulthood;however,the mechanisms by which gestational diabetes mellitus(GDM)predisposes offspring to metabolic disorders remain *** To quantify the nerve axons,macrophages,and vasculature in the pancreas from adult offspring born from mouse dams with *** GDM was induced by *** of streptozotocin(STZ)in ICR mouse *** 12 wk old,fasting blood glucose levels were determined in *** 15 wk old,female offspring born from dams with and without GDM were sacrificed and pancreata were processed for *** quantified the density of sensory[calcitonin gene-related peptide(CGRP)]and tyrosine hydroxylase(TH)axons,blood vessels(endomucin),and macro-phages(CD68)in the splenic pancreas using confocal *** Offspring mice born from STZ-treated dams had similar body weight and blood glucose values compared to offspring born from vehicle-treated ***,the density of CGRP+and TH+axons,endomucin+blood vessels,and CD68+macrophages in the exocrine pancreas was significantly greater in offspring from mothers with GDM vs control ***,the microvasculature in the islets was significantly greater,but not the number of macrophages within the islets of offspring born from dams with GDM compared to control *** GDM induces neuronal,vascular,and inflammatory changes in the pancreas of adult progeny,which may partially explain the higher propensity for offspring of mothers with GDM to develop metabolic diseases.

关键词： Gestational diabetes mellitus Immunohistochemistry Confocal microscopy Pancreas Offspring

endoscopic vacuum assisted closure therapy for esophagopericardial fistula in a 16-year-old male:A case report

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World Journal of Gastrointestinal endoscopy 2024年第9期16卷 533-539页

作者： Simón muñoz-González Samir Quejada-Cuesta Daniel González-Arroyave Carlos M Ardila Department of Surgery University of AntioquiaMedellin 050010AntioquiaColombia Department of Surgery Pontificia Universidad BolivarianaMedellín 050031AntioquiaColombia Department of Basic Sciences University of AntioquiaMedellín 050010AntioquiaColombia

BACKGROUND esophagopericardial fistula(ePF)is a rare,life-threatening condition with limited scientific literature and no established management *** case report highlights a successful multidisciplinary approach and the innovative use of endoscopic vacuum assisted closure(endoVAC)therapy in treating this complex *** SUMMARY A 16-year-old male with a history of esophageal atresia and colon interposition presented with progressive chest pain,fever,and *** revealed an ePF with associated pleural and pericardial *** management with an esophageal stent failed,prompting the use of an endoVAC *** patient underwent multiple endoVAC device changes and received broad-spectrum antibiotics and nutritional *** fistula successfully closed,and the patient recovered,demonstrating no new symptoms at a 6-month *** endoVAC therapy can effectively manage ePF,providing a minimally invasive treatment option.

关键词： esophagopericardial fistula endoscopic vacuum assisted closure esophageal atresia multidisciplinary approach Pleural effusion Case report

退行性帕金森综合征中脑和脑桥MRI形态分析及其与临床和CSF相关性的初步研究

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国际医学放射学杂志 2023年第5期 618-618页

作者： C.Painous S.Pascual-Diaz e.mu?oz-Moreno V.Sánchez J.C.Pariente A.Prats-Galino 王聪惠高丽娟

摘要目的分析神经退变性帕金森综合征病人和对照组（CS）的脑干MRI形态，探讨其与临床和脑脊液（CSF）指标的相关性。方法收集84例受试者的人口统计学和临床指

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